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1. 发明申请

WO2012074234A2 FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETER AND METHOD FOR CONCENTRATING IONS FOR FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY 审中-公开
标题翻译： FOURIER变压离子共振质谱仪和用于浓缩离子的方法用于FOURIER变换离子循环共振质谱法
公开(公告)号：WO2012074234A2
公开(公告)日：2012-06-07
申请号：PCT/KR2011/008866
申请日：2011-11-21
申请人： KOREA BASIC SCIENCE INSTITUTE , CHOI, Myoung Choul , PARK, A Leum , KIM, Hyun Sik , KIM, Seung Yong , YOO, Jong Shin
发明人： CHOI, Myoung Choul , PARK, A Leum , KIM, Hyun Sik , KIM, Seung Yong , YOO, Jong Shin
IPC分类号： G01N27/62 , H01J49/26
CPC分类号： H01J49/02 , H01J49/0027 , H01J49/065 , H01J49/38
摘要： A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) includes: an ionization source generating ions; a deceleration lens, on which the ions generated by the ionization source and spatially dispersed are incident, selectively decelerating the incident ions so as to decrease the distance between the ions; and an ion cyclotron resonance cell on which the ions passing through the deceleration lens are incident. By preventing dispersing of ions due to mass difference and converging the ions using the deceleration lens, the mass range that can be measured at one time can be extended. Also, measurement sensitivity can be improved since the ions are effectively introduced to the ICR cell.
摘要翻译：傅里叶变换离子回旋共振质谱仪（FT-ICR MS）包括：产生离子的电离源; 由离子源产生的并且空间分散的离子入射的减速透镜选择性地使入射离子减速以减小离子之间的距离; 以及通过减速透镜的离子入射到其上的离子回旋共振单元。通过防止由于质量差导致的离子分散和使用减速透镜会聚离子，可以延长一次可以测量的质量范围。此外，由于离子被有效地引入ICR单元，所以可以提高测量灵敏度。

2. 发明申请

WO2011078544A3 ION INJECTOR, MASS SPECTROMETER COMPRISING THE SAME AND METHOD FOR FOCUSING IONS USING THE SAME 审中-公开
公开(公告)号：WO2011078544A3
公开(公告)日：2011-06-30
申请号：PCT/KR2010/009141
申请日：2010-12-21
申请人： KOREA BASIC SCIENCE INSTITUTE , CHOI, Myoung Choul , KIM, Hyun Sik , YOO, Jong Shin
发明人： CHOI, Myoung Choul , KIM, Hyun Sik , YOO, Jong Shin
IPC分类号： H01J37/30 , H01J49/26
摘要： An ion injector may include: a first electrode comprising a first region allowing ions to pass; and a second electrode disposed to enclose one end of the first electrode. The second electrode may include: a second region aligned with the first region to allow the ions to pass; and a protruding portion extending along the path of the ions passing through the second region. A mass spectrometer may be configured by disposing the ion injector adjacent to a skimmer.

3. 发明申请

WO2011081352A3 APPARATUS FOR ELECTROSPRAY IONIZATION AND METHOD FOR ELECTROSPRAY IONIZATION USING THE SAME 审中-公开
公开(公告)号：WO2011081352A3
公开(公告)日：2011-07-07
申请号：PCT/KR2010/009254
申请日：2010-12-23
申请人： KOREA BASIC SCIENCE INSTITUTE , KANG, Duk Jin , CHOI, Myoung Choul , YOO, Jong Shin , KIM, Hyun Sik
发明人： KANG, Duk Jin , CHOI, Myoung Choul , YOO, Jong Shin , KIM, Hyun Sik
IPC分类号： G01N27/26 , H01J49/04 , G01N33/48 , G01N33/68
摘要： An apparatus for electrospray ionization may include: a platform including an inlet port, a first channel connected to the inlet port, a second channel connected to the first channel, and an outlet port connected to the second channel; a nebulizer provided in the first channel and configured to spray inert gas to a sample sprayed into the first channel through the inlet port; and a focusing lens provided in the second channel and configured to focus ions produced from the sprayed sample toward the outlet port.

4. 发明申请

WO2007091754A1 TANDEM FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETER 审中-公开
标题翻译： TANDEM FOURIER变换离子循环共振质谱仪
公开(公告)号：WO2007091754A1
公开(公告)日：2007-08-16
申请号：PCT/KR2006/003618
申请日：2006-09-12
申请人： KOREA BASIC SCIENCE INSTITUTE , KIM, Hyun Sik , CHOI, Myoung Choul , YOO, Jong Shin
发明人： KIM, Hyun Sik , CHOI, Myoung Choul , YOO, Jong Shin
IPC分类号： G01N27/62
CPC分类号： G01N27/62
摘要： A tandem Fourier transform ion cyclotron resonance mass spectrometer is provided. In the mass spectrometer, the ions selected by a FT-ICR mass analyzer, which can perform an ion selection process and a mass measurement process with a time interval between the processes, are transmitted through an ion guide to a collision cell, which is located a predetermined distance from the FT-ICR mass analyzer, to split into fragment ions. The fragment ions are transmitted to the FT-ICR mass analyzer that measures the mass of the fragment ions. The fragment ions are generated in the collision cell 60 established separately from the FT- ICR mass analyzer 40 according to the mass spectrometer. Accordingly, It can solve various problems (e.g., the radius reduction of cyclotron motion of colliding ions, or the removal of periphery gas after generating the fragment ions) occurred in a tandem mass spectrometer using a conventional tandem-in-time mass analysis method. Also, a high resolution and hith sensitivity measurement can be achieved. Moreover, when a reagent gas instead of a collision gas in the collision cell is injected, the gas phase reaction of the selected ions and the reagent gas can be observed, and the mass of the ions generated in the gas phase reaction can be measured.
摘要翻译：提供了一种串联傅里叶变换离子回旋共振质谱仪。在质谱仪中，可以进行离子选择处理的FT-ICR质量分析器选择的离子和在处理之间的时间间隔的质量测量过程通过离子导向器传输到位于距离FT-ICR质量分析器预定的距离，以分裂为碎片离子。碎片离子传输到测量碎片离子质量的FT-ICR质量分析仪。在根据质谱仪与FT-ICR质量分析器40分开设置的碰撞单元60中产生碎片离子。因此，可以使用常规的串联质量分析方法来解决在串联质谱仪中发生的各种问题（例如，产生碰撞离子的回旋加速器运动的半径减小或产生碎片离子之后的外围气体的去除）。此外，可以实现高分辨率和高灵敏度测量。此外，当注入反应气体代替碰撞气体中的碰撞气体时，可以观察到所选择的离子和反应气体的气相反应，并且可以测量在气相反应中产生的离子的质量。

5. 发明申请

WO2012053799A1 FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETER USING ULTRA-WIDEBAND RF AMPLIFIER AND METHOD FOR IMPROVING SIGNAL OF FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETER 审中-公开
标题翻译：使用超宽带RF放大器的FOURIER变压离子共振质谱仪和改进FOURIER变换离子循环共振质谱仪的信号的方法
公开(公告)号：WO2012053799A1
公开(公告)日：2012-04-26
申请号：PCT/KR2011/007740
申请日：2011-10-18
申请人： KOREA BASIC SCIENCE INSTITUTE , CHOI, Myoung Choul , KIM, Hyun Sik , KIM, Seung Yong
发明人： CHOI, Myoung Choul , KIM, Hyun Sik , KIM, Seung Yong
IPC分类号： G01N27/62 , H01L21/265 , H05H13/00
CPC分类号： H01J49/38
摘要： A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) may include: a signal generator generating a sinusoidal, first voltage signal having a DC offset; a voltage amplifier receiving the first voltage signal from the signal generator and generating a second voltage signal by amplifying the first voltage signal; and an ion cyclotron resonance (ICR) trap receiving the second voltage signal and generating an ion cyclotron motion centered on the position determined by the DC offset.
摘要翻译：傅立叶变换离子回旋共振质谱仪（FT-ICR MS）可以包括：产生具有DC偏移的正弦，第一电压信号的信号发生器; 电压放大器，从信号发生器接收第一电压信号，并通过放大第一电压信号产生第二电压信号; 以及离子回旋共振（ICR）陷阱，其接收第二电压信号并产生以由DC偏移确定的位置为中心的离子回旋加速器运动。

6. 发明申请

WO2011081329A2 METHOD FOR DISCOVERING PHARMACOLOGICALLY ACTIVE SUBSTANCE OF NATURAL PRODUCTS USING HIGH RESOLUTION MASS SPECTROMETRY AND PHARMACOLOGICAL ACTIVITY TEST 审中-公开
标题翻译：利用高分辨质谱法和药理活性测定法发现天然产物的药理活性物质的方法
公开(公告)号：WO2011081329A2
公开(公告)日：2011-07-07
申请号：PCT/KR2010/008988
申请日：2010-12-15
申请人： KOREA BASIC SCIENCE INSTITUTE , PARK, Kyu Hwan , KIM, Hyun Sik , KWON, Kyung Hoon , YOO, Jong Shin
发明人： PARK, Kyu Hwan , KIM, Hyun Sik , KWON, Kyung Hoon , YOO, Jong Shin
IPC分类号： G01N30/72 , G01N33/15 , B01D15/08
CPC分类号： G01N30/06 , G01N30/8686 , G01N30/96 , G01N33/6848 , G01N2030/8809 , G01N2030/8813 , G01N2500/00 , Y10T436/174614 , Y10T436/24 , Y10T436/25 , Y10T436/25375
摘要： Disclosed is a method for discovering pharmacologically active substances from natural products at high speed, including: obtaining an activity profile by testing pharmacological activity of a plurality of samples; obtaining a mass profile based on a mass spectrum resulting from analysis of the samples by mass spectrometry; and determining molecular weight of pharmacologically active substances by comparing and analyzing the activity profile and the mass profile. The disclosed method allows fast discovery of pharmacologically active substances by performing high resolution mass spectrometry for numerous components included in an extract sample of natural products and comparing with the activity test data. The information about the intensity of the activity of the pharmacologically active substances of the natural products allows effective utilization of the natural products.
摘要翻译：公开了一种从天然产物中高速发现药理活性物质的方法，包括：通过测试多个样品的药理活性来获得活性曲线; 基于通过质谱法分析样品产生的质谱获得质量分布图; 并通过比较和分析活性曲线和质量曲线来确定药理活性物质的分子量。所公开的方法通过对包含在天然产物的提取物样品中的许多组分进行高分辨质谱并且与活性测试数据进行比较而允许药理活性物质的快速发现。有关天然产物药理活性物质活性强度的信息可以有效利用天然产物。

7. 发明申请

WO2008126976A1 APPARATUS FOR SIGNAL IMPROVEMENT OF FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETER 审中-公开
标题翻译： FOURIER转换离子共振质谱仪信号改进装置
公开(公告)号：WO2008126976A1
公开(公告)日：2008-10-23
申请号：PCT/KR2007/006649
申请日：2007-12-18
申请人： KOREAN BASIC SCIENCE INSTITUTE , KIM, Sung Hwan , KIM, Hyun Sik , CHOI, Myoung Choul , YOO, Jong Shin
发明人： KIM, Sung Hwan , KIM, Hyun Sik , CHOI, Myoung Choul , YOO, Jong Shin
IPC分类号： G01N27/62
CPC分类号： G01N27/622
摘要： An apparatus for signal improvement of Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. The apparatus includes trapping electrodes that are disposed to be spaced from each other and face each other; excitation and detection electrodes that are disposed between the trapping electrodes and are aligned at a predetermined angle with the trapping electrodes so as to form a trap; first control electrodes that are connected to the excitation and detection electrodes through capacitors and are electrically independent of the other electrodes; and second control electrodes that are disposed on the trapping electrodes and are electrically in¬ dependent of the other electrodes.
摘要翻译：傅里叶变换离子回旋共振（FT-ICR）质谱仪信号改进装置。该装置包括：彼此间隔开并相互面对地设置的捕获电极; 激发和检测电极，其设置在捕获电极之间并且与捕获电极以预定角度对准以形成陷阱; 第一控制电极，其通过电容器连接到激励和检测电极，并且与其他电极电独立; 以及第二控制电极，其设置在捕获电极上并与其它电极电依赖。

8. 发明申请

WO2008054093A1 3-DIMENSIONAL DIFFERENTIAL PUMPING SYSTEM AND METHOD THEREOF 审中-公开
标题翻译：三维差分泵送系统及其方法
公开(公告)号：WO2008054093A1
公开(公告)日：2008-05-08
申请号：PCT/KR2007/005304
申请日：2007-10-26
申请人： KOREAN BASIC SCIENCE INSTITUTE , CHOI, Myoung Choul , YOO, Jong Shin , KIM, Hyun Sik
发明人： CHOI, Myoung Choul , YOO, Jong Shin , KIM, Hyun Sik
IPC分类号： G01N27/62
CPC分类号： G01N27/622 , H01J49/067 , H01J49/24 , H01J49/38
摘要： A differential pumping system in which a vacuum chamber is manufactured to have a plurality of vacuum pumps and conductance limit plates between the vacuum pumps. The dif¬ ferential pumping system in which an ion is implanted from an ionization source, passes through the vacuum chamber and is detected by a detection unit includes a plurality of vacuum pumps in the vacuum chamber and one or more conductance limit plates between the vacuum pumps, and the conductance limit plates form an angle less than 90° with the transmission direction of the ion. According to such a constitution, higher degree of vacuum and the ion transmission efficiency are maintained without increasing the length of the vacuum chamber. Furthermore, it is possible to minimize the attenuation of an ion detection signal due to a collision with a neighboring neutral molecule, improving the sensitivity of an ion detection device.
摘要翻译：一种差分泵送系统，其中制造真空室以在真空泵之间具有多个真空泵和电导限制板。其中从离子源注入离子的差分泵送系统通过真空室并由检测单元检测，包括真空室中的多个真空泵和真空泵之间的一个或多个导电极限板，并且电导极限板与离子的透射方向形成小于90°的角度。根据这种结构，在不增加真空室的长度的情况下，保持更高的真空度和离子传递效率。另外，由于与邻近的中性分子发生碰撞，能够使离子检测信号的衰减最小化，能够提高离子检测装置的灵敏度。

9. 发明申请

WO2012115323A1 CURRENT REGULATION APPARATUS 审中-公开
标题翻译：现行规管设备
公开(公告)号：WO2012115323A1
公开(公告)日：2012-08-30
申请号：PCT/KR2011/007554
申请日：2011-10-12
申请人： LG INNOTEK CO., LTD. , KIM, Young Jong , KIM, Hyun Sik , KIM, Taek Soo , HUH, Dong Young
发明人： KIM, Young Jong , KIM, Hyun Sik , KIM, Taek Soo , HUH, Dong Young
IPC分类号： G05F3/02
CPC分类号： H02M3/33523 , H02M3/33507 , H05B33/0842
摘要： A current regulation apparatus is provided. The current regulation apparatus includes a trans unit, a first switching unit, a voltage detection unit, a voltage comparison unit, and a control unit. The trans unit includes an auxiliary winding unit. The first switching unit controls an operation of the trans unit. The voltage detection unit detects a voltage induced to the auxiliary winding unit. The voltage comparison unit compares a voltage detected by the voltage detection unit and a reference voltage. The control unit adjusts a turn-on section of the first switching unit according to an output voltage of the voltage comparison unit.
摘要翻译：提供电流调节装置。电流调节装置包括转换单元，第一开关单元，电压检测单元，电压比较单元和控制单元。传动单元包括辅助卷绕单元。第一切换单元控制跨单元的操作。电压检测单元检测到辅助绕组单元感应的电压。电压比较单元将由电压检测单元检测的电压与参考电压进行比较。控制单元根据电压比较单元的输出电压来调整第一开关单元的接通部分。

10. 发明申请

WO2007120001A1 PULSE WIDTH MODULATION APPARATUS AND APPARATUS FOR DRIVING LIGHT SOURCE HAVING THE SAME 审中-公开
标题翻译：脉冲宽度调制装置及其驱动光源的装置
公开(公告)号：WO2007120001A1
公开(公告)日：2007-10-25
申请号：PCT/KR2007/001856
申请日：2007-04-17
申请人： LG INNOTEK CO., LTD , KIM, Taek Soo , KIM, Hyun Sik
发明人： KIM, Taek Soo , KIM, Hyun Sik
IPC分类号： H05B41/36
CPC分类号： H05B41/3927
摘要： Provided are a pulse width modulation (PWM) apparatus and a light source-driving apparatus including the PWM apparatus. The PWM apparatus includes a voltage division part, a capacitor part, a first operational amplifier, a first noise reduction part, and a second operational amplifier. The voltage division part divides and outputs an input voltage. The capacitor part charged by an input current or discharged for provides a charge voltage. The first operational amplifier operates according to a result of comparing a divided voltage output from the voltage division part with the charge voltageoutput from the capacitor part. The first noise reduction part removes a high frequency noise of the divided voltage. The second operational amplifier converts a signal generated from the capacitor part into a pulse width modulation signal by a dimming control signal.
摘要翻译：提供了包括PWM装置的脉宽调制（PWM）装置和光源驱动装置。 PWM装置包括分压部分，电容器部分，第一运算放大器，第一降噪部分和第二运算放大器。分压部分分压输出电压。由输入电流或放电充电的电容器部分提供充电电压。第一运算放大器根据将分压部分的分压输出与来自电容器部分的充电电压输出进行比较的结果进行工作。第一降噪部分去除分压电压的高频噪声。第二运算放大器通过调光控制信号将从电容器部分产生的信号转换为脉宽调制信号。

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