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1. 发明申请

WO9850546A3 B CELL RECEPTOR ASSOCIATED PROTEINS 审中-公开
标题翻译： B细胞受体相关蛋白
公开(公告)号：WO9850546A3
公开(公告)日：1999-02-04
申请号：PCT/US9808424
申请日：1998-05-06
申请人： INCYTE PHARMA INC , BANDMAN OLGA , HILLMAN JENNIFER L , GOLI SURYA K , CAPITANT SHERRY A
发明人： BANDMAN OLGA , HILLMAN JENNIFER L , GOLI SURYA K , CAPITANT SHERRY A
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12 , A61K35/00 , A61K38/17 , C07K16/18 , C12Q1/68 , G01N33/50 , G01N33/60 , G01N33/68
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides B cell receptor associated proteins (BCRP) and polynucleotides which identify and encode BCRP. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of BCRP.

2. 发明申请

WO9858052A3 DISEASE ASSOCIATED PROTEIN KINASES 审中-公开
标题翻译：疾病相关蛋白激酶
公开(公告)号：WO9858052A3
公开(公告)日：1999-06-10
申请号：PCT/US9812813
申请日：1998-06-19
申请人： INCYTE PHARMA INC , BANDMAN OLGA , HILLMAN JENNIFER L , CORLEY NEIL C , GUEGLER KARL J , LAL PREETI , GOLI SURYA K , SHAH PURVI
发明人： BANDMAN OLGA , HILLMAN JENNIFER L , CORLEY NEIL C , GUEGLER KARL J , LAL PREETI , GOLI SURYA K , SHAH PURVI
IPC分类号： A61K38/00 , C12N9/12 , C12N15/54 , A61K48/00 , C12Q1/68
CPC分类号： C12N9/1205 , A61K38/00
摘要： The invention provides human disease associated protein kinases and polynucleotides (collectively designated DAPK) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing and treating disorders associated with expression of human disease associated protein kinases.
摘要翻译：本发明提供了识别和编码它们的人类疾病相关蛋白激酶和多核苷酸（统称为DAPK）。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供用于诊断和治疗与人类疾病相关蛋白激酶的表达相关的疾病的方法。

3. 发明申请

WO0015770A3 HUMAN SERINE/THREONINE PROTEIN KINASES 审中-公开
标题翻译：人类丝氨酸/丝氨酸蛋白激酶
公开(公告)号：WO0015770A3
公开(公告)日：2000-07-06
申请号：PCT/US9921595
申请日：1999-09-16
申请人： INCYTE PHARMA INC , BANDMAN OLGA , TANG Y TOM , GOLI SURYA K , CORLEY NEIL C , GUEGLER KARL J , GORGONE GINA A , HILLMAN JENNIFER L
发明人： BANDMAN OLGA , TANG Y TOM , GOLI SURYA K , CORLEY NEIL C , GUEGLER KARL J , GORGONE GINA A , HILLMAN JENNIFER L
IPC分类号： C12N15/09 , A61K38/00 , A61K38/45 , A61K45/00 , A61P1/00 , A61P1/18 , A61P3/00 , A61P3/10 , A61P5/14 , A61P5/38 , A61P7/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/08 , A61P27/02 , A61P27/06 , A61P27/12 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/08 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12Q1/68 , C12N9/00
CPC分类号： C12N9/1205 , A61K38/00 , C12Y207/01037
摘要： The invention provides human serine/threonine protein kinases (HSTK) and polynucleotides which identify and encode HSTK. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HSTK.
摘要翻译：本发明提供人丝氨酸/苏氨酸蛋白激酶（HSTK）和识别和编码HSTK的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HSTK表达相关的病症的方法。

4. 发明申请

WO9831815A3 SUBUNITS OF NADH DEHYDROGENASE 审中-公开
标题翻译： NADH脱氢酶的亚基
公开(公告)号：WO9831815A3
公开(公告)日：1998-10-22
申请号：PCT/US9723970
申请日：1997-12-17
申请人： INCYTE PHARMA INC , BANDMAN OLGA , GOLI SURYA K , HILLMAN JENNIFER L
发明人： BANDMAN OLGA , GOLI SURYA K , HILLMAN JENNIFER L
IPC分类号： A61K38/00 , C12N9/02 , C12N15/53 , C12P21/08 , A61K38/44 , C07K16/40 , C12N15/11 , C12Q1/68 , G01N33/50
CPC分类号： C12N9/0036 , A61K38/00
摘要： The present invention provides four NADH dehydrogenase subunits (designated individually as NDS-1, NDS-2, NDS-3, and NDS-4 and collectively as NDS) and polynucleotides which identify and encode NDS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NDS and a method for producing NDS. The invention also provides for use of NDS and agonists, antibodies, or antagonists specifically binding NDS, in the prevention and treatment of diseases associated with expression of NDS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NDS for the treatment of diseases associated with the expression of NDS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NDS.

5. 发明申请

WO9825956A3 Human GTP-binding proteins 审中-公开
标题翻译：人类GTP结合蛋白
公开(公告)号：WO9825956A3
公开(公告)日：1998-09-11
申请号：PCT/US9722317
申请日：1997-12-08
申请人： INCYTE PHARMA INC , HILLMAN JENNIFER L , BANDMAN OLGA , HAWKINS PHILIP R , GOLI SURYA K
发明人： HILLMAN JENNIFER L , BANDMAN OLGA , HAWKINS PHILIP R , GOLI SURYA K
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , C12N15/12 , A61K38/46
CPC分类号： C07K14/4722 , A61K38/00
摘要： The present invention provides three novel GTP-binding proteins (designated individually as BND-1, BND-2, and BND-3, and collectively as BND) and polynucleotides which identify and encode BND. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding BND and a method for producing BND. The invention also provides for use of BND and agonists, antibodies, or antagonists specifically binding BND, in the prevention and treatment of diseases associated with expression of BND. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding BND for the treatment of diseases associated with the expression of BND. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding BND.
摘要翻译：本发明提供七种人类Ras蛋白（RASP）和识别和编码RASP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与RASP表达相关的疾病的方法。

6. 发明申请

WO9818822A2 NOVEL HUMAN LIM PROTEINS 审中-公开
标题翻译：新人LIM蛋白质
公开(公告)号：WO9818822A2
公开(公告)日：1998-05-07
申请号：PCT/US9718717
申请日：1997-10-10
申请人： INCYTE PHARMA INC , GOLI SURYA K , HILLMAN JENNIFER L , BANDMAN OLGA
发明人： GOLI SURYA K , HILLMAN JENNIFER L , BANDMAN OLGA
IPC分类号： A61K38/00 , C07K14/47 , A61K38/17 , C07K16/18 , C12N15/12
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides three human LIM proteins (designated individually as HLIM-1, HLIM-2, and HLIM-3, and collectively as HLIM) and polynucleotides which identify and encode HLIM. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HLIM and a method for producing HLIM. The invention also provides for use of HLIM and agonists, antibodies, or antagonists specifically binding HLIM, in the prevention and treatment of diseases associated with expression of HLIM. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HLIM for the treatment of diseases associated with the expression of HLIM. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HLIM.
摘要翻译：本发明提供了三种人LIM蛋白（分别命名为HLIM-1，HLIM-2和HLIM-3，并且共同称为HLIM）和鉴定和编码HLIM的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码HLIM的核酸序列的宿主细胞和生产HLIM的方法。本发明还提供了用于预防和治疗与HLIM表达相关的疾病的HLIM和特异性结合HLIM的激动剂，抗体或拮抗剂。另外，本发明提供反义分子用于编码HLIM的多核苷酸用于治疗与HLIM表达相关的疾病。本发明还提供了利用多核苷酸或其片段或其补体以及特异性结合HLIM的抗体的诊断测定法。

7. 发明申请

WO9806841A3 TWO HUMAN NSP-LIKE PROTEINS 审中-公开
标题翻译：两种人类NSP样蛋白
公开(公告)号：WO9806841A3
公开(公告)日：1998-05-07
申请号：PCT/US9713469
申请日：1997-07-24
申请人： INCYTE PHARMA INC , BANDMAN OLGA , AU YOUNG JANICE , GOLI SURYA K , HILLMAN JENNIFER
发明人： BANDMAN OLGA , AU-YOUNG JANICE , GOLI SURYA K , HILLMAN JENNIFER
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/28 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/28 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/08 , A61K31/70 , A61K38/17 , C12Q1/68
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K2319/00
摘要： The present invention provides polynucleotides which identify and encode two human NSP-like proteins (NSPLP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NSPLP. The invention also provides for the use of substantially purified NSPLP, antagonists, and in pharmaceutical compositions for the treatment of diseases associated with the expression of NSPLP. Additionally, the invention provides for the use of antisense molecules to NSPLP in pharmaceutical compositions for treatment of diseases associated with the expression of NSPLP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding NSPLP or anti-NSPLP antibodies which specifically bind to NSPLP.

8. 发明申请

WO9836068A3 HUMAN P24 VESICLE PROTEINS 审中-公开
标题翻译：人类P24 VESICLE蛋白质
公开(公告)号：WO9836068A3
公开(公告)日：1998-10-22
申请号：PCT/US9802813
申请日：1998-02-12
申请人： INCYTE PHARMA INC , GOLI SURYA K , BANDMAN OLGA
发明人： GOLI SURYA K , BANDMAN OLGA
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/68 , A61K38/17 , C12N15/11 , G01N33/50
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides two human p24 vesicle trafficking proteins (designated individually as Hp24-1 and Hp24-2 and collectively as Hp24) and polynucleotides which identify and encode Hp24. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Hp24 and a method for producing Hp24. The invention also provides for agonists, antibodies, or antagonists specifically binding Hp24, and their use, in the prevention and treatment of diseases associated with expression of Hp24. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Hp24 for the treatment of diseases associated with the expression of Hp24. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Hp24.

9. 发明申请

WO0006728A8 PHOSPHORYLATION EFFECTORS 审中-公开
标题翻译：磷化效应
公开(公告)号：WO0006728A8
公开(公告)日：2001-07-05
申请号：PCT/US9917132
申请日：1999-07-28
申请人： INCYTE PHARMA INC , HILLMAN JENNIFER L , LAL PREETI , TANG Y TOM , CORLEY NEIL C , GUEGLER KARL J , BAUGHN MARIAH R , PATTERSON CHANDRA , BANDMAN OLGA , AU YOUNG JANICE , GORGONE GINA A , YUE HENRY , AZIMZAI YALDA , REDDY ROOPA , LU DYUNG AINA M , SHIH LEO L
发明人： HILLMAN JENNIFER L , LAL PREETI , TANG Y TOM , CORLEY NEIL C , GUEGLER KARL J , BAUGHN MARIAH R , PATTERSON CHANDRA , BANDMAN OLGA , AU-YOUNG JANICE , GORGONE GINA A , YUE HENRY , AZIMZAI YALDA , REDDY ROOPA , LU DYUNG AINA M , SHIH LEO L
IPC分类号： A61K38/00 , C07K14/47 , C12N9/12 , C12N15/12 , A61K38/17 , C07K16/18 , C12N5/10
CPC分类号： C12N9/12 , A61K38/00 , C07K14/4702
摘要： The invention provides human phosphorylation effectors (PHSP) and polynucleotides which identify and encode PHSP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of PHSP.
摘要翻译：本发明提供鉴定和编码PHSP的人磷酸化作用子（PHSP）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与PHSP表达相关的障碍的方法。

10. 发明申请

WO0012711A8 HUMAN MEMBRANE CHANNEL PROTEINS 审中-公开
标题翻译：人膜通道蛋白
公开(公告)号：WO0012711A8
公开(公告)日：2001-05-10
申请号：PCT/US9920468
申请日：1999-09-02
申请人： INCYTE PHARMA INC , AU YOUNG JANICE , BANDMAN OLGA , TANG Y TOM , REDDY ROOPA , HILLMAN JENNIFER L , YUE HENRY , LAL PREETI , CORLEY NEIL C , GUEGLER KARL J , GORGONE GINA , BAUGHN MARIAH R , AZIMZAI YALDA
发明人： AU-YOUNG JANICE , BANDMAN OLGA , TANG Y TOM , REDDY ROOPA , HILLMAN JENNIFER L , YUE HENRY , LAL PREETI , CORLEY NEIL C , GUEGLER KARL J , GORGONE GINA , BAUGHN MARIAH R , AZIMZAI YALDA
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C12N15/12 , A61K38/17 , C07K16/18 , C07K16/28 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705
摘要： The invention provides new human membrane channel proteins (MECHP) and polynucleotides which identify and encode MECHP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of MECHP.
摘要翻译：本发明提供新的人膜通道蛋白（MECHP）和识别和编码MECHP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与MECHP表达相关的紊乱的方法。

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