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    • 3. 发明申请
    • WIPE FOR USE WITH A GERMICIDAL SOLUTION
    • WIPE使用杀菌溶液
    • WO2012107847A3
    • 2012-11-01
    • PCT/IB2012050201
    • 2012-01-16
    • KIMBERLY CLARK COCOLMAN CHARLES WFORTHOFER MARSHA RMAJORS MARK BHASHA DENNIS L
    • COLMAN CHARLES WFORTHOFER MARSHA RMAJORS MARK BHASHA DENNIS L
    • A47L13/17
    • A61K8/416A01N33/12A61K8/0208A61K8/84A61Q17/005D06M13/46D06M15/61D06M16/00A01N2300/00A01N25/24A01N25/34
    • An antimicrobial wipe that contains a polymer coating having a synergistic combination of ingredients for providing controlled release of an antimicrobial agent and also good antimicrobial efficacy is provided. One such ingredient is a high molecular weight polyamideamine release agent. Due to the polycationic nature of the release agent, it is able to adhere to the wipe, which is generally formed from fibers having a negative surface charge (e.g., cellulosic fibers). In this manner, the release agent can occupy binding sites on the wipe to inhibit the antimicrobial agent from adhering thereto, thus allowing it to be expressed in the germicidal solution to kill microbes on the desired surface. The adherence of the release agent to the wipe is even further enhanced by crosslinking the polyamideamine to increase its molecular weight, thereby enabling it to form a structural network that physically adheres to the wipe and that blocks the antimicrobial agent from binding thereto. Furthermore, the polyamideamine is amidated so that it contains secondary and/or tertiary amides. A cell permeabilizer is also employed in the polymer coating to enhance the efficacy of the antimicrobial agent during use. More particularly, polycationic materials are particularly useful in permeabilizing the outer cell membrane without adversely impacting the ability of the polyamideamine to release the antimicrobial agent within the wipe.
    • 提供了一种抗微生物擦拭物,其包含具有协同组合的用于提供抗微生物剂的受控释放的成分以及良好的抗微生物功效的聚合物涂层。 一种这样的成分是高分子量聚酰胺胺脱模剂。 由于脱模剂的聚阳离子性质,其能够粘附到通常由具有负表面电荷的纤维(例如纤维素纤维)形成的擦拭物上。 以这种方式,脱模剂可以占据擦拭物上的结合位点以抑制抗微生物剂粘附到其上,从而允许其在杀菌溶液中表达以杀死所需表面上的微生物。 通过交联聚酰胺胺以增加其分子量,脱模剂对擦拭物的粘附性进一步增强,从而使其形成物理粘附在擦拭物上并阻止抗微生物剂结合的结构网络。 此外,聚酰胺胺被酰胺化,使得其含有仲和/或叔酰胺。 在聚合物涂层中还使用细胞渗透剂,以增强抗微生物剂在使用过程中的功效。 更具体地,聚阳离子材料特别可用于透化外细胞膜,而不会不利地影响聚酰胺胺在擦拭物内释放抗微生物剂的能力。