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2. 发明申请

WO2009066221A1 TEMPERATURE SENSOR AND BIOSENSOR USING THE SAME 审中-公开
标题翻译：使用温度传感器和生物传感器
公开(公告)号：WO2009066221A1
公开(公告)日：2009-05-28
申请号：PCT/IB2008/054798
申请日：2008-11-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PENTERMAN, Roel , VAN LIEROP, Steven , IMMINK, Albert, H., J. , BROER, Dirk, J.
发明人： PENTERMAN, Roel , VAN LIEROP, Steven , IMMINK, Albert, H., J. , BROER, Dirk, J.
IPC分类号： G01K11/00 , G01K11/12
CPC分类号： G01K11/125 , G01K11/00
摘要： Embodiments of the invention relates to a temperature sensor and an analytical device comprising the same. The temperature sensor comprises a carrier (11) with a detection surface (12) on which temperature indicating agents (14) are present and, optionally, at which target components can collect and optionally bind to specific capture elements. An incident light beam (Ll) is transmitted into the carrier and evanescent wave excitation is inducedat the detection surface (12). The amount of light in the reflected light beam (L2) or an optical, e.g. luminescence response is then detected by a light detector (31). In one example, evanescent light is affected (absorbed, scattered) by temperature indicating agents and optionally target components and/or label particles at the binding surface (12) and will therefore be missing in a frustrated total internal reflected light beam (L2). This can be used to determine the temperature of the detection area and optionally the amount of target components at the binding surface (12) from the amount of light in the reflected light beam (L2, L2a, L2b). A magnetic field generator (41) is optionally used to generate a magnetic field (B) at the binding surface (12) by which magnetic label particles (1) can be manipulated, for example attracted or repelled.
摘要翻译：本发明的实施例涉及一种温度传感器和包括该温度传感器的分析装置。温度传感器包括具有检测表面（12）的载体（11），其上存在温度指示剂（14），并且可选地，目标组分可以收集并任选地结合到特定捕获元件。入射光束（L1）被传输到载体中，并且在检测表面（12）处诱导ev逝波激发。反射光束（L2）中的光量或光学器件的光量。然后通过光检测器（31）检测发光响应。在一个实例中，渐逝光受温度指示剂影响（吸收，散射），并且可选地在结合表面（12）处的靶组分和/或标记颗粒，因此将在沮丧的全内反射光束（L2）中丢失。这可以用于根据反射光束（L2，L2a，L2b）中的光量来确定检测区域的温度和可选地在结合表面（12）处的目标成分的量。可选地，磁场发生器（41）用于在绑定表面（12）处产生磁场（B），通过该磁场可以操纵磁性标签颗粒（1），例如吸引或排斥磁场。

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