专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1987005608A1 NOVEL PEPTIDE DERIVATIVES 审中-公开
标题翻译：新肽衍生物
公开(公告)号：WO1987005608A1
公开(公告)日：1987-09-24
申请号：PCT/SE1987000141
申请日：1987-03-19
申请人： KABIVITRUM AB
发明人： KABIVITRUM AB , ARIELLY, Salo , GUSTAVSSON, Stig, Ake, Ingemar
IPC分类号： C07K05/08
CPC分类号： C07K5/06026 , C07K5/0817
摘要： Tripeptide derivatives, characterized by general formula: R1 - X - D-Arg - A - Arg - NH - R2 wherein R1 is hydrogen, alpha - or beta -naphtyl residue, lower alkyl residue which may be substituted with a carboxyl group, unsubstituted or substituted phenyl- or phenylalkyl residue. X is (I), (II), (III) or a single bond with the proviso that when R1 is hydrogen then and only then X is a single bond; A = Gly or Sar; R2 = an aromatic or heterocyclic residue which gives a compound R2-NH2 by enzymatic hydrolysis, which can be determined quantitatively; or disalts and trisalts of inorganic or organic acids thereof, process for their preparation and method for determination of serine proteases, especially Factor Xa; or components which can interact with serine proteases or zymogen forms thereof.
摘要翻译：以通式表示的三肽衍生物：R1-X-D-Arg-A-Arg-NH-R2其中R1是氢，α-或β-萘基残基，可被羧基取代的低级烷基残基，未取代或未取代的取代的苯基或苯基烷基残基。 X是（I），（II），（III）或单键，条件是当R1是氢时，只有X是单键; A = Gly或Sar; R2 =通过酶水解得到化合物R2-NH2的芳族或杂环残基，其可以定量测定; 或其无机或有机酸的三卤化物，其制备方法和丝氨酸蛋白酶，特别是因子Xa的测定方法; 或可与丝氨酸蛋白酶或其酶原形式相互作用的组分。

IPRDB

热门服务

关于我们

友情链接

联系方式