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1. 发明申请

WO2007023408A2 IMAGE-BASED PLANNING METHODS AND APPARATUS FOR TARGETED THERAPY 审中-公开
标题翻译：基于图像的规划方法和设备治疗方法
公开(公告)号：WO2007023408A2
公开(公告)日：2007-03-01
申请号：PCT/IB2006052758
申请日：2006-08-09
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS CORP , BUSCH HEINRICH , SCHWEIZER BERND
发明人： BUSCH HEINRICH , SCHWEIZER BERND
IPC分类号： A61B5/055 , A61B6/03 , A61B8/08
CPC分类号： G06T7/0012 , A61B5/0059 , A61B5/4839 , A61B6/032 , A61B6/037 , A61B6/507 , A61B8/481 , A61B8/488 , G06T2207/10076 , G06T2207/30004 , G06T2207/30096
摘要： The present invention relates generally to biomedical devices. In particular, the present invention provides a method and apparatus for delivering a patient-specifically optimized treatment plan for targeted drug therapy that takes into account the individual 4- D redistribution of the given targeted agent. An improvement in clinical outcome can be achieved in terms of disease response and survival rates and/or in terms of quality of life.
摘要翻译：本发明一般涉及生物医学装置。特别地，本发明提供了一种用于递送针对靶向药物治疗的患者特别优化的治疗计划的方法和装置，该方案和装置考虑到给定靶向药物的单独4-D再分配。在疾病反应和存活率方面和/或在生活质量方面，可以实现临床结果的改善。

2. 发明申请

WO2007117801A3 DIRTY ISOTOPE PET RECONSTRUCTION 审中-公开
标题翻译： DIRTY同位素PET重建
公开(公告)号：WO2007117801A3
公开(公告)日：2010-05-27
申请号：PCT/US2007063561
申请日：2007-03-08
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS CORP , SCHWEIZER BERND , VON BUSCH HEINRICH
发明人： SCHWEIZER BERND , VON BUSCH HEINRICH
IPC分类号： G06T5/00 , A61B5/00
CPC分类号： G06T11/006 , A61B6/037 , G01T1/1611 , G01T1/2985 , G06T2211/424
摘要： A method for use in dirty isotope positron imaging uses information about a measured characteristic of an object (118) to generate a spurious coincidence correction. The spurious imaging correction is applied to data from a positron imaging examination of the object. The corrected data is used to generate a human readable image indicative of the object.
摘要翻译：用于脏同位素正电子成像的方法使用关于物体（118）的测量特性的信息来产生伪符号校正。虚拟成像校正被应用于来自物体的正电子成像检查的数据。校正后的数据用于生成表示对象的人类可读取图像。

3. 发明申请

WO2009031073A2 MULTI-TREATMENT PLANNING APPARATUS AND METHOD 审中-公开
标题翻译：多处理规划设备及方法
公开(公告)号：WO2009031073A2
公开(公告)日：2009-03-12
申请号：PCT/IB2008053429
申请日：2008-08-26
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , VON BUSCH HEINRICH , GEORGI JENS-CHRISTOPH , SCHWEIZER BERND
发明人： VON BUSCH HEINRICH , GEORGI JENS-CHRISTOPH , SCHWEIZER BERND
IPC分类号： G06F19/00
CPC分类号： G06F19/3437 , G06F19/3456 , G06F19/3481 , G16H50/50
摘要： A treatment planning apparatus (100) includes a treatment modeler (102). The treatment (104) modeler uses models (1121-N) of a plurality of treatment modalities in a treatment space (104) to generate a treatment protocol (110) that includes one or more the modalities in the treatment space. In one implementation, a treatment modality includes the removal of targeted treatment agents from an object.
摘要翻译：治疗计划装置（100）包括治疗建模器（102）。治疗（104）建模者使用治疗空间（104）中的多种治疗方式的模型（1121-N）来产生包括治疗空间中的一种或多种模态的治疗方案（110）。在一个实施方案中，治疗方式包括从对象中去除靶向治疗剂。

4. 发明申请

WO2008056322A3 AN APPARATUS, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR THERAPY PLANNING IN TREATMENT OF A PATIENT 审中-公开
标题翻译：用于治疗患者的设备，方法，计算机可读介质和用于治疗计划的用途
公开(公告)号：WO2008056322A3
公开(公告)日：2008-11-13
申请号：PCT/IB2007054495
申请日：2007-11-06
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , VON BUSCH HEINRICH , SCHWEIZER BERND , GEORGI JENS C
发明人： VON BUSCH HEINRICH , SCHWEIZER BERND , GEORGI JENS C
IPC分类号： G06F19/00
CPC分类号： G06F19/3481
摘要： An apparatus, method, system, computer-readable medium and use for individual patient therapy planning of diseases such as cancer for different therapy modalities, such as radiation therapy and chemotherapy is provided. A new aspect of the invention is that the degree of bone marrow depression of the patient is related to the count of immature blood platelets, which are measured before each treatment. Some embodiments of the invention provide an advantage allowing reducing the level of uncertainty in the prediction of the risk of bone marrow depression, and thus enabling to safely improve the therapy effect by an increase of the radiation dosage and/or chemical dosage to the individual patient while the risk for bone marrow depression is minimized.
摘要翻译：提供了用于诸如放射疗法和化疗等不同疗法形式的癌症的疾病的个体患者疗法规划的设备，方法，系统，计算机可读介质和用途。本发明的一个新方面是患者的骨髓抑制程度与每次治疗前测量的未成熟血小板计数有关。本发明的一些实施例提供了允许降低预测骨髓抑制风险的不确定性水平的优点，并且因此能够通过增加对个体患者的辐射剂量和/或化学剂量来安全地改善治疗效果而骨髓抑制的风险最小化。

5. 发明申请

WO2008059426A2 A SYSTEM FOR DETERMINING A DISTRIBUTION OF RADIOACTIVE AGENTS IN A SUBJECT 审中-公开
标题翻译：用于确定主体中放射性物质分布的系统
公开(公告)号：WO2008059426A2
公开(公告)日：2008-05-22
申请号：PCT/IB2007054578
申请日：2007-11-12
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , GEORGI JENS-CHRISTOPH , SCHWEIZER BERND , VON BUSCH HEINRICH
发明人： GEORGI JENS-CHRISTOPH , SCHWEIZER BERND , VON BUSCH HEINRICH
CPC分类号： G01T1/161 , A61B6/4258
摘要： This invention relates to a system for determining a biodistribution of radioactive agents in a subject. According to the invention, a detector system comprising two or more detectors arranged to be attached to the subject at localized areas is used for detecting the radiation emitted from the imaging agents at localized tissues within the subject. The measuring results in separate radiation data sets associated to the tissues. The detectors are further being arranged to adapt the measuring rate to the pharmacokinetic behavior of the tissues in order to capture all relevant data points. A processor then uses the data sets for determining the radioactivity within each respective tissue and based thereon the biodistribution within the subject.
摘要翻译：本发明涉及用于确定受试者中放射性试剂生物分布的系统。根据本发明，包括两个或更多个检测器的检测器系统被布置成在局部区域处附接到受试者，用于检测在受试者内的局部组织处从成像剂发射的辐射。测量结果与组织相关联的单独辐射数据集。检测器还被布置成使测量速率适应组织的药代动力学行为，以捕获所有相关的数据点。然后，处理器使用数据集来确定每个相应组织内的放射性，并且基于该对象内的生物分布。

6. 发明申请

WO2010032168A2 METHOD FOR GENERATION OF ATTENUATION MAP IN PET-MR 审中-公开
标题翻译： PET-MR中产生衰减图的方法
公开(公告)号：WO2010032168A2
公开(公告)日：2010-03-25
申请号：PCT/IB2009053946
申请日：2009-09-09
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , SCHWEIZER BERND , SALOMON ANDRE FRANK
发明人： SCHWEIZER BERND , SALOMON ANDRE FRANK
IPC分类号： G06T7/00
CPC分类号： G01R33/481 , G01T1/1603 , G06T11/005 , G06T2211/424
摘要： A magnetic resonance (MR) image segmentation processor (32) is configured to identify one or more geometrical regions of a subject using an MR image of the subject. An emission data reconstruction processor (40) is configured to generate an attenuation map (54) of the subject by assigning initial attenuation values (52) to the geometrical regions of the subject, and to: (i) process (56) emission data acquired from the subject to generate an emission image (58) of the subject, the processing employing the attenuation map of the subject; (ii) update (60) the attenuation map based on corrections calculated using the emission image of the subject; and (iii) iterate operations (i) and (ii) to iteratively generate a reconstructed emission image of the subject.
摘要翻译：磁共振（MR）图像分割处理器（32）被配置为使用对象的MR图像来识别对象的一个或多个几何区域。发射数据重建处理器（40）被配置为通过将初始衰减值（52）分配给对象的几何区域来产生对象的衰减图（54），并且：（i）处理（56）获取的发射数据从所述对象产生所述对象的发射图像（58），所述处理采用所述对象的衰减图; （ii）基于使用对象的发射图像计算的校正来更新（60）衰减图; 和（iii）迭代操作（i）和（ii）以迭代地产生所述对象的重建发射图像。

7. 发明申请

WO2007116333A3 PRODUCTION OF X-RAY IMAGES CONTAINING A REDUCED PROPORTION OF SCATTERED RADIATION 审中-公开
标题翻译：包含减少辐射散射比例的X射线图像的生产
公开(公告)号：WO2007116333A3
公开(公告)日：2008-01-24
申请号：PCT/IB2007051095
申请日：2007-03-28
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , SCHWEIZER BERND , OVERDICK MICHAEL
发明人： SCHWEIZER BERND , OVERDICK MICHAEL
IPC分类号： G21K1/02
CPC分类号： G21K1/025
摘要： The invention relates to a method, to an X-ray apparatus for performing the method and to a detector arrangement intended for the latter, for producing X-ray images containing a reduced proportion of scattered radiation. The X-ray radiation is detected in this case by a detector arrangement comprising two X-ray detectors, there being provided in the first X-ray detector openings through which the second X-ray detector is able to detect scattered radiation and primary radiation by separate detector elements. The signals given by the second X-ray detector are used to determine the proportion of scattered radiation that is contained in the image produced by the first X-ray detector and to largely free the first image of the proportion of scattered radiation.
摘要翻译：本发明涉及一种用于执行该方法的X射线设备和用于后者的检测器装置的方法，用于产生包含减少的散射辐射比例的X射线图像。在这种情况下，通过包括两个X射线检测器的检测器装置检测X射线辐射，其中设置在第一X射线检测器开口中，第二X射线检测器通过该开口检测散射的辐射和主辐射，分离的检测器元件。由第二X射线检测器给出的信号用于确定由第一X射线检测器产生的图像中包含的散射辐射的比例，并且大部分地消除第一个图像的散射辐射的比例。

8. 发明申请

WO2010106449A3 FUNCTIONAL IMAGING 审中-公开
标题翻译：功能成像
公开(公告)号：WO2010106449A3
公开(公告)日：2010-12-29
申请号：PCT/IB2010050579
申请日：2010-02-09
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , SOLF TORSTEN , SCHWEIZER BERND , WEIBRECHT MARTIN , RIBBING CAROLINA
发明人： SOLF TORSTEN , SCHWEIZER BERND , WEIBRECHT MARTIN , RIBBING CAROLINA
IPC分类号： A61B6/00 , G06F19/00 , G06T11/00
CPC分类号： A61B6/00 , A61B5/055 , A61B5/743 , A61B6/037 , A61B6/463 , A61B6/545 , A61B8/463 , A61B8/481 , A61B8/585 , G06F19/321 , G16H15/00
摘要： A method includes obtaining an image of a region of interest of a subject, wherein the image is generated with image data produced by an imaging system used to scan the subject, obtaining a signal indicative of a physiological state of the subject before the scan, and displaying both the image and data indicative of the physiological state. In another aspect, a method includes correcting, via a processor, a tracer uptake value for a target region of interest based on a tracer uptake correction factor.
摘要翻译：一种方法包括获得对象感兴趣区域的图像，其中使用由用于扫描对象的成像系统产生的图像数据来生成图像，获得指示扫描之前对象的生理状态的信号，以及显示指示生理状态的图像和数据。在另一方面，一种方法包括：通过处理器，基于示踪剂摄取校正因子来校正目标感兴趣区域的示踪剂吸收值。

9. 发明申请

WO2006000998A2 X-RAY DETECTOR 审中-公开
标题翻译： X射线探测器
公开(公告)号：WO2006000998A2
公开(公告)日：2006-01-05
申请号：PCT/IB2005052091
申请日：2005-06-24
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , SCHWEIZER BERND , VOGTMEIER GEREON , ENGEL KLAUS JUERGEN
发明人： SCHWEIZER BERND , VOGTMEIER GEREON , ENGEL KLAUS JUERGEN
IPC分类号： G04G21/04
CPC分类号： G01T1/1648
摘要： The invention refers to X-ray devices, an X-ray detector and a method of correcting intensity signals. An X-ray detector then comprises for determining the intensity of X-rays, which comprise a proportion of primary radiation having an irradiation direction and a proportion of scattered radiation, at least a first sensor element and second sensor elements, which are each provided for converting the X-rays into first and second intensity signals, and a filter element, which is provided for decreasing the proportion of scattered radiation in the intensity of the X-rays, wherein the second sensor elements are arranged in irradiation direction behind the filter element and wherein the first sensor element fastened to the filter element is provided for determining the intensity of the X-rays before leaving the filter element. The proportion of the scattered radiation calculated from the measuring data of the first and second sensor elements is provided for correcting the second intensity signals for the following image generation.
摘要翻译：本发明涉及X射线装置，X射线检测器和校正强度信号的方法。然后，X射线检测器包括用于确定X射线的强度，X射线包括具有照射方向和散射辐射比例的一次辐射的比例，至少第一传感器元件和第二传感器元件，其被设置用于将X射线转换成第一强度信号和第二强度信号;以及滤波器元件，其被设置用于减小X射线强度中的散射辐射的比例，其中第二传感器元件沿照射方向布置在滤光元件的后面并且其中提供紧固到过滤元件的第一传感器元件用于确定离开过滤元件之前的X射线的强度。提供从第一和第二传感器元件的测量数据计算的散射辐射的比例，用于校正用于后续图像生成的第二强度信号。

10. 发明申请

WO2009153683A2 RADIOLOGICAL IMAGING INCORPORATING LOCAL MOTION MONITORING, CORRECTION, AND ASSESSMENT 审中-公开
标题翻译：包含本地运动监测，校正和评估的放射成像
公开(公告)号：WO2009153683A2
公开(公告)日：2009-12-23
申请号：PCT/IB2009052297
申请日：2009-06-01
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , BRINKS RALPH , FISCHER ALEXANDER , MARTIN RECUERO ANA BELEN , GEORGI JENS-CHRISTOPH , SCHWEIZER BERND , PAULUS TIMO MARKUS
发明人： BRINKS RALPH , FISCHER ALEXANDER , MARTIN RECUERO ANA BELEN , GEORGI JENS-CHRISTOPH , SCHWEIZER BERND , PAULUS TIMO MARKUS
IPC分类号： G06T11/00
CPC分类号： G06T11/005 , G06T2211/412
摘要： A radiological imaging method comprises: acquiring radiological lines of response (LOR's) from a subject; grouping the acquired LOR's into time intervals such that each group of LOR's (20) was acquired during a selected time interval; identifying a region of interest (60, 74) for each time interval based on LOR's grouped into that time interval; for each time interval, determining a positional characteristic (102) of the region of interest identified for that time interval based on LOR's grouped into that time interval; for each time interval, spatially adjusting LOR's grouped into that time interval based on the positional characteristic of the region of interest identified for that time interval; and reconstructing at least the spatially adjusted LOR's to generate a motion compensated reconstructed image.
摘要翻译：放射学成像方法包括：从受试者获取放射线响应（LOR）; 将获得的LOR分组成时间间隔，使得在选定的时间间隔内获取每组LOR（20）; 基于分组到该时间间隔中的LOR，为每个时间间隔识别感兴趣区域（60,74）; 对于每个时间间隔，基于分组到该时间间隔中的LOR确定针对该时间间隔标识的兴趣区域的位置特征（102）; 对于每个时间间隔，基于针对该时间间隔识别的感兴趣区域的位置特性，空间调整LOR被分组为该时间间隔; 以及至少重建空间调整的LOR以产生运动补偿重建图像。

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