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1. 发明申请

WO2012138537A1 COMPOSITIONS AND METHODS FOR TREATMENT OF OVARIAN, PERITONEAL, AND FALLOPIAN TUBE CANCER 审中-公开
标题翻译： OVARIAN，PERITONEAL和FALLOPIAN TUBE CANCER的组合物和方法
公开(公告)号：WO2012138537A1
公开(公告)日：2012-10-11
申请号：PCT/US2012/031181
申请日：2012-03-29
申请人： IMMUNOGEN, INC. , WHITEMAN, Kathleen R. , O'LEARY, James J. , LUTZ, Robert John
发明人： WHITEMAN, Kathleen R. , O'LEARY, James J. , LUTZ, Robert John
IPC分类号： A61K39/00 , C12P21/08
CPC分类号： C07K16/2803 , A61K39/39558 , C07K2317/24 , A61K2300/00
摘要： The disclosure relates to anti-cancer drug combinations, pharmaceutical compositions for treating ovarian, peritoneal, or fallopian tube cancer. Specifically, the disclosure is based on the discovery that the administration of a CD56 antibody linked to a cytotoxic compound (e.g." an immunoconjugate) in combination with a chemotherapeutic agent (in particular a gemcitabine compound, a topotecan compound, and a doxorubicin compound), improves the therapeutic index in the treatment of ovarian, peritoneal, or fallopian tube cancer over and above the additive effects of the anticancer agents used alone. Combinations of the CD56 antibody, or fragment thereof, linked to a cytotoxic compound plus an additional chemotherapeutic agent have a synergistic effect in the ovarian cancer therapeutic index. Further disclosed are methods of modulating the growth of selected cell populations, such as ovarian, peritoneal, or fallopian tube cancer cells, by administering a therapeutically effective amount of such combinations.
摘要翻译：本公开涉及抗癌药物组合，用于治疗卵巢，腹膜或输卵管癌的药物组合物。具体地，本公开是基于以下发现：与化学治疗剂（特别是吉西他滨化合物，拓扑替康化合物和多柔比星化合物）联合的细胞毒性化合物（例如“免疫偶联物”）的CD56抗体的施用，改善治疗卵巢，腹膜或输卵管癌的治疗指标，超过单独使用的抗癌剂的加和效应。与细胞毒性化合物加上另外的化学治疗剂连接的CD56抗体或其片段的组合具有进一步公开了通过施用治疗有效量的这种组合来调节所选细胞群体如卵巢，腹膜或输卵管癌细胞的生长的方法。

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