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1. 发明申请

WO2010041214A1 INTEGRATED MICROFLUIDIC DEVICE 审中-公开
标题翻译：集成微流体设备
公开(公告)号：WO2010041214A1
公开(公告)日：2010-04-15
申请号：PCT/IB2009/054422
申请日：2009-10-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LASANCE, Clemens, J., M. , PONJEE, Marc, W., G. , COLLINS, Paul, L. , FISH, David, A.
发明人： LASANCE, Clemens, J., M. , PONJEE, Marc, W., G. , COLLINS, Paul, L. , FISH, David, A.
IPC分类号： B01L3/00 , B01L7/00
CPC分类号： B01L7/525 , B01L3/50851 , B01L2200/10 , B01L2200/12 , B01L2200/147 , B01L2300/0645 , B01L2300/0816 , B01L2300/0829 , B01L2300/0851 , B01L2300/1827
摘要： The present invention provides an integrated micro fluidic device (100) comprising a plurality of fluidic chambers (20) provided on a substrate (19), the plurality of fluidic chambers (20) being logically organized in rows and columns, each fluidic chamber (20) comprising a fluidic region (21), the area under the fluidic region (21) being divided into a plurality of segments (22), each segment (22) comprising a heater (23) integrated in the substrate (19), each heater (23) of each segment (22) being individually drivable. The device (100) furthermore comprises a plurality of temperature sensors (32) integrated in the substrate (19), each temperature sensor (32) being individually drivable. Furthermore, a control circuit is provided for individually driving the heaters (23) and temperature sensors (32), the control circuit being separated in location from the heaters (23). The present invention also provides a method for making such an integrated microfluidic device (100).
摘要翻译：本发明提供了一种集成微流体装置（100），其包括设置在基板（19）上的多个流体室（20），所述多个流体室（20）以行和列逻辑组织，每个流体室（20 ）包括流体区域（21），所述流体区域（21）下方的区域被分成多个段（22），每个段（22）包括集成在所述衬底（19）中的加热器（23），每个加热器每个段（22）的（23）可单独驱动。装置（100）还包括集成在基板（19）中的多个温度传感器（32），每个温度传感器（32）可单独驱动。此外，设置有用于单独驱动加热器（23）和温度传感器（32）的控制电路，所述控制电路与加热器（23）的位置分离。本发明还提供了一种制造这种集成微流体装置（100）的方法。

2. 发明申请

WO2009019658A2 INTEGRATED MICROFLUIDIC DEVICE WITH LOCAL TEMPERATURE CONTROL 审中-公开
标题翻译：具有局部温度控制的集成微流体装置
公开(公告)号：WO2009019658A2
公开(公告)日：2009-02-12
申请号：PCT/IB2008/053157
申请日：2008-08-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , FISH, David, A. , COLLINS, Paul, L.
发明人： FISH, David, A. , COLLINS, Paul, L.
IPC分类号： B01L7/00 , B01L3/00
CPC分类号： B01L7/52 , B01L3/502707 , B01L2200/147 , B01L2300/024 , B01L2300/0609 , B01L2300/0627 , B01L2300/0816 , B01L2300/0819 , B01L2300/1805 , B01L2300/1827
摘要： An integrated microfluidic device having a chamber (11-MN) for heating a fluid, multiple heating elements for heating different parts of the chamber, multiple temperature sensing elements (Rs, D1) for localized sensing of temperature of fluid at different parts of the chamber, and a controller for controlling the heating elements according to temperatures of the different parts sensed by the temperature sensing elements. This can enable more uniform heating of the chamber. The device can be formed of low temperature poly silicon on a glass substrate. The heating element can be a resistor or a TFT transistor (T5).
摘要翻译：具有用于加热流体的腔室（11-MN）的集成微流体装置，用于加热腔室的不同部分的多个加热元件，用于温度的局部感测的多个温度感测元件（Rs，D1）的流体在腔室的不同部分处，以及控制器，用于根据由温度感测元件感测的不同部分的温度来控制加热元件。这可以使腔室的加热更均匀。该器件可以由玻璃衬底上的低温多晶硅形成。加热元件可以是电阻器或TFT晶体管（T5）。

3. 发明申请

WO2009147555A1 HIGH VOLTAGE DRIVE CIRCUIT WITH IMPROVED POWER EFFICIENCY AND REDUCED SIZE 审中-公开
标题翻译：具有提高功率效率和减小尺寸的高电压驱动电路
公开(公告)号：WO2009147555A1
公开(公告)日：2009-12-10
申请号：PCT/IB2009/052059
申请日：2009-05-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , FISH, David, A. , COLLINS, Paul, L. , AYRES, John, R., A.
发明人： FISH, David, A. , COLLINS, Paul, L. , AYRES, John, R., A.
IPC分类号： H03K17/10 , H03K17/0814
CPC分类号： H03K17/102 , H03K17/08142 , H03K2217/0036
摘要： A high voltage power supply circuit comprising: -a control transistor (N1) having a control voltage input on a first gate electrode to switch the control transistor off when a first control voltage is applied to the first gate electrode and to switch the control transistor on when a second control voltage is applied to the first gate electrode, 5 -at least two cascoded transistors (N2, N3) coupled in series with the control transistor, and -a biasing circuit (10) connected to second and third gate electrodes of the two cascoded transistors, respectively, the biasing circuit being adapted to switch the at least two cascoded transistors off when the first control voltage is applied to the first gate electrode and 10 to switchthe at least two cascoded transistors on when the second control voltage is applied to the first gate electrode, the steady state voltage drop across each of the at least two cascoded transistors being greater than the threshold voltage of each transistorwhen the first controlvoltage is applied to the first gate electrode.
摘要翻译：一种高压电源电路，包括： - 控制晶体管（N1），其具有在第一栅电极上输入的控制电压，以在第一控制电压施加到所述第一栅极时切换所述控制晶体管并且将所述控制晶体管导通当向第一栅电极施加第二控制电压时，至少两个与控制晶体管串联耦合的并联光电晶体管（N2，N3）和 - 与第二栅电极的第二和第三栅电极连接的偏置电路（10）两个级联晶体管分别适用于当第一控制电压被施加到第一栅电极时切换至少两个级联的晶体管，并且当第二控制电压施加到第二控制电压时将该至少两个级联晶体管切换第一栅电极，至少两个级联晶体管中的每一个上的稳态电压降大于冷却时每个晶体管的阈值电压 st控制电压施加到第一栅电极。

4. 发明申请

WO2009053889A2 MANIPULATION OF PARTICLES BY DIELECTROPHORESIS 审中-公开
标题翻译：通过电化学处理颗粒的方法
公开(公告)号：WO2009053889A2
公开(公告)日：2009-04-30
申请号：PCT/IB2008/054305
申请日：2008-10-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , COLLINS, Paul, L.
发明人： COLLINS, Paul, L.
IPC分类号： B03C5/02
CPC分类号： B03C5/028
摘要： The present invention provides a dielectrophoretic device for manipulation of at least a first and a second type of particles (1, 2) present in a sample fluid. The device comprises at least one array (3) of electrodes (4), the array (3) comprising at least a plurality of electrodes (4) in a first region (5) and a plurality of electrodes (4) in a second region (6), driving means (32) for driving the electrodes (4) of the first and second region (5, 6) of the array (3) to generate a travelling wave dielectrophoretic force to be exerted on the at least first and second types of particles (1, 2), and a controller (30) for controlling the driving means (32), the controller (30) being adapted for first driving the electrodes (4) of the first and second region (5, 6) with a same driving signal and subsequently changing the driving signal to electrodes (4) of at least one of the first and second region (5, 6) so as to separate at least some particles (1) of the first type from the particles (2) of the second type. The present invention also provides a method for forming such a dielectrophoretic device, a method for manipulation of at least a first and a second type of particles (1, 2) present in a sample fluid and a controller (30) for controlled driving of electrodes (4) of such a dielectrophoretic device.
摘要翻译：本发明提供了用于操纵存在于样品流体中的至少第一和第二类型的颗粒（1,2）的介电泳设备。所述装置包括至少一个电极阵列（3），所述阵列（3）包括在第一区域（5）中的至少多个电极（4）和在第二区域中的多个电极（4）（6），用于驱动阵列（3）的第一和第二区域（5,6）的电极（4）的驱动装置（32），以产生要施加在至少第一和第二部分上的行波介电电泳力控制器（30）适于首先驱动第一和第二区域（5,6）的电极（4），其中，所述控制器（30）用于控制驱动装置（32）具有相同的驱动信号，随后将驱动信号改变为第一和第二区域（5,6）中的至少一个的电极（4），以便将至少一些第一类型的颗粒（1）与颗粒（ 2）第二类。本发明还提供了一种用于形成这种介电电泳装置的方法，用于操纵存在于样品流体中的至少第一和第二类型的颗粒（1,2）的方法和用于控制驱动电极的控制器（30）（4）的这种介电电泳装置。

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