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1. 发明申请

WO2015150513A1 METHOD TO SPORULATE COCCIDIAL OOCYSTS PURIFIED FROM ANIMAL FAECES, SPORULATED OOCYSTS OBTAINED WITH THIS METHOD AND A VACCINE CONTAINING THESE SPORULATED OOCYSTS 审中-公开
标题翻译：从动物体内培养合成的OOCYSTS的方法，用这种方法获得的运动的OOCYSTS和含有这些运动的OOCYSTS的疫苗
公开(公告)号：WO2015150513A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/057298
申请日：2015-04-02
申请人： INTERVET INTERNATIONAL B.V. , INTERVET INC.
发明人： SCHETTERS, Theodorus Petrus Maria , GEVERS, Koen
IPC分类号： C12N1/10 , A61K39/012 , C12M1/12 , C12M1/26
CPC分类号： C12N3/00 , A61K39/012 , C12M27/10 , C12M33/14 , C12N1/10
摘要： The invention pertains to a method to sporulate coccidial oocysts purified from animal faeces (5), the method comprising providing the purified oocysts as a layer (40) on a supporting surface (22), maintaining the layer at least intermittently in an oxygen containing gaseous environment (60) having a relative humidity of at least 15% and maintaining the temperature of the oocysts between 19°C and 37°C. The invention also pertains to sporulated oocysts obtained with this method and to a vaccine containing such sporulated oocysts.
摘要翻译：本发明涉及从动物粪便中纯化的球虫卵囊的方法（5），所述方法包括将提纯的卵囊作为层（40）提供在支撑表面（22）上，将该层至少间歇地保持在含氧气体环境（60）具有至少15％的相对湿度，并保持卵囊的温度在19℃和37℃之间。本发明还涉及用该方法获得的孢子形成的卵囊和含有这种形成孢子的卵囊的疫苗。

2. 发明申请

WO2014154847A1 VACCINE AGAINST RHIPICEPHALUS TICKS 审中-公开
标题翻译： VACCINE反对RHIPICEPHALUS TICKS
公开(公告)号：WO2014154847A1
公开(公告)日：2014-10-02
申请号：PCT/EP2014/056248
申请日：2014-03-28
申请人： INTERVET INTERNATIONAL B.V. , INTERVET INC.
发明人： SCHETTERS, Theodorus Petrus Maria , JANSEN, Theodorus
IPC分类号： A61K39/00 , A61P33/14
CPC分类号： A61K39/0003 , A61K9/107 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55566 , A61K2039/55577 , A61K2039/70
摘要： The present invention generally relates to the fields of parasitology and immunology, and especially to a vaccine against Rhipicephalus ticks. In particular the invention relates to a composition comprising a first and a second protein, in particular Bm86 and Subolesin proteins, including their homologs or immunogenic fragments; to the use of such a composition as a vaccine against Rhipicephalus ticks, and to the use of the first and the second isolated proteins for the vaccination of a target against Rhipicephalus ticks.
摘要翻译：本发明一般涉及寄生虫学和免疫学领域，尤其涉及针对蜱螨的疫苗。特别地，本发明涉及包含第一和第二蛋白质，特别是Bm86和亚金属蛋白质的组合物，包括其同源物或免疫原性片段; 使用这种组合物作为针对胭脂红蜱的疫苗，以及使用第一和第二种分离的蛋白质用于针对蜱螨的接种疫苗。

3. 发明申请

WO2015150512A1 A METHOD TO PURIFY COCCIDIAL OOCYSTS FROM ANIMAL FAECES, A SYSTEM SUITABLE FOR APPLYING THIS METHOD AND OOCYSTS OBTAINED THEREWITH 审中-公开
标题翻译：一种从动物实验中筛选合适的OOCYSTS的方法，适用于本方法的系统和获得的OOCYSTS的方法
公开(公告)号：WO2015150512A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/057294
申请日：2015-04-02
申请人： INTERVET INTERNATIONAL B.V. , INTERVET INC.
发明人： GEVERS, Koen , SCHETTERS, Theodorus Petrus Maria
IPC分类号： C12N1/02 , C12N1/10
CPC分类号： C12N1/10 , C12N1/02
摘要： The invention pertains to a method to purify coccidial oocysts having dimensions between Dmin and Dmax from faeces comprising the steps of collecting the faeces containing the coccidial oocysts from host animals, diluting the faeces in an aqueous medium, separating a coarse fraction comprising macroscopic particulate matter from the diluted faeces and collecting an aqueous fraction containing the oocysts, characterised in that the method further comprises sieving the aqueous fraction over a first sieve deck having mesh openings to let the oocysts pass, to obtain an aqueous filtrate comprising the oocysts and a first residue comprising particles larger than the oocysts,and sieving the aqueous filtrate over a second sieve deck having mesh openings to obstruct passing of the oocysts through this sieve deck, to obtain a second residue comprising the purified oocysts and a waist filtrate comprising particles smaller than the oocysts. The invention also pertains to a system suitable for applying this method and to oocysts obtained therewith.
摘要翻译：本发明涉及一种从粪便中净化Dmin和Dmax之间的尺寸的球虫卵囊的方法，包括以下步骤：从宿主动物中收集含有球虫卵囊的粪便，在水性介质中稀释粪便，将包含肉眼可见颗粒物质的粗级分从稀释的粪便并收集含有卵囊的含水部分，其特征在于，所述方法还包括在具有筛孔的第一筛板上筛分含水部分以使卵囊通过，以获得包含卵囊的含水滤液和含有大于卵囊的颗粒，并且在含有筛孔的第二筛板上筛分含水滤液以阻止卵囊通过该筛甲板，获得包含纯化的卵囊的第二残留物和包含小于卵囊的颗粒的腰滤液。本发明还涉及适用于该方法的系统和由其获得的卵囊。

4. 发明申请

WO2012089748A1 CANINE BABESIOSIS VACCINE ANTIGEN 审中-公开
公开(公告)号：WO2012089748A1
公开(公告)日：2012-07-05
申请号：PCT/EP2011/074120
申请日：2011-12-28
申请人： INTERVET INTERNATIONAL B.V. , SCHETTERS, Theodorus Petrus Maria , MOUBRI-MENAGE, Karina , KLEUSKENS, Jos , ROHWER, Andreas
发明人： SCHETTERS, Theodorus Petrus Maria , MOUBRI-MENAGE, Karina , KLEUSKENS, Jos , ROHWER, Andreas
IPC分类号： A61K39/00 , A61K39/002 , A61K39/018 , C07K14/44
CPC分类号： C07K14/44 , A61K39/018 , A61K2039/5156 , A61K2039/523 , A61K2039/53 , A61K2039/552 , A61K2039/55566 , A61K2039/55577 , C07H21/04 , C07K16/20 , G01N2333/44
摘要： The present invention relates to the field of veterinary parasitology, especially of canine Babesiosis. In particular the invention relates to a polypeptide being a novel canine Babesia antigen (CBA), or fragments thereof, and to compositions comprising this antigen, to nucleic acids encoding the antigen, antibodies against the antigen, and medical uses of this antigen, fragments, antibodies, or encoding nucleic acids. In particular the invention relates to the use of such components in vaccines against canine Babesiosis.
摘要翻译：本发明涉及兽类寄生虫学领域，特别是犬巴贝氏菌病。特别地，本发明涉及一种新型犬贝贝斯抗原（CBA）或其片段，以及包含该抗原的组合物，编码抗原的核酸，针对抗原的抗体，以及该抗原的片段，抗体或编码核酸。特别地，本发明涉及这样的组分在针对犬贝桑病的疫苗中的用途。

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