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1. 发明申请

WO2017042716A1 MULTI-BED SORBENT TUBES AND USE THEREOF 审中-公开
标题翻译：多层管道管及其使用
公开(公告)号：WO2017042716A1
公开(公告)日：2017-03-16
申请号：PCT/IB2016/055368
申请日：2016-09-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： KNOBEL, Hugo Hubertus , SOERS, Ruud Johannes Theodorus , NIJSEN, Tamara Mathea Elisabeth , WEDA, Johannes
IPC分类号： G01N33/98 , B01J20/00 , G01N33/538
CPC分类号： G01N33/98 , G01N33/497 , G01N33/538
摘要： Exhaled breath analysis in health and disease is an area of growing clinical interest with the potential to be adopted through the whole respiratory healthcare continuum. However, currently there is no standard for exhaled breath collection, and the optimal way to preconcentrate the highly humid exhaled breath is not known. Described is an optimized combination of sorbent materials and sample handling methods that allows quantitative capturing of exhaled molecules over a broad range in highly humid conditions. The invention can be applied in pre-concentration units of future devices for exhaled breath analysis, for example at the bedside.
摘要翻译：健康和疾病呼气分析是临床兴趣日益增加的领域，具有通过整个呼吸保健连续体采用的潜力。然而，目前没有呼气呼气的标准，并且预先浓缩高湿度呼出呼气的最佳方式是未知的。描述了吸附剂材料和样品处理方法的优化组合，其允许在高湿度条件下在宽范围内定量捕集呼出分子。本发明可以应用于未来呼出气体分析装置的预浓缩单元，例如在床边。

2. 发明申请

WO2015124468A1 METHOD OF DETECTING ARDS AND SYSTEMS FOR DETECTING ARDS 审中-公开
标题翻译：检测ARDS和ARDS检测系统的方法
公开(公告)号：WO2015124468A1
公开(公告)日：2015-08-27
申请号：PCT/EP2015/052806
申请日：2015-02-11
申请人： KONINKLIJKE PHILIPS N.V.
发明人： WEDA, Johannes , VINK, Teunis Johannes , WANG, Yuanyue , BOS, Lieuwe Durk Jacobus , NIJSEN, Tamara Mathea Elisabeth
IPC分类号： A61B5/08 , G01N33/497 , A61M16/00
CPC分类号： A61B5/082 , A61B5/097 , A61B5/7275 , A61B5/7282 , A61B5/74 , A61B2505/03 , A61M16/024 , A61M16/04 , A61M16/06 , A61M16/085 , A61M16/0875 , A61M16/1045 , A61M2016/0033 , A61M2230/437 , G01N33/497 , G01N2033/4975
摘要： The invention is directed to a system and method for providing an ARDS indication of a patient comprising a sampling device for obtaining a gas sample of the exhaled breath of a patient, a measuring unit for measuring a content of n-octane in the exhaled breath of a patient, a controller which is able to distinguish if the patient has or may develop ARDS based on the content of n-octanein the exhaled breath of a patient resulting in a ARDS indication of the patient and provided with a protocol for providing output regarding the ARDS indication of the patient, and a user interface for indicating the ARDS indication to a user.
摘要翻译：本发明涉及一种用于提供患者的ARDS指示的系统和方法，所述系统和方法包括用于获得患者的呼出气体的气体样本的取样装置，用于测量呼出气中正辛烷含量的测量单元患者，控制器，其能够区分患者是否具有或可能基于患者的呼出气体的正辛烷值的内容产生ARDS，导致患者的ARDS指示并且提供了用于提供关于患者的输出的协议患者的ARDS指示，以及用于向用户指示ARDS指示的用户界面。

3. 发明申请

WO2023083720A1 GENERATING AN INDICATOR OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 审中-公开
公开(公告)号：WO2023083720A1
公开(公告)日：2023-05-19
申请号：PCT/EP2022/080894
申请日：2022-11-07
申请人： KONINKLIJKE PHILIPS N.V.
发明人： NIJSEN, Tamara Mathea Elisabeth , BOU JAWDE, Samer , DE VRIES, Jan Johannes Gerardus , ÑAÑEZ OJEDA, Pablo Andres
IPC分类号： A61B5/093 , A61B5/083 , A61B5/087 , A61B5/00
摘要： Provided are concepts for generating an indicator of chronic obstructive pulmonary disease (COPD) in a subject. In particular, an elasticated bag suitable for inflation is utilised, such that a change in a measurable characteristic of the elasticated during exhalation of the subject is detected. The change in the measurable characteristic may be analyzed so as to generate an indicator of COPD. Thus, this indicator may be used by a skilled professional in deciding whether to further investigate the possible presence of COPD.

4. 发明申请

WO2015197808A1 APPARATUS, SYSTEM, METHOD AND COMPUTER PROGRAM FOR ASSESSING THE RISK OF AN EXACERBATION AND/OR HOSPITALIZATION 审中-公开
标题翻译：设备，系统，方法和计算机程序，用于评估实施和/或医院化的风险
公开(公告)号：WO2015197808A1
公开(公告)日：2015-12-30
申请号：PCT/EP2015/064487
申请日：2015-06-26
申请人： KONINKLIJKE PHILIPS N.V.
发明人： NIJSEN, Tamara Mathea Elisabeth , BARRETTO, Chevone Marie , CHIAU, Choo Chiap , KLEE, Mareike
IPC分类号： A61B5/11 , A61B5/00
CPC分类号： A61B5/7275 , A61B5/08 , A61B5/1118 , A61B5/4815 , G06F19/00
摘要： The present invention relates to an apparatus, a system (100), a method (200), and a computer program for assessing the risk of an exacerbation and/or hospitalization. A patient's physical activity is measured (e.g., by an accelerometer (110)) during an active period of time (e.g., during awake hours) and during arest period of time (e.g., during sleep hours) to gather first and second activity data. A risk of exacerbation and/or hospitalization is assessed (e.g., by a risk assessment unit (120)) based on an expression involving the respective activity data duringactive and rest periods fulfilling a predetermined relationship with respect to a predetermined activity level. For instance, low activity data during active periods and high activity data during rest periods indicates an increased risk of exacerbation and/or hospital readmission for the patient.
摘要翻译：本发明涉及一种用于评估恶化和/或住院风险的装置，系统（100），方法（200）和计算机程序。在活跃的时间段（例如，在醒来时间）期间和在第一时间段期间（例如，在睡眠时间期间）来测量患者的身体活动（例如，通过加速度计（110））以收集第一和第二活动数据。基于在相对于预定活动水平达到预定关系的活动期和休息期间涉及相应活动数据的表达来评估（例如由风险评估单元（120））进行加重和/或住院的风险。例如，活动期间的低活动数据和休息期间的高活动数据表示患者的加重和/或医院重新入院的风险增加。

5. 发明申请

WO2013144790A1 METHOD AND SYSTEM FOR FILTERING GAS CHROMATOGRAPHY-MASS SPECTROMETRY DATA 审中-公开
标题翻译：用于过滤气相色谱质谱数据的方法和系统
公开(公告)号：WO2013144790A1
公开(公告)日：2013-10-03
申请号：PCT/IB2013/052242
申请日：2013-03-21
申请人： KONINKLIJKE PHILIPS N.V.
发明人： NIJSEN, Tamara Mathea Elisabeth , D'ANGELO, Marina
IPC分类号： G01N30/86 , G06K9/00 , H01J49/00
CPC分类号： G01N30/86 , G01N30/8617 , G01N30/8634 , G06K9/00503 , H01J49/0036
摘要： This invention relates to a system for and a method of filtering at least a part of gas chromatography-mass spectrometry data, the method comprising: providing gas chromatography-mass spectrometry data (301) for a gas mixture comprising data representing one or more gas chromatography elution peaks obtained for at least one sample, and filtering the gas chromatography-mass spectrometry data (301) to reduce the amount of data, wherein the filtering comprises taking into account predetermined data representing one or more elution peaks previously determined to be false positives (305) and/or predetermined data representing one or elution peaks previously determined to be true positives (304). In this way, unreliable elution peaks are removed in an expedient manner reducing the amount of data e.g. used for a later alignment process speeding up the processing time and also improving the data quality. Fig.2
摘要翻译：本发明涉及一种用于过滤气相色谱 - 质谱数据的至少一部分的系统和方法，所述方法包括：提供用于气体混合物的气相色谱 - 质谱数据（301），其包含表示一种或多种气相色谱对至少一个样品获得的洗脱峰，并过滤气相色谱 - 质谱数据（301）以减少数据量，其中过滤包括考虑预先确定为假阳性的一个或多个洗脱峰的预定数据（ 305）和/或表示先前确定为真阳性的一个或洗脱峰的预定数据（304）。以这种方式，以方便的方式去除不可靠的洗脱峰，从而减少数据量。用于稍后的校准过程，加快了处理时间，并提高了数据质量。图2

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