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1. 发明申请

WO2006007835A2 AMMONIUM SALTS AND AMMONIUM SALT/MINERAL SALT CLATHRATE COMPOUNDS FOR USE AS VEHICLE AND EFFECTIVE FORM FOR PHARMACO-MEDICAL APPLICATIONS AND FOR USE AS PHASE TRANSFER AGENTS FOR CHEMICAL APPLICATIONS 审中-公开
标题翻译：铵盐和铵盐MINERALSALZCLATHRATE用于医药医疗和AS PHASENTRANSFERMIITEL用于化学应用运输及活性形式
公开(公告)号：WO2006007835A2
公开(公告)日：2006-01-26
申请号：PCT/DE2005001288
申请日：2005-07-20
申请人： KASCH HELMUT , REUTER UWE , OETTMEIER RALF
发明人： KASCH HELMUT , REUTER UWE , OETTMEIER RALF
IPC分类号： C07C211/63
CPC分类号： C07C211/63 , C07C215/90 , C07C237/04 , C07C237/34
摘要： The invention relates to ammonium salts and stable storable ammonium salt/mineral salt clathrate compounds (inclusion compounds) having acidic dibasic acid residues such as hydrocarbonate, to methods for producing them and to pharmaco-medical and chemical synthetic applications for said compounds. According to the invention, compounds for pharmaco-medical and chemical synthetic applications are produced which comprise the ammonium salt and ammonium/mineral salt clathrate compounds (inclusion compounds, clusters) having acidic dibasic anionic acid residues of general formula (I) * x mole mineral salt, wherein R1, R2, R3 and R4 = alkyl and substituted alkyl straight-chain or branched, optionally having an alcohol, ether, silylether, ester, amino or amide function, H or aryl-alkyl, whereby aryl is an aromatic or heteroaromatic ring having optionally additional substituents, such as alkyl having 1 to 4 C atoms, OH, NR*
摘要翻译：本发明涉及的铵盐和具有酸性二元酸残基如碳酸氢盐稳定可储存AmmoniumsalzMineralsalzclathrate（包含化合物），它们的制备方法以及这些化合物的药理医疗和化学合成应用程序的方法。本发明的目的是这样来实现在对于药理医疗和化学合成应用中，包括铵和具有通式的酸性二元阴离子氨基酸残基（I），其中R1，R2，R3，和铵/ Mineralsalzclathrate（包合物，簇）的化合物 R4 =烷基和取代的烷基的直链或支链的，任选地具有另外的醇，醚，甲硅烷基醚，酯，氨基或酰胺官能团，H或芳基 - 烷基，而被芳基是任选地具有另外的取代基的芳族或杂芳族环如具有1至4个碳原子，烷基OH，NR * <子 - 是

2. 发明申请

WO2006007835A8 Ammonium salts and ammonium salt/mineral salt clathrate compounds for use as vehicle and effective form for pharmaco-medical applications and for use as phase transfer agents for chemical applications 审中-公开
标题翻译：铵盐和铵盐MineralsalzclathratAmmonium盐和铵盐/矿物盐Clate R作为运输和活性形式F}用作车辆和有效的形式为药理医疗应用和使用dizinische和作为相转移剂F}的化学应用为r药学mehrate化合物化学应用相转移剂
公开(公告)号：WO2006007835A8
公开(公告)日：2006-06-29
申请号：PCT/DE2005001288
申请日：2005-07-20
申请人： KASCH HELMUT , REUTER UWE , OETTMEIER RALF
发明人： KASCH HELMUT , REUTER UWE , OETTMEIER RALF
IPC分类号： C07C211/63
CPC分类号： C07C211/63 , C07C215/90 , C07C237/04 , C07C237/34
摘要： The invention relates to ammonium salts and stable storable ammonium salt/mineral salt clathrate compounds (inclusion compounds) having acidic dibasic acid residues such as hydrocarbonate, to methods for producing them and to pharmaco-medical and chemical synthetic applications for said compounds. According to the invention, compounds for pharmaco-medical and chemical synthetic applications are produced which comprise the ammonium salt and ammonium/mineral salt clathrate compounds (inclusion compounds, clusters) having acidic dibasic anionic acid residues of general formula (I) * x mole mineral salt, wherein R1, R2, R3 and R4 = alkyl and substituted alkyl straight-chain or branched, optionally having an alcohol, ether, silylether, ester, amino or amide function, H or aryl-alkyl, whereby aryl is an aromatic or heteroaromatic ring having optionally additional substituents, such as alkyl having 1 to 4 C atoms, OH, NR* 2 with R* 2 = 0, alkyl with alkyl of from 1 to 4 C atoms or H, COOH, COOR, CN, NO 2 and the cationic positive N + optionally is part of an active agent, Y = a dibasic acid residue of an organic dicarboxylic acid or CO 3 , corresponding to HY - = HCO 3
摘要翻译：本发明涉及的铵盐和具有酸性二元酸残基如碳酸氢盐稳定可储存AmmoniumsalzMineralsalzclathrate（包含化合物），它们的制备方法以及这些化合物的药理医疗和化学合成应用程序的方法。本发明的目的是这样来实现在对于药理医疗和化学合成应用中，包括铵和具有通式的酸性二元阴离子氨基酸残基（I），其中R1，R2，R3，和铵/ Mineralsalzclathrate（包合物，簇）的化合物 R4 =烷基和取代的烷基的直链或支链的，任选地具有另外的醇，醚，甲硅烷基醚，酯，氨基或酰胺官能团，H或芳基 - 烷基，而被芳基是任选地具有另外的取代基的芳族或杂芳族环如碳原子数1〜4的烷基，OH，NR * _{2 R * _{2 = 0烷基与至4 C-Atomem或H，COOH的1烷基，COOR，CN，NO _{2 应被理解和positivized n中的阳离子^{+ 是活性成分的任选部分，Y =有机二羧酸或CO _{的二元酸残基3 中，对应于HY ^{- = HC0 ₃}}}}}}

3. 发明申请

WO9842729A3 STEROID SULFAMATES, METHOD FOR THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译：甾体磺酸盐，其生产方法及其用途
公开(公告)号：WO9842729A3
公开(公告)日：1999-01-14
申请号：PCT/DE9800813
申请日：1998-03-18
申请人： KNOELL HANS FORSCHUNG EV , ROSSENDORF FORSCHZENT , KASCH HELMUT , SCHUMANN WINFRIED , ROEMER JOHANNES , STEINBACH JOERG
发明人： KASCH HELMUT , SCHUMANN WINFRIED , ROEMER JOHANNES , STEINBACH JOERG
IPC分类号： A61K51/00 , A61K31/565 , A61P5/30 , A61P15/12 , A61P35/00 , A61P43/00 , C07J41/00 , C07J53/00 , C07J63/00 , C07J71/00 , C07J
CPC分类号： C07J53/004 , C07J63/008 , C07J71/0031 , Y02P20/55
摘要： The invention relates to novel estratrienes of general formula (I) containing several sulfamoyoxy groups per molecule (m = 1-5). They are produced by reacting the appropriate steroid alcohols with sulfamoy or n-alkyl or alkanoylsulfamoyl chloride in the presence of a buffer or a base. The compounds of formula (I) are characterized by a high sulfatase activity and are therefore suitable for the treatment of diseases responding to sulfatase inhibition. The high target specificity of the inventive compounds in relation to sulfatase and estrogen transcription assays enable said compounds, which are provided with a radiolabel e.g. [18F] fluorine instead of F, to be used as potential markers in tumor diagnosis.

4. 发明申请

WO2004067547A3 NOVEL STEROIDS AND STEROID MIMETICS, METHOD FOR THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译：新类固醇和制造业类固醇模拟，方法和用途
公开(公告)号：WO2004067547A3
公开(公告)日：2004-11-04
申请号：PCT/DE2004000152
申请日：2004-01-28
申请人： KASCH HELMUT , LIEDTKE BEATRICE
发明人： KASCH HELMUT , LIEDTKE BEATRICE
IPC分类号： C07J1/00 , C07J75/00
CPC分类号： C07J1/00
摘要： The invention relates to the production and use of novel 14ß-alkyl-18-norsteroids, 8α,14ß-dialkyl-18-norsteroids, spiro[cyclopentano-perhydronaph-thalin]-3,1`-pentanes or hexanes in addition to 14ß-fluoro-15ß,17ß-dihydroxy-steroids, by reacting 17-hydroxy-14,15-epoxi-steroids with water-free acids or Lewis acids and followed by derivatisation. The resulting compounds can be used as intermediate products for or as medicaments in human and veterinary medicine, whereby the emphasis is on improving inflammatory processes, hormone replacement therapy and the use thereof as enzyme inhibitors in the treatment of tumours.

5. 发明申请

WO0145678A3 MEDICAMENT, A METHOD FOR ITS PRODUCTION AND THE USE THEREOF 审中-公开
标题翻译：药物，方法ITS和使用
公开(公告)号：WO0145678A3
公开(公告)日：2002-04-11
申请号：PCT/EP0013036
申请日：2000-12-20
申请人： ID PHARMA GMBH , KASCH HELMUT , GOLDSCHMIDT CARSTEN
发明人： KASCH HELMUT , GOLDSCHMIDT CARSTEN
IPC分类号： A61K31/565 , A61K45/06 , C07C237/10 , C07C271/44 , C07C271/58 , C07C275/42 , C07J41/00 , A61K31/46 , A61K31/165 , A61K31/195 , A61K31/245 , A61K31/445 , A61K31/58 , A61K35/78
CPC分类号： C07J41/0055 , A61K31/565 , A61K45/06 , C07C237/10 , C07C271/44 , C07C271/58 , C07C275/42 , C07J41/0016 , C07J41/0038 , C07J41/0044 , A61K31/245 , A61K2300/00
摘要： The invention relates to a composition which comprises as its constituents (a) a local anaesthetic and (b) an anti-inflammatory compound and/or an immunostimulant compound and/or a compound which acts as a supporting material for the local anaesthetic. The invention also relates to a method for the production and use of said composition.
摘要翻译：本发明涉及包括局部麻醉剂和（b）包含作为组分（a）一种抗炎化合物和/或免疫刺激化合物和/或用作用于局部麻醉剂化合物的载体，以及它们的制备和它们的用途的组合物。

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