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1. 发明申请

WO2017158238A1 A COATING FOR IMPROVED TISSUE ADHESION 审中-公开
标题翻译：改善组织粘合性的涂层
公开(公告)号：WO2017158238A1
公开(公告)日：2017-09-21
申请号：PCT/FI2017/050170
申请日：2017-03-15
申请人： ID CREATIONS OY
发明人： KANGASNIEMI, Ilkka , PEREZ, J. Pablo , DRNOVŠEK, Nataša , LORENZETTI, Martina
IPC分类号： A61L27/30 , A61L27/36
CPC分类号： A61L27/306 , A61L27/06 , A61L27/3691 , A61L27/54
摘要： The invention relates to a coating consisting essentially of titanium dioxide wherein at least 20 % of the titanium dioxide has a crystalline structure of anatase and/or rutile; the coating has a roughness comprising indentations, wherein at least 50 % of the indentations have a maximum depth of 1-50 nm and a maximum width of 1-50 nm; the coating is treatable to achieve a water contact angle of 0-20°; the coating is treatable to be negatively charged or positively charged; and the coating exhibits an improved attachment of mammalian tissue cells, which improved attachment is such that when a substrate coated with the above coating is compared to the same uncoated substrate, at least 100 % more cells remain attached on the coated substrate than on the uncoated substrate.
摘要翻译：本发明涉及基本上由二氧化钛组成的涂层，其中至少20％的二氧化钛具有锐钛矿和/或金红石的晶体结构; 该涂层具有包括压痕的粗糙度，其中至少50％的压痕具有1-50nm的最大深度和1-50nm的最大宽度; 涂层是可处理的以实现0-20°的水接触角。该涂层可处理为带负电或带正电; 并且涂层表现出改善的哺乳动物组织细胞的附着，这种改进的附着使得当用上述涂层涂覆的基材与相同的未涂覆基材相比时，涂覆的基材上保留附着至少100％的细胞比未涂覆的基材上附着的细胞多至少100％基板

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