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1. 发明申请

WO2010018489A1 APPARATUS AND METHOD FOR A MICROFLUIDIC SYSTEM FOR CREATING A CONCENTRATION GRADIENT 审中-公开
标题翻译：用于创建浓度梯度的微流体系统的装置和方法
公开(公告)号：WO2010018489A1
公开(公告)日：2010-02-18
申请号：PCT/IB2009/053403
申请日：2009-08-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DEN TOONDER, Jacob, M., J. , GILLIES, Murray, F. , CATTANEO, Stefano , VAN AMERONGEN, Hendrik, H.
发明人： DEN TOONDER, Jacob, M., J. , GILLIES, Murray, F. , CATTANEO, Stefano , VAN AMERONGEN, Hendrik, H.
IPC分类号： B01F13/00 , B01F5/06 , G01N33/50
CPC分类号： B01F13/0059 , B01F5/061 , B01F5/0646 , B01F5/0647 , B01F2005/0621 , B01F2005/0636
摘要： The present invention relates to a microfluidic device (200) for creating a concentration gradient which includes a microfluidic channel (202) including two or more inlets for introducing fluid solutions, two or more channel segments (208, 224, 226, 228), a ridged element (210, 216, 218, 220) including a plurality of ridges (212) in and/or on an interior wall (214) in at least one segment, wherein the ridged element (210, 216, 218, 220) creates a localized secondary flow effect and a local mixing effect in the at least one segment of the channel (202) for the formation of a concentration gradient over the width of the channel (202).
摘要翻译：本发明涉及一种用于产生浓度梯度的微流体装置（200），该微流体装置包括微流体通道（202），该微流体通道包括用于引入流体溶液的两个或更多个入口，两个或更多个通道段（208,224,226,228），脊状元件（210,216,218,220）包括在至少一个部分中的内壁（214）中和/或内壁上的多个脊（212），其中所述脊状元件（210,216,218,220）产生通道（202）的至少一个区段中的局部二次流动效应和局部混合效应，用于在通道（202）的宽度上形成浓度梯度。

2. 发明申请

WO2008114199A2 AN ACTUATOR DEVICE AND A METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：执行器装置及其制造方法
公开(公告)号：WO2008114199A2
公开(公告)日：2008-09-25
申请号：PCT/IB2008/050992
申请日：2008-03-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , GILLIES, Murray, F. , PONJEE, Marc, W., G. , CATTANEO, Stefano , JOHNSON, Mark, T. , DEN TOONDER, Jacob, M., J. , DE GOEDE, Judith, M. , BROER, Dirk, J. , WILDERBEEK, Johannes, T., A. , MOL, Grietje, N. , TALEN, Wim
发明人： GILLIES, Murray, F. , PONJEE, Marc, W., G. , CATTANEO, Stefano , JOHNSON, Mark, T. , DEN TOONDER, Jacob, M., J. , DE GOEDE, Judith, M. , BROER, Dirk, J. , WILDERBEEK, Johannes, T., A. , MOL, Grietje, N. , TALEN, Wim
IPC分类号： B81B3/00
CPC分类号： B81B3/0021 , B81B2201/038 , B81B2201/058 , H02N1/004
摘要： An actuator device (100) comprising a substrate (102), an electrode structure (105) provided in and/or on the substrate (102), and an actuator unit (107) being movable relative to the substrate (102) upon application of an electrical signal to the electrode structure (105), wherein the actuator unit (107) is made of a dielectric material.
摘要翻译：一种致动器装置（100），包括衬底（102），设置在衬底（102）中和/或衬底（102）上的电极结构（105），以及致动器单元（107），其可在施加电信号到电极结构（105），其中致动器单元（107）由电介质材料制成。

3. 发明申请

WO2010070538A1 MICROELECTRONIC DEVICE FOR MEASURING CELL ADHESION 审中-公开
标题翻译：用于测量细胞粘附的微电子装置
公开(公告)号：WO2010070538A1
公开(公告)日：2010-06-24
申请号：PCT/IB2009/055590
申请日：2009-12-09
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , GILLIES, Murray, F. , CATTANEO, Stefano , VOSSEN, Franciscus, J. , VAN AMERONGEN, Hendrik, H.
发明人： GILLIES, Murray, F. , CATTANEO, Stefano , VOSSEN, Franciscus, J. , VAN AMERONGEN, Hendrik, H.
IPC分类号： G01N27/02 , G01N33/487 , C12M1/34
CPC分类号： G01N33/48728
摘要： The present invention relates to a microelectronic device (10) for measuring cell adhesion to a surface. To allow measuring of the adherence of low-coverage, non-confluent cell types, a microelectronic device (10) is proposed comprising: a sample chamber (11) for insertion of cells (18), an impedance electrode unit (140) comprising an array of impedance electrodes (14) arranged in said sample chamber (11), a counter electrode unit (17) comprising at least one counter electrode (17; 171, 172) arranged in said sample chamber (11), and -an impedance measurement unit (16) for separately measuring impedance measurement signals representing the impedance between said impedance electrodes (14) and said at least one counter electrode (17) over time, the cell adhesion being derived from said impedance measurement signals.
摘要翻译：本发明涉及一种用于测量细胞与表面粘附的微电子装置（10）。为了允许测量低覆盖率，非汇合电池类型的粘附性，提出了一种微电子器件（10），其包括：用于插入电池（18）的样品室（11），阻抗电极单元（140），包括布置在所述样品室（11）中的阻抗电极阵列（14），包括布置在所述样品室（11）中的至少一个对电极（17; 171,172））的对电极单元（17），以及 - 阻抗测量单元（16），用于分别测量表示所述阻抗电极（14）和所述至少一个对电极（17）之间的阻抗的阻抗测量信号，所述阻抗测量信号随着时间推移得到所述阻抗测量信号。

4. 发明申请

WO2010018499A1 APPARATUS AND METHOD FOR PERFORMING CELLULAR SUSCEPTIBILITY TESTING 审中-公开
标题翻译：用于执行细胞不稳定性测试的装置和方法
公开(公告)号：WO2010018499A1
公开(公告)日：2010-02-18
申请号：PCT/IB2009/053437
申请日：2009-08-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , CATTANEO, Stefano , GILLIES, Murray, F. , ISAKSSON, Bo Joakim , STAPERT, Hendrik, R. , PENTERMAN, Roel
发明人： CATTANEO, Stefano , GILLIES, Murray, F. , ISAKSSON, Bo Joakim , STAPERT, Hendrik, R. , PENTERMAN, Roel
IPC分类号： C12Q1/18 , G01N33/50
CPC分类号： C12Q1/18 , C12M23/16 , C12M41/46 , G01N33/5014
摘要： The present invention relates to a method and apparatus for performing cellular susceptibility testing via a concentration gradient in a microfluidic device (200) including a microfluidic channel (202), comprising the steps of trapping one or more single cells to be tested in one or more defined positions on an inner surface of the channel (202); applying a stable and predictable concentration gradient of a substance through the channel (202) with the cells to be tested; incubating the cells to be tested within the concentration gradient, wherein, based upon the defined positions of the cells, an individual substance concentration at the location of each cell is known; and determining a concentration- dependent property of the cells, including at least one of a minimum inhibitory concentration, a minimum bactericidal concentration and a threshold concentration of the substance which leads to a certain cell reaction from the defined positions of the cells within the stable and predictable concentration gradient.
摘要翻译：本发明涉及一种用于通过包括微流体通道（202）的微流体装置（200）中的浓度梯度进行细胞敏感性测试的方法和装置，包括以下步骤：将一个或多个待测试的单个细胞捕获在一个或多个在通道（202）的内表面上限定位置; 通过通道（202）将物质的稳定和可预测的浓度梯度与待测试的细胞施加; 在浓度梯度内培养要测试的细胞，其中基于细胞的限定位置，已知每个细胞位置处的单个物质浓度; 以及确定所述细胞的浓度依赖性质，其包括所述物质的最小抑制浓度，最小杀菌浓度和阈值浓度中的至少一种，其导致来自所述细胞的稳定位置内的稳定和可预测的浓度梯度。

5. 发明申请

WO2009118690A2 MICROFLUIDIC DEVICE AND METHOD 审中-公开
标题翻译：微流体装置和方法
公开(公告)号：WO2009118690A2
公开(公告)日：2009-10-01
申请号：PCT/IB2009/051235
申请日：2009-03-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN ZON, Hans , GILLIES, Murray, F. , CRAUS, Cristian, B. , CATTANEO, Stefano
发明人： VAN ZON, Hans , GILLIES, Murray, F. , CRAUS, Cristian, B. , CATTANEO, Stefano
IPC分类号： H02K44/04
CPC分类号： H02K44/04 , B01L3/50273 , B01L2400/0415 , B01L2400/043 , B03C1/023 , B03C1/286 , F04B19/006
摘要： The present invention relates to a microfluidic device and a corresponding method for pumping of high conductivity liquids comprising: -a microfluidic channel (26; 80; 101) for containing an electrically conductive liquid, in particular a liquid having a high conductivity, -at least two electric field electrodes (21, 22; 71, 72; 91, 92) for generating electric fields, -at least one magnetic field electrode (21, 22; 75, 76; 93, 94) for generating a magnetic field in a direction substantially perpendicular to said electric fields, -a voltage source (23; 74; 95) for providing electric potentials to said at least two electric field electrodes (21, 22; 71, 72; 91, 92) for generating said electric fields, -a current source (23; 78, 79; 96, 97) for providing an electric current to said at least two magnetic field electrodes (21, 22; 75, 76; 93, 94) for generating said magnetic field, wherein said voltage source (23; 74; 95) and said current source (23; 78, 79; 96, 97) are adapted to simultaneously provide said electric potential and electric current, respectively, to said electrodes to obtain a Lorentz force acting on the high conductivity liquid in the direction (27; 81; 99) of said microfluidic channel (26; 80; 101).
摘要翻译：本发明涉及一种用于泵送高电导率液体的微流体装置和相应的方法，包括： - 微流体通道（26; 80; 101），用于容纳导电液体，特别是具有高导电性的液体，至少用于产生电场的两个电场电极（21,22; 71,72; 91,92）， - 至少一个磁场电极（21,22; 75,76; 93,94），用于在方向上产生磁场大致垂直于所述电场的电压源，用于向所述至少两个用于产生所述电场的至少两个电场电极（21,22; 71,72; 91,92）提供电位的电压源（23; 74; 95）用于向所述至少两个磁场电极（21,22; 75,76; 93,94）提供电流以产生所述磁场的电流源（23; 78,79; 96,97），其中所述电压源（23; 74; 95）和所述电流源（23; 78,79; 96,97）适于同时进行分别向所述电极提供所述电位和电流，以获得在方向（27; 27）上作用在高电导率液体上的洛伦兹力。 81; 99）所述微流体通道（26; 80; 101）。

6. 发明申请

WO2009034514A2 DIELECTROPHORETIC DEVICE AND METHOD FOR CELL MEMBRANE STUDIES 审中-公开
标题翻译：分光光度装置和细胞膜研究方法
公开(公告)号：WO2009034514A2
公开(公告)日：2009-03-19
申请号：PCT/IB2008/053622
申请日：2008-09-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE HOOG, Thomas, J. , GILLIES, Murray, F. , CATTANEO, Stefano , MERKLE, Dennis , VAN DAM, Dirkjan, B. , SIBILLE, Jérémie
发明人： DE HOOG, Thomas, J. , GILLIES, Murray, F. , CATTANEO, Stefano , MERKLE, Dennis , VAN DAM, Dirkjan, B. , SIBILLE, Jérémie
CPC分类号： B03C5/005 , B03C5/026
摘要： A dielectrophoretic device and method is described for manipulating one or more particles, e.g. living cells. The device comprises a plurality of electrodes in the form of a DEP cage, and a particle movement detection system for detecting movement of the one or more particles within the cage. Particle movement is indicative of passing through the cross-over frequency. The particle movement detection system includes a particle presence sensor and this can be located eccentrically with respect to a trapping point of the DEP cage. The device and method may be used for classification, identification, of quantification of diseased versus healthy cells, for diagnosis, for medical research and development and in therapy. They are particularly useful for investigating living cells whose cell membrane alters in conductivity or permeability.
摘要翻译：描述了用于操纵一个或多个颗粒的介电泳装置和方法，例如，活细胞。该装置包括多个DEP笼形式的电极以及用于检测笼内的一个或多个颗粒的运动的颗粒运动检测系统。粒子移动表示穿过交叉频率。粒子运动检测系统包括粒子存在传感器，并且这可以相对于DEP笼的捕集点偏心地定位。该装置和方法可以用于分类，鉴定，定量病变与健康细胞，诊断，用于医学研究和开发以及治疗。它们对于研究细胞膜电导率或渗透性改变的活细胞特别有用。

7. 发明申请

WO2009027927A2 DIELECTROPHORETIC DEVICE FOR MANIPULATION OF PARTICLES 审中-公开
标题翻译：用于操作颗粒的电子设备
公开(公告)号：WO2009027927A2
公开(公告)日：2009-03-05
申请号：PCT/IB2008/053417
申请日：2008-08-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , CATTANEO, Stefano , GILLIES, Murray, F. , DE HOOG, Thomas, J. , VAN DAM, Dirkjan, B.
发明人： CATTANEO, Stefano , GILLIES, Murray, F. , DE HOOG, Thomas, J. , VAN DAM, Dirkjan, B.
IPC分类号： B03C5/02 , B03C5/00
CPC分类号： B03C5/005 , B03C5/026 , B03C5/028
摘要： The present invention provides a dielectrophoretic device comprising an array (10) of electrodes (1), there being a space (2) in between every two neighboring electrodes (1), and driving means for driving the electrodes (1) of the array (10) to generate a traveling wave dielectrophoretic force. The array (10) of electrodes (1) is formed such that the space (2) in between every two neighboring electrodes (1) has a decreasing width in a longitudinal direction of the electrodes (1). The dielectrophoretic device according to embodiments of the invention can be sued for performing manipulation of particles (5) in small, non-flowing volumes of particles suspensions. The present invention furthermore provides a method for manufacturing such a dielectrophoretic device and a method for manipulating particles (5) by using such a dielectrophoretic device.
摘要翻译：本发明提供一种包括电极阵列（10）的介电电泳装置，在每两个相邻的电极（1）之间有一个空间（2），以及用于驱动阵列的电极（1）的驱动装置 10）产生行波介电电泳力。电极（1）的阵列（10）形成为使得每两个相邻电极（1）之间的空间（2）在电极（1）的纵向上具有减小的宽度。根据本发明的实施方案的介电泳设备可以用于在小的，不流动的体积的颗粒悬浮液中进行颗粒（5）的操作。本发明还提供了制造这种介电电泳装置的方法以及通过使用这种介电电泳装置来操纵颗粒（5）的方法。

8. 发明申请

WO2009053880A1 DEVICE AND METHOD FOR THE MONITORING OF THE MOVEMENT OF CELLS 审中-公开
标题翻译：用于监测细胞运动的装置和方法
公开(公告)号：WO2009053880A1
公开(公告)日：2009-04-30
申请号：PCT/IB2008/054293
申请日：2008-10-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , GILLIES, Murray, F. , MERKLE, Dennis , VULTO, Simone, I., E. , CATTANEO, Stefano , DE HOOG, Thomas, J.
发明人： GILLIES, Murray, F. , MERKLE, Dennis , VULTO, Simone, I., E. , CATTANEO, Stefano , DE HOOG, Thomas, J.
IPC分类号： G01N33/50
CPC分类号： B03C5/026 , G01N33/5029
摘要： The present invention relates to a device for the monitoring of very small movements of cells, in particular when undergoing chemotaxis. The device is based on electrode units (3) comprising a number of electrodes for creating electrical fields surrounding an optical detector (2), e.g. an integrated PIN diode. A gradient of growth factor (stimulant) is obtained in a stimulant gradient chamber (1) with various methods, including the use of microfluidic methods or patterning a hydrogel layer on top of the electronics. The device is capable of measuring very small movements of cells (C) and so is ideally suited to fast sensitive chemotaxis assays.
摘要翻译：本发明涉及用于监测细胞移动非常小的装置，特别是在经历趋化性时。该装置基于包括用于产生围绕光学检测器（2）的电场的多个电极的电极单元（3），例如，集成PIN二极管。在刺激梯度室（1）中通过各种方法获得生长因子（兴奋剂）的梯度，包括使用微流体方法或在电子器件顶部图案化水凝胶层。该装置能够测量细胞的非常小的运动（C），因此非常适用于快速敏感的趋化性测定。

9. 发明申请

WO2009053870A2 DEVICE AND METHOD FOR THE MONITORING OF THE MOVEMENT OF CELLS 审中-公开
标题翻译：用于监测细胞运动的装置和方法
公开(公告)号：WO2009053870A2
公开(公告)日：2009-04-30
申请号：PCT/IB2008/054195
申请日：2008-10-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , CATTANEO, Stefano , GILLIES, Murray, F. , VULTO, Simone, I., E. , DE HOOG, Thomas, J. , MERKLE, Dennis , JOHNSON, Mark, T.
发明人： CATTANEO, Stefano , GILLIES, Murray, F. , VULTO, Simone, I., E. , DE HOOG, Thomas, J. , MERKLE, Dennis , JOHNSON, Mark, T.
IPC分类号： C12M1/34 , G01N33/487 , G01N33/50 , G01N15/10
CPC分类号： B03C5/028 , G01N15/1031
摘要： The present invention relates to a device for the monitoring of very small movements of cells, in particular when undergoing chemotaxis. The invention makes use of various ways of electrical detection, like capacitance or impedance measurements. In this way the detection of the movement of cells can be done in situ, which accelerates the chemotaxis assay and increases the accuracy of the measurements. The device according to the present invention particularly comprises a stimulant gradient chamber (1) for providing a concentration gradient of a stimulant, said stimulant gradient chamber (1) having a cell inlet (12) for the inlet of cells (C), - an electrical sensor (2) placed in a measurement area for measuring an electrical parameter which changes in response to a movement of cells (C) in the surrounding of said sensor (2) and for generating a detection signal, and a signal evaluation unit (3) for evaluating said detection signal.
摘要翻译：本发明涉及用于监测细胞移动非常小的装置，特别是在经历趋化性时。本发明利用电检测的各种方式，如电容或阻抗测量。以这种方式，可以原位完成细胞运动的检测，这加速了趋化性测定并提高了测量的准确性。根据本发明的装置特别地包括用于提供兴奋剂的浓度梯度的刺激剂梯度室（1），所述刺激剂梯度室（1）具有用于细胞入口（C）的细胞入口（12）， - 电传感器（2）放置在测量区域中，用于测量响应于所述传感器（2）周围的单元（C）的移动而变化并用于产生检测信号的电参数，以及信号评估单元（3）），用于评估所述检测信号。

10. 发明申请

WO2009050630A1 A CHEMOTAXIS ASSAY BASED ON OSCILLATING GRADIENTS OF CHEMOTACTIC AGENTS 审中-公开
标题翻译：基于化学药剂振荡梯度的化学测定法
公开(公告)号：WO2009050630A1
公开(公告)日：2009-04-23
申请号：PCT/IB2008/054192
申请日：2008-10-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , GILLIES, Murray, F. , MERKLE, Dennis , CATTANEO, Stefano , JOHNSON, Mark, T.
发明人： GILLIES, Murray, F. , MERKLE, Dennis , CATTANEO, Stefano , JOHNSON, Mark, T.
IPC分类号： G01N33/542 , G01N33/543 , G01N33/50
CPC分类号： G01N33/542 , G01N33/5029 , G01N33/54366
摘要： The present invention is concerned with the method of detecting movement of cells in oscillating gradients. The present invention is further concerned with providing a device for detecting movement of cells in reversing gradients.
摘要翻译：本发明涉及检测振荡梯度下的电池移动的方法。本发明还涉及提供一种用于检测反转梯度下的电池移动的装置。

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