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1. 发明申请

WO2013040502A2 PROCESSES AND KITS TO DETECT AND MONITOR FOR DIAGNOSTIC BIOMARKERS FOR POST TRAUMATIC STRESS DISORDER (PTSD) AND TO DIFFERENTIATE BETWEEN SUICIDAL AND NON-SUICIDAL FORM OF THE DISORDER 审中-公开
标题翻译：用于检测和监测诊断后创伤性应激障碍（PTSD）的诊断性生物标志物以及区分自身与非自杀疾病形式的疾病
公开(公告)号：WO2013040502A2
公开(公告)日：2013-03-21
申请号：PCT/US2012055639
申请日：2012-09-14
申请人： JACKSON H M FOUND MILITARY MED , BANYAN BIOMARKERS INC , POLLARD HARVEY , ZHANG LEI , EIDELMAN OFER , URSANO ROBERT J , LI HE , SU TUNG-PIN , WANG KEVIN KA-WANG , HAYES RONALD L
发明人： POLLARD HARVEY , ZHANG LEI , EIDELMAN OFER , URSANO ROBERT J , LI HE , SU TUNG-PIN , WANG KEVIN KA-WANG , HAYES RONALD L
IPC分类号： G01N33/68 , G01N33/53
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/5438 , G01N2333/4703 , G01N2333/4706 , G01N2333/4727 , G01N2333/52 , G01N2333/9015 , G01N2800/28 , G01N2800/30 , G01N2800/301 , G01N2800/52 , G01N2800/60
摘要： Life-threatening traumas such as terrorist attacks, war, disasters, mental or physical assault, severe accidents and violence frequently provoke emotional and behavioral disturbances known as post-traumatic stress disorder (PTSD) and suicide related thereto. Accurate diagnosis and treatment planning for PTSD and suicide remain difficult. The discovery of specific markers creates new opportunities for more accurate clinical assessments identifying groups that may experience better outcomes when exposed to an intervention. The present invention provides a process of detection of P-11, UBE3A, STY1, EMAP-11, SIP1, ORC5L, DCX, SCYE protein in a biological sample of a subject suspected of suffering from PTSD and/or having suicidal tendencies, and provides additional PTSD markers which are specific to gender.
摘要翻译：诸如恐怖袭击，战争，灾难，精神或身体攻击，严重事故和暴力等危及生命的创伤经常引起称为创伤后应激障碍（PTSD）和与其相关的自杀的情绪和行为障碍。准确诊断和治疗PTSD和自杀计划仍然困难。特定标志物的发现为更准确的临床评估创造了新的机会，从而确定接触干预后可能会有更好结果的群体。本发明提供了在怀疑患有PTSD和/或具有自杀倾向的受试者的生物样品中检测P-11，UBE3A，STY1，EMAP-11，SIP1，ORC5L，DCX，SCYE蛋白的方法，额外的性别特异性PTSD标记。

2. 发明申请

WO2010019553A3 BIOMARKER DETECTION PROCESS AND ASSAY OF NEUROLOGICAL CONDITION 审中-公开
标题翻译：生物标记检测过程和神经病学条件的测定
公开(公告)号：WO2010019553A3
公开(公告)日：2010-07-08
申请号：PCT/US2009053376
申请日：2009-08-11
申请人： BANYAN BIOMARKERS INC , WANG KEVIN KA-WANG , HAYES RONALD L , MULLER UWE R , ZHANG ZHIQUN
发明人： WANG KEVIN KA-WANG , HAYES RONALD L , MULLER UWE R , ZHANG ZHIQUN
IPC分类号： G01N33/68 , G01N33/53
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2871 , G01N2800/60
摘要： The subject invention provides a robust, quantitative, and reproducible process and assay for diagnosis of a neurological condition in a subject. The invention provides measurement of two or more biomarkers in a biological fluid such as CSF or serum resulting in a synergistic mechanism for determining the extent of neurological damage in a subject with an abnormal neurological condition and for discerning subtypes thereof or tissue types subjected to damage.
摘要翻译：本发明提供用于诊断受试者神经病症的鲁棒，定量和可再现的方法和测定。本发明提供生物流体如CSF或血清中的两种或更多种生物标志物的测量，从而产生用于确定具有异常神经病症状况的受试者的神经损伤程度和受到损伤的辨别性亚型或组织类型的神经损伤程度的协同机制。

3. 发明申请

WO2011011334A2 SYNERGISTIC BIOMARKER ASSAY OF NEUROLGICAL CONDITION USING S-100ß 审中-公开
标题翻译：用S-100ß进行神经营养状态的协同生物标记物测定
公开(公告)号：WO2011011334A2
公开(公告)日：2011-01-27
申请号：PCT/US2010042469
申请日：2010-07-19
申请人： BANYAN BIOMARKERS INC , WANG KEVIN KA-WANG , STREETER JACKSON , HAYES RONALD L
发明人： WANG KEVIN KA-WANG , STREETER JACKSON , HAYES RONALD L
IPC分类号： G01N33/68 , G01N33/53
CPC分类号： G01N33/6896 , G01N2333/4727
摘要： Processes and assays are provided for detecting and determining the magnitude of traumatic brain injury such as that from impact or percussive trauma or stroke. The inventive assays and processes recognize a synergistic correlation between detection of S-IOOb and one or more other injury specific biomarkers.
摘要翻译：提供过程和分析用于检测和确定创伤性脑损伤的程度，例如来自撞击或撞击创伤或中风的损伤。本发明的测定和方法识别S-100b和一种或多种其它损伤特异性生物标志物的检测之间的协同相关性。

4. 发明申请

WO2011123844A3 MARKERS AND ASSAYS FOR DETECTION OF NEUROTOXICITY 审中-公开
标题翻译：用于检测神经毒性的标记和测定
公开(公告)号：WO2011123844A3
公开(公告)日：2012-05-03
申请号：PCT/US2011031029
申请日：2011-04-01
申请人： BANYAN BIOMARKERS INC , JEROMIN ANDREAS , GLUSHAKOVA OLENA , WANG KEVIN KA-WANG , ZHANG ZHIQUN , HAYES RONALD L
发明人： JEROMIN ANDREAS , GLUSHAKOVA OLENA , WANG KEVIN KA-WANG , ZHANG ZHIQUN , HAYES RONALD L
IPC分类号： G01N33/68 , C12Q1/68 , G01N33/15 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/142 , C12Q2600/158 , G01N33/6896 , G01N2333/47 , G01N2333/91142 , G01N2333/96425 , G01N2500/10 , G01N2800/28
摘要： A process and assay for diagnosing neurotoxicity in a subject is provided. The extent of a neurotoxic insult to a subject is assessed through the measurement of one or more biomarkers in a biological fluid, such as CSF or serum. Other uses and advantages afforded include pre-market drug discovery, monitoring, drug neurotoxicity screening and post market assessment of safety and monitoring for drug of known potential neurotoxicity.
摘要翻译：提供了用于诊断受试者的神经毒性的方法和测定。通过测量生物流体如CSF或血清中的一种或多种生物标志物来评估对受试者的神经毒性损伤的程度。提供的其他用途和优点包括市场前药物发现，监测，药物神经毒性筛选和市场后评估安全性和已知潜在神经毒性药物监测。

5. 发明申请

WO2011032155A3 MICRO-RNA, AUTOANTIBODY AND PROTEIN MARKERS FOR DIAGNOSIS OF NEURONAL INJURY 审中-公开
标题翻译：微RNA，自体抗体和蛋白质标志物用于神经损伤的诊断
公开(公告)号：WO2011032155A3
公开(公告)日：2011-10-06
申请号：PCT/US2010048789
申请日：2010-09-14
申请人： BANYAN BIOMARKERS INC , WANG KEVIN KA-WANG , ZHANG ZHIQUN , LIU MING CHENG , HAYES RONALD L
发明人： WANG KEVIN KA-WANG , ZHANG ZHIQUN , LIU MING CHENG , HAYES RONALD L
IPC分类号： G01N33/53 , C12Q1/68 , C40B40/08 , G01N33/68
CPC分类号： G01N33/6896 , C07K16/18 , C12Q1/6883 , C12Q2600/178 , G01N33/5308 , G01N33/564 , G01N2800/28
摘要： Processes and materials are provided for the detection, diagnosis, or determination of the severity of a neurological injury or condition, including traumatic brain injury, multiple-organ injury, stroke, Alzeimer's disease, Pakinson disease and Chronic Traumatic Encephalopathy (CTE),. The processes and materials include biomarkers detected or measured in a biological sample such as whole blood, serum, plasma, or CSF. Such biomarkers include Tau and GFAP proteins, their proteolytic breakdown products, brain specific or enriched micro-RNA, and brain specific or enriched protein directed autoantibodies. The processes and materials are operable to detect the presence of absence of acute, subacute or chronic brain injuries and predict outcome for the brain injury.
摘要翻译：提供了用于检测，诊断或确定的神经学损伤或病症，包括外伤性脑损伤，多发性器官损伤，中风，Alzeimer氏病，帕金森病和慢性创伤性脑病（CTE）的严重程度的方法和材料，。过程和材料包括在生物样品如全血，血清，血浆或CSF中检测或测量的生物标记。这样的生物标记包括Tau和GFAP蛋白，它们的蛋白水解分解产物，脑特异性或富集的微RNA，以及脑特异性或富集蛋白的定向自身抗体。这些过程和材料可用于检测是否存在急性，亚急性或慢性脑损伤并预测脑损伤的结果。

6. 发明申请

WO2006122237A3 IMAGING OF NEURAL AND ORGAN INJURY OR DAMAGE 审中-公开
标题翻译：神经损伤或损伤成像
公开(公告)号：WO2006122237A3
公开(公告)日：2009-04-09
申请号：PCT/US2006018222
申请日：2006-05-11
申请人： UNIV FLORIDA , WANG KEVIN KA-WANG , HAYES RONALD L , BAXTER LEWIS R , PROKAI LASZLO
发明人： WANG KEVIN KA-WANG , HAYES RONALD L , BAXTER LEWIS R , PROKAI LASZLO
IPC分类号： A61K49/00
CPC分类号： A61K51/04 , A61K51/08 , A61K51/088
摘要： In vivo determination of regional damage with neural and organ injury specific imaging agents. Rapid, and non-invasive imaging compositions and methods for assessment of the extent of neurotoxic cell loss or nervous system damage resulting from nervous system injury due to ischemia, stroke, trauma, chemical or electrical insult, acute drug overdose or exposure to substance abuse (such as "recreational drugs") infection or other insults. The same or similar rapid, and non-invasive imaging compositions and methods for assessment of the extent of the organ injury comprises any damage;, injury or infection, functional failure to specific organs such as liver, kidney, prostate, lung, skeletal muscle, heart, pancreas, stomach, small and large intestine, bladder and the reproductive system as well as damage, injury or infection, functional failure to multi-organs, trauma-hemorrhagic shock and sepsis, hi particular, neural and organ damage is detected via protease inhibitor-based radionuclide- labeled imaging ligand binding to overactivated proteases (calpains, caspases, cathepsins, proteasome, metalloproteases, granzyme B or other proteases) that are specific to neural or organ injury or damage.
摘要翻译：用神经和器官损伤特异性成像剂进行体内区域损伤测定。用于评估由于缺血，中风，创伤，化学或电气侮辱，急性药物过量或暴露于药物滥用引起的神经系统损伤引起的神经毒性细胞损失或神经系统损伤的程度的快速和非侵入性成像组合物和方法（如“娱乐性药物”）感染或其他侮辱。用于评估器官损伤程度的相同或相似的快速和非侵入性成像组合物和方法包括任何损伤，损伤或感染，对特定器官如肝，肾，前列腺，肺，骨骼肌，心脏，胰腺，胃，小肠和大肠，膀胱和生殖系统以及损伤，损伤或感染，多器官功能衰竭，创伤性出血性休克和败血症。特别是通过蛋白酶检测神经和器官损伤基于抑制剂的放射性核素标记的成像配体与特异于神经或器官损伤或损伤的过度活化的蛋白酶（钙蛋白酶，半胱天冬酶，组织蛋白酶，蛋白酶体，金属蛋白酶，粒酶B或其他蛋白酶）结合。

7. 发明申请

WO2011088026A3 BIOMARKERS OF LIVER INJURY 审中-公开
标题翻译：生物标记的肝损伤
公开(公告)号：WO2011088026A3
公开(公告)日：2011-12-22
申请号：PCT/US2011020797
申请日：2011-01-11
申请人： UNIV FLORIDA , BANYAN BIOMARKERS INC , SVETLOV STANISLAV I , HAYES RONALD L , WANG KA-WANG KEVIN , OLI MONIKA
发明人： SVETLOV STANISLAV I , HAYES RONALD L , WANG KA-WANG KEVIN , OLI MONIKA
IPC分类号： G01N33/68 , C12Q1/25 , G01N33/573
CPC分类号： C12Q1/00 , G01N33/573 , G01N2800/08
摘要： Novel, sensitive and specific markers for diagnostics and monitoring of liver injuries, including, but not limited to ischemic liver damage, are provided. This includes identification several enzymes of arginine/urea/nitric oxide cycle, sulfuration enzymes and spectrin breakdown related products, among others.
摘要翻译：提供了用于诊断和监测肝损伤的新型，敏感和特异性标记，包括但不限于缺血性肝损伤。这包括识别精氨酸/尿素/一氧化氮循环的几种酶，硫酸酶和血影蛋白分解相关产物等。

8. 发明申请

WO2009100131A3 PROCESS TO DIAGNOSE OR TREAT BRAIN INJURY 审中-公开
标题翻译：过程诊断或治疗脑损伤
公开(公告)号：WO2009100131A3
公开(公告)日：2009-11-19
申请号：PCT/US2009033080
申请日：2009-02-04
申请人： BANYAN BIOMARKERS INC , WANG KEVIN , HAYES RONALD L
发明人： WANG KEVIN , HAYES RONALD L
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/914 , G01N2800/28 , G01N2800/2871
摘要： A process for diagnosing and treating a neurological condition in a subject is provided that includes assaying a biological sample of a subject for the presence of one or more biomarkers; diagnosing a neurological condition based on a ratio of one or more of the biomarkers in the sample; and administering a therapeutic to the subject to alter the ratio of one or more biomarkers. The diagnosis numerous neurological conditions such as brain injury, or multiple organ injury is provided.
摘要翻译：提供了用于诊断和治疗受试者的神经病症的方法，其包括测定受试者的生物样品以存在一种或多种生物标志物; 基于样品中一种或多种生物标志物的比例诊断神经病症; 以及向受试者施用治疗剂以改变一种或多种生物标志物的比例。提供了许多神经学病症如脑损伤或多器官损伤的诊断。

9. 发明申请

WO2006047417A3 DETECTION OF CANNABINOID RECEPTOR BIOMARKERS AND USES THEREOF 审中-公开
标题翻译：大麻素受体生物标志物的检测及其应用
公开(公告)号：WO2006047417A3
公开(公告)日：2006-09-08
申请号：PCT/US2005038185
申请日：2005-10-21
申请人： UNIV FLORIDA , SVETLOV STANISLAV , HAYES RONALD L , WANG KEVIN
发明人： SVETLOV STANISLAV , HAYES RONALD L , WANG KEVIN
IPC分类号： G01N33/567 , A01N63/00 , A61K48/00 , C07K1/00 , C07K14/00 , C07K17/00 , G01N33/53 , G01N33/566
CPC分类号： G01N33/6896 , C07K16/28 , G01N33/948 , G01N2500/00 , G01N2800/28
摘要： Traumatic insult to the brain leads to a degradation of low molecular weight of CB1 receptor and generation of high molecular weight complexes in cortex and hippocampus, as assessed by both N-terminal and C-terminal specific antibody. The formation and release of CB1 oligomers was dramatically increased into CSF within 1 hour following traumatic brain insult. Novel CB1 receptor-based, prognostic markers of traumatic brain injury, subarachnoid hemorrhage, epilepsy, stroke, alcohol or substance/chemical-induced brain injury and other forms of brain injury, in addition to targeting CB1 receptor for therapeutic neuroprotection in TB1 are disclosed.
摘要翻译：如通过N末端和C末端特异性抗体所评估的，对大脑的创伤性侮辱导致CB1受体的低分子量降解和皮层和海马中高分子量复合物的产生。在创伤性脑损伤后1小时内，CB1寡聚体的形成和释放显着增加至CSF。公开了基于CB1受体的创伤性脑损伤，蛛网膜下出血，癫痫，中风，酒精或物质/化学诱导的脑损伤和其他形式的脑损伤的预后标志物，除了靶向CB1受体用于TB1中的治疗性神经保护。

10. 发明申请

WO2008008819A3 DIAGNOSIS AND TREATMENT OF NEUROLOGICAL INFLAMMATION 审中-公开
标题翻译：诊断和治疗神经性炎症
公开(公告)号：WO2008008819A3
公开(公告)日：2008-12-11
申请号：PCT/US2007073233
申请日：2007-07-11
申请人： UNIV FLORIDA , OTTENS ANDREW K , GOLD MARK S , KOBEISSY FIRAS H , WANG KEVIN KW , HAYES RONALD L
发明人： OTTENS ANDREW K , GOLD MARK S , KOBEISSY FIRAS H , WANG KEVIN KW , HAYES RONALD L
IPC分类号： A61K49/00 , C07H21/04 , C07K14/00 , G01N33/48
CPC分类号： G01N33/6896 , G01N33/6863 , G01N2800/40 , G01N2800/52
摘要： Drug abuse (METH and MDMA) animals are showing a pro-inflammatory phenotype similar to that of TBI. Detection of cytokines in neurological injury is shown. Methods of treatment of neurological chemical injury include the use of an anti-inflammatory agents due to the elevation of inflammatory related cytokines.
摘要翻译：药物滥用（METH和MDMA）动物显示出类似于TBI的促炎表型。显示神经损伤中细胞因子的检测。治疗神经性化学损伤的方法包括由于炎症相关细胞因子升高而使用抗炎剂。

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