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    • 2. 发明申请
    • PROCESS FOR THE PREPARATION OF CHIRAL GLYCIDYLPHTHALIMIDE IN HIGHLY OPTICAL PURITY
    • 在高光学纯度下制备丙二酰胆碱酯酶的方法
    • WO2007132990A1
    • 2007-11-22
    • PCT/KR2007/002154
    • 2007-05-02
    • RSTECH CORPORATIONKANG, Hyun BinQUAN, Long GuoLEE, Jae KwanKIM, Seong-Jin
    • KANG, Hyun BinQUAN, Long GuoLEE, Jae KwanKIM, Seong-Jin
    • C07D405/06
    • C07D405/06
    • The present invention relates to a process for the preparation of highly optical pure glycidylphthalimide. More particularly, the present invention relates to a process for the preparation of chiral glycidylphthalimide, which comprises the steps of reacting an optically active 3-susbstituted 1-amino-2-propanol acid addition salt with phthalic anhydride in a presence of a base to obtain N -(3-substituted-2-hydroxypropyl)phthalimide and subjecting the obtained compound to an epoxide cyclization reaction to prepare the targeted glycidylphthalimide. According to the process, the chirality of the starting material is substantially retained throughout overall procedures. Therefore, the process can prepare the targeted glycidylphthalimide in an optically pure form having 99%ee or higher. And, the reactions are carried out under mild conditions through overall procedures and in a single reaction vessel without any special purification. This increases the yield of the target compound.
    • 本发明涉及制备高光学纯缩水甘油基邻苯二甲酰亚胺的方法。 更具体地说,本发明涉及手性缩水甘油基邻苯二甲酰亚胺的制备方法,该方法包括以下步骤:在碱的存在下使光学活性的3-取代的1-氨基-2-丙醇酸加成盐与邻苯二甲酸酐反应,得到 N-(3-取代-2-羟基丙基)邻苯二甲酰亚胺,并使所得化合物进行环氧化物环化反应,制备目标缩水甘油基邻苯二甲酰亚胺。 根据该方法,起始原料的手性基本上保留在整个方法中。 因此,该方法可以制备具有99%ee或更高的光学纯形式的目标缩水甘油基邻苯二甲酰亚胺。 而且,反应在温和条件下通过总体程序和在单个反应容器中进行而没有任何特别的纯化。 这增加了目标化合物的产率。
    • 4. 发明申请
    • METHOD FOR TRANSMITTING SCAN DATA OF WIRELESS INPUT DEVICE AND IR PROTOCOL THEREFOR
    • 传输无线输入设备扫描数据的方法及其IR协议
    • WO2006137642A1
    • 2006-12-28
    • PCT/KR2006/001514
    • 2006-04-21
    • CELRUN CO., LTD.LEE, Jae Kwan
    • LEE, Jae Kwan
    • H04Q9/00
    • G06F3/0231
    • The present invention relates to a method for transmitting the scan data of a wireless input device. The method comprises the steps of: when a general key is pressed while a function key remains pressed, successively transmitting a make code for the function key and a make code for the general key; transmitting a break code for the general key when the general key is depressed; and, when the function key remains pressed after the depressing of the general key, re¬ transmitting the make code for the function key before transmitting a make code for a general key to be pressed afterward. When general keys are pressed and depressed for several times while a function key remains pressed, a make code for the function key is generated after the depressing of one general key and before the pressing of another general key. Thus, the transmission error of the make code for the function key can be avoided and the IR protocol can be simplified. Specifically, inputs of two different general keys can be distinguished with a time interval of about 14.4 msec.
    • 本发明涉及一种用于发送无线输入设备的扫描数据的方法。 该方法包括以下步骤:当功能键保持按压时按下通用键,连续发送用于功能键的制作代码和通用键的制作代码; 当通用键被按下时,传送一般键的中断码; 并且当在按下通用键之后功能键保持按压时,在发送用于将要按下的通用键的制作代码之前,重新发送功能键的制作代码。 当按下功能键时按下并按下一般按键几次,在按下一个普通键并按下另一个常规键之前产生功能键的制作代码。 因此,可以避免功能键的制造代码的传输错误,并且可以简化IR协议。 具体来说,两个不同的通用键的输入可以区分大约14.4毫秒的时间间隔。
    • 5. 发明申请
    • PROCESS FOR THE EFFICIENT PREPARATION OF 3-HYDROXY PYRROLIDINE AND DERIVATIVES THEREOF
    • 有效制备3-羟基吡咯烷酮及其衍生物的方法
    • WO2009011551A2
    • 2009-01-22
    • PCT/KR2008/004193
    • 2008-07-17
    • RSTECH CORPORATIONQUAN, Long GuoLEE, Jae KwanHONG, Mei HuaKIM, Kwang SubPARK, Kwang Sik
    • QUAN, Long GuoLEE, Jae KwanHONG, Mei HuaKIM, Kwang SubPARK, Kwang Sik
    • C07D207/12
    • C07D207/12
    • The present invention relates to an effective process for the preparation of 3-hydroxypyrrolidine or derivatives thereof. The process comprises (a) protecting a hydroxyl group of 4-halo-3-hydroxybutyric acid, (b) reducing an ester group of the compound obtained from the step (a) to obtain a corresponding alcohol compound, (c) reacting the compound obtained from the step (b) with sulfonyl halide to produce a corresponding sulfonate compound, (d) reacting the compound obtained from the step (c) with an amine to obtain 3-hydroxy-protected pyrrolidine compound, and (e) deprotecting the compound obtained from the step (d) to produce the targeted 3-hydroxypyrrolidine or derivatives thereof. The process provides 3-hydroxypyrrolidine or derivatives thereof with high optical purity, because optical purity of the starting material is substantially retained. In the process, each of the steps is carried out in a mild condition and does not require any special purification. This means that the process is useful and adequate for industrial mass production of 3-hydroxypyrrolidine and derivatives thereof having high optical purity.
    • 本发明涉及一种制备3-羟基吡咯烷或其衍生物的有效方法。 该方法包括(a)保护4-卤-3-羟基丁酸的羟基,(b)还原由步骤(a)获得的化合物的酯基,得到相应的醇化合物,(c)使化合物 (b)由磺酰卤获得以产生相应的磺酸盐化合物,(d)使由步骤(c)获得的化合物与胺反应,得到3-羟基保护的吡咯烷化合物,和(e)使化合物 (d)得到目标3-羟基吡咯烷或其衍生物。 该方法提供具有高光学纯度的3-羟基吡咯烷酮或其衍生物,因为起始原料的光学纯度基本保持不变。 在该过程中,每个步骤在温和条件下进行,并且不需要任何特殊的纯化。 这意味着该方法对于具有高光学纯度的3-羟基吡咯烷及其衍生物的工业批量生产是有用和充分的。
    • 6. 发明申请
    • ENZYMES COATED WITH IONIC LIQUID
    • 用离子液体包裹的酶
    • WO2003057871A1
    • 2003-07-17
    • PCT/KR2003/000067
    • 2003-01-13
    • POSCOPOSTECH FOUNDATIONKIM, Mahn-JooLEE, Jae Kwan
    • KIM, Mahn-JooLEE, Jae Kwan
    • C12N9/20
    • C12P41/003C12N9/20C12N9/96
    • Disclosed is an ionic liquid-coated enzyme, wherein the ionic liquid is an organic salt which presents as a liquid phase at a temperature of about 150°C or below. The ionic liquid-coated enzyme according to the present invention remarkably improves enzyme functions, such as enantioselectivity and stability, when the enzyme which may be lipase is coated with an ionic liquid. Further, even in the case of when the ionic liquid-coated enzyme is reused, the enantiomeric excess, enantioselectivity, and activity are not degenerated. The coated enzyme is usable as a catalyst for providing a chiral intermediate required in the synthesis of chiral pesticides, medicines, natural chemicals, and so on.
    • 公开了一种离子液体包被的酶,其中离子液体是在约150℃或更低的温度下作为液相呈现的有机盐。 当可用脂肪酶的酶用离子液体包被时,根据本发明的离子液体包被酶显着地改善酶功能,如对映选择性和稳定性。 此外,即使在重新使用离子液体包被的酶的情况下,对映体过量,对映选择性和活性也不会退化。 涂覆的酶可用作提供合成手性农药,药物,天然化学品等所需的手性中间体的催化剂。