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1. 发明申请

WO2008003515A1 SMALL STREPTOCOCCUS PYOGENES ANTIGENS AND THEIR USE 审中-公开
标题翻译：小肠杆菌抗原及其使用
公开(公告)号：WO2008003515A1
公开(公告)日：2008-01-10
申请号：PCT/EP2007/006027
申请日：2007-07-06
申请人： INTERCELL AG , MEINKE, Andreas , NAGY, Eszter , VON GABAIN, Alexander , BERGER, Manfred , SENN, Beatrice , SCHUNN, Michael
发明人： MEINKE, Andreas , NAGY, Eszter , VON GABAIN, Alexander , BERGER, Manfred , SENN, Beatrice , SCHUNN, Michael
IPC分类号： C07K16/00
CPC分类号： C07K14/315 , A61K39/00
摘要： The present invention relates to a peptide consisting of one antigen of Streptococcus pyogenes ( S. pyogenes ) of any of the SEQ ID NOS: 1 to 7 or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing a S. pyogenes infection; a method for identifying a ligand capable of binding to said peptide; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.
摘要翻译：本发明涉及由化脓性链球菌（Streptococcus pyogenes）的一种抗原组成的肽

2. 发明申请

WO2008084072A2 PROTECTIVE PROTEINS OF S. AGALACTIAE, COMBINATIONS THEREOF AND METHODS OF USING THE SAME 审中-公开
标题翻译： S. AGALACTIAE的保护性蛋白质，其组合及其使用方法
公开(公告)号：WO2008084072A2
公开(公告)日：2008-07-17
申请号：PCT/EP2008/050227
申请日：2008-01-10
申请人： INTERCELL AG , SENN, Beatrice , NAGY, Eszter , MEINKE, Andreas , VON GABAIN, Alexander , MAIERHOFER, Barbara , STIERSCHNEIDER, Ulrike , BERGER, Manfred , NEUBAUER, Christina , COHEN, Katherine
发明人： SENN, Beatrice , NAGY, Eszter , MEINKE, Andreas , VON GABAIN, Alexander , MAIERHOFER, Barbara , STIERSCHNEIDER, Ulrike , BERGER, Manfred , NEUBAUER, Christina , COHEN, Katherine
IPC分类号： A61K38/00
CPC分类号： A61K39/092 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/315 , C07K16/1275
摘要： The invention relates to a composition comprising at least two protective proteins against Streptococcus agalactiae (S. agalactiae) or functionally active variant thereof; a protective peptide against S. agalactiae; one or more nucleic acid(s) encoding the at least two proteins and/or the protective peptide; a method of producing the composition; a pharmaceutical composition, especially a vaccine, comprising the composition and/or at least one protective peptide; methods for producing antibodies; a mixture of antibodies against the at least two proteins of the composition; the use of the composition and/or at least one protective peptide and/or one or more nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; methods of diagnosing a S. agalactiae infection; a method for identifying a ligand capable of binding the composition and/or at least one protective peptide; and the use of the composition and/or at least one protective peptide for the isolation and/or purification and/or identification of an interaction partner of the composition and/or peptide.
摘要翻译：本发明涉及一种组合物，其包含至少两种针对无乳链球菌（无乳链球菌）或其功能活性变体的保护性蛋白质; 针对无乳糖乳杆菌的保护性肽; 编码所述至少两种蛋白质和/或保护性肽的一种或多种核酸; 一种制备该组合物的方法; 包含该组合物和/或至少一种保护性肽的药物组合物，特别是疫苗; 生产抗体的方法; 针对组合物的至少两种蛋白质的抗体的混合物; 组合物和/或至少一种保护性肽和/或一种或多种核酸用于制备用于免疫或治疗受试者的药物的用途; 诊断无乳乳酸菌感染的方法; 用于鉴定能够结合组合物和/或至少一种保护性肽的配体的方法; 以及组合物和/或至少一种保护性肽用于分离和/或纯化和/或鉴定组合物和/或肽的相互作用配偶体的用途。

3. 发明申请

WO2010089340A2 PEPTIDES PROTECTIVE AGAINST E. FAECALIS, METHODS AND USES RELATING THERETO 审中-公开
标题翻译：抗生素的保护作用与其相关的E. FAECALIS，方法和用途
公开(公告)号：WO2010089340A2
公开(公告)日：2010-08-12
申请号：PCT/EP2010/051341
申请日：2010-02-04
申请人： INTERCELL AG , NAGY, Eszter , SENN, Beatrice , HANNER, Markus , BERGER, Manfred , MEINKE, Andreas , VON GABAIN, Alexander , MURRAY, Barbara , SINGH, Kavindra V.
发明人： NAGY, Eszter , SENN, Beatrice , HANNER, Markus , BERGER, Manfred , MEINKE, Andreas , VON GABAIN, Alexander , MURRAY, Barbara , SINGH, Kavindra V.
IPC分类号： C07K14/315 , C07K16/12 , G01N33/569
CPC分类号： C07K14/335 , A61K39/012 , A61K2039/55566 , C07K16/1267 , G01N33/56916
摘要： The present invention relates to a protective peptide of Enterococcus faecalis (E. faecalis) or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing an E. faecalis infection; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.
摘要翻译：本发明涉及粪肠球菌（粪肠球菌）或其功能性活性变体的保护性肽，任选地还包含另外的氨基酸残基; 编码该核酸的核酸; 包含所述肽或所述核酸的药物组合物; 与抗原特异性结合的抗体或功能活性片段; 产生所述抗体的杂交瘤细胞系; 一种生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制备用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 一种诊断粪肠球菌感染的方法; 以及所述肽用于分离和/或纯化和/或鉴定肽的相互作用配偶体的用途。

4. 发明申请

WO2009115508A2 PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE AND COMPOSITIONS, METHODS AND USES RELATING THERETO 审中-公开
标题翻译：抗生素保护措施
公开(公告)号：WO2009115508A2
公开(公告)日：2009-09-24
申请号：PCT/EP2009/053119
申请日：2009-03-17
申请人： INTERCELL AG , MEINKE, Andreas , TEUBENBACHER, Astrid , SENN, Beatrice , ZERBS, Manuel , HANNER, Markus , PIKALO, Jutta , NAGY, Eszter , GIEFING, Carmen , VON GABAIN, Alexander
发明人： MEINKE, Andreas , TEUBENBACHER, Astrid , SENN, Beatrice , ZERBS, Manuel , HANNER, Markus , PIKALO, Jutta , NAGY, Eszter , GIEFING, Carmen , VON GABAIN, Alexander
IPC分类号： C07K14/315 , C07K16/12 , G01N33/68 , A61K39/09
CPC分类号： A61K39/092 , C07K14/3156 , G01N33/56944 , G01N2333/3156 , G01N2469/20
摘要： The present invention relates to a protective peptide of Streptococcus pneumoniae (S. pneumoniae) or a functionally active variant of the protective peptide; a composition comprising at least two protective peptides or functionally active variants thereof; a composition comprising at least two proteins selected from the group consisting of i) a first type of protective peptide or functionally active variant thereof, ii) a second type of protective peptide or functionally active variant thereof and iii) a supportive peptide or a functionally active variant thereof; one or more nucleic acid(s) encoding the protective peptide or functionally active variant thereof or the at least two proteins comprised in the composition; a pharmaceutical composition comprising the protective peptide or functionally active variant thereof, the composition, or the nucleic acid(s); a method of producing an antibody using the protective peptide or functionally active variant thereof or the composition; the use of the protective peptide or functionally active variant thereof and/or the composition and/or the nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; a method of diagnosing a S. pneumoniae infection using the protective peptide or a functionally active variant thereof, the composition or a primer and/or probe specific for the nucleic acid(s); a method for identifying a ligand capable of binding to a protective peptide or functionally active variant thereof; and the use of a protective peptide or functionally active variant thereof for the isolation and/or purification and/or identification of an interaction partner of the peptide.
摘要翻译：本发明涉及肺炎链球菌（Streptococcus pneumoniae）（肺炎链球菌）的保护肽或保护性肽的功能活性变体; 包含至少两种保护性肽或其功能活性变体的组合物; 包含至少两种选自i）第一类保护性肽或其功能活性变体的蛋白质的组合物，ii）第二类型的保护性肽或其功能活性变体，和iii）支持肽或功能活性其变体; 一种或多种编码保护性肽或其功能活性变体的核酸或组合物中包含的至少两种蛋白质; 包含保护性肽或其功能活性变体，组合物或核酸的药物组合物; 使用保护性肽或其功能活性变体或组合物制备抗体的方法; 保护性肽或其功能活性变体和/或组合物和/或核酸在制备用于免疫或治疗受试者的药物中的用途; 使用保护性肽或其功能活性变体来诊断肺炎链球菌感染的方法，所述组合物或对所述核酸特异性的引物和/或探针; 用于鉴定能够结合保护性肽或其功能活性变体的配体的方法; 以及使用保护性肽或其功能活性变体来分离和/或纯化和/或鉴定肽的相互作用配偶体。

5. 发明申请

WO2007042326A3 NEISSERIA MENINGITIDIS ANTIGENS 审中-公开
公开(公告)号：WO2007042326A3
公开(公告)日：2007-04-19
申请号：PCT/EP2006/009934
申请日：2006-10-13
申请人： INTERCELL AG , NAGY, Eszter , MEINKE, Andreas , VON GABAIN, Alexander , HANNER, Markus , NOIGES, Birgit , GELBMANN, Dieter , SENN, Beatrice , LINGNAU, Karen
发明人： NAGY, Eszter , MEINKE, Andreas , VON GABAIN, Alexander , HANNER, Markus , NOIGES, Birgit , GELBMANN, Dieter , SENN, Beatrice , LINGNAU, Karen
IPC分类号： C07K14/22 , C07K19/00 , C12N15/11 , C12N15/62 , A61K39/095
摘要： The present invention relates to a peptide consisting of antigen of N . meningitidis of any of the SEQ ID NOS: 1 to 184 or a functional active fragment or derivative thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, containing a polypeptide comprising or consisting of said peptide or said nucleic acid; a nucleic acid coding for said polypeptide or a nucleic acid complementary to the same; an antibody or functional active fragment thereof; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing a N. meningitidis infection; a method for identifying a ligand capable of binding to said peptide; and the use said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.

6. 发明申请

WO2008031133A2 BORRELIA ANTIGENS 审中-公开
标题翻译： BORRELIA抗原
公开(公告)号：WO2008031133A2
公开(公告)日：2008-03-20
申请号：PCT/AT2007/000439
申请日：2007-09-14
申请人： INTERCELL AG , LUNDBERG, Urban , MEINKE, Andreas , NAGY, Eszter , VON GABAIN, Alexander , NOIGES, Birgit , GELBMANN, Dieter , POLJAK, Albina , TRISKA, Christine
发明人： LUNDBERG, Urban , MEINKE, Andreas , NAGY, Eszter , VON GABAIN, Alexander , NOIGES, Birgit , GELBMANN, Dieter , POLJAK, Albina , TRISKA, Christine
IPC分类号： C07K14/20
CPC分类号： C07K7/08 , A61K39/00 , A61K2039/53 , C07K7/06 , C07K14/20 , Y02A50/401
摘要： The present invention relates to isolated nucleic acid molecules which encode a protein, isolated nucleic acid molecules which encode a hyperimmune serum reactive antigen, a vector which comprises such nucleic acid molecule, a host cell comprising such vector, a hyperimmune reactive antigen from Borrelia species, proteins which are preferably hyperimmune serum reactive antigens, hyperimmune serum reactive antigens, antigens, a process for producing such proteins, hyperimmune serum reactive antigens or antigens, a process for producing a cell which expresses such protein, hyperimmune serum reactive antigen or antigen, an antibody binding to such protein, hyperimmune serum reactive antigen or antigen, a hybridoma cell producing such antibody, methods for producing such antibody, a pharmaceutical composition comprising such nucleic acid molecule, protein, hyperimmune serum reactive antigen, antigen or antibody, the use of such nucleic acid molecule, protein, hyperimmune serum reactive antigen, antigen or antibody for the manufacture of a medicament, methods for identifying an antagonist capable of reducing or inhibiting the interaction activity of such protein, hyperimmune serum reactive antigen or antigen, methods for diagnosing an infection and methods for the treatment of an infection. More specifically such proteins, hyperimmune serum reactive antigens or antigens are produced by or associated with bacterial pathogens causing Lyme disease or bacterial infections caused by Borrelia burgdorferi s.l.
摘要翻译：本发明涉及编码蛋白质的分离的核酸分子，编码超免疫血清反应性抗原的分离的核酸分子，包含该核酸分子的载体，包含该载体的宿主细胞，来自疏螺旋体属物种的超免疫反应性抗原，优选为超免疫血清反应性抗原的蛋白质，超免疫血清反应性抗原，抗原，制备此类蛋白质的方法，超免疫血清反应性抗原或抗原，生产表达此类蛋白质的细胞的方法，超免疫血清反应性抗原或抗原，抗体结合这种蛋白质，超免疫血清反应性抗原或抗原，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，蛋白质，超免疫血清反应性抗原，抗原或抗体的药物组合物，使用此类核酸酸分子，蛋白质，超免疫血清反应蚂蚁用于制备药物的抗原，抗原或抗体，用于鉴定能够降低或抑制这种蛋白质，超免疫血清反应性抗原或抗原的相互作用活性的拮抗剂的方法，用于诊断感染的方法和用于治疗感染的方法。更具体地，这种蛋白质，超免疫血清反应性抗原或抗原由细菌病原体产生或与细菌病原体相关，引起莱姆病或由布氏疏螺旋体引起的细菌感染。

7. 发明申请

WO2010092176A2 NONTYPABLE HAEMOPHILUS INFLUENZAE ANTIGENS 审中-公开
标题翻译：不可替代的海马流感病毒抗体
公开(公告)号：WO2010092176A2
公开(公告)日：2010-08-19
申请号：PCT/EP2010/051871
申请日：2010-02-15
申请人： INTERCELL AG , VON GABAIN, Alexander , NAGY, Eszter , MEINKE, Andreas , SELAK, Sanja , HANNER, Markus , SMIDT, Margarita , WEISSGRAM, Michaela , NOIGES, Birgit , SEIDEL, Stefan , BACHER, Julia , SATKE, Christina , SCHUELER, Wolfgang , OLEKSIEWICZ, Martin
发明人： VON GABAIN, Alexander , NAGY, Eszter , MEINKE, Andreas , SELAK, Sanja , HANNER, Markus , SMIDT, Margarita , WEISSGRAM, Michaela , NOIGES, Birgit , SEIDEL, Stefan , BACHER, Julia , SATKE, Christina , SCHUELER, Wolfgang , OLEKSIEWICZ, Martin
IPC分类号： A61K39/12
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/53
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a nontypable Haemophilus influenzae (H. influenzae) species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a nontypable Haemophilus influenzae species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by nontypable Haemophilus influenzae . Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with nontypable Haemophilus influenzae and methods for the treatment or prevention of an infection with nontypable Haemophilus influenzae.
摘要翻译：本发明涉及编码来自不可流行的流感嗜血杆菌（流感嗜血杆菌）物种的抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了来自不可渗透的流感嗜血杆菌物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。更具体地说，这种抗原由不流行的流感嗜血杆菌引起的细菌感染产生或与其相关。此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原，用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制该抗原的相互作用活性的方法，用于诊断不可流行的流感嗜血杆菌的感染的方法和用于治疗或预防感染非典型流感嗜血杆菌。

8. 发明申请

WO2008155291A2 CHLAMYDIA ANTIGENS 审中-公开
标题翻译： CHLAMYDIA抗原
公开(公告)号：WO2008155291A2
公开(公告)日：2008-12-24
申请号：PCT/EP2008/057456
申请日：2008-06-13
申请人： INTERCELL AG , MEINKE, Andreas , NAGY, Eszter , NOIGES, Birgit , ASKLIN, Johanna , VON GABAIN, Alexander
发明人： MEINKE, Andreas , NAGY, Eszter , NOIGES, Birgit , ASKLIN, Johanna , VON GABAIN, Alexander
IPC分类号： C07K14/295
CPC分类号： C07K14/295 , A61K39/118 , G01N33/56927 , G01N2469/20
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a Chlamydia species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Chlamydia species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by Chlamydia pneumoniae . Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with Chlamydia and methods for the treatment or prevention of an infection with Chlamydia .
摘要翻译：本发明涉及编码来自衣原体物种的抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了来自衣原体物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。更具体地，这样的抗原由衣原体引起的细菌感染产生或与其相关

9. 发明申请

WO2008135446A2 KLEBSIELLA ANTIGENS 审中-公开
标题翻译： KLEBSIELLA抗原
公开(公告)号：WO2008135446A2
公开(公告)日：2008-11-13
申请号：PCT/EP2008/055214
申请日：2008-04-29
申请人： INTERCELL AG , BAKSHI, Sharmila , CIPPS, Thomas , HANNER, Markus , PIKALO, Jutta , SATKE, Christina , NAGY, Eszter , LUNDBERG, Urban , ZIERER, Dagmar , MEINKE, Andreas , NOIGES, Birgit , STIERSCHNEIDER, Ulrike , VON GABAIN, Alexander
发明人： BAKSHI, Sharmila , CIPPS, Thomas , HANNER, Markus , PIKALO, Jutta , SATKE, Christina , NAGY, Eszter , LUNDBERG, Urban , ZIERER, Dagmar , MEINKE, Andreas , NOIGES, Birgit , STIERSCHNEIDER, Ulrike , VON GABAIN, Alexander
IPC分类号： C07K14/26 , C07K16/12 , A61K39/395 , A61P31/04
CPC分类号： C07K14/26 , A61K39/00 , A61K39/0266 , A61K45/06 , A61K2039/505 , A61K2039/55505 , A61K2039/55566 , C07K16/1228 , C07K2317/21
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae .
摘要翻译：本发明涉及编码抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了来自克雷伯氏菌属物种的抗原，以及其片段和变体，产生这种抗原的方法，以及表达这种抗原的细胞的制备方法。此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原，用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制该抗原的相互作用活性的方法，用于诊断感染的方法以及用于治疗或预防感染的方法。更具体地，这样的抗原由导致院内感染或由肺炎克雷伯杆菌引起的细菌感染的细菌病原体产生或与之相关。

10. 发明申请

WO2010136562A2 MORAXELLA CATARRHALIS ANTIGENS 审中-公开
标题翻译： MORAXELLA CATARRHALIS抗原
公开(公告)号：WO2010136562A2
公开(公告)日：2010-12-02
申请号：PCT/EP2010/057414
申请日：2010-05-28
申请人： INTERCELL AG , VON GABAIN, Alexander , NAGY, Eszter , MEINKE, Andreas , SELAK, Sanja , HANNER, Markus , SMIDT, Margarita , FLOR, Julia , NOIGES, Birgit , SCHUELER, Wolfgang , SCHIRMER, Ulrike , SALLETMAYER, Verena , NEZHYBA, Mario , SEIDEL, Stefan , OLEKSIEWICZ, Martin
发明人： VON GABAIN, Alexander , NAGY, Eszter , MEINKE, Andreas , SELAK, Sanja , HANNER, Markus , SMIDT, Margarita , FLOR, Julia , NOIGES, Birgit , SCHUELER, Wolfgang , SCHIRMER, Ulrike , SALLETMAYER, Verena , NEZHYBA, Mario , SEIDEL, Stefan , OLEKSIEWICZ, Martin
IPC分类号： A61K38/04
CPC分类号： C07K14/212 , A61K39/00
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a Moraxella catarrhalis (Meat) species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Moraxella catarrhalis species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell which expresses such antigen. More specifically, such antigens are produced by or associated with bacterial infections caused by Moraxella catarrhalis. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with Moraxella catarrhalis and methods for the treatment or prevention of an infection with Moraxella catarrhalis.
摘要翻译：本发明涉及编码来自卡他莫拉菌（肉）物种的抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。此外，本发明提供了卡他莫拉菌属物种的抗原，以及其片段和变体，产生这种抗原的方法，以及用于产生表达这种抗原的细胞的方法。更具体地说，这些抗原是由卡他莫拉菌引起的细菌感染产生或与之相关的。此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原，用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制此类抗原的相互作用活性的方法，用于诊断卡他莫拉菌的感染的方法和用于治疗或预防感染卡他莫拉菌。

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