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1. 发明申请

WO2010067220A3 AUTONOMOUS DETECTOR MODULE AS A BUILDING BLOCK FOR SCALABLE PET AND SPECT SYSTEMS 审中-公开
公开(公告)号：WO2010067220A3
公开(公告)日：2010-06-17
申请号：PCT/IB2009/055107
申请日：2009-11-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , DEGENHARDT, Carsten , FRACH, Thomas , PRESCHER, Gordian
发明人： DEGENHARDT, Carsten , FRACH, Thomas , PRESCHER, Gordian
IPC分类号： G01T1/164
摘要： When detecting scintillation events in a nuclear imaging system, time- stamping and energy-gating processing is incorporated into autonomous detection modules (ADM) (14) to reduce downstream processing. Each ADM (14) is removably coupled to a detector fixture (13), and comprises a scintillation crystal array (66) and associated light detect or (s) (64), such as a silicon photomultiplier or the like. The light detector(s) (64) is coupled to a processing module (62) in or on the ADM (14), which performs the energy gating and time-stamping.

2. 发明申请

WO2010073137A1 CMOS IMAGER WITH SINGLE PHOTON COUNTING CAPABILITY 审中-公开
标题翻译：具有单光子计数能力的CMOS成像器
公开(公告)号：WO2010073137A1
公开(公告)日：2010-07-01
申请号：PCT/IB2009/055194
申请日：2009-11-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , PRESCHER, Gordian , DEGENHARDT, Carsten , BALLIZANY, Rob , SCHMITZ, Anja , FRACH, Thomas
发明人： PRESCHER, Gordian , DEGENHARDT, Carsten , BALLIZANY, Rob , SCHMITZ, Anja , FRACH, Thomas
IPC分类号： G01S11/00 , H04N9/04
CPC分类号： H04N9/045 , G01S17/023 , G01S17/10 , G01S17/89 , H04N5/3696
摘要： A color imaging device comprises: one or more arrays (10, RA, GA, BA) of color selective photodetectors (R, G, B) configured to acquire a color image of a subject; a set of avalanche photodiode photodetectors (APD) arranged to acquire a luminance image of the subject; and digital image processing circuitry (30) configured to process the acquired color image and the acquired luminance image to generate an output image of the subject. In some embodiments the avalanche photodiode photodetectors are configured to perform photon counting. In some embodiments, the one or more arrays comprise an imaging array (10) including the color-selective photodetectors (R, G, B) distributed across the imaging array with the set of avalanche photodiode photodetectors (APD) interspersed amongst the color-selective photodetectors.
摘要翻译：彩色成像装置包括：被配置为获取被摄体的彩色图像的彩色选择性光电检测器（R，G，B）的一个或多个阵列（10，RA，GA，BA）布置成获取被摄体的亮度图像的一组雪崩光电二极管光电检测器（APD）以及数字图像处理电路（30），被配置为处理所获取的彩色图像和所获取的亮度图像以生成被摄体的输出图像。在一些实施例中，雪崩光电二极管光电探测器被配置为执行光子计数。在一些实施例中，一个或多个阵列包括成像阵列（10），该成像阵列包括分布在成像阵列上的颜色选择性光电检测器（R，G，B），其中所述一组雪崩光电二极管光电检测器（APD）散布在颜色选择性光电探测器。

3. 发明申请

WO2010070487A2 TEMPERATURE COMPENSATION CIRCUIT FOR SILICON PHOTOMULTIPLIERS AND OTHER SINGLE PHOTON COUNTERS 审中-公开
标题翻译：硅光电子器件和其他单光子计数器的温度补偿电路
公开(公告)号：WO2010070487A2
公开(公告)日：2010-06-24
申请号：PCT/IB2009/055186
申请日：2009-11-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , FRACH, Thomas , PRESCHER, Gordian , DEGENHARDT, Carsten
发明人： FRACH, Thomas , PRESCHER, Gordian , DEGENHARDT, Carsten
IPC分类号： G01T1/20
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/2018
摘要： A PET scanner (8) includes a ring of detector modules (10) encircling an imaging region (12). Each of the detector modules includes at least one detector pixel (24,34). Each detector pixel includes a scintillator (20, 30) optically coupled to one or more sensor APDs (54) that are biased in a breakdown region in a Geiger mode. The sensor APDs output a pulse in response to the light from the scintillator corresponding to a single incident radiation photon. A reference APD (26, 36) also biased in a breakdown region in a Geiger mode is optically shielded from light and outputs a temperature dependent signal. At least one temperature compensation circuit (40) adjusts a bias voltage applied to the sensor APDs based on the temperature dependent signal.
摘要翻译： PET扫描器（8）包括围绕成像区域（12）的检测器模块环（10）。每个检测器模块包括至少一个检测器像素（24,34）。每个检测器像素包括光学耦合到以盖革模式偏置在击穿区域中的一个或多个传感器APD（54）的闪烁体（20,30）。传感器APD响应于来自闪烁体的对应于单个入射辐射光子的光输出脉冲。在Geiger模式中也被偏置在击穿区域中的参考APD（26,36）被光学屏蔽并输出与温度相关的信号。至少一个温度补偿电路（40）根据温度依赖信号来调节施加到传感器APD的偏置电压。

4. 发明申请

WO2010140070A2 SOLID-STATE PET DETECTOR SYSTEM WITH IMPROVED CAPABILITIES FOR QUANTIFICATION 审中-公开
标题翻译：具有改进的量化能力的固态PET检测器系统
公开(公告)号：WO2010140070A2
公开(公告)日：2010-12-09
申请号：PCT/IB2010/051928
申请日：2010-05-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , DEGENHARDT, Carsten , BUCKLER, Andrew
发明人： DEGENHARDT, Carsten , BUCKLER, Andrew
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/2018 , G01T1/249
摘要： A nuclear medical imaging system employing radiation detection modules with pixelated scintillator crystals includes a scatter detector (46) configured to detect and label scattered and non-scattered detected radiation events stored in a list mode memory (44). Coincident pairs of both scattered and non-scattered radiation events are detected and the corresponding lines of response (LOR) are determined. A first image representation of the examination region can be reconstructed using the LORs corresponding to both scattered and non-scattered detected radiation events to generate a lower resolution image (60) with good noise statistics. A second higher resolution image (62) of all or a subvolume of the examination region can be generated using LORs that correspond to non-scattered detected radiation events. A quantification processor is configured to extract at least one metric, e.g. volume, count rate, standard uptake value (SUV), or the like, from at least one of the lower resolution image, the higher resolution image, or a combined image (64).
摘要翻译：采用具有像素化闪烁体晶体的放射线检测模块的核医学成像系统包括：散射检测器（46），被配置为检测并标记存储在列表模式存储器（44）中的散射和非散射的检测到的辐射事件。检测到散射和非散射辐射事件的重合对，并确定相应的响应行（LOR）。可以使用对应于散射和非散射检测的辐射事件的LOR来重建检查区域的第一图像表示，以生成具有良好噪声统计的较低分辨率图像（60）。可以使用对应于非散射检测到的辐射事件的LOR来生成检查区域的全部或子体积的第二较高分辨率图像（62）。量化处理器被配置为提取至少一个度量，例如，从较低分辨率图像，较高分辨率图像或组合图像（64）中的至少一个获取体积，计数率，标准摄取值（SUV）等。

5. 发明申请

WO2009040690A2 PRECLINICAL TIME OF FLIGHT PET IMAGING 审中-公开
标题翻译：飞行PET成像的准备时间
公开(公告)号：WO2009040690A2
公开(公告)日：2009-04-02
申请号：PCT/IB2008/053438
申请日：2008-08-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , DEGENHARDT, Carsten , BUCKLER, Andrew
发明人： DEGENHARDT, Carsten , BUCKLER, Andrew
CPC分类号： G01T1/2985 , A61B6/037 , A61B6/508 , G01R33/481
摘要： A preclinical positron emission tomography (PET) imaging method includes acquiring time-of-flight localized PET imaging data from one or more non-human animal subjects and reconstructing the acquired data to form an image. In an illustrative PET scanner includes: radiation detectors (12) viewing an examination region; a subject support assembly (14) supporting a plurality of preclinical subjects in the examination region for simultaneous PET imaging; coincidence electronics (20) acquiring time-of-flight localized PET imaging data from the preclinical subjects using the radiation detectors; and reconstruction electronics (22) that (i) perform a filtering operation based at least in part on the time-of flight information, the filtering operation including at least one of discarding non-probative time-of-flight localized PET imaging data and associating time-of-flight localized PET imaging data with individual preclinical subjects and (ii) reconstruct the filtered data to form images of the preclinical subjects.
摘要翻译：临床前正电子发射断层摄影（PET）成像方法包括从一个或多个非人类动物对象获取飞行时间定位的PET成像数据，并重建所获取的数据以形成图像。在说明性PET扫描仪中包括：观察检查区域的辐射检测器（12）对象支撑组件（14），其支撑所述检查区域中的多个临床前对象以用于同时PET成像; 重合电子装置（20）使用辐射检测器从临床前受试者获取飞行时间局部PET成像数据; 和重建电子装置（22），其（i）至少部分基于飞行时间信息来执行滤波操作，所述滤波操作包括丢弃非证实飞行时间定位的PET成像数据和关联飞行时间局部PET成像数据与个体临床前受试者进行比较，和（ii）重建过滤数据以形成临床前受试者的图像。

6. 发明申请

WO2009024895A2 REFLECTOR AND LIGHT COLLIMATOR ARRANGEMENT FOR IMPROVED LIGHT COLLECTION IN SCINTILLATION DETECTORS 审中-公开
标题翻译：反射器和光收缩装置改进光学检测器中的光收集
公开(公告)号：WO2009024895A2
公开(公告)日：2009-02-26
申请号：PCT/IB2008/053230
申请日：2008-08-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , SCHULZ, Volkmar , DEGENHARDT, Carsten , GRIESMER, Jerome, J. , COOKE, Steven, E.
发明人： SCHULZ, Volkmar , DEGENHARDT, Carsten , GRIESMER, Jerome, J. , COOKE, Steven, E.
IPC分类号： G01T1/20
CPC分类号： G01T1/2002 , G01T1/202
摘要： In nuclear imaging, when a gamma ray strikes a scintillator, a burst of visible light is created. That light is detected by a photodetector and processed by downstream electronics. It is desirable to harness as much of the burst of light as possible and get it to the photodetector. In a detector element (18), a first reflective layer (44) partially envelops a scintillation crystal (34). The first reflective layer (44) diffuses the scintillated light. A second reflective layer (46) and a support component reflective layer (48) prevent the light from leaving the scintillation crystal (34) by any route except a light emitting face (36) of the scintillator (34). In another embodiment, a light concentrator (50) is coupled to the scintillator (34) and channels the diffuse light onto a light sensitive portion of a photodetector (38). The reflective layers (44, 46, 48) and the concentrator (50) ensure that all or nearly all of the light emitted by the scintillator (34) is received by the photodetector (38).
摘要翻译：在核成像中，当伽马射线撞击闪烁体时，产生可见光的突发。该光被光检测器检测并由下游电子器件处理。最好利用尽可能多的光线，并将其送到光检测器。在检测器元件（18）中，第一反射层（44）部分地包围闪烁晶体（34）。第一反射层（44）扩散闪烁的光。第二反射层（46）和支撑部件反射层（48）通过除了闪烁体（34）的发光面（36）之外的任何路线防止光离开闪烁晶体（34）。在另一个实施例中，聚光器（50）耦合到闪烁体（34），并将漫射光通过光电检测器（38）的光敏部分。反射层（44,46,48）和聚光器（50）确保由闪烁体（34）发射的全部或几乎全部的光被光电检测器（38）接收。

7. 发明申请

WO2007089962A1 SPECT DETECTOR ELIMINATING THE DEPTH-OF-INTERACTION PROBLEM 审中-公开
标题翻译： SPECT检测器消除了深度相互关系的问题
公开(公告)号：WO2007089962A1
公开(公告)日：2007-08-09
申请号：PCT/US2007/060365
申请日：2007-01-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , DEGENHARDT, Carsten , WIECZOREK, Herfried
发明人： DEGENHARDT, Carsten , WIECZOREK, Herfried
IPC分类号： G01T1/164 , G01T1/166
CPC分类号： G01T1/1644 , A61B6/037
摘要： At least one radiation detection head (16) is disposed adjacent a field of view (20) to detect radiation from the field of view (20). The radiation detection head (16) includes a collimator (60), including an opening (62), through which radiation rays emanating from the field of view (20) pass, and a detection system (44) forming an arcuate surface (68) focused on the collimator opening (62) for detecting radiation so that radiation rays received through the collimator opening (62) strike the arcuate surface substantially perpendicular to an incremental area of the arcuate surface (68) at which the radiation strikes.
摘要翻译：至少一个放射线检测头（16）邻近视场（20）设置以检测来自视野（20）的辐射。放射线检测头（16）包括准直器（60），该准直器（60）包括通过该视场（20）发出的辐射线通过的开口（62）和形成弓形表面（68）的检测系统（44）集中于用于检测辐射的准直器开口（62），使得通过准直器开口（62）接收的辐射线基本上垂直于辐射所在的弓形表面（68）的增量区域进入弓形表面。

8. 发明申请

WO2007106674A2 NUCLEAR MEDICINE IMAGING SYSTEM WITH HIGH EFFICIENCY TRANSMISSION MEASUREMENT 审中-公开
标题翻译：具有高效率传输测量的核医学成像系统
公开(公告)号：WO2007106674A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/063271
申请日：2007-03-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , WIECZOREK, Herfried , PETRILLO, Michael, J. , DEGENHARDT, Carsten
发明人： WIECZOREK, Herfried , PETRILLO, Michael, J. , DEGENHARDT, Carsten
CPC分类号： G01T1/1648 , A61B6/032 , A61B6/037 , G01T1/1615 , G01T1/2985
摘要： A nuclear medicine imaging system that includes a plurality of detectors arranged about an imaging region. A transmission source can be provided opposite the detectors and rotating about the imaging region to obtain different imaging angles. The nuclear imaging system provides for the ability to acquire high sensitivity transmission data with high emission data spatial resolution.
摘要翻译：一种核医学成像系统，包括围绕成像区域布置的多个检测器。传输源可以与检测器相对地设置并围绕成像区域旋转以获得不同的成像角度。核成像系统提供以高发射数据空间分辨率获取高灵敏度传输数据的能力。

9. 发明申请

WO2008011436A3 METHOD AND SYSTEM FOR IMPROVED TOF PET RECONSTRUCTION 审中-公开
公开(公告)号：WO2008011436A3
公开(公告)日：2008-01-24
申请号：PCT/US2007/073730
申请日：2007-07-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , LAURENCE, Thomas , GRIESMER, Jerome, J. , KOLTHAMMER, Jeffrey, A. , THON, Andreas , BRINKS, Ralph , DEGENHARDT, Carsten
发明人： LAURENCE, Thomas , GRIESMER, Jerome, J. , KOLTHAMMER, Jeffrey, A. , THON, Andreas , BRINKS, Ralph , DEGENHARDT, Carsten
IPC分类号： G01T1/29
摘要： A time of flight positron emission tomography apparatus (100) includes a detector (106), a data acquisition system (120), a coincidence system (122) and a reconstructor (129). Various elements of an imaging chain influence the temporal resolution of the system (100) so that positron data collected along different lines of response is characterized by different temporal resolutions. The different temporal resolutions are used to estimate the positions of detected events along their respective lines of response.

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