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1. 发明申请

WO2013030535A3 METHOD OF PREPARING CARRIER LIQUIDS 审中-公开
公开(公告)号：WO2013030535A3
公开(公告)日：2013-03-07
申请号：PCT/GB2012/052028
申请日：2012-08-20
申请人： IOTA NANOSOLUTIONS LIMITED , FOSTER, Alison Jayne , LONG, James , RANNARD, Steven Paul , WANG, Dong
发明人： FOSTER, Alison Jayne , LONG, James , RANNARD, Steven Paul , WANG, Dong
IPC分类号： A01N25/04 , A61K8/04 , A61K9/107 , A61K47/30 , A61Q19/00 , B82Y5/00
摘要： The invention provides a method for the preparation of a carrier liquid which comprises the steps of: (I) preparing a single phase solution comprising: (a) a solvent or a mixture of miscible solvents, (b) a liquid carrier material, which is soluble in solvent (a), and (c) a dopant material which is also soluble in solvent (a); (II) cooling (preferably freezing) the single phase solution produced in step (I) to a temperature at which at least both the solvent (a) and carrier material (b) become solid; and (III) removing solid solvent (a) from the cooled (frozen) single phase solution in vapour form, such that the remaining cooled (frozen) carrier material (b) and dopant material (c) are returned to ambient temperature thus providing a product of liquid carrier material (b) having dopant material (c) dispersed therein.

2. 发明申请

WO2011128623A2 IMPROVEMENTS RELATING TO ANTIVIRAL COMPOSITIONS 审中-公开
标题翻译：关于抗病毒组合物的改进
公开(公告)号：WO2011128623A2
公开(公告)日：2011-10-20
申请号：PCT/GB2011/000549
申请日：2011-04-08
申请人： IOTA NANOSOLUTIONS LIMITED , FOSTER, Alison Jayne , LONG, James , RANNARD, Steven Paul , WANG, Dong , DUNCALF, David John
发明人： FOSTER, Alison Jayne , LONG, James , RANNARD, Steven Paul , WANG, Dong , DUNCALF, David John
IPC分类号： A61K9/51
CPC分类号： A61K9/10 , A61K9/5123 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5192 , A61K31/427 , A61K31/4725 , A61K31/513 , A61K31/536 , A61K47/10 , A61K47/32 , A61K47/38
摘要： The present invention provides a composition and an antiviral drug preparation, each comprising at least one water-insoluble antiviral drug and at least one water-soluble carrier material, wherein the water-insoluble antiviral drug is dispersed through the water-soluble carrier material in nano-disperse form. The present invention further provides processes for preparing the compositions and drug preparations, and also aqueous nano-dispersions obtained by combining water and the compositions.
摘要翻译：本发明提供一种组合物和抗病毒药物制剂，每种组合物和抗病毒药物制剂各自包含至少一种水不溶性抗病毒药物和至少一种水溶性载体材料，其中所述水不溶性抗病毒药物通过纳米级的水溶性载体材料分散 - 分散形式。本发明还提供了制备组合物和药物制剂的方法，以及通过将水和组合物组合获得的水性纳米分散体。

3. 发明申请

WO2008007152A3 PREPARATION OF PHARMACEUTICAL FORMULATIONS 审中-公开
公开(公告)号：WO2008007152A3
公开(公告)日：2008-01-17
申请号：PCT/GB2007/050409
申请日：2007-07-13
申请人： UNILEVER PLC , DUNCALF, David John , RANNARD, Steven Paul , LONG, James , WANG, Dong , ELPHICK, Andrew James , STANIFORTH, John , CHAUVIN, Daniele , FOSTER, Alison Jayne
发明人： DUNCALF, David John , RANNARD, Steven Paul , LONG, James , WANG, Dong , ELPHICK, Andrew James , STANIFORTH, John , CHAUVIN, Daniele , FOSTER, Alison Jayne
IPC分类号： A61K9/16 , A61K31/167 , A61K31/192 , A61K31/60
摘要： A process for the production of a composition comprising a water-insoluble opioid which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble opioid, ii) a water soluble carrier, and iii) a solvent for each of the opioid and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the opioid in the carrier.

4. 发明申请

WO2008007150A1 PREPARATION OF PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物的制备
公开(公告)号：WO2008007150A1
公开(公告)日：2008-01-17
申请号：PCT/GB2007/050407
申请日：2007-07-13
申请人： UNILEVER PLC , ELPHICK, Andrew James , STANIFORTH, John , WANG, Dong , DUNCALF, David John , RANNARD, Steven Paul , LONG, James , FOSTER, Alison Jayne
发明人： ELPHICK, Andrew James , STANIFORTH, John , WANG, Dong , DUNCALF, David John , RANNARD, Steven Paul , LONG, James , FOSTER, Alison Jayne
IPC分类号： A61K9/16 , A61K31/167 , A61K31/192 , A61K31/60
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble paracetamol or NSAID which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble paracetamol or NSAID, ii) a water soluble carrier, and iii) a solvent for each of the paracetamol or NSAID and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the paracetamol or NSAID in the carrier.
摘要翻译：一种制备包含水不溶性对乙酰氨基酚或NSAID的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）水不溶性对乙酰氨基酚或NSAID，ii）水溶性载体，和iii）溶剂，并且b）喷雾干燥该混合物以除去该溶剂或每种溶剂，并获得载体中对乙酰氨基酚或NSAID的基本上无溶剂的纳米分散体。

5. 发明申请

WO2008007151A2 PROCESSES FOR PREPARING PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：制备药物组合物的方法
公开(公告)号：WO2008007151A2
公开(公告)日：2008-01-17
申请号：PCT/GB2007/050408
申请日：2007-07-13
申请人： UNILEVER PLC , DUNCALF, David John , RANNARD, Steven Paul , LONG, James , WANG, Dong , ELPHICK, Andrew James , STANIFORTH, John , FOSTER, Alison Jayne
发明人： DUNCALF, David John , RANNARD, Steven Paul , LONG, James , WANG, Dong , ELPHICK, Andrew James , STANIFORTH, John , FOSTER, Alison Jayne
IPC分类号： A61K9/16 , A61K31/167 , A61K31/192 , A61K31/60
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble triptan which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble triptan, ii) a water soluble carrier, and iii) a solvent for each of the triptan and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the triptan in the carrier.
摘要翻译：一种制备包含水不溶性曲坦的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）不溶于水的曲坦，ii）水溶性载体，和iii）曲坦和载体，以及b）喷雾干燥混合物以除去或溶解各种溶剂，并获得载体中曲坦的基本上无溶剂的纳米分散体。

6. 发明申请

WO2010020518A2 IMPROVEMENTS RELATING TO NANODISPERSE COMPOSITIONS 审中-公开
标题翻译：关于纳米复合材料的改进
公开(公告)号：WO2010020518A2
公开(公告)日：2010-02-25
申请号：PCT/EP2009/059546
申请日：2009-07-24
申请人： UNILEVER PLC , UNILEVER N.V. , ANGUS, Doris , DUNCALF, David John , FOSTER, Alison Jayne , RANNARD, Steven Paul , WANG, Dong
发明人： ANGUS, Doris , DUNCALF, David John , FOSTER, Alison Jayne , RANNARD, Steven Paul , WANG, Dong
CPC分类号： A61K9/1694 , A61K9/1623 , A61K9/1635 , B01J2/04
摘要： A process for the production of a soluble composition comprising a water- insoluble active which comprises either the steps of: a) providing a liquid mixture comprising: i) a dissolved water-insoluble active, ii) a dissolved water-soluble carrier, iii) a solvent for each of the active and the carrier, and b) spray-granulating the mixture to remove the, or each, solvent and obtain a substantially solvent-free nano-dispersion of the water-insoluble active in the carrier said water-insoluble active being in nano-particles having a size range of 999-20 nm; or, the steps of: a) providing a substantially solvent-free powder comprising a water-insoluble active dispersed in a water soluble carrier, said water-insoluble active being in nano-particles having a size range of 999-20 nm, and, b) spray-granulating the powder to obtain larger and denser particles. The invention also relates to solvent-free, granular products with a particle size in the range 20 microns to 10mm and a bulk-density of greater than 0.4g/cm3 comprising a water-soluble carrier material, the carrier material having dispersed therein a water-insoluble active, wherein on addition of water the carrier dissolves to form an aqueous dispersion of the active with a peak (z-average) particle size of below 800nm, preferably below 500nm and more preferably below 200nm. The invention also relates to an analogous "reverse" process in which the active is water soluble and the carrier is oil soluble.
摘要翻译：一种用于生产包含水不溶性活性物质的可溶性组合物的方法，其包括以下步骤：a）提供液体混合物，其包含：i）溶解的水不溶性活性物质，ii）溶解的水溶性载体，iii）用于活性物质和载体中的每一种的溶剂，以及b）将混合物喷雾造粒以除去溶剂或每种溶剂，并获得载体中不溶于水的活性物质的基本上无溶剂的纳米分散体，所述水不溶性活性纳米颗粒的尺寸范围为999〜20nm; 或者步骤：a）提供基本上无溶剂的粉末，其包含分散在水溶性载体中的不溶于水的活性物质，所述水不溶性活性物质的尺寸范围为999-20nm， b）将粉末喷雾造粒以获得更大和更致密的颗粒。本发明还涉及粒径在20微米至10mm范围内的无溶剂颗粒状产品，其中堆积密度大于0.4g / cm3，包括水溶性载体材料，载体材料中分散有水其中在加入水时，载体溶解以形成具有低于800nm，优选低于500nm，更优选低于200nm的峰（z-平均）粒度的活性物质的水分散体。本发明还涉及类似的“反向”方法，其中活性物质是水溶性的并且载体是油溶性的。

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