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1. 发明申请

WO2013024157A3 COMBINATIONS OF ANTI -HCV - ENTRY FACTOR ANTIBODIES, PROTEIN KINASE INHIBITORS OR ALISPORIVIR FOR THE TREATMENT AND THE PREVENTION OF HCV INFECTION 审中-公开
标题翻译：抗-HCV-入侵因子抗体，蛋白激酶抑制剂或ALISPORIVIR用于治疗和预防HCV感染的组合
公开(公告)号：WO2013024157A3
公开(公告)日：2013-04-11
申请号：PCT/EP2012066108
申请日：2012-08-17
申请人： INST NAT SANTE RECH MED , BAUMERT THOMAS , UNIVERSITAUEPSILON DE STRASBOURG
发明人： BAUMERT THOMAS
IPC分类号： A61K39/395 , A61P31/12 , C07K16/28
CPC分类号： A61K45/06 , A61K31/702 , A61K39/39533 , C07K16/28 , C07K16/2896 , A61K2300/00
摘要： The present invention provides combinations for use in the treatment or the prevention of HCV infection. In particular, combinations are provided that comprise two host-targeting agents, such as for example at least one anti-HCV-entryfactor antibody and at least one protein kinase inhibitor, or at least one anti-HCV-entry factor antibody and alisporivir, or at least one protein kinase inhibitor and alisporivir, wherein the two host-targeting agents act in a highly synergistic manner to inhibit HCV entry and infection in susceptible cells. Also provided are pharmaceutical compositions and kits comprising such combinations and methods of using these compositions and kits for treating or preventing HCV infection.
摘要翻译：本发明提供用于治疗或预防HCV感染的组合。特别地，提供了包含两种宿主靶向试剂（例如至少一种抗-HCV入门因子抗体和至少一种蛋白激酶抑制剂）或至少一种抗HCV进入因子抗体和阿利替霉素的组合，或至少一种蛋白激酶抑制剂和alisporivir，其中两种宿主 - 靶向剂以高度协同的方式起作用以抑制敏感细胞中的HCV进入和感染。还提供了药物组合物和试剂盒，其包含使用这些组合物和用于治疗或预防HCV感染的试剂盒的组合和方法。

2. 发明申请

WO2010034670A3 HOST CELL KINASES AS TARGETS FOR ANTIVIRAL THERAPIES AGAINST HCV INFECTION 审中-公开
标题翻译： HOST细胞作为抗HCV感染的抗病毒治疗目标
公开(公告)号：WO2010034670A3
公开(公告)日：2010-11-18
申请号：PCT/EP2009062095
申请日：2009-09-18
申请人： INST NAT SANTE RECH MED , BAUMERT THOMAS , LUPBERGER JOACHIM
发明人： BAUMERT THOMAS , LUPBERGER JOACHIM
IPC分类号： A61P31/14 , A61K31/00 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K39/395 , A61K48/00 , G01N33/50
CPC分类号： G01N33/5041 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/11 , C12N2760/20211 , C12N2770/24211 , C12Q1/485 , G01N2333/186
摘要： The present invention provides several networks of cellular protein kinases as potential targets for medical intervention against hepatitis C virus (HCV) infection and HCV-related diseases and disorders in mammals, including humans. The invention relates to therapeutic protocols and pharmaceutical compositions designed to inhibit the activity of one or more of these protein kinases for the prevention and/or treatment of infections and diseases caused by HCV. The invention also relates to methods for the identification of kinase inhibitors that may be used to treat and/or prevent HCV infections and HCV-related diseases.
摘要翻译：本发明提供了几种细胞蛋白激酶网络作为涉及丙型肝炎病毒（HCV）感染和哺乳动物包括人类中HCV相关疾病和疾病的医学干预的潜在靶标。本发明涉及旨在抑制一种或多种这些蛋白激酶用于预防和/或治疗HCV引起的感染和疾病的治疗方案和药物组合物。本发明还涉及用于鉴定可用于治疗和/或预防HCV感染和HCV相关疾病的激酶抑制剂的方法。

3. 发明申请

WO2013024156A3 COMBINATIONS OF ANTI-HCV-ENTRY FACTOR ANTIBODIES AND INTERFERONS FOR THE TREATMENT AND THE PREVENTION OF HCV INFECTION 审中-公开
标题翻译：用于治疗和预防HCV感染的抗HCV-入口因子抗体和干扰素的组合
公开(公告)号：WO2013024156A3
公开(公告)日：2013-04-11
申请号：PCT/EP2012066101
申请日：2012-08-17
申请人： INST NAT SANTE RECH MED , UNIV STRASBOURG , BAUMERT THOMAS
发明人： BAUMERT THOMAS
IPC分类号： A61K39/395 , A61P31/12 , C07K16/28
CPC分类号： A61K45/06 , A61K31/702 , A61K38/21 , A61K39/39541 , C07K16/28 , C07K16/2896 , A61K2300/00
摘要： The present invention provides combinations for use in the treatment or the prevention of HCV infection. In particular, combinations are provided that comprise at least one anti-HCV-entry factor antibody and at least one interferon, wherein the anti-HCV-entry factor antibody and interferon act in a highly synergistic manner to inhibit HCV infection of susceptible cells. Also provided are pharmaceutical compositions and kits comprising such combinations and methods of using these compositions and kits for treating or preventing HCV infection.
摘要翻译：本发明提供了用于治疗或预防HCV感染的组合。具体而言，提供了包含至少一种抗HCV侵入因子抗体和至少一种干扰素的组合，其中抗HCV侵入因子抗体和干扰素以高度协同的方式起作用以抑制易感细胞的HCV感染。还提供了包含这些组合的药物组合物和试剂盒以及使用这些组合物和试剂盒治疗或预防HCV感染的方法。

4. 发明申请

WO2004039530A3 ADAPTIVE, FEEDBACK-CONTROLLED MATERIAL PROCESSING USING ULTRA-SHORT LASER PULSES 审中-公开
标题翻译：超短激光脉冲自适应反馈控制的资料处理
公开(公告)号：WO2004039530A3
公开(公告)日：2004-11-18
申请号：PCT/DE0303530
申请日：2003-10-23
申请人： UNIV KASSEL , BAUMERT THOMAS , ASSION ANDREAS , WOLLENHAUPT MATTHIAS
发明人： BAUMERT THOMAS , ASSION ANDREAS , WOLLENHAUPT MATTHIAS
IPC分类号： B23K26/03 , B23K26/06 , B23K26/067 , B23K26/36
CPC分类号： B23K26/067 , B23K26/032 , B23K26/0604 , B23K26/0613 , B23K26/0624 , B23K26/361
摘要： The invention relates to material processing using laser pulses and to a method and device for the microstructured, ablative processing of material (22), said processing being achieved in one or more sequential process steps by individual laser pulses. (14). According to the invention, ultra-short laser pulses are shaped in a precise manner with the aid of a phase modulator (12), the material (22) is irradiated with said pulses and the quality of the working process that results from the irradiation is recorded and evaluated using computer technology (32). This can, for example, be carried out with the aid of a signal emitted by laser-induced breakdown spectroscopy (LIBS). Said evaluation signal is evaluated by an optimisation algorithm and the information thus obtained is used immediately to calculate additional, potentially more suitable laser pulse forms, which are in turn set by the computer-controlled (34, 36) phase modulator (12). The material (22) is irradiated again with said new laser pulses (14), in such a way that the same conditions prevail on the material (22) as during the preceding pulse. The iteration is continued until an optimum efficiency is reached for the processing of the material.
摘要翻译：本发明是在材料加工用激光脉冲的字段。它涉及一种用于材料（22）的微结构化烧蚀加工的方法和装置，其中，在由单独的激光脉冲（14）的一个或几个连续的工艺步骤在材料上的操作。根据与相位调制器（12）的帮助下，本发明的超短激光脉冲在被照射材料（22）与它的特定形状，并且检测的质量由照射工作过程的计算机技术（32）并评价进行。这可以通过从激光诱导击穿光谱（LIBS）的信号的方法进行，例如。根据本发明，通过从ptimierungsalgorithmus该评价信号进行评价，得到的信息被直接用于进一步的计算，即由计算机控制的（34，36）相位调制器（12）依次反复调整可能更合适的激光脉冲的形状。这些新的激光脉冲（14）再次照射到材料（22），以这样的方式在相同的条件为准的材料（22），如前面的脉冲（14）。迭代继续进行，直至一个最佳效率在材料的加工中。

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