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1. 发明申请

WO1996001818A1 SULFONAMIDE DERIVATIVES OF AZOLONES ANTI-HELICOBACTER AGENTS 审中-公开
标题翻译：阿洛莫隆抗真菌剂的磺酰胺衍生物
公开(公告)号：WO1996001818A1
公开(公告)日：1996-01-25
申请号：PCT/EP1995002619
申请日：1995-07-05
申请人： JANSSEN PHARMACEUTICA N.V. , HEERES, Jan , STOKBROEKX, Raymond, Antoine , MOSTMANS, Joseph, Hector , VAN DER VEKEN, Louis, Jozef, Elisabeth
发明人： JANSSEN PHARMACEUTICA N.V.
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D249/12
摘要： The invention is concerned with the compounds having formula (I) the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R , R and R each independently are hydrogen or C1-4alkyl; R and R each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R is C1-4alkyl; or phenyl optionally substituted with halo, C1-4alkylcarbonylamino, C1-4alkyloxy, C1-4alkyl or nitro; Z is C=O or CHOH; and (1) is a radical of formula ((a-1), (a-2), (a-3), (a-4), (a-5), (a-6), or (a-7). Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine.
摘要翻译：本发明涉及具有式（I）的药学上可接受的加成盐及其立体化学异构形式的化合物，其中Y是CH或N; R 1，R 2和R 3各自独立地是氢或C 1-4烷基; R 4和R 5各自独立地为氢，卤素，C 1-4烷基，C 1-4烷氧基，羟基，三氟甲基，三氟甲氧基或二氟甲氧基; R 6是C 1-4烷基; 或任选被卤素，C 1-4烷基羰基氨基，C 1-4烷氧基，C 1-4烷基或硝基取代的苯基; Z是C = O或CHOH; 和（1）是式（a-1），（a-2），（a-3），（a-4），（a-5），（a-6） 7）。包含所述化合物的组合物，其制备方法以及这些化合物作为药物的用途。

2. 发明申请

WO1995027704A1 ANTI-HELICOBACTER ESTER AND CARBAMATE DERIVATIVES OF AZOLONES 审中-公开
标题翻译：丙二醇的抗真菌剂和碳酸盐衍生物
公开(公告)号：WO1995027704A1
公开(公告)日：1995-10-19
申请号：PCT/EP1995001184
申请日：1995-03-29
申请人： JANSSEN PHARMACEUTICA N.V. , HEERES, Jan , MOSTMANS, Joseph, Hector , HENDRICKX, Robert, Jozef, Maria , VAN DER VEKEN, Louis, Jozef, Elisabeth , STOKBROEKX, Raymond, Antoine , VAN DER AA, Marcel, Jozef, Maria
发明人： JANSSEN PHARMACEUTICA N.V.
IPC分类号： C07D249/12
CPC分类号： C07D401/04 , C07D233/70 , C07D249/12 , C07D401/10
摘要： The invention is concerned with the compounds having formula (I), the pharmaceutically acceptable acid addition salts and the stereochemically isomeric form thereof, wherein X and Y are CH or N; R , R and R are hydrogen or C1-4 alkyl; R and R are hydrogen, halo, C1-4 alkyl, C1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R is C1-6 alkyl, hydroxy C1-6 alkyl, C1-4 alkyloxy C1-6 alkyl, phenyl or phenyl C1-4 alkyl; Z is C=O or CHOH; and (a) is a radical of formula (a-1), (a-2), (a-3), (a-4), (a-5), (a-6) or (a-7); compositions comprising said compounds, processes for preparing the same and the use of these compounds for treating Helicobacter related diseases.
摘要翻译：本发明涉及具有式（I）的化合物，其药学上可接受的酸加成盐及其立体化学异构形式，其中X和Y是CH或N; R 1，R 2和R 3是氢或C 1-4烷基; R 4和R 5是氢，卤素，C 1-4烷基，C 1-4烷氧基，羟基，三氟甲基，三氟甲氧基或二氟甲氧基; R 6是C 1-6烷基，羟基C 1-6烷基，C 1-4烷氧基C 1-6烷基，苯基或苯基C 1-4烷基; Z是C = O或CHOH; 和（a）是式（a-1），（a-2），（a-3），（a-4），（a-5），（a-6）或（a-7） ; 包含所述化合物的组合物，其制备方法以及这些化合物用于治疗幽门螺杆菌相关疾病的用途。

3. 发明申请

WO1996001822A1 ANTI-HELICOBACTER ACYL DERIVATIVES OF AZOLONES 审中-公开
标题翻译：丙二醇的抗真菌ACYL衍生物
公开(公告)号：WO1996001822A1
公开(公告)日：1996-01-25
申请号：PCT/EP1995002618
申请日：1995-07-05
申请人： JANSSEN PHARMACEUTICA N.V. , HEERES, Jan , STOKBROEKX, Raymond, Antoine , MOSTMANS, Joseph, Hector , VAN DER VEKEN, Louis, Jozef, Elisabeth
发明人： JANSSEN PHARMACEUTICA N.V.
IPC分类号： C07D403/12
CPC分类号： C07D401/04 , C07D233/70 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention is concerned with the compounds having formula (I), the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R , R and R each independently are hydrogen or C1-4alkyl; R and R each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R is hydrogen; or R is phenyl optionally substituted with halo; pyridinyl; furanyl; thienyl; 3-chlorobenzo[b]thien-2-yl; trifluoromethyl; C1-4alkyloxycarbonyl; dihalophenylcyclopropanyl; C3-6cycloalkyl; adamantyl; C2-6alkenyl optionally substituted with halophenyl; or C1-4alkyl optionally substituted with halo, phenyl, halophenyl, dihalophenyl, phenyloxy, piperidinyl, pyrrolidinyl, piperazinyl, C1-4alkylpiperazinyl, C1-4alkyl-carbonylpiperazinyl, C1-4alkyloxycarbonylpiperazinyl, phthalimino, amino, mono- or di(C1-20)alkylamino or C3-6cycloalkylamino; Z is C=O or CHOH; and (1) is a radical of formula (a-1), (a-2), (a-3), (a-4), (a-5), (a-6), or (a-7). Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine.
摘要翻译：本发明涉及具有式（I）的化合物，其药学上可接受的加成盐和立体化学异构形式，其中Y是CH或N; R 1，R 2和R 3各自独立地是氢或C 1-4烷基; R 4和R 5各自独立地为氢，卤素，C 1-4烷基，C 1-4烷氧基，羟基，三氟甲基，三氟甲氧基或二氟甲氧基; R 6是氢; 或R 6为任选被卤素取代的苯基; 吡啶基; 呋喃基; 噻吩; 3-氯苯并[b]噻吩-2-基; 三氟甲基; C1-4alkyloxycarbonyl; dihalophenylcyclopropanyl; 3-6环; 金刚; 任选被卤代苯基取代的C 2-6烯基; 哌啶基，吡咯烷基，哌嗪基，C 1-4烷基哌嗪基，C 1-4烷基 - 羰基哌嗪基，C 1-4烷氧基羰基哌嗪基，邻苯二甲酰亚氨基，氨基，单或二（C1-20）烷基氨基或C 3-6环烷基氨基; Z是C = O或CHOH; （a-3），（a-4），（a-5），（a-6）或（a-7）中的基团，式（a-1），（a-2），（a-3））。包含所述化合物的组合物，其制备方法以及这些化合物作为药物的用途。

4. 发明申请

WO1994018978A1 SUBSTITUTED AZOLONE DERIVATIVES FOR TREATING DISEASES CAUSED BY HELICOBACTER 审中-公开
标题翻译：用于治疗由HELICOBACTER引起的疾病的替代AZOLONE衍生物
公开(公告)号：WO1994018978A1
公开(公告)日：1994-09-01
申请号：PCT/EP1994000380
申请日：1994-02-09
申请人： JANSSEN PHARMACEUTICA N.V. , HEERES, Jan , MOSTMANS, Joseph, Hector , VAN DER EYCKEN, Luc, Alfons, Leo , ODDS, Frank, Christopher , STOKBROEKX, Raymond, Antoine , VAN DER AA, Marcel, Jozef, Maria
发明人： JANSSEN PHARMACEUTICA N.V.
IPC分类号： A61K31/495
CPC分类号： C07D401/04 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/505 , C07D233/70 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07F7/1804
摘要： The use for the manufacture of a medicament for treating Helicobacter-related diseases of a compound of formula (I), a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein X and Y each independently are CH or N; R , R and R each independently are hydrogen or C1-4alkyl; R and R each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; Z is C = O or CHOH; and Ar is phenyl optionally substituted with up to three substituents selected from hydroxy, C1-4alkyl, C1-4alkyloxy, halo, trifluoromethyl, triC1-4alkylsilyloxy, nitro, amino and cyano or pyridinyl substituted with hydroxy or C1-4alkyloxy; and (a) is a radical of formula (a-1), (a-2), (a-3), (a-4), (a-5), (a-6), or (a-7).
摘要翻译：用于制备用于治疗式（I）化合物，其药学上可接受的酸加成盐或其立体化学异构体形式的幽门螺杆菌相关疾病的药物的用途，其中X和Y各自独立地是CH或N; R 1，R 2和R 3各自独立地是氢或C 1-4烷基; R 4和R 5各自独立地为氢，卤素，C 1-4烷基，C 1-4烷氧基，羟基，三氟甲基，三氟甲氧基或二氟甲氧基; Z是C = O或CHOH; 并且Ar是任选被至多三个选自羟基，C 1-4烷基，C 1-4烷氧基，卤素，三氟甲基，三C 1-4烷基甲硅烷氧基，硝基，氨基和氰基的取代基取代的苯基或被羟基或C 1-4烷氧基取代的吡啶基。和（a）是式（a-1），（a-2），（a-3），（a-4），（a-5），（a-6）或（a-7））。

5. 发明申请

WO1996001821A1 ANTI-HELICOBACTER HETEROCYCLIC DERIVATIVES OF AZOLONES 审中-公开
标题翻译：丙二醇的抗真菌剂杂环衍生物
公开(公告)号：WO1996001821A1
公开(公告)日：1996-01-25
申请号：PCT/EP1995002616
申请日：1995-07-05
申请人： JANSSEN PHARMACEUTICA N.V. , HEERES, Jan , STOKBROEKX, Raymond, Antoine , WILLEMS, Marc , HENDRICKX, Robert, Jozef, Maria
发明人： JANSSEN PHARMACEUTICA N.V.
IPC分类号： C07D403/12
CPC分类号： C07D401/14 , C07D403/12 , C07D413/12 , C07D417/14
摘要： The invention is concerned with the compounds having formula (I), the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R , R and R each independently are hydrogen or C1-4alkyl; R and R each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R is pyridinyl optionally substituted with up to two C1-4alkyl groups; di(C1-4alkyl)hydroxypyridinyl; di(C1-4alkyl)C1-4alkyloxypyridinyl; pyridazinyl optionally substituted with C1-4alkyloxy; pyrimidinyl optionally substituted with hydroxy or C1-4alkyloxy; thiazolyl optionally substituted with C1-4alkyl; thiadiazolyl optionally substituted with C1-4alkyl; benzoxazolyl or benzothiazolyl; or R is pyrazinyl or pyridazinyl substituted with C1-4alkyl; Z is C=O or CHOH; and (a) is a radical of formula (a-1), (a-2), (a-3), (a-4), (a-5), (a-6), or (a-7). Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine.
摘要翻译：本发明涉及具有式（I）的化合物，其药学上可接受的加成盐和立体化学异构形式，其中Y是CH或N; R 1，R 2和R 3各自独立地是氢或C 1-4烷基; R 4和R 5各自独立地为氢，卤素，C 1-4烷基，C 1-4烷氧基，羟基，三氟甲基，三氟甲氧基或二氟甲氧基; R 6是任选被至多两个C 1-4烷基取代的吡啶基; 二（C 1-4烷基）羟基吡啶基; 二（C 1-4烷基）C1-4alkyloxypyridinyl; 任选被C 1-4烷氧基取代的哒嗪基; 任选被羟基或C 1-4烷氧基取代的嘧啶基; 任选被C 1-4烷基取代的噻唑基; 任选被C 1-4烷基取代的噻二唑基; 苯并恶唑基或苯并噻唑基; 或R 6是被C 1-4烷基取代的吡嗪基或哒嗪基; Z是C = O或CHOH; 和（a）是式（a-1），（a-2），（a-3），（a-4），（a-5），（a-6）或（a-7））。包含所述化合物的组合物，其制备方法以及这些化合物作为药物的用途。

6. 发明申请

WO1996001820A1 ANTI-HELICOBACTER UREA AND THIOUREA DERIVATIVES OF AZOLONES 审中-公开
标题翻译：丙二醇的抗真菌尿素和硫脲衍生物
公开(公告)号：WO1996001820A1
公开(公告)日：1996-01-25
申请号：PCT/EP1995002617
申请日：1995-07-05
申请人： JANSSEN PHARMACEUTICA N.V. , HEERES, Jan , STOKBROEKX, Raymond, Antoine , WILLEMS, Marc , VAN DER AA, Marcel, Jozef, Maria
发明人： JANSSEN PHARMACEUTICA N.V.
IPC分类号： C07D403/04
CPC分类号： C07D401/04 , C07D233/70 , C07D249/12 , C07D403/04
摘要： The invention is concerned with the compounds having formula (I) the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; Y is CH or N; R , R and R each independently are hydrogen or C1-4alkyl; R and R each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R is C1-4alkyl; C1-4alkyl substituted with arylcyclohexyl; aryl or arylcarbonyl; wherein aryl is phenyl optionally substituted with one or two substituents selected from halo and C1-4alkyl; Z is C=O or CHOH; and (1) is a radical of formula (a-1), (a-2), (a-3), (a-4), (a-5), (a-6), or (a-7). Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine.
摘要翻译：本发明涉及具有式（I）化合物的药学上可接受的加成盐和其立体化学异构形式的化合物，其中X是O或S; Y是CH或N; R 1，R 2和R 3各自独立地是氢或C 1-4烷基; R 4和R 5各自独立地为氢，卤素，C 1-4烷基，C 1-4烷氧基，羟基，三氟甲基，三氟甲氧基或二氟甲氧基; R 6是C 1-4烷基; 被芳基环己基取代的C 1-4烷基; 芳基或芳基羰基; 其中芳基是任选被一个或两个选自卤素和C 1-4烷基的取代基取代的苯基; Z是C = O或CHOH; （a-3），（a-4），（a-5），（a-6）或（a-7）中的基团，式（a-1），（a-2），（a-3））。包含所述化合物的组合物，其制备方法以及这些化合物作为药物的用途。

7. 发明申请

WO1992014731A1 4-[(2-BENZOTHIAZOLYL)METHYLAMINO]-'alpha'-[(3,4-DIFLUOROPHENOXY)METHYL]-1-PIPERIDINEETHANOL 审中-公开
标题翻译： 4 - （（2-苯并噻唑基）甲氨基） - （ALPHA） - （（3,4-二氟苯氧基）甲基）-1-哌啶乙醇
公开(公告)号：WO1992014731A1
公开(公告)日：1992-09-03
申请号：PCT/EP1992000356
申请日：1992-02-14
申请人： JANSSEN PHARMACEUTICA N.V. , STOKBROEKX, Raymond, Antoine , GRAUWELS, Gilbert, Arthur, Jules
发明人： JANSSEN PHARMACEUTICA N.V.
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： A compound of formula (I), the racemic mixture, the (S)-form and the acid addition salts thereof, said compound having anti-stroke properties. Pharmaceutical compositions containing this compound as active ingredient and a method of preparing said compound and pharmaceutical compositions.

8. 发明申请

WO1997026258A1 ANGIOGENESIS INHIBITING PYRIDAZINAMINES 审中-公开
标题翻译：血管生成抑制吡咯烷胺
公开(公告)号：WO1997026258A1
公开(公告)日：1997-07-24
申请号：PCT/EP1997000201
申请日：1997-01-14
申请人： JANSSEN PHARMACEUTICA N.V. , STOKBROEKX, Raymond, Antoine , VAN DER AA, Marcel, Jozef, Maria , WILLEMS, Marc , MEERPOEL, Lieven , LUYCKX, Marcel, Gerebernus, Maria , TUMAN, Robert, W.
发明人： JANSSEN PHARMACEUTICA N.V.
IPC分类号： C07D417/04
CPC分类号： C07D417/04 , C07D417/14
摘要： This invention concerns compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is CH or N; m is 2 or 3 and n is 1, 2 or 3; wherein 1 or 2 C-atoms of the CH2 groups of the (a) moiety, which may also contain one double bond, may be substituted with C1-6alkyl, amino, aminocarbonyl, mono- or di(C1-6alkyl)amino, C1-6alkyloxycarbonyl, C1-6alkylcarbonylamino, hydroxy or C1-6alkyloxy; and/or 2 C-atoms of said CH2 groups may be bridged with C2-4alkanediyl; R is hydrogen, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, amino, mono- or di(C1-6alkyl)amino, Ar, ArNH-, C3-6cycloalkyl, hydroxymethyl or benzyloxymethyl; R and R are hydrogen, or taken together may form a bivalent radical of the formula -CH=CH-CH=CH-; in case X represents CH then L is a radical L , L or L ; or in case X represents N then L is a radical L or L ; L is Ar-C1-6alkyloxy, Ar-oxy, Ar-thio, Ar-carbonylamino, di-Ar-methyloxy-, N-Ar-piperazinyl, N-Ar-homopiperazinyl, 2-benzimidazolinonyl, Ar-NR -, Ar-Alk-NR -, Ar-NR -Alk-NR - or Het-NR -; L is Ar, Ar-carbonyl, Ar-CH=CH-CH2-, naphtalenyl or Het; L is C1-6alkyl substituted with one or two radicals selected from Ar, Ar-oxy, or Ar-thio, further optionally substituted with cyano or hydroxy; 2,2-dimethyl-1,2,3,4-tetrahydro-naphtalenyl; 2,2-dimethyl-1H-2,3-dihydroindenyl; Ar-piperidinyl or Ar-NR -Alk-; R and R are each independently selected from hydrogen or C1-6alkyl; Alk is C1-6alkanediyl; their preparation, compositions containing them and their use as a medicine.
摘要翻译：本发明涉及式（I）的化合物，N-氧化物形式，其药学上可接受的酸加成盐和立体化学异构形式，其中X是CH或N; m为2或3，n为1,2或3; 其中也可以含有一个双键的（a）部分的CH 2基团的1或2个C原子可以被C 1-6烷基，氨基，氨基羰基，一或二（C 1-6烷基）氨基，C 1 1-6烷氧基羰基，C 1-6烷基羰基氨基，羟基或C 1-6烷氧基; 和/或所述CH 2基团的2个C原子可以与C 2-4烷二基桥接; R 1是氢，C 1-6烷基，C 1-6烷氧基，C 1-6烷硫基，氨基，单或二（C 1-6烷基）氨基，Ar，ArNH-，C 3-6环烷基，羟甲基或苄氧基甲基; R 2和R 3是氢或一起可以形成式-CH = CH-CH = CH-的二价基团; 在X表示CH的情况下，L是基团L 1，L 2或L 3; 或者在X表示N的情况下，L是基团L 2或L 3; L 1是Ar-C 1-6烷氧基，Ar-氧基，Ar-硫基，Ar-羰基氨基，二-Ar-甲氧基 - ，N-Ar-哌嗪基，N-Ar-高哌嗪基，2-苯并咪唑啉酮基，Ar- Ar-Alk-NR 4 - ，Ar-NR 4 -Alk-NR 5 - 或Het-NR 4 - ; L 2是Ar，Ar-羰基，Ar-CH = CH-CH 2 - ，萘基或Het; L 3是被一个或两个选自Ar，Ar-氧基或Ar-硫基的基团取代的C 1-6烷基，进一步任选被氰基或羟基取代; 2,2-二甲基-1,2,3,4-四氢naphtalenyl; 2,2-二甲基-1H-2,3-二氢; Ar-哌啶基或Ar-NR 4 -Alk-; R 4和R 5各自独立地选自氢或C 1-6烷基; Alk是C1-6烷二基; 其制剂，含有它们的组合物及其作为药物的用途。

9. 发明申请

WO1997015572A1 LUBELUZOLE N-OXIDE 审中-公开
公开(公告)号：WO1997015572A1
公开(公告)日：1997-05-01
申请号：PCT/EP1996004608
申请日：1996-10-21
申请人： JANSSEN PHARMACEUTICA N.V. , STOKBROEKX, Raymond, Antoine
发明人： JANSSEN PHARMACEUTICA N.V.
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： The present invention is concerned with lubeluzole N-oxide(s), compositions containing the N-oxide(s), methods of preparing these and their use as a medicine, in particular in the treatment of conditions involving cerebral hypoxia.
摘要翻译：本发明涉及鲁贝鲁唑N-氧化物，含有N-氧化物的组合物，其制备方法及其作为药物的用途，特别是涉及脑缺氧的病症的治疗。

10. 发明申请

WO1996013499A1 APOLIPOPROTEIN-B SYNTHESIS INHIBITORS 审中-公开
标题翻译： APOLIPOPROTEIN-B合成抑制剂
公开(公告)号：WO1996013499A1
公开(公告)日：1996-05-09
申请号：PCT/EP1995004111
申请日：1995-10-19
申请人： JANSSEN PHARMACEUTICA N.V. , HEERES, Jan , BACKX, Leo, Jacobus, Jozef , HENDRICKX, Robert, Jozef, Maria , VAN DER EYCKEN, Luc, Alfons, Leo , DE CHAFFOY DE COURCELLES, Didier, Robert, Guy, Gabriël
发明人： JANSSEN PHARMACEUTICA N.V.
IPC分类号： C07D405/14
CPC分类号： C07D417/14 , C07D405/14 , C07D413/14
摘要： The present invention provides novel compounds of formula (I), the N-oxides, the stereochemically isomeric forms thereof, and the pharmaceutically acceptable acid addition salts thereof, wherein A and B taken together form a bivalent radical of formula: -N=CH- (a), -CH=N- (b), -CH2-CH2- (c), -CH=CH- (d), -C(=O)-CH2- (e), -CH2-C(=O)- (f); R is hydrogen, C1-6alkyl, or halo; R is hydrogen or halo; R is hydrogen; C1-8alkyl; C3-6cycloalkyl or C1-8 alkyl substituted with hydroxy, oxo, C3-6cycloalkyl or aryl. Het is five- or six membered optionally substituted heterocyclic ring. The use as a medicine, especially as a lipid lowering agent is disclosed as well as pharmaceutical compositions and processes for preparing compounds and compositions.
摘要翻译：本发明提供了新的式（I）化合物，其N-氧化物，其立体化学异构体形式及其药学上可接受的酸加成盐，其中A和B一起形成下式的二价基团：-N = CH- （a）中，-CH = N-（b），-CH 2 -CH 2 - （c），-CH = CH-（d），-C（= O）-CH 2 - （e） O） - （f）; R 1是氢，C 1-6烷基或卤素; R 2是氢或卤素; R 3是氢; C1-8烷基; C 3-6环烷基或被羟基，氧代，C 3-6环烷基或芳基取代的C 1-8烷基。 Het是五或六元任选取代的杂环。公开了作为药物的使用，特别是作为降脂剂的用途以及用于制备化合物和组合物的药物组合物和方法。

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