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1. 发明申请

WO2006126152A1 GLUCOSE SENSOR 审中-公开
标题翻译：葡萄糖传感器
公开(公告)号：WO2006126152A1
公开(公告)日：2006-11-30
申请号：PCT/IB2006/051599
申请日：2006-05-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HERPEN, Maarten , BALISTRERI, Marcello , PRESURA, Cristian
发明人： VAN HERPEN, Maarten , BALISTRERI, Marcello , PRESURA, Cristian
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/6826 , A61B5/6838
摘要： A system for the non- invasive measurement of glucose concentration in a live subject is disclosed. The system exploits the metabolic heat conformation method, and comprises temperature sensing means for measuring the body heat in respect of the subject and means for measuring the concentration of haemoglobin and oxygenated haemoglobin in the blood of the subject. The system further comprises irradiating means for irradiating a portion of the live subject, a detector for collecting the measuring beam reflected by the live subject, means for determining from the reflected measuring beam, the blood flow velocity in respect of the live subject, and means for determining glucose concentration in the live subject as a function of the body heat, the haemoglobin and oxygenated haemoglobin concentrations and the blood flow velocity.
摘要翻译：公开了一种用于活体受试者中葡萄糖浓度无创测量的系统。该系统利用代谢热构象方法，并且包括用于测量对象的身体热量的温度感测装置和用于测量受试者血液中血红蛋白和氧合血红蛋白浓度的装置。该系统还包括用于照射活体的一部分的照射装置，用于收集由活体受体反射的测量光束的检测器，用于根据反射的测量光束确定关于活体的血流速度的装置，以及装置用于测定活体受试者中的葡萄糖浓度作为体热，血红蛋白和氧合血红蛋白浓度和血流速度的函数。

2. 发明申请

WO2006067699A1 INVESTIGATION OF BODY STRUCTURES 审中-公开
标题翻译：身体结构调查
公开(公告)号：WO2006067699A1
公开(公告)日：2006-06-29
申请号：PCT/IB2005/054261
申请日：2005-12-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PRESURA, Cristian , VAN HERPEN, Maarten
发明人： PRESURA, Cristian , VAN HERPEN, Maarten
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/0095 , A61B5/02007 , A61B5/489
摘要： A pulsed radiation beam is directed toward a body structure having a configuration or physical characteristic that changes over time, the radiation being pulsed at a pulse modulation frequency. A detector detects acoustic oscillations set up in the body resultant from the incident pulsed radiation and produces an output signal representative of one or more parameters of the acoustic oscillations. A control system controls operation of the radiation delivery and a processor to process the detector output signal. The pulse modulation frequency of the pulsed radiation is changed over a predetermined range of modulation frequencies and the processor determines the structure resonant frequency from the detector output.
摘要翻译：脉冲辐射束指向具有随时间变化的配置或物理特性的体结构，辐射以脉冲调制频率脉冲。检测器检测由入射脉冲辐射产生的身体中产生的声振荡并产生表示声振荡的一个或多个参数的输出信号。控制系统控制辐射传送的操作和处理器来处理检测器输出信号。脉冲辐射的脉冲调制频率在调制频率的预定范围内改变，并且处理器从检测器输出确定结构谐振频率。

3. 发明申请

WO2007074422A2 A NON-INVASIVE SYSTEM AND METHOD FOR MEASURING SKIN HYDRATION OF A SUBJECT 审中-公开
标题翻译：用于测量受试者皮肤水化的非入侵系统和方法
公开(公告)号：WO2007074422A2
公开(公告)日：2007-07-05
申请号：PCT/IB2006/055034
申请日：2006-12-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN GOGH, Antonius , VAN HERPEN, Maarten
发明人： VAN GOGH, Antonius , VAN HERPEN, Maarten
IPC分类号： A61B5/00 , A61B5/103
CPC分类号： A61B5/0095 , A61B5/01 , A61B5/14532 , A61B5/14546 , A61B5/441 , A61B5/4869
摘要： A non- invasive system and method for measuring skin hydration of a subject comprising a thermistor (7) used in transient mode to obtain a measurement of the thermal conductivity of the skin of the subject and a processor (8) for determining a skin hydration value from the thermal conductivity measurement. The system for measuring skin hydration may be comprised in a non-invasive system for detecting blood analyte concentration, preferably glucose, including a spectroscopic device having e.g. an infrared source (2) which generates infrared beam (3) and detector (6) for detecting transmitted radiation through portion 1 (e.g. finger) of a subject. The system may also include skin hydrator (9) which moisturises the skin connected in a control loop to the system for measuring skin hydration. The system for detecting blood analyte concentration may include a photoacoustic device or a metabolic heat conformation device.
摘要翻译：一种用于测量受试者的皮肤水合的非侵入性系统和方法，包括在瞬态模式中使用的热敏电阻（7），以获得对象皮肤热导率的测量值和用于确定皮肤水合值的处理器（8）从热导率测量。用于测量皮肤水合的系统可以包含在用于检测血液分析物浓度的非侵入性系统中，优选葡萄糖，包括具有例如血液的分光装置。产生用于检测通过被摄体的部分1（例如手指）的透射辐射的红外光束（3）和检测器（6）的红外源（2）。该系统还可以包括皮肤水分器（9），其将在控制回路中连接的皮肤保湿到用于测量皮肤水合的系统。用于检测血液分析物浓度的系统可以包括光声装置或代谢热构造装置。

4. 发明申请

WO2007072293A2 BIOSENSOR WITH ONE-DIMENSIONAL SUB-DIFFRACTION-LIMITED APERTURES COMPOSED OF A GRID AND A POLARIZER 审中-公开
标题翻译：具有一个网格和一个偏振器的一维亚衍射极限孔径生物传感器
公开(公告)号：WO2007072293A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006/054750
申请日：2006-12-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , VAN HERPEN, Maarten , BROER, Dirk J. , PEETERS, Emiel , KLUNDER, Derk J.W. , STAPERT, Hendrik R.
发明人： VAN HERPEN, Maarten , BROER, Dirk J. , PEETERS, Emiel , KLUNDER, Derk J.W. , STAPERT, Hendrik R.
IPC分类号： G01N21/00
CPC分类号： G01N21/648 , Y10T436/11
摘要： A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed. In the context of the present invention the biosensor comprises a grid (120) defined as arrays of apertures with the apertures having a first dimension below and a second dimension above the diffraction limit of the excitation light (102) in a medium, a polarizer (115), and luminophores (117) positioned in a volume selected from the group consisting of: the volume inside the apertures of the grid (120), the volume in between the array of slits (120) and the polarizer (115) and a volume that extends into the polarizer (115), wherein the grid (120) providing a transmission axis extending in a first direction and the polarizer (115) providing a transmission axis extending in a second direction, the first direction and the second direction being substantially perpendicular with respect to each other, wherein the excitation radiation (102) is polarized such that it is substantially suppressed by one of the at least one grid (120) and polarizer (115) and substantially not suppressed by the other of the at least one grid (120) and polarizer (115).
摘要翻译：公开了一种用于检测由至少一个发光体产生的发光辐射的方法和传感器。在本发明的上下文中，生物传感器包括被限定为孔阵列的网格（120），其中孔径具有在介质中的激发光（102）的衍射极限以下的第一维度和第二维度，偏振器（（120）的体积，狭缝阵列（120）和偏振器（115）之间的体积以及一个或多个发光体（117），所述发光体（117）位于从由以下各项组成的组中选择的体积中：其中所述栅格（120）提供在第一方向上延伸的透射轴并且所述偏振器（115）提供在第二方向上延伸的透射轴，所述第一方向和所述第二方向基本上是相对于彼此垂直，其中所述激发辐射（102）被极化，使得所述激发辐射（102）基本上被所述至少一个栅格（120）和偏振器（115）中的一个抑制并且基本上不被所述o 至少一个格栅（120）和偏振器（115）的一部分。

5. 发明申请

WO2007004168A1 PHOTO-ACOUSTIC SPECTROMETER APPARATUS 审中-公开
标题翻译：光声光谱仪器
公开(公告)号：WO2007004168A1
公开(公告)日：2007-01-11
申请号：PCT/IB2006/052198
申请日：2006-06-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HERPEN, Maarten
发明人： VAN HERPEN, Maarten
IPC分类号： G01N21/39 , G01N29/24 , G01J3/433 , H01S3/139
CPC分类号： G01J3/10 , G01J3/4338 , G01N21/1702 , G01N21/39 , G01N29/032 , G01N29/2425 , G01N2021/391 , G01N2201/0696 , G01N2291/0215
摘要： A photo acoustic detection cell (6) is located within the optical cavity (3) of a cavity enhanced absorption spectroscopy apparatus (3,4,5). When a sample in the cell (6) absorbs radiation from a pulsed radiation beam coupled into the cavity (3) pressure waves are generated that are detected by a microphone (9). A detected signal (10) output by the microphone (9) may be processed to determine a value for the concentration of an absorber in the sample.
摘要翻译：光声检测单元（6）位于腔增强吸收光谱仪（3,4,5）的光腔（3）内。当细胞（6）中的样品从耦合到空腔（3）中的脉冲辐射束吸收辐射时，产生由麦克风（9）检测到的压力波。可以处理由麦克风（9）输出的检测信号（10），以确定样品中吸收剂浓度的值。

6. 发明申请

WO2006087683A1 BREATH TEST FOR TOTAL ORGANIC CARBON 审中-公开
标题翻译：总有机碳的呼吸试验
公开(公告)号：WO2006087683A1
公开(公告)日：2006-08-24
申请号：PCT/IB2006/050508
申请日：2006-02-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HERPEN, Maarten
发明人： VAN HERPEN, Maarten
IPC分类号： A61B5/097 , G01N33/497
CPC分类号： A61B5/097 , G01N33/0014 , G01N33/0047 , G01N33/497 , Y10T436/204998 , Y10T436/218
摘要： A total amount of volatile organic compounds (VOCs) in a breath sample (101) is detected by oxidizing/burning (120) the VOCs to form CO 2 and H 2 O, and the amounts of one or both of these compounds are measured (130). CO 2 and H 2 O molecules in the breath sample (101) are removed (110) before the VOCs are converted (120) to CO 2 and H 2 O. Because one VOC molecule contains multiple carbon and hydrogen atoms, the number of formed CO 2 and H 2 O molecules will be substantially larger than the original number of VOC molecules, thereby improving the sensitivity of the detection.
摘要翻译：通过氧化/燃烧（120）VOC来检测呼吸样品（101）中的挥发性有机化合物（VOC）的总量，以形成CO 2和H 2 O ，并且测量这些化合物中的一种或两种的量（130）。在将VOC转化（120）之前，将呼吸样品（101）中的CO 2 2和H 2 O 2 O分子除去（110）至CO 2 和H 2 O。由于一个VOC分子含有多个碳原子和氢原子，因此形成的CO 2 H 2 O 2 O 2 O分子的数量将显着大于VOC分子的原始数量，从而改善灵敏度的检测。

7. 发明申请

WO2007122557A2 NON-INVASIVE GLUCOSE SENSOR 审中-公开
标题翻译：非入侵式葡萄糖传感器
公开(公告)号：WO2007122557A2
公开(公告)日：2007-11-01
申请号：PCT/IB2007/051395
申请日：2007-04-18
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GmBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HERPEN, Maarten , SUCH, Olaf , VON-BASUM, Golo
发明人： VAN HERPEN, Maarten , SUCH, Olaf , VON-BASUM, Golo
CPC分类号： A61B5/412 , A61B5/083 , A61B5/14532 , A61B5/1455
摘要： Apparatus and method for sensing HO activity, and in particular blood glucose level based on an analyte level determination, the analyte being carboxyhemoglobin. In a preferred embodiment, HO activity and/or blood glucose level are extrapolated from Hb-CO level by determining an intermediate CO level. The apparatus and method are preferably non invasive.
摘要翻译：用于感测HO活性的装置和方法，特别是基于分析物水平测定的血糖水平，所述分析物是碳氧血红蛋白。在优选的实施方案中，通过确定中间CO水平，从Hb-CO水平外推HO活性和/或血糖水平。该装置和方法优选地是非侵入性的。

8. 发明申请

WO2006126154A1 NON-INVASIVE MEASUREMENT OF BLOOD ANALYTES USING THERMAL EMISSION SPECTROSCOPY 审中-公开
标题翻译：使用热发射光谱分析血液分析仪的非侵入性测量
公开(公告)号：WO2006126154A1
公开(公告)日：2006-11-30
申请号：PCT/IB2006/051601
申请日：2006-05-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN GOGH, Antonius , VAN HERPEN, Maarten , BALISTRERI, Marcello
发明人： VAN GOGH, Antonius , VAN HERPEN, Maarten , BALISTRERI, Marcello
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/015
摘要： A system is disclosed for the non- invasive measurement of an analyte concentration in body tissue. The system comprises means (16) for detecting a thermal emission spectrum (13) emitted by the body tissue, such as a finger, and interference filtering means (11) , for spatially separating the thermal emission spectrum to create a plurality of spectral patterns and measuring in respect of each of a plurality of said spectral patterns a spectral intensity at a first, reference set of wavelengths, and a second set of wavelengths dependent on the analyte being measured. The concentration of the analyte is then determined from the spectral measurements.
摘要翻译：公开了用于非侵入性测量身体组织中的分析物浓度的系统。该系统包括用于检测诸如手指的身体组织发射的热发射光谱（13）的装置（16）和用于在空间上分离热发射光谱以产生多个光谱图案的干涉滤光装置（11）针对多个所述光谱图案中的每一个测量第一参考波长组的光谱强度，以及取决于被测量的分析物的第二组波长。然后从光谱测量确定分析物的浓度。

9. 发明申请

WO2006067697A2 METHOD AND APPARATUS FOR DETECTING ABNORMALITY IN TOOTH STRUCTURE 审中-公开
标题翻译：用于检测牙齿结构异常的方法和装置
公开(公告)号：WO2006067697A2
公开(公告)日：2006-06-29
申请号：PCT/IB2005/054259
申请日：2005-12-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HERPEN, Maarten
发明人： VAN HERPEN, Maarten
IPC分类号： A61B5/00 , A61B5/103 , A61B8/08
CPC分类号： A61B5/0088 , A61B5/0095 , A61B5/08
摘要： An illuminating radiation beam is directed toward a potentially or actually carious structure (particularly a tooth). A detector detects acoustic oscillations set up in the structure resultant from the illuminating radiation and produces an output signal dependent upon the magnitude of the oscillations detected. Signals from the detector are processed to predict the presence or magnitude of carious infection of the structure.
摘要翻译：照射辐射束指向可能或实际上龋齿的结构（特别是牙齿）。检测器检测建立在由照射辐射产生的结构中的声振荡，并且根据检测到的振荡的幅度产生输出信号。处理来自检测器的信号以预测该结构的蛀牙感染的存在或程度。

10. 发明申请

WO2007072300A3 SYSTEM FOR NON-INVASIVE MEASUREMENT OF BLOOD GLUCOSE CONCENTRATION 审中-公开
公开(公告)号：WO2007072300A3
公开(公告)日：2007-06-28
申请号：PCT/IB2006/054773
申请日：2006-12-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BALISTRERI, Marcello , VAN HERPEN, Maarten , VAN GOGH, Antonius
发明人： BALISTRERI, Marcello , VAN HERPEN, Maarten , VAN GOGH, Antonius
IPC分类号： A61B5/00
摘要： A system and method for non-invasive measurement of glucose concentration in a live subject including a thermal emission spectroscopy (TES) device 10, an optical coherence tomography (OCT) device 20 or near infrared diffuse reflectance (NIDR) device. The TES 10 generates a signal indicative of the absorbtion of glucose, from which the blood glucose concentration is determined and the OCT device 20 generates a signal indicative of the scattering coefficient of a portion of the live subject, from which the blood glucose concentration is determined. The signals generated by the TES and OCT devices along with signals generated by sensors for measuring the body heat and surface temperature of the subject are used in the metabolic heat conformation (MHC) method of determining blood glucose concentration. The system may include a photoacoustic sensor for generating a signal indicative of thermo-elastic skin properties from which the blood glucose concentration is also determined.

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