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1. 发明申请

WO2011112731A2 HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：组胺类受体的治疗疾病的杂环抑制剂
公开(公告)号：WO2011112731A2
公开(公告)日：2011-09-15
申请号：PCT/US2011/027771
申请日：2011-03-09
申请人： KALYPSYS, INC. , BORCHARDT, Allen , DAVIS, Robert , BEAUREGARD, Clay , BECKER, Daniel , GAMACHE, Daniel , NOBLE, Stewart, A. , HELLBERG, Mark, R. , KLIMKO, Peter, G. , ZHIHAI, Qui , PAYNE, Joseph, E. , YANNI, John
发明人： BORCHARDT, Allen , DAVIS, Robert , BEAUREGARD, Clay , BECKER, Daniel , GAMACHE, Daniel , NOBLE, Stewart, A. , HELLBERG, Mark, R. , KLIMKO, Peter, G. , ZHIHAI, Qui , PAYNE, Joseph, E. , YANNI, John
IPC分类号： C07D471/04 , C07D498/04 , C07D487/04 , A61K31/437 , A61K31/519 , A61P29/00 , A61P37/00
CPC分类号： C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H 1 R and/or H 4 R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译：本发明涉及可用作H1R和/或H4R抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病的化合物和方法。

2. 发明申请

WO2011112687A2 HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：用于治疗疾病的杂环胺受体杂环抑制剂
公开(公告)号：WO2011112687A2
公开(公告)日：2011-09-15
申请号：PCT/US2011/027701
申请日：2011-03-09
申请人： KALYPSYS, INC. , BORCHARDT, Allen , DAVIS, Robert , BEAUREGARD, Clay , GAMACHE, Daniel , HELLBERG, Mark , KLIMKO, Peter, G. , YANNI, John
发明人： BORCHARDT, Allen , DAVIS, Robert , BEAUREGARD, Clay , GAMACHE, Daniel , HELLBERG, Mark , KLIMKO, Peter, G. , YANNI, John
IPC分类号： C07D495/14 , A61K31/519 , A61K31/381 , A61P29/00 , A61P37/00
CPC分类号： A61K31/381 , A61K31/519 , C07D495/14
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译：本发明涉及可用作H1R和/或H4R抑制剂的化合物和方法，用于治疗或预防炎症，自身免疫，变应性和眼部疾病。

3. 发明申请

WO2011112766A3 HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE 审中-公开
公开(公告)号：WO2011112766A3
公开(公告)日：2011-09-15
申请号：PCT/US2011/027817
申请日：2011-03-10
申请人： KALYPSYS, INC. , BORCHARDT, Allen , DAVIS, Robert , NOBLE, Stewart, A.
发明人： BORCHARDT, Allen , DAVIS, Robert , NOBLE, Stewart, A.
IPC分类号： C07D487/04 , C07D405/14 , C07D403/04 , A61K31/4985 , A61K31/496 , A61P37/08 , A61P29/00 , A61P11/06
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H 4 R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.

4. 发明申请

WO2010098839A1 PDE 1 INHIBITORS FOR OPHTHALMIC DISORDERS 审中-公开
标题翻译： PDE 1抑制性眼病
公开(公告)号：WO2010098839A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/000534
申请日：2010-02-24
申请人： INTRA-CELLULAR THERAPIES, INC. , DAVIS, Robert , FIENBERG, Allen, A.
发明人： DAVIS, Robert , FIENBERG, Allen, A.
IPC分类号： A61K31/535
CPC分类号： A61K31/535
摘要： Compounds that inhibit phosphodiesterase 1 (PDE1) are useful to treat glaucoma or elevated intraocular pressure. The PDE1 inhibitors may be administered as monotherapy or in combination with additional intraocular-pressure lowering agents. In addition, the invention provides ophthalmic compositions comprising PDE 1 inhibitors and optionally one or more additional intraocular pressure- lowering agents. Topical and systemic therapy may be used.
摘要翻译：抑制磷酸二酯酶1（PDE1）的化合物可用于治疗青光眼或升高的眼内压。 PDE1抑制剂可以作为单一疗法或与额外的眼压降低剂组合施用。此外，本发明提供了包含PDE 1抑制剂和任选的一种或多种另外的眼内压降低剂的眼用组合物。可以使用局部和全身治疗。

5. 发明申请

WO2011152835A1 CONTACT LENS PACKAGING METHODS AND SYSTEMS 审中-公开
标题翻译：联系人镜头包装方法和系统
公开(公告)号：WO2011152835A1
公开(公告)日：2011-12-08
申请号：PCT/US2010/037468
申请日：2010-06-04
申请人： COOPERVISION INTERNATIONAL HOLDING COMPANY, LP , COOPERVISION, INC. , DAVIS, Robert
发明人： DAVIS, Robert
IPC分类号： B65B61/26 , B65B23/22 , B65D75/30 , B65B23/00 , B65D75/28
CPC分类号： B65B25/008 , B65B61/26 , B65D2203/02 , B65D2585/545
摘要： Methods and systems for producing packaged contact lenses are described. A stock product that includes a contact lens located in a contact lens packaging solution in a sealed contact lens package is provided. The stock product has one or more printing surfaces. The stock product is directed to a labeling station to produce a customer-tailored labeled product. The labeled product includes printed customer-specific indicia directly on the printing surface of the stock product. Manufacturing systems that include such labeling stations are also described. Utilizing the present methods and systems, contact lenses are labeled and supplied to different customers based on customer requirements.
摘要翻译：描述了用于生产包装的隐形眼镜的方法和系统。提供了一种股票产品，其包括位于密封隐形眼镜包装中的隐形眼镜包装溶液中的隐形眼镜。库存产品具有一个或多个打印面。股票产品指向标签站，以生产客户定制的标签产品。标签产品包括直接在库存产品的印刷表面上印刷的客户特定标记。还描述了包括这种贴标站的制造系统。使用本方法和系统，隐形眼镜根据客户要求进行标签并提供给不同的客户。

6. 发明申请

WO2009131567A1 ANTEGRADE COLONIC INSTILLATION APPARATUS 审中-公开
公开(公告)号：WO2009131567A1
公开(公告)日：2009-10-29
申请号：PCT/US2008/061034
申请日：2008-04-21
申请人： Haleys Pump Company , MOMBRINIE, Bruno , EIDSEN, Jeff Brian , EIDSEN, Cindy Carol , PETERSON, Joe , DAVIS, Robert
发明人： MOMBRINIE, Bruno , EIDSEN, Jeff Brian , EIDSEN, Cindy Carol , PETERSON, Joe , DAVIS, Robert
IPC分类号： A61M5/00 , A61M35/00
CPC分类号： A61M3/0258 , A61M2210/1064
摘要： The present invention provides an apparatus for instilling fluid into a patient having an intestinal stoma so as to administer an antegrade colonic enema. The portable instillation apparatus comprising in combination: a fluid reservoir, a pump assembly, a control module, a fluid delivery tube and an intestinal stoma catheter wherein the control module is operable to automatically deliver a predetermined volume of instillation fluid at a specific flow rate and pressure range suitable for a particular patient. The portable instillation apparatus utilities a gear pump manifold and a robust empty reservoir detection mechanism, facilitating the portability, durability and reliability of the apparatus overcoming the disadvantages of traditional peristaltic pump mechanisms. The portable instillation apparatus maximizes the ease of transport and use of the device while also enabling a method for a patient to self-administer an antegrade colonic enema within a short time period and without intervention.
摘要翻译：本发明提供了一种用于将流体滴入患有肠口的患者以便施用顺行性结肠灌肠剂的装置。便携式滴注装置组合包括：流体储存器，泵组件，控制模块，流体输送管和肠造口导管，其中控制模块可操作以自动地以特定流速输送预定体积的滴注液，适用于特定患者的压力范围。便携式滴管装置使用齿轮泵歧管和坚固的空容器检测机构，便于克服传统蠕动泵机构的缺点的装置的便携性，耐久性和可靠性。便携式滴注装置最大化装置的运输和使用的便利性，同时还使得患者能够在短时间内自主施用顺行性结肠灌肠并且无需干预的方法。

7. 发明申请

WO2008043132A1 AN ADHESIVE STRIP 审中-公开
标题翻译：粘合带
公开(公告)号：WO2008043132A1
公开(公告)日：2008-04-17
申请号：PCT/AU2007/001516
申请日：2007-10-05
申请人： DAVIS, Robert
发明人： DAVIS, Robert
IPC分类号： A61F5/56
CPC分类号： A61F5/56
摘要： An adhesive strip (10) to be placed between the lips of a user to aid in retaining the user's lips closed so that user is forced to breath through their nose. The strip (10) is formed of flexible sheet material (11) and is of an arcuate configuration when flat so that it has a radially inner edge (20) and a radially outer edge (21). The strip (10) has a first major surface (14) and a second major surface (15), with the surfaces (14, 15) having an adhesive to engage the lips of the user.
摘要翻译：将粘合带（10）放置在使用者的嘴唇之间，以帮助保持使用者的嘴唇闭合，以便使用者被迫通过他们的鼻子呼吸。条带（10）由柔性片材（11）形成并且在平坦时具有弓形构造，使得其具有径向内边缘（20）和径向外边缘（21）。条带（10）具有第一主表面（14）和第二主表面（15），表面（14,15）具有粘合剂以接合使用者的嘴唇。

8. 发明申请

WO2013028506A2 PICTURE FRAME WITH REMOVABLE MOUNTING SYSTEM 审中-公开
标题翻译：具有可拆卸安装系统的图像框架
公开(公告)号：WO2013028506A2
公开(公告)日：2013-02-28
申请号：PCT/US2012/051317
申请日：2012-08-17
申请人： DAVIS, Robert , ENHOLM, Jennie , YANKELLO, Francis M.
发明人： DAVIS, Robert , ENHOLM, Jennie , YANKELLO, Francis M.
IPC分类号： A47G1/06 , B23P11/00
CPC分类号： B44C5/02 , G09F15/0025 , Y10T29/49947
摘要： A picture frame comprises a frame member defining an opening and a front surface and a rear surface. First and second substantially parallel grooves are formed on either the front or rear surface, and at least one spline is provided which can be releasably located within the first or second grooves. Further, a method of mounting a work on a picture frame is provided and comprises placing the work face down on a work surface, and placing the frame member over the work so that the front surface of the frame member is touching the work. The work is folded over the edge of the frame member to be adjacent the rear surface of the frame member. A spline is inserted into the one of parallel grooves so as to capture the work in the groove by the force of the spline.
摘要翻译：相框包括限定开口和前表面和后表面的框架构件。在前表面或后表面上形成有第一和第二基本上平行的凹槽，并且设置至少一个可以可释放地位于第一或第二凹槽内的花键。此外，提供了将工件安装在相框上的方法，包括将工作面向下放置在工作表面上，并将框架构件放置在工件上，使得框架构件的前表面接触工件。工件被折叠在框架构件的边缘上以邻近框架构件的后表面。花键被插入到一个平行的槽中，以便通过花键的力捕获槽中的工件。

9. 发明申请

WO2013006128A1 CURTAIN AIRBAG FOR A MOTOR VEHICLE 审中-公开
标题翻译：用于汽车的窗帘安全气囊
公开(公告)号：WO2013006128A1
公开(公告)日：2013-01-10
申请号：PCT/SE2012/050721
申请日：2012-06-27
申请人： AUTOLIV DEVELOPMENT AB , DAVIS, Robert , RADOSAVLJEVIC, Daniel , LIM, Justin
发明人： DAVIS, Robert , RADOSAVLJEVIC, Daniel , LIM, Justin
IPC分类号： B60R21/232 , B60R21/233
CPC分类号： B60R21/232 , B60R21/213
摘要： The present invention relates to a curtain airbag (2) for a motor vehicle with a main chamber (9), which is provided for attachment at the edge of a lateral upper roof edge (1) with a drawn down protrusion (4), wherein the curtain airbag (2) com- prises a chamber (6) at an area, which is provided for arrangement at the drawn down protrusion (4), which chamber (6) is arranged in a manner for stabilising the area bearing on the drawn down protrusion (4) by inflating previously to the inflation of the main chamber (9).
摘要翻译：本发明涉及一种用于具有主室（9）的机动车辆的帘式安全气囊（2），其被设置成用于在侧向上屋顶边缘（1）的边缘处具有拉伸突起（4），其中，帘式安全气囊（2）包括一个设置在下拉突起（4）处的区域的腔室（6），该腔室（6）以一定的方式设置，用于使被拉伸（4）通过先前充气到主室（9）的膨胀。

10. 发明申请

WO2011133224A1 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2011133224A1
公开(公告)日：2011-10-27
申请号：PCT/US2011/000719
申请日：2011-04-22
申请人： INTRA-CELLULAR THERAPIES, INC. , MATES, Sharon , LI, Peng , TOMESCH, John, Charles , DAVIS, Robert , WENNOGLE, Lawrence, P. , ZHANG, Qiang
发明人： MATES, Sharon , LI, Peng , TOMESCH, John, Charles , DAVIS, Robert , WENNOGLE, Lawrence, P. , ZHANG, Qiang
IPC分类号： A61K38/27 , A61P5/06
CPC分类号： C07D471/16 , A61K31/44 , C07D471/04
摘要： The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving 5-HT 2A receptor, serotonin transporter (SERT) and/or pathways involving dopamine D 2 receptor signaling systems.
摘要翻译：本发明涉及如本文所述的游离，固体，药学上可接受的盐和/或基本上纯的形式的特定取代的杂环稠合的γ-咔啉及其前药，其药物组合物，以及用于治疗涉及5-HT2A 受体，血清素转运蛋白（SERT）和/或涉及多巴胺D2受体信号传导系统的途径。

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