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1. 发明申请

WO2010058339A3 IMAGING A TURBID MEDIUM 审中-公开
标题翻译：成像一个TURBID MEDIUM
公开(公告)号：WO2010058339A3
公开(公告)日：2010-07-22
申请号：PCT/IB2009055115
申请日：2009-11-17
申请人： KONINKL PHILIPS ELECTRONICS NV , BAKKER LEVINUS P , VAN DER MARK MARTINUS B , DECKERS JACOBUS A J M , VAN DER VOORT MARJOLEIN , LEPROUX ANAIS
发明人： BAKKER LEVINUS P , VAN DER MARK MARTINUS B , DECKERS JACOBUS A J M , VAN DER VOORT MARJOLEIN , LEPROUX ANAIS
IPC分类号： A61B5/00 , G01N21/47
CPC分类号： A61B5/411 , A61B5/0091 , A61B5/4312 , A61B2562/146 , G01N21/4795
摘要： An imaging system for imaging a turbid medium (1) comprises a holder (2) to receive the turbid medium. A fluid (22) surrounds at least part of the turbid medium. A pressure system (30) controls the hydrostatic pressure of the fluid. Notably, the imaging system of the invention images the turbid medium at different pressures applied to the turbid medium by the fluid. From a combination of the measured data or reconstructed images made at different pressures in the turbid medium, inhomogeneities are distinguished from a homogeneous surrounding. The fluid can be chosen to perform both the function of optical impedance matching between the turbid medium and its surroundings as well as the controlled application of hydrostatic pressure to the turbid medium.
摘要翻译：用于对混浊介质（1）成像的成像系统包括用于接收混浊介质的支架（2）。流体（22）包围混浊介质的至少一部分。压力系统（30）控制流体的静水压力。值得注意的是，本发明的成像系统在不同的压力下通过流体对混浊介质施加不同的压力来对混浊介质成像。根据混合介质中测量数据或不同压力下重建图像的组合，将不均匀性与均匀周围区分开来。可以选择流体来执行混浊介质与其周围环境之间的光阻抗匹配功能以及对混浊介质的流体静压力的受控应用。

2. 发明申请

WO2009019653A2 OPTICAL TWO-WAY SWITCH 审中-公开
标题翻译：光学两路开关
公开(公告)号：WO2009019653A2
公开(公告)日：2009-02-12
申请号：PCT/IB2008053143
申请日：2008-08-05
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN BEEK MICHAEL C , VAN DER MARK MARTINUS B , BAKKER LEVINUS P , VAN DER VOORT MARJOLEIN
发明人： VAN BEEK MICHAEL C , VAN DER MARK MARTINUS B , BAKKER LEVINUS P , VAN DER VOORT MARJOLEIN
IPC分类号： G02B6/35
CPC分类号： G02B6/3512 , A61B5/0059 , A61B5/0062 , A61B5/0073 , A61B5/0091 , A61B5/4312 , G02B6/3504 , G02B6/3556 , G02B6/3558
摘要： The invention relates to an optical imaging method for imaging an object comprising the following steps: - coupling light from a light source to an illumination position for illuminating the object, with the illumination position being selected from a plurality of illumination positions for illuminating the object using an optical switch, with the optical switch being optically coupled to the light source and to the plurality of illumination positions; - collecting light emanating from the object at least one collection position, with the light emanating from the object as a result of coupling light from the light source to the selected illumination position for illuminating the object. According to the invention the method is amended in that the method further comprises the following step: - coupling light collected at a collection position through the optical switch. The method allows to couple the process of receiving light from the object to be imaged to the process of coupling light from the light source to the object to be imaged. The invention also relates to an optical switch for use in the method.
摘要翻译：本发明涉及一种用于对物体进行成像的光学成像方法，包括以下步骤： - 将来自光源的光耦合到用于照亮物体的照明位置，其中照明位置选自多个照明位置，用于使用光学开关，光学开关光学耦合到光源和多个照明位置; - 从所述对象发出的至少一个收集位置的光，由于将来自所述光源的光耦合到用于照亮所述物体的所选择的照明位置的结果，从所述物体发出的光。根据本发明，该方法被修改为，该方法还包括以下步骤： - 通过光学开关耦合在收集位置收集的光。该方法允许将从要成像的对象接收光的处理耦合到将来自光源的光耦合到要成像的对象的处理。本发明还涉及一种用于该方法的光开关。

3. 发明申请

WO2008146195A3 DEVICE FOR IMAGING AN INTERIOR OF AN OPTICALLY TURBID MEDIUM USING DIFFUSE OPTICAL TOMOGRAPHY AND ULTRASOUND 审中-公开
标题翻译：用于成像使用DIFFUSE OPTICAL TOMOGRAPHY和ULTRASOUND的光学涡卷介质内部的装置
公开(公告)号：WO2008146195A3
公开(公告)日：2009-01-29
申请号：PCT/IB2008051958
申请日：2008-05-19
申请人： KONINKL PHILIPS ELECTRONICS NV , ENTREKIN ROBERT R , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P , COMPEN HENDRIKUS A C M , DEHN FRANK , VAN DER VAART NIJS C , DECKERS JACOBUS A J M , SUIJVER JAN F
发明人： ENTREKIN ROBERT R , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P , COMPEN HENDRIKUS A C M , DEHN FRANK , VAN DER VAART NIJS C , DECKERS JACOBUS A J M , SUIJVER JAN F
IPC分类号： A61B5/00 , A61B8/08
CPC分类号： A61B5/4312 , A61B5/0073 , A61B5/0091 , A61B8/0825 , A61B8/5238
摘要： The invention relates to a device for imaging the interior of a volume of an object using diffuse optical tomography and ultrasound. According to the invention a volume in which the object is accommodated and into which optical and ultrasound signals are sent is bound by a wall structure comprising entrance and exit positions for both the optical and ultrasound signals. In this way, the object can be positioned relative to the wall structure resulting in a well-defined measurement geometry. The invention improves the comparability of scans of an object that have been made at different points in time as the positioning of the object in a first scan can be precisely reproduced in a further scan relative to the wall structure.
摘要翻译：本发明涉及一种使用漫射光学层析成像和超声波成像物体体积内部的装置。根据本发明，其中容纳物体并且发送光学和超声信号的体积被包括光学和超声信号两者的入射和出射位置的壁结构所约束。以这种方式，物体可以相对于壁结构定位，从而产生明确的测量几何形状。本发明改进了在不同时间点进行的物体的扫描的可比性，因为可以在相对于墙壁结构的进一步扫描中精确地再现第一扫描中的物体的定位。

4. 发明申请

WO2008146198A2 DEVICE FOR IMAGING AN INTERIOR OF AN OPTICALLY TURBID MEDIUM USING DIFFUSE OPTICAL TOMOGRAPHY AND ULTRASOUND 审中-公开
标题翻译：用于使用差分光学层析成像和超声波成像光学浊度介质的内部的装置
公开(公告)号：WO2008146198A2
公开(公告)日：2008-12-04
申请号：PCT/IB2008051992
申请日：2008-05-21
申请人： KONINKL PHILIPS ELECTRONICS NV , BAKKER LEVINUS P , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , HARBERS RIK , SUIJVER JAN F
发明人： BAKKER LEVINUS P , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , HARBERS RIK , SUIJVER JAN F
IPC分类号： A61B5/00 , A61B8/08
CPC分类号： A61B5/4312 , A61B5/0073 , A61B5/0091 , A61B8/0825 , A61B8/5238
摘要： The invention relates to a device for imaging the interior of a volume of an object using diffuse optical tomography and ultrasound. According to the invention a volume in which the object is accommodated and into which optical and ultrasound signals are sent is bound by a wall structure comprising entrance and exit positions for both the optical and ultrasound signals. In this way, the object can be positioned relative to the wall structure resulting in a well-defined measurement geometry. The invention improves the comparability of scans of an object that have been made at different points in time as the positioning of the object in a first scan can be precisely reproduced in a further scan relative to the wall structure.
摘要翻译：本发明涉及一种使用漫射光学断层摄影术和超声波对物体的体积内部进行成像的设备。根据本发明，物体被容纳在其中并且光信号和超声信号被发送到其中的体积由包括光信号和超声信号的入口和出口位置的壁结构限定。通过这种方式，物体可以相对于壁结构定位，从而得到明确的测量几何形状。本发明改进了在不同时间点产生的物体扫描的可比性，因为在第一次扫描中物体的定位可以在相对于壁结构的进一步扫描中被精确再现。

5. 发明申请

WO2008059437A3 DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：用于成像涡轮介质内部的装置
公开(公告)号：WO2008059437A3
公开(公告)日：2008-07-10
申请号：PCT/IB2007054601
申请日：2007-11-13
申请人： KONINKL PHILIPS ELECTRONICS NV , BAKKER LEVINUS P , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C
发明人： BAKKER LEVINUS P , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (55) comprising a receptacle (20) with the receptacle (20) comprising a measurement volume (15) for receiving the turbid medium (55). The device (1) is adapted such that the inner surface of the receptacle (20), including at least part of the optical channels (70) is covered with a layer (80).
摘要翻译：本发明涉及一种用于对包含容器（20）的浑浊介质（55）的内部成像的装置（1），所述容器（20）包括用于接收混浊介质（55）的测量体积（15）。设备（1）适于使得包括至少部分光通道（70）的容器（20）的内表面被层（80）覆盖。

6. 发明申请

WO2007057798A3 DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：用于成像涡轮介质内部的装置
公开(公告)号：WO2007057798A3
公开(公告)日：2007-09-27
申请号：PCT/IB2006053972
申请日：2006-10-27
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P , RAS ARNOLDUS J M J
发明人： VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P , RAS ARNOLDUS J M J
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0073 , A61B5/0091 , A61B2562/146
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (55) comprising a receptacle (20) with the receptacle (20) comprising a measurement volume (15) for receiving the turbid medium (55). The device (1) is adapted such that the device (1) further comprises a further receptacle (60), arranged to be inserted into the receptacle (20), with the further receptacle (60) comprising a restricted measurement volume (75) for receiving the turbid medium (55).
摘要翻译：本发明涉及一种用于对包括容器（20）的混浊介质（55）的内部进行成像的设备（1），容器（20）包括用于接收混浊介质（55）的测量容积（15）。所述装置（1）适于使得所述装置（1）还包括布置成插入到所述容器（20）中的另外的容器（60），其中所述另外的容器（60）包括限制的测量容积（75），用于接收混浊介质（55）。

7. 发明申请

WO2007060598A3 A METHOD OF, SYSTEM FOR, AND MEDICAL IMAGE ACQUISITION SYSTEM FOR IMAGING AN INTERIOR OF A TURBID MEDIUM TAKING INTO ACCOUNT THE GEOMETRY OF THE TURBID MEDIUM 审中-公开
标题翻译：用于形成涡轮介质的内部的系统和用于摄像机的医疗图像采集系统的方法，用于涡轮介质的几何
公开(公告)号：WO2007060598A3
公开(公告)日：2007-09-07
申请号：PCT/IB2006054341
申请日：2006-11-20
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P
发明人： VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P
IPC分类号： G01N21/49 , A61B5/00
CPC分类号： G01N21/4795 , G01N2021/1787 , G01N2021/4766 , G01N2021/6439
摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume; coupling transmission input light (65) from a transmission light source into the receiving volume, with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45); detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light from the light source into the receiving volume through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and to a medical image acquisition system both using the method. The method, system, and medical image acquisition system are adapted such that an improved way of obtaining data relating to the exterior of the turbid medium (45) is realized. The object of the invention is realized in that the method further comprises the following steps: - coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume, with the receiving volume comprising the turbid medium (45) and with the combination of the geometry input light (70, 75, 80) and the interface (60) being chosen for creating a contrast between the turbid medium (45) and its surroundings; detection of the contrast (60) between the turbid medium (45) and its surroundings through use of a contrast photodetector unit; reconstructing an image of an interior of the turbid medium (45) using a the detected contrast (60). The system for imaging an interior of a turbid medium (45) and the medical image acquisition device are adapted to further comprise a geometry light source and a contrast photodetector unit.
摘要翻译：本发明涉及一种对混浊介质（45）内部进行成像的方法，包括以下步骤：在接收容积内容纳混浊介质（45）; 将透射输入光（65）从透射光源耦合到接收体积中，所述透射输入光（65）被选择为使得其能够传播通过混浊介质（45）; 通过使用传输光电检测器单元将从光源的输入光耦合到接收体积中的结果，检测从接收体积发出的透射输出光。本发明还涉及一种用于使浑浊介质（45）的内部成像和使用该方法的医学图像采集系统的成像系统。调整方法，系统和医学图像采集系统，从而实现获得与混浊介质（45）的外部相关的数据的改进方式。本发明的目的是通过该方法进一步包括以下步骤：将几何输入光（70,75,80）从几何光源耦合到接收体积中，其中接收体积包括混浊介质（45）并且选择所述几何输入光（70,75,80）和所述界面（60）的组合以在所述混浊介质（45）及其周围环境之间产生对比度; 通过使用对比度光电检测器单元检测混浊介质（45）与其周围环境之间的对比度（60）; 使用检测到的对比度（60）重建混浊介质（45）的内部的图像。用于对浑浊介质（45）和医学图像采集装置的内部成像的系统适于进一步包括几何光源和对比度光电检测器单元。

8. 发明申请

WO2007060586A3 METHOD AND DEVICE FOR OPTICAL IMAGING OF A TURBID MEDIUM 审中-公开
标题翻译：用于光学介质的光学成像的方法和装置
公开(公告)号：WO2007060586A3
公开(公告)日：2007-09-07
申请号：PCT/IB2006054317
申请日：2006-11-17
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P
发明人： VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091 , A61B5/1455 , A61B5/14551
摘要： Disclosed is a method and a device for optical imaging of a turbid medium. This method comprises a reference measurement of reference intensities of light emanating from the turbid medium at a reference blood oxygen saturation (SaO2) in the turbid medium and a reference imaging step for reconstructing a reference image of the turbid medium from the measured reference intensities. Furthermore the method comprises a contrast measurement of the contrast intensity of the light emanating from the turbid medium at a contrast blood oxygen saturation (SaO2) level in the turbid medium and a contrast imaging step for reconstructing a contrast image of the turbid medium from the measured contrast intensities. A comparison is made between the contrast image to the reference image of the turbid medium.
摘要翻译：公开了一种用于混浊介质的光学成像的方法和设备。该方法包括在混浊介质中的参考血氧饱和度（SaO 2）下从混浊介质发出的光的参考强度的参考测量和用于从测量的参考强度重建混浊介质的参考图像的参考成像步骤。此外，该方法包括在混浊介质中的对比度血氧饱和度（SaO 2）水平上对从混浊介质发出的光的对比度强度进行对比度测量，以及对比度成像步骤，用于从测量值中重建混浊介质的对比度图像对比强度。对比图像与混浊介质的参考图像进行比较。

9. 发明申请

WO2009013692A3 MULTIMODALITY MATCHING MEDIUM FOR DIFFUSE OPTICAL TOMOGRAPHY AND ULTRASOUND MEASUREMENTS 审中-公开
标题翻译：用于弥散性光学造影和超声波测量的多功能匹配介质
公开(公告)号：WO2009013692A3
公开(公告)日：2009-03-12
申请号：PCT/IB2008052910
申请日：2008-07-21
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN DER MARK MARTINUS B , ENTREKIN ROBERT R , VAN BEEK MICHAEL C , BAKKER LEVINUS P , VAN DER VAART NIJS C
发明人： VAN DER MARK MARTINUS B , ENTREKIN ROBERT R , VAN BEEK MICHAEL C , BAKKER LEVINUS P , VAN DER VAART NIJS C
IPC分类号： A61B5/00 , A61B8/08 , A61K49/22 , G01N21/17 , G01N21/47 , G01N21/49 , G01N29/24 , G01N29/28
CPC分类号： A61K49/0002 , A61B5/0035 , A61B5/0091 , A61B5/4312 , A61B8/0825 , A61B8/4272 , A61B8/429 , A61B8/4416 , A61B2562/146 , A61K49/226
摘要： The invention relates to a matching medium (100) that is used to optically couple an optically turbid medium (100) to its surroundings during diffuse optical tomography measurements. Generally, an optical matching medium makes it hard to acoustically couple the turbid medium to its surroundings efficiently. According to the invention, this problem is solved by using a matching medium that matches both the optical and acoustic characteristics of the turbid medium to the optical and acoustic characteristics of the surroundings of the turbid medium. The invention explains how a multimodality matching medium can be obtained that both optically and acoustically couples human tissue to its surroundings.
摘要翻译：本发明涉及一种匹配介质（100），其用于在漫射光学层析成像测量期间将光学混浊介质（100）光学耦合到其周围环境。通常，光学匹配介质使得难以有效地将混浊介质与其周围环境耦合。根据本发明，通过使用与混浊介质的光学和声学特性匹配的匹配介质与混浊介质周围的光学和声学特性相匹配来解决该问题。本发明解释了如何获得将人体组织光学和声学耦合到其周围环境的多模式匹配介质。

10. 发明申请

WO2007060602A3 A METHOD AND DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：一种用于成像涡轮介质内部的方法和装置
公开(公告)号：WO2007060602A3
公开(公告)日：2007-10-25
申请号：PCT/IB2006054349
申请日：2006-11-21
申请人： KONINKL PHILIPS ELECTRONICS NV , BAKKER LEVINUS P , T HOOFT GERT , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C
发明人： BAKKER LEVINUS P , T HOOFT GERT , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091
摘要： The invention relates to a method and device (1) for imaging an interior of a turbid medium (55). A turbid medium (55) inside a measurement volume (15) is irradiated from a plurality of source positions (25a) with light from a light source (5), and light emanating from the measurement volume (15) is detected from a plurality of detection positions (25b). An image of the interior of the turbid medium (55) is reconstructed from the detected light. In both the method and the device (1), detector signals can be amplified for each source position-detection position pair by a multi-gain amplification unit comprising an amplifier circuit (60). The amplification factor is selected from a number of possible amplification factors based on detected signal strength in the prior art. According to the invention, however, the method and device are adapted such that the amplification factor is selected for at least one source position-detection position pair on the basis of an estimate of expected electrical signal strength.
摘要翻译：本发明涉及一种用于对浑浊介质（55）的内部进行成像的方法和装置（1）。从多个源位置（25a）利用来自光源（5）的光照射测量体积（15）内部的混浊介质（55），并且从测量体积（15）发出的光从多个检测位置（25b）。从检测到的光重建混浊介质（55）的内部的图像。在方法和装置（1）中，通过包括放大器电路（60）的多增益放大单元，可以为每个源位置检测位置对放大检测器信号。基于现有技术中检测到的信号强度，从多个可能的放大因子中选择放大因子。然而，根据本发明，所述方法和装置被适配成使得根据预期的电信号强度的估计为至少一个源位置检测位置对选择放大系数。

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