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2. 发明申请

WO2011153308A2 IN VITRO METHOD AND APPARATUS FOR DETERMINING EFFICACY AND ACTION MECHANISMS OF A TOPICAL COMPOSITION ON VARIOUS SKIN COLOR TYPES 审中-公开
标题翻译：用于确定各种皮肤颜色类型的局部组合物的效力和作用机制的体外方法和装置
公开(公告)号：WO2011153308A2
公开(公告)日：2011-12-08
申请号：PCT/US2011038869
申请日：2011-06-02
申请人： INTEGRATED BOTAN TECHNOLOGIES LLC , DUEVA-KOGANOV OLGA V , KOGANOV MICHAEL , DUEV ARTYOM
发明人： DUEVA-KOGANOV OLGA V , KOGANOV MICHAEL , DUEV ARTYOM
IPC分类号： G01N33/15 , C40B30/06 , G09B23/28
CPC分类号： G01N33/4833 , G01N21/293 , G01N33/15 , G01N2201/061 , G01N2500/10 , G01N2500/20
摘要： The present invention relates to in vitro methods for determining efficacy of topical compositions on various skin color types. These methods involve providing an artificial skin apparatus configured to approximate the color and diffuse reflectance characteristics of a predetermined human skin color type. The artificial skin apparatus includes an artificial skin substrate combined with a color background, with the color background correlating to the human skin color type. A topical composition of interest is applied to the artificial skin substrate of the artificial skin apparatus and then pre-irradiated. The pre-irradiated topical composition is then analyzed using relevant experimental techniques or assays for at least one efficacy parameter, including, for example, anti-ageing, photoprotective, sun protective, UVA/UVB protective, UVAI protective, photostabilizing, and photosensitizing activities and action mechanisms of the topical composition on various skin color types. Also provided is an artificial skin apparatus and kit for use with the in vitro method.
摘要翻译：本发明涉及用于确定局部组合物对各种肤色类型的功效的体外方法。这些方法涉及提供一种人造皮肤装置，其被配置为近似预定人肤色类型的颜色和漫反射特性。人造皮肤装置包括与彩色背景组合的人造皮肤基底，其颜色背景与人类皮肤颜色类型相关。将感兴趣的局部组合物施用于人造皮肤装置的人造皮肤基质，然后进行预照射。然后使用相关实验技术或测定方法分析预先照射的局部组合物至少一种功效参数，包括例如抗衰老，光保护性，防晒性，UVA / UVB保护性，UVAI保护性，光稳定化和光敏化活性，以及局部组合物在各种皮肤颜色类型上的作用机制。还提供了用于体外方法的人造皮肤装置和试剂盒。

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