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1. 发明申请

WO2012093353A1 AUTOMATIC QUANTIFICATION OF ASYMMETRY 审中-公开
标题翻译：自动量化不对称
公开(公告)号：WO2012093353A1
公开(公告)日：2012-07-12
申请号：PCT/IB2012/050025
申请日：2012-01-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , THIELE, Frank, Olaf
发明人： THIELE, Frank, Olaf
IPC分类号： G06T7/60
CPC分类号： G06T7/0014 , A61B5/0042 , G06T7/68 , G06T2207/10104 , G06T2207/30016
摘要： An apparatus detects asymmetry in an object, such as a brain. The apparatus includes a processor programmed to fit a three-dimensional image of the object to a preselected shape, such as a standard brain atlas. The processor projects the three- dimensional image of the object to a two-dimensional surface image. The processor compares corresponding mirror image symmetric voxel pairs on the left and right sides of the surface image. The processor generates at least one of an asymmetry map and an asymmetry index based on the deviations in the pixel pairs. The processor can also mask, before the comparison, pixels of the surface image which are asymmetric in a normal brain.
摘要翻译：一种装置检测物体（例如大脑）中的不对称性。该装置包括被编程为将物体的三维图像拟合成预选形状的处理器，例如标准脑图集。处理器将对象的三维图像投影到二维表面图像。处理器比较表面图像左侧和右侧的对应镜像对称体素对。处理器基于像素对中的偏差来生成不对称图和非对称性索引中的至少一个。在比较之前，处理器还可以掩盖在正常大脑中不对称的表面图像的像素。

2. 发明申请

WO2012147016A1 DIAGNOSTIC BRAIN IMAGING 审中-公开
标题翻译：诊断脑成像
公开(公告)号：WO2012147016A1
公开(公告)日：2012-11-01
申请号：PCT/IB2012/051990
申请日：2012-04-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , THIELE, Frank, Olaf
发明人： THIELE, Frank, Olaf
IPC分类号： A61B6/03 , G06T7/00
CPC分类号： A61B6/501 , A61B6/037 , A61B6/481 , A61B6/508 , A61B6/5217 , G06T7/001 , G06T7/33 , G06T2207/10104 , G06T2207/10108 , G06T2207/30016
摘要： A radiological imaging apparatus (10) acquires a radiological brain image of a subject after administration of a radio tracer binding to a target substance indicative of a clinical pathology. In one embodiment, the clinical pathology is amyloid deposits in the brain at a level correlative with Alzheimer's disease and the target substance is amyloid deposits. A processor (C) tests for the clinical pathology by: performing non-rigid registration of the brain image with a positive template (32P) indicative of having the clinical pathology and with a negative template (32N) indicative of not having the clinical pathology; generating positive and negative result metrics (36P, 36N) quantifying closeness of the registration with the positive and negative template respectively; and generating a test result (54) based on the positive result metric and the negative result metric. An independent test result is generated by quantifying a second mode of an intensity histogram for the brain image.
摘要翻译：放射线成像装置（10）在施用结合指示临床病理学的靶物质的无线电示踪剂之后获取受试者的放射性脑图像。在一个实施方案中，临床病理学是与阿尔茨海默病相关的水平的脑中的淀粉样蛋白沉积物，并且靶物质是淀粉样沉积物。处理器（C）通过以下方式测试临床病理学：用指示具有临床病理学的阳性模板（32P）和指示没有临床病理学的阴性模板（32N）进行脑图像的非刚性配准; 产生正负结果指标（36P，36N），分别对正模型和负模板的注册接近度进行量化; 以及基于正结果度量和否定结果度量来生成测试结果（54）。通过量化脑图像的强度直方图的第二模式来产生独立的测试结果。

3. 发明申请

WO2013072843A1 METHOD TO COMPUTE AND PRESENT BRAIN AMYLOID IN GRAY MATTER 审中-公开
标题翻译：计算和存在灰质中的脑亚胺的方法
公开(公告)号：WO2013072843A1
公开(公告)日：2013-05-23
申请号：PCT/IB2012/056379
申请日：2012-11-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH
发明人： THIELE, Frank, Olaf , WENZEL, Fabian
IPC分类号： A61B6/03 , G01T1/29 , G06T7/00
CPC分类号： A61B5/0035 , A61B5/0042 , A61B5/055 , A61B6/037 , A61B6/466 , A61B6/501 , A61B6/5247 , G01R33/481 , G06T7/0012 , G06T7/0014 , G06T2207/10088 , G06T2207/10104 , G06T2207/30016
摘要： An imaging work station (20) includes one or more processors programmed to receive (170)an image depicting a distribution of a radiotracer in a brain or other region of interest. The radiotracer includes at least one of [18F]-Flutemetamol, [18F]-Florbetaben, and [18F]-Florbetapir which highlights amyloid deposits. The image and a template or an MRI image of the region of interest which includes a segmented anatomical feature, such as gray matter, are registered (180)to a common space. A volume representation of the image which depicts the distribution of the radiotracer in the segmented gray matter and suppresses the radiotracer outside of the segmented anatomical feature in white matter is extracted (210).
摘要翻译：成像工作站（20）包括被编程为接收（170）描绘大脑或其他感兴趣区域中的放射性示踪剂的分布的图像的一个或多个处理器。放射性示踪剂包括突出淀粉样蛋白沉积物的[18 F] - 十六烷基胺，[18 F] - 格列贝星和[18F] - 格列贝皮中的至少一种。包括分割的解剖特征（例如灰质）的感兴趣区域的图像和模板或MRI图像被记录（180）到公共空间。提取了描绘分段灰质中放射性示踪剂的分布并且抑制白质中分段解剖特征之外的放射性示踪剂的图像的体积表示（210）。

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