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1. 发明申请

WO2015150360A1 BIOMARKERS FOR ASSESSING HIV 审中-公开
标题翻译：用于评估艾滋病毒的生物标志物
公开(公告)号：WO2015150360A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/056977
申请日：2015-03-31
申请人： IDCGS CLINICA DE DIAGNOSTICOS MEDICOS , CENTRO DE GENOMAS , BIOCRATES LIFE SCIENCES AG
发明人： DA SILVA, Ismael Dale Cotrim Guerreiro , LOTURCO, Edson Guimaraes , DIAZ, Ricoardo Soubie , KOAL, Therese
IPC分类号： G01N33/569 , G01N33/92 , G01N33/68
CPC分类号： G01N33/92 , C12Q1/70 , G01N33/56988 , G01N33/6812 , G01N33/6893 , G01N2333/47 , G01N2405/04 , G01N2405/08 , G01N2560/00 , G01N2800/52
摘要： The present invention relates to metabolic biomarker sets for assessing HIV. In preferred embodiments, the present invention relates to the use of biomarker sets for screening and/or diagnosing HIV infection, for prediction of immunologic response of a mammalian subject to antiretroviral therapy and/or prognosis of HIV disease progression, and for monitoring of HIV disease activity in a mammalian subject.In other embodiments, the invention relates to methods for screening and/or diagnosing HIV infection, for prediction of immunologic response of a mammalian subject to antiretroviral therapy and/or prognosis of HIV disease progression, and for monitoring of HIV disease activity in a mammalian subject, as well as to a kit adapted to carry out the methods. By employing the specific biomarkers and the method according to the present invention it becomes possible to more properly and reliably assess HIV. In particular, it becomes possible to screen for and diagnose HIV in a patient with high accuracy and predict early in advance the patient's therapeutic response to antiretroviral therapy.
摘要翻译：本发明涉及用于评估HIV的代谢生物标志物组。在优选的实施方案中，本发明涉及用于筛选和/或诊断HIV感染的生物标志物组的用途，用于预测哺乳动物受试者的抗逆转录病毒治疗和/或预防HIV疾病进展的免疫应答以及用于监测HIV疾病在其他实施方案中，本发明涉及用于筛选和/或诊断HIV感染的方法，用于预测哺乳动物受试者的抗逆转录病毒治疗和/或预防HIV疾病进展的免疫应答以及HIV的监测哺乳动物受试者的疾病活动，以及适于实施该方法的试剂盒。通过使用特定的生物标志物和根据本发明的方法，可以更正确和可靠地评价HIV。特别地，可以高精度地筛选和诊断患者中的HIV并预先提前预测患者对抗逆转录病毒疗法的治疗反应。

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