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1. 发明申请

WO2010089773A2 PROCESS FOR PREPARATION OF NITROPYRIDINE DERIVATIVES 审中-公开
标题翻译：制备硝基吡啶衍生物的方法
公开(公告)号：WO2010089773A2
公开(公告)日：2010-08-12
申请号：PCT/IN2010/000055
申请日：2010-02-02
申请人： INDOCO REMEDIES LIMITED , VYAS, Ketan Dhansukhlal , NAIR, Ranjeet , JADHAV, Vidyadhar Kashinath , BHATT, Nikunj , DESHMUKH, Sandip Kacharu , PANSARE, Prakash Popat , SINGH, Rajesh Kumar , PANANDIKAR, Aditi Milind
发明人： VYAS, Ketan Dhansukhlal , NAIR, Ranjeet , JADHAV, Vidyadhar Kashinath , BHATT, Nikunj , DESHMUKH, Sandip Kacharu , PANSARE, Prakash Popat , SINGH, Rajesh Kumar , PANANDIKAR, Aditi Milind
IPC分类号： C07D213/68
CPC分类号： C07D213/73 , C07D213/68 , C07D213/74
摘要： Disclosed here is a process for the preparation of nitropyridine derivatives of Formula (I) and its salt and precursors such as halogenated amino pyridines; Wherein; R 1 is selected from amino group, hydroxyl group, acyl group, alkyl amino group, halogen atom, -NH - C (O) - R 3 ; Where R 3 is branched or linear alkyl group having 1 - 6 carbon atoms, or cycloalkyl group having 3 - 6 carbon atoms; R 2 is selected from hydroxyl group, halogen atom, alkoxy group,
摘要翻译：这里公开了制备式（I）的硝基吡啶衍生物及其盐和前体如卤代氨基吡啶的方法; 其中： R1选自氨基，羟基，酰基，烷基氨基，卤素原子，-NH-C（O）-R3; 其中R3是具有1-6个碳原子的支链或直链烷基或具有3-6个碳原子的环烷基; R2选自羟基，卤素原子，烷氧基，

2. 发明申请

WO2019073481A1 PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE AND ITS INTERMEDIATES 审中-公开
公开(公告)号：WO2019073481A1
公开(公告)日：2019-04-18
申请号：PCT/IN2018/050643
申请日：2018-10-10
申请人： INDOCO REMEDIES LIMITED
发明人： KUDUVA, Srinivasan Subramanian , DESHMUKH, Sandip Kacharu , BODHKHE, Prashant Shahajirao , RAMESAN, Palangat Vayalileveetil , PANANDIKAR, Aditi Milind
IPC分类号： C07D409/12
CPC分类号： C07D409/12 , C07D215/20
摘要： The present invention discloses to a process for the preparation of brexpiprazole and its pharmaceutically acceptable salt. The present invention further discloses novel intermediates and process for the preparation of the novel intermediates of brexpiprazole. The invention also discloses a process for purification of brexpiprazole to reduce or eliminate impurities.

3. 发明申请

WO2009081417A2 PROCESS FOR PREPARATION OF OLOPAT ADINE HYDROCHLORIDE 审中-公开
标题翻译：制备奥曲汀盐酸氯化物的方法
公开(公告)号：WO2009081417A2
公开(公告)日：2009-07-02
申请号：PCT/IN2008/000780
申请日：2008-11-20
申请人： INDOCO REMEDIES LIMITED , VYAS Ketan Dhansukhlal , NAIR Ranjeet , CHAVAN Rajendra Vasantrao , SHELKE Yogesh Vishwas , PANANDIKAR, Aditi Milind
发明人： VYAS Ketan Dhansukhlal , NAIR Ranjeet , CHAVAN Rajendra Vasantrao , SHELKE Yogesh Vishwas , PANANDIKAR, Aditi Milind
IPC分类号： C07D313/12
CPC分类号： C07D313/12
摘要： Disclosed herein is a process for preparation of compound 11 - (Z) - [3 - (Dimethylamino) propylidene] - 6, 11 - dihydrodibenz [b, e] oxepin -2 - yl - acetic acid (Olopatadine) and its pharmaceutically acceptable salt; comprising reacting carboxylic acid protected 11 - oxo - 6, 11 - Dihydrodibenz [b, e] oxepin - 2 - acetic acid with 3 - dimethylaminopropyl triphenyl phosphonium halide in presence of a suitable base and an organic solvent.
摘要翻译：本文公开了制备化合物11 - （Z） - [3-（二甲基氨基）亚丙基] -6,11-二氢二苯并[b，e]氧杂七环素-2-基 - 乙酸（奥洛他定）及其药学上可接受的盐 ; 包括在合适的碱和有机溶剂的存在下，使羧酸保护的11-氧代-6,11-二氢二苯并[b，e]氧杂七环素-2-乙酸与3-二甲基氨基丙基三苯基鏻卤化物反应。

4. 发明申请

WO2018142422A1 PROCESS FOR THE PREPARATION OF DAPAGLIFLOZIN 审中-公开
公开(公告)号：WO2018142422A1
公开(公告)日：2018-08-09
申请号：PCT/IN2018/050048
申请日：2018-02-01
申请人： INDOCO REMEDIES LIMITED
发明人： KUDUVA, Srinivasan Subramanian , DESHMUKH, Sandip Kacharu , RAMESAN, Palangat Vayalileveetil , PANANDIKAR, Aditi Milind
IPC分类号： C07D309/10
CPC分类号： C07D309/10
摘要： The present invention discloses a novel process for the preparation of Dapagliflozin (S)-propylene glycol hydrate of Formula II. (Formula II)

5. 发明申请

WO2012032540A1 PROCESS FOR PREPARATION OF FLUORINATED TRIAZOLE COMPOUND 审中-公开
标题翻译：氟化三唑化合物的制备方法
公开(公告)号：WO2012032540A1
公开(公告)日：2012-03-15
申请号：PCT/IN2011/000607
申请日：2011-09-05
申请人： INDOCO REMEDIES LIMITED , RAJADHYAKSHA, Mangesh Narayan , NAIR, Ranjeet , P V Ramesan , K. Johnson , PANANDIKAR, Aditi Milind
发明人： RAJADHYAKSHA, Mangesh Narayan , NAIR, Ranjeet , P V Ramesan , K. Johnson , PANANDIKAR, Aditi Milind
IPC分类号： C07D249/04
CPC分类号： C07D249/04 , Y02P20/55
摘要： The present invention discloses a process for the preparation of 1-[(2,6-difluorophenyl)methyl]-1 H -1,2,3-triazole-4-carboxamide of Formula (I), comprising regioselective cycloaddition of 2,6-difluorobenzyl halide of Formula (II), wherein X is chloride, bromide or iodide; with a compound of Formula (IX); in which R is -COOR 1 , wherein R 1 is hydrogen, C 1 -C 4 linear or branched alkyl group, or-CN, or-CONH 2 or -CH 2 OR 2 j wherein R 2 is hydrogen or hydroxyl protecting group; in presence of an azide, Cu(I) species and a catalyst.
摘要翻译：本发明公开了制备式（I）的1 - [（2,6-二氟苯基）甲基] -1H-1,2,3-三唑-4-甲酰胺的方法，该方法包括：式（II）的二氟苄基卤化物，其中X是氯，溴或碘; 与式（IX）的化合物反应; 其中R是-COOR 1，其中R 1是氢，C 1 -C 4直链或支链烷基，或-CN或-CONH 2或-CH 2 OR 2，其中R 2是氢或羟基保护基; 在叠氮化物，Cu（I）物质和催化剂的存在下。

6. 发明申请

WO2016178246A1 PROCESS FOR THE PREPARATION OF ALOGLIPTIN 审中-公开
标题翻译：制备阿格列汀的方法
公开(公告)号：WO2016178246A1
公开(公告)日：2016-11-10
申请号：PCT/IN2016/050122
申请日：2016-05-03
申请人： INDOCO REMEDIES LIMITED
发明人： NAIR, Ranjeet , RAMESAN, Palangat Vayalileveetil , PANANDIKAR, Aditi Milind
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07C51/412 , C07C63/08
摘要： The invention concerns a process for the preparation of 2-[[6-[(3R) -3-amino-l-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-l(2H)- pyrimidinyl]methyl]benzonitrile commonly known as alogliptin and its pharmaceutically acceptable benzoate salt. Alogliptin is a dipeptidyl peptidase-4 inhibitor (DPP-4) that is designed to slow the inactivation of incretin hormones glucagon-like peptide-1 (GLP-1) and glucose- dependent insulinotropic peptide (GIP). It is used as antidiabetic drug. Formula (I)
摘要翻译：本发明涉及制备2 - [[6 - [（3R）-3-氨基-1-哌啶基] -3,4-二氢-3-甲基-2,4-二氧代-1（2H） - 嘧啶基]甲基]苄腈，通常称为奥曲肽及其药学上可接受的苯甲酸盐。阿格列汀是一种二肽基肽酶-4抑制剂（DPP-4），旨在减缓肠降血糖素激素类胰高血糖素样肽-1（GLP-1）和葡萄糖依赖性促胰岛素肽（GIP）的失活。用作抗糖尿病药。式（I）

7. 发明申请

WO2012023147A1 PROCESS FOR THE PREPARATION OF TAPENTADOL 审中-公开
标题翻译：制备TAPENTADOL的方法
公开(公告)号：WO2012023147A1
公开(公告)日：2012-02-23
申请号：PCT/IN2011/000546
申请日：2011-08-16
申请人： INDOCO REMEDIES LIMITED , RAJADHYAKSHA, Mangesh, Narayan , NAIR, Ranjeet , DESHMUKH, Sandip Kacharu , KHABALE, Somnath Ambadas , PANANDIKAR, Aditi Milind
发明人： RAJADHYAKSHA, Mangesh, Narayan , NAIR, Ranjeet , DESHMUKH, Sandip Kacharu , KHABALE, Somnath Ambadas , PANANDIKAR, Aditi Milind
IPC分类号： C07C213/00 , C07C215/54
CPC分类号： C07C213/00 , C07C309/66 , C07C309/73 , C07C215/54
摘要： Disclosed herein is an improved process for the preparation of 3-[(2R,3R)-1- (dimethylamino)-2-methylpentan-3-yl] phenol of Formula - I and its pharmaceutically acceptable salt which comprises the reaction of (S)-1-(dimethylamino)-2-methylpentan- 3-one of formula VIII with 3 - bromo anisole of formula II under Grignard conditions to get the compound (2S, 3R)-1- (dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3- ol of formula V followed by activation of the -OH group of the formula V to convert into sulfonate esters of formula IX, which are on reductive deoxygenation to yield (2R,3R)-3- (3-methoxyphenyl)-N,N,2-trimethylpentan-1 -amine of formula VII and demethylation of formula VII to obtain the compound 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3- yl]phenol of Formula - 1.
摘要翻译：本文公开了制备式I的3 - [（2R，3R）-1-（二甲基氨基）-2-甲基戊-3-基]苯酚及其药学上可接受的盐的改进方法，其包括（S ） - （二甲基氨基）-2-甲基戊-3-酮与式II的3-溴苯甲醚在格氏条件下反应，得到化合物（2S，3R）-1-（二甲基氨基）-3-（3- 甲氧基苯基）-2-甲基戊-3-醇，随后活化式V的-OH基团以转化为式IX的磺酸酯，其为还原性脱氧，得到（2R，3R）-3- （3-甲氧基苯基）-N，N，2-三甲基戊-1-胺和式VII的去甲基化，得到化合物3 - [（2R，3R）-1-（二甲基氨基）-2-甲基戊-3-基）苯基。

8. 发明申请

WO2018066004A1 PROCESS FOR THE PREPARATION OF DORAOLZMIDE HYDROCHLORIDE 审中-公开
标题翻译：制备多洛唑胺盐酸盐的方法
公开(公告)号：WO2018066004A1
公开(公告)日：2018-04-12
申请号：PCT/IN2017/050453
申请日：2017-10-06
申请人： INDOCO REMEDIES LIMITED
发明人： SHETH, Nilima , KUDUVA, Srinivasan Subramanian , RAMESAN, Palangat Vayalileveetil , PANANDIKAR, Aditi Milind
IPC分类号： C07D495/00
摘要： The present invention discloses an improved process for the preparation of dorzolamide hydrochloride the compound of Formula I.
摘要翻译：本发明公开了用于制备式I化合物的盐酸多佐胺的改进方法。

9. 发明申请

WO2016128995A1 PROCESS FOR THE PREPARATION OF SGLT INHIBITOR COMPOUNDS 审中-公开
标题翻译：制备SGLT抑制剂化合物的方法
公开(公告)号：WO2016128995A1
公开(公告)日：2016-08-18
申请号：PCT/IN2016/050048
申请日：2016-02-09
申请人： INDOCO REMEDIES LIMITED
发明人： NAIR, Ranjeet , RAMESAN, Palangat Vayalileveetil , DESHMUKH, Sandip Kacharu , PANANDIKAR, Aditi Milind
IPC分类号： C07H1/00 , C07D309/10
CPC分类号： C07H7/04 , C07H1/00
摘要： The present invention DISCLOSES a novel process for preparing sodium glucose transporters 2 (SGLT2) inhibitor compounds of Formula IX. Wherein, R is halogen, alkyl or alkoxy group; and Ar is aryl group, substituted or unsustituted monocyclic polycyclic or heterocyclic ring selected from the residues A, B, C or D as given below.
摘要翻译：本发明公开了制备式IX的葡萄糖转运蛋白2（SGLT2）抑制剂化合物的新方法。其中R为卤素，烷基或烷氧基; 并且Ar是选自下面给出的残基A，B，C或D的芳基，取代或未取代的单环多环或杂环。

10. 发明申请

WO2013105109A1 PROCESS FOR THE PREPARATION OF TAPENTADOL 审中-公开
标题翻译：制备TAPENTADOL的方法
公开(公告)号：WO2013105109A1
公开(公告)日：2013-07-18
申请号：PCT/IN2012/000735
申请日：2012-11-08
申请人： INDOCO REMEDIES LIMITED
发明人： RAJADHYAKSHA, Mangesh Narayan , NAIR, Ranjeet , PANANDIKAR, Aditi Milind
IPC分类号： C07C213/08 , C07C215/54 , C07C213/10
CPC分类号： B23C5/2472 , C07B2200/07 , C07C213/08 , C07C213/10 , Y10T407/2222 , C07C215/54
摘要： Disclosed herein is a process for the preparation of the compound 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol comprising a) reacting compound (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-ol with a mixture of methanesulfonic acid and dimethyl sulfide to get the compound (2R)-3-(3-hydroxyphenyl)-N,N,2-trimethyl-3-pentene-1-amine (VIII); b) catalytic hydrogenation of the compound of Formula VIII or its acid addition salt yields mixture of diastereomeric compounds 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol and 3-[(2R,3S)-1-(dimethylamino)-2-methylpentan-3-yl]phenol; c) converting the above diastereomeric mixture into acid addition salt followed by precipitating the 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol in an alcohol using anti-solvent.
摘要翻译：本文公开了一种制备化合物3 - [（2R，3R）-1-（二甲基氨基）-2-甲基戊-3-基]苯酚的方法，包括：a）使化合物（2S，3R）-1-（二甲基氨基）-3-（3-甲氧基苯基）-2-甲基戊-3-醇与甲磺酸和二甲基硫醚的混合物，得到化合物（2R）-3-（3-羟基苯基）-N，N，2-三甲基 - 3-戊烯-1-胺（VIII）; b）式VIII或其酸加成盐的化合物的催化氢化产生非对映体化合物3 - [（2R，3R）-1-（二甲基氨基）-2-甲基戊-3-基]苯酚和3 - [（2R ，3S）-1-（二甲基氨基）-2-甲基戊-3-基]苯酚; c）将上述非对映异构体混合物转化成酸加成盐，然后使用反溶剂在醇中沉淀3 - [（2R，3R）-1-（二甲基氨基）-2-甲基戊-3-基]苯酚。

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