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1. 发明申请

WO2022195000A1 BIOCATALYTICAL COMPOSITION AND USE FOR GENERATION OF IMMUNOLIGAND-PAYLOAD CONJUGATES 审中-公开
公开(公告)号：WO2022195000A1
公开(公告)日：2022-09-22
申请号：PCT/EP2022/056952
申请日：2022-03-17
申请人： INOFEA AG , NBE-THERAPEUTICS AG
发明人： SHAHGALDIAN, Patrick , BRIAND, Manon , CORVINI, Philippe F.-X. , CORRERO, Maria Rita , DUDAL, Yves , GRAWUNDER, Ulf , GEBLEUX, Rémy , BEERLI, Roger R.
IPC分类号： A61K38/43 , B82Y5/00 , C12N9/96 , C12N11/04 , C12N11/14 , G01N33/549 , G01N33/547 , C07K1/107 , B82Y15/00 , C12N9/64
摘要： The present invention relates to a composition comprising a solid carrier, a capture moiety, afunctional protein, a first linker connecting the capture moiety to the solid carrier, a second linker connecting the functional protein to the capture moiety, a first protective layer fully embedding the solid carrier, fully or partially embedding the first linker and not or partially embedding the capture moiety, a second protective layer fully or partially embedding the capture moiety, fully embedding the second linker and fully or partially embedding the functional protein.

2. 发明申请

WO2021224375A1 METHOD TO PRODUCE BIOCATALYTICAL COMPOSITIONS 审中-公开
公开(公告)号：WO2021224375A1
公开(公告)日：2021-11-11
申请号：PCT/EP2021/061960
申请日：2021-05-06
申请人： INOFEA AG
发明人： SHAHGALDIAN, Patrick , CORRERO, Maria, Rita , GROSSNIKLAUS, Lars , TIMM, Anna, Maria , DUDAL, Yves, Victor, René , CORVINI, Philippe F.-X
IPC分类号： C12N9/96 , C12N9/20 , C12N11/14 , C07K17/14
摘要： The present invention relates to a method of producing a composition, the composition comprising a solid carrier, a functional constituent and a protective layer to protect the functional constituent.

3. 发明申请

WO2016177688A1 METHOD OF REVERSIBLY FUNCTIONALIZING A SOLID SURFACE 审中-公开
标题翻译：可靠的功能化固体表面的方法
公开(公告)号：WO2016177688A1
公开(公告)日：2016-11-10
申请号：PCT/EP2016/059814
申请日：2016-05-03
申请人： INOFEA AG
发明人： SHAHGALDIAN, Patrick , CORVINI, Philippe , DUDAL, Yves , MORIDI, Negar
IPC分类号： G01N33/543 , G01N33/551
CPC分类号： G01N33/543 , G01N33/54353 , G01N33/551
摘要： A method of reversibly functionalizing a solid surface (1) comprises the steps of: (i) providing host molecules (2) to the solid surface (1), (ii) covalently immobilizing the host molecules (2) on the solid surface (1), (iii) adding a functional polymer (3) having multiple guest moieties (31) to the solid surface (1), (iv) at least some of the multiple guest moieties (31) of the functional polymer (3) forming supramolecular inclusion complexes with a plurality of the host molecules (2) immobilized on the solid surface (1) such that the functional polymer (3) is bound to the solid surface (1), (v) providing competitor molecules (2) to the functional polymer (3), (vi) the competitor molecules (2) forming supramolecular inclusion complexes with the at least some of the multiple guest moieties (31) of the functional polymer (3), (vii) releasing the functional polymer (3) from the solid surface (1), and (viii) removing the functional polymer (3). The method according to the invention allows for regenerating and changing functionalities of the surface particularly also in place. Thereby the method allows for an efficient reversible modification of more or less any type of surfaces which can be used in a large number of applications.
摘要翻译：将固体表面（1）可逆地官能化的方法包括以下步骤：（i）向固体表面（1）提供主体分子（2），（ii）将主体分子（2）共价固定在固体表面（1）上），（iii）将具有多个客体部分（31）的官能聚合物（3）加入到固体表面（1）中，（iv）官能聚合物（3）的多个客体部分（31）中的至少一些形成超分子与固定在固体表面（1）上的多个宿主分子（2）的包合配合物，使得官能聚合物（3）与固体表面（1）结合，（v）向功能性聚合物（2）提供竞争分子（2）聚合物（3），（vi）竞争剂分子（2）与官能聚合物（3）的多个客体部分（31）中的至少一些形成超分子包合物，（vii）将功能性聚合物（3）从固体表面（1）和（viii）去除官能聚合物（3）。根据本发明的方法允许再生和改变表面的功能，特别是就地。因此，该方法允许有效地可逆地修改可以在大量应用中使用的或多或少的任何类型的表面。

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