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1. 发明申请

WO2010101849A1 N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS 审中-公开
标题翻译：用作WNT信号调节剂的N-（异氟烷基）亚甲基，2-（异丁基）亚芳基取代的乙酰胺
公开(公告)号：WO2010101849A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/025813
申请日：2010-03-01
申请人： IRM LLC , CHENG, Dai , ZHANG, Guobao , HAN, Dong , GAO, Wenqi , PAN, Shifeng
发明人： CHENG, Dai , ZHANG, Guobao , HAN, Dong , GAO, Wenqi , PAN, Shifeng
IPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/44 , A61P35/00
CPC分类号： A61K31/541 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formulae 1 and 2 and methods for modulating the Wnt signaling pathway using these compounds, wherein A 1 , A 2 , B, Y and Z all represent rings.
摘要翻译：本发明涉及式1和化合物2以及使用这些化合物调节Wnt信号通路的方法，其中A1，A2，B，Y和Z都代表环。

2. 发明申请

WO2010027746A2 HEDGEHOG PATHWAY MODULATORS 审中-公开
标题翻译： HEDGEHOG路径调制器
公开(公告)号：WO2010027746A2
公开(公告)日：2010-03-11
申请号：PCT/US2009/054802
申请日：2009-08-24
申请人： IRM LLC , CHENG, Dai , HAN, Dong , ZHANG, Guobao , WAN, Yongqin , XIE, Yun Feng , JIANG, Jiqing , GAO, Wenqi , PAN, Shifeng
发明人： CHENG, Dai , HAN, Dong , ZHANG, Guobao , WAN, Yongqin , XIE, Yun Feng , JIANG, Jiqing , GAO, Wenqi , PAN, Shifeng
IPC分类号： A61K31/47 , C07D401/02
CPC分类号： C07D401/12 , A61K31/47 , C07D217/04 , C07D217/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07D513/04
摘要： The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
摘要翻译：本发明提供了调节刺猬蛋白信号通路活性的方法，化合物和组合物。特别地，本发明提供了一种抑制由诸如Ptc丧失功能，刺猬获得功能，平滑功能增益或Gli功能增益等表现形成的异常生长状态的方法，包括使细胞接触与足量的式（I）化合物反应。

3. 发明申请

WO2012003189A1 COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY 审中-公开
标题翻译：用于调制WNT信号通路的组合物和方法
公开(公告)号：WO2012003189A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042215
申请日：2011-06-28
申请人： IRM LLC , NOVARTIS AG , CHENG, Dai , ZHANG, Guobao , HAN, Dong , GAO, Wenqi , PAN, Shifeng , SHEN, Lichun , LELETI, Rajender Reddy
发明人： CHENG, Dai , ZHANG, Guobao , HAN, Dong , GAO, Wenqi , PAN, Shifeng , SHEN, Lichun , LELETI, Rajender Reddy
IPC分类号： C07D213/56 , C07D237/08 , C07D279/12 , C07D401/12 , C07D401/14 , C07D403/12 , A61K31/44 , A61P35/00
CPC分类号： C07D417/14 , A61K31/50 , A61K31/541 , A61K45/06 , C07D213/56 , C07D237/08 , C07D279/12 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R 1 , R 2 , R 3 are as defined herein.
摘要翻译：本发明涉及使用具有式（1）和（3）的化合物调节Wnt信号通路的组合物和方法：其中A，B，Y和Z均表示环，并且R 1，R 2，R 3如本文所定义。

4. 发明申请

WO2007131201A2 COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS 审中-公开
标题翻译：化合物和组合物作为HEDGEHOG途径调节剂
公开(公告)号：WO2007131201A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/068292
申请日：2007-05-04
申请人： IRM LLC , GAO, Wenqi , JIANG, Jiqing , WAN, Yongqin , CHENG, Dai , HAN, Dong , WU, Xu , PAN, Shifeng
发明人： GAO, Wenqi , JIANG, Jiqing , WAN, Yongqin , CHENG, Dai , HAN, Dong , WU, Xu , PAN, Shifeng
CPC分类号： C07C255/57 , C07C235/56 , C07C237/40 , C07C2601/14 , C07D413/04
摘要： The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
摘要翻译：本发明提供了调节刺猬蛋白信号传导途径活性的方法。具体而言，本发明提供了抑制由表型如Ptc功能缺失，刺猬功能获得，平滑功能获得或Gli功能获得引起的异常生长状态的方法，包括使细胞与足量的式I化合物接触。

5. 发明申请

WO2008014291A2 COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS 审中-公开
标题翻译：化合物和组合物作为HEDGEHOG PATHWAY调制器
公开(公告)号：WO2008014291A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/074268
申请日：2007-07-24
申请人： IRM LLC , CHENG, Dai , HAN, Dong , GAO, Wenqi , JIANG, Jiqing , PAN, Shifeng , WAN, Yongqin , JIN, Qihui
发明人： CHENG, Dai , HAN, Dong , GAO, Wenqi , JIANG, Jiqing , PAN, Shifeng , WAN, Yongqin , JIN, Qihui
IPC分类号： C07D413/14 , C07D401/12 , C07D233/64 , C07D471/04 , A61K31/4709 , A61K31/4164 , A61K31/5377 , A61K31/55 , A61P35/00 , A61P17/06
CPC分类号： C07D413/14 , C07D233/64 , C07D401/12 , C07D471/04
摘要： The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
摘要翻译：本发明提供了一种调节刺猬蛋白信号通路活性的方法。特别地，本发明提供了一种抑制由诸如Ptc丧失功能，刺猬获得功能，平滑功能增益或Gli功能增益等表现形成的异常生长状态的方法，包括使细胞接触与足量的式I化合物反应。

6. 发明申请

WO2008011611A3 COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS 审中-公开
公开(公告)号：WO2008011611A3
公开(公告)日：2008-01-24
申请号：PCT/US2007/074048
申请日：2007-07-20
申请人： IRM LLC , PAN, Shifeng , LIU, Yi , XIE, Yun Feng , CHENG, Dai , WAN, Yongqin , HAN, Dong , YANG, Yang , GAO, Wenqi , JIANG, Jiqing , BURSULAYA, Badry , CHAMBERLAIN, Philip , KARANEWSKY, Donald S. , WANG, Xia
发明人： PAN, Shifeng , LIU, Yi , XIE, Yun Feng , CHENG, Dai , WAN, Yongqin , HAN, Dong , YANG, Yang , GAO, Wenqi , JIANG, Jiqing , BURSULAYA, Badry , CHAMBERLAIN, Philip , KARANEWSKY, Donald S. , WANG, Xia
IPC分类号： C07D231/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D491/048 , A61K31/415 , A61K31/44 , A61P17/00 , A61P19/02
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1, 4, 5-trisphosphate 3-kinase B (ITPKb).

7. 发明申请

WO2005016528A2 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF RECEPTOR TYROSINE KINASE ACTIVITY 审中-公开
标题翻译：作为受体酪氨酸激酶活性的抑制剂的化合物和组合物
公开(公告)号：WO2005016528A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/026373
申请日：2004-08-13
申请人： IRM LLC , CHENG, Dai , DING, Qiang , HAN, Dong , GRAY, Nathanael Schiander , ZHANG, Guobao
发明人： CHENG, Dai , DING, Qiang , HAN, Dong , GRAY, Nathanael Schiander , ZHANG, Guobao
IPC分类号： B01L
CPC分类号： C07D473/16 , C07D473/18 , C07D473/34 , C07D473/40
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with cSRC, Lck, FGFR3, Flt3, TrkB, Bmx, and/or PFGFRα kinase activity.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与cSRC，Lck，FGFR3，Flt3，TrkB，Bmx和/或PFGFRα激酶活性相关的疾病或病症的方法。

8. 发明申请

WO2008094737A2 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS 审中-公开
标题翻译：化合物和组合物作为激酶抑制剂
公开(公告)号：WO2008094737A2
公开(公告)日：2008-08-07
申请号：PCT/US2008/050807
申请日：2008-01-10
申请人： IRM LLC , THE SCRIPPS RESEARCH INSTITUTE , WINZELER, Elizabeth , GRAY, Nathanael S. , HAN, Dong , CHENG, Dai
发明人： WINZELER, Elizabeth , GRAY, Nathanael S. , HAN, Dong , CHENG, Dai
IPC分类号： A61K31/52 , A61K31/5377 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/662 , A61K45/06 , A61P33/06 , C07D473/16 , C07D473/18 , C07D473/34
CPC分类号： A61K31/52 , A61K31/5377 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/662 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D413/12 , C07D417/14 , Y02A50/411
摘要： The invention provides a class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with kinase activity, particularly malaria.
摘要翻译：本发明提供了一类化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与激酶活性特别是疟疾相关的疾病或病症的方法。

9. 发明申请

WO2010033080A1 MODULATOR, DEMODULATOR AND MODULATOR-DEMODULATOR 审中-公开
标题翻译：调制器，调制器和调制解调器
公开(公告)号：WO2010033080A1
公开(公告)日：2010-03-25
申请号：PCT/SG2008/000360
申请日：2008-09-19
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , HAN, Dong , ZHENG, Yuanjin
发明人： HAN, Dong , ZHENG, Yuanjin
IPC分类号： H04L27/00
CPC分类号： H04L27/12
摘要： A modulator, a demodulator and a modulator-demodulator are provided. A modulator includes a first intermediate signal processing path adapted to route a first intermediate signal; a second intermediate signal processing path adapted to route a second intermediate signal; a first amplifier coupled into the first intermediate signal processing path; a second amplifier coupled into the second intermediate signal processing path; and a chopper circuit coupled into the first intermediate signal processing path; wherein the chopper circuit is adapted to process the first intermediate signal in dependence on first baseband data; wherein the first amplifier is adapted to amplify the first intermediate signal processed by the chopper circuit in dependence on second baseband data; and wherein the second amplifier is adapted to amplify the second intermediate signal in dependence on the second baseband data.
摘要翻译：提供了调制器，解调器和调制器解调器。调制器包括适于路由第一中间信号的第一中间信号处理路径; 适于路由第二中间信号的第二中间信号处理路径; 耦合到所述第一中间信号处理路径中的第一放大器; 耦合到所述第二中间信号处理路径中的第二放大器; 以及斩波电路，其耦合到所述第一中间信号处理路径中; 其中所述斩波电路适于根据第一基带数据处理所述第一中间信号; 其中所述第一放大器适于根据第二基带数据放大由所述斩波电路处理的第一中间信号; 并且其中所述第二放大器适于根据所述第二基带数据放大所述第二中间信号。

10. 发明申请

WO2015103764A1 MONITORING AN OBJECT TO PREVENT AN OCCURRENCE OF AN ISSUE 审中-公开
标题翻译：监控对象以防止发生事件
公开(公告)号：WO2015103764A1
公开(公告)日：2015-07-16
申请号：PCT/CN2014/070429
申请日：2014-01-10
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , CONTRERAS, Robert Antonio , PAN, Rong , DONTULA, Rajesh , HAN, Dong , WANG, Jun , QIN, Guo-Xiang , NADHAN, Easwaran
发明人： CONTRERAS, Robert Antonio , PAN, Rong , DONTULA, Rajesh , HAN, Dong , WANG, Jun , QIN, Guo-Xiang , NADHAN, Easwaran
IPC分类号： H04L29/06
CPC分类号： H04L41/065 , H04L41/046 , H04L41/0654 , H04L41/069 , H04L43/16 , H04L63/1408 , H04L63/20
摘要： Monitoring an object to prevent an occurrence of an issue includes monitoring an object based on a number of parameters, categorizing messages of the object into categories while monitoring for a recurrence of a pattern of messages, detecting a potential issue with the object based on the recurrence of the pattern of messages, and alerting an operations manager agent of the potential issue to prevent an occurrence of the issue.
摘要翻译：监视对象以防止发生问题包括基于多个参数来监视对象，将对象的消息分类成类别，同时监视消息模式的重复，基于重复检测对象的潜在问题的消息模式，并提醒运营经理代理潜在的问题，以防止发生问题。

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