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1. 发明申请

WO2008115871A1 BIOSENSOR CARTRIDGE AND BIOSENSOR MOUNTING SYSTEM WITH INTEGRAL FLUID STORAGE AND FLUID SELECTION MECHANISMS 审中-公开
标题翻译：具有整体流体储存和流体选择机制的生物传感器盒和生物传感器安装系统
公开(公告)号：WO2008115871A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/057233
申请日：2008-03-17
申请人： IA, INC. , DOWNWARD, James, G. , ERB, Judith , SCHMIDT, Daniel, P.
发明人： DOWNWARD, James, G. , ERB, Judith , SCHMIDT, Daniel, P.
IPC分类号： G01N21/00
CPC分类号： G01N21/05 , G01N21/648 , G01N21/7703 , G01N2021/0346 , G01N2021/7709 , G01N2021/7736
摘要： Some embodiments of the invention comprise a biosensor cartridge which optically, fluidically, and/or mechanically couples to an evanescent sensing measurement apparatus having annularizing illumination elements, said biosensor cartridge and measurement apparatus being used for detecting the presence of chemically or biologically active substances binding to said biosensor present within an aqueous media, such as and without limitation, the presence of specific proteins in blood or urine. Some embodiments comprise an integrated biosensor cartridge having a flow channel and a plurality of storage cavities, fluid flow in the cartridge controlled by valving mechanisms for directing a plurality of fluids through the cartridge, the order and amounts of such fluids passing through the cartridge being externally controlled and required for the detection and measurement of specific chemically or biologically active substances.
摘要翻译：本发明的一些实施例包括一种生物传感器盒，其在光学上，流体上和/或机械上耦合到具有环形照明元件的ev逝感测测量装置，所述生物传感器盒和测量装置用于检测结合到...的化学或生物活性物质的存在所述生物传感器存在于水性介质中，例如但不限于血液或尿液中特定蛋白质的存在。一些实施例包括具有流动通道和多个存储空腔的集成生物传感器盒，所述盒中的流体流由用于引导多个流体通过盒的阀机构控制，通过盒的这种流体的顺序和数量在外部对特定的化学或生物活性物质进行检测和测量所需的控制和要求。

2. 发明申请

WO2003003063A2 FIBER-OPTIC SENSOR ARRAY 审中-公开
标题翻译：光纤传感器阵列
公开(公告)号：WO2003003063A2
公开(公告)日：2003-01-09
申请号：PCT/US2002/020596
申请日：2002-06-27
申请人： IA, INC. , PRIUSKA, Eric, M. , SMITH, Richard, H. , ERB, Judith, L. , DOWNWARD, James, G. , ULRICH, Otho, E.
发明人： PRIUSKA, Eric, M. , SMITH, Richard, H. , ERB, Judith, L. , DOWNWARD, James, G. , ULRICH, Otho, E.
IPC分类号： G02B
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N33/533 , G01N33/54306 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482
摘要： A method for performing a rapid, homogenous assays for monitoring the reactions of a binding target, by immobilizing a fluorescent-capable chelate complex that is derivatized so as to posses recognition binding ligands, labeling the complex with a labeled second chelator that is added to the assay thereby forming a fluorescent mixed chelate, and measuring the fluorescent mixed chelate, whereby the measurement of the label enable monitoring of the reaction of the binding target. A rapid assay for performing the above method including a first chelating molecule, a fluorescent-capable ion complexed with the first chelating molecule, a second chelating molecule for reacting with the fluorescent-capable ion complexed with the first chelating molecule, and a measuring device for measuring fluorescent resulting from the second chelating molecule reacting with the fluorescent-capable ion complexed with the first chelating molecule. A biosensor for monitoring molecular interactions between receptors, including a biosensor having attached thereto a fluorescent-capable ion complexed with a first chelating molecule, whereby upon exposure to a second chelating molecule said complex becomes fluorescent is also provided.
摘要翻译：通过固定衍生化的具有荧光能力的螯合复合物以便具有识别结合配体，进行用于监测结合靶标的反应的快速，均质测定的方法，用标记的第二螯合剂添加到测定中，由此形成荧光混合螯合物，并测量荧光混合螯合物，由此标记的测量能够监测结合目标的反应。用于进行上述方法的快速测定法包括第一螯合分子，与第一螯合分子复合的能够发荧光的离子，与能够与第一螯合分子复合的能够发荧光的离子反应的第二螯合分子，以及测量装置测量由第二螯合分子与与第一螯合分子络合的可荧光离子反应产生的荧光。一种用于监测受体之间的分子相互作用的生物传感器，包括生物传感器，其上附着有与第一螯合分子复合的可荧光离子，由此当暴露于第二螯合分子时，所述复合物变成荧光的也被提供。

3. 发明申请

WO2014036531A1 HEMOSTASIS SENSOR AND METHOD THEREOF 审中-公开
标题翻译： HEMOSTASIS传感器及其方法
公开(公告)号：WO2014036531A1
公开(公告)日：2014-03-06
申请号：PCT/US2013/057734
申请日：2013-08-30
申请人： ACCUMED RADIAL SYSTEMS, LLC. , COHEN, Mauricio, Gabriel , RYAN, James, Patrick , DOWNWARD, James, G. , KOROTKO, Joseph, R.
发明人： COHEN, Mauricio, Gabriel , RYAN, James, Patrick , DOWNWARD, James, G. , KOROTKO, Joseph, R.
IPC分类号： A61B5/00
CPC分类号： A61B17/1325 , A61B5/026 , A61B5/0261 , A61B5/4836 , A61B8/06 , A61B17/135 , A61B17/1355
摘要： An apparatus (100) and method for capturing sensor readings (88) relating to one or more blood flow attributes (87) of a patient (90) at or around a puncture site (89) when the patient (90) is being subjected to hemostasis process by a health care provider (92). A wide range of different sensor technologies and component configurations can be utilized. The apparatus (100) can operate as a fully stand-alone device, a fully integrated component of a hemostasis treatment tool, or any configuration between the two polar extremes of integration/stand-alone.
摘要翻译：一种装置（100）和方法，用于当患者（90）正在经历时，捕获与穿刺部位（89）处或周围相关的患者（90）的一个或多个血流属性（87）的传感器读数（88）卫生保健提供者的止血过程（92）。可以使用各种不同的传感器技术和部件配置。装置（100）可以作为完全独立的装置，止血治疗工具的完全集成的部件，或两个极化的极化极限/独立之间的任何构型来运行。

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