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1. 发明申请

WO2003000891A2 MORE PROTEIN-PROTEIN INTERACTIONS IN THE INNER EAR 审中-公开
标题翻译：更多蛋白质 - 蛋白质相互作用在内部
公开(公告)号：WO2003000891A2
公开(公告)日：2003-01-03
申请号：PCT/EP2002/008065
申请日：2002-06-21
申请人： HYBRIGENICS , INSTITUT PASTEUR , DAVIET, Laurent , LEGRAIN, Pierre , PETIT, Christine , BOËDA, Batiste , EL-AMRAOUI, Aziz
发明人： DAVIET, Laurent , LEGRAIN, Pierre , PETIT, Christine , BOËDA, Batiste , EL-AMRAOUI, Aziz
IPC分类号： C12N15/12
CPC分类号： G01N33/5014 , A61K38/00 , C07K14/47 , C07K16/18 , C07K16/28 , C07K2317/32 , C07K2317/34 , G01N33/5008 , G01N33/5091 , G01N33/68 , G01N33/6887 , G01N33/6893 , G01N2500/00
摘要： The present invention relates to protein-protein interactions involved in deafness or in hearing disorders and/or diseases. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.
摘要翻译：本发明涉及涉及耳聋或听力紊乱和/或疾病的蛋白质 - 蛋白质相互作用。更具体地，本发明涉及编码多肽的多肽或多核苷酸的复合物，多肽的片段，复合物的抗体，由于蛋白质 - 蛋白质相互作用而鉴定的选择性相互作用域（SID3），用于筛选药剂的方法其调节能够调节蛋白质 - 蛋白质相互作用的蛋白质和药物组合物的相互作用。

2. 发明申请

WO2002086122A3 PROTEIN-PROTEIN INTERACTIONS IN ADIPOCYTES 审中-公开
公开(公告)号：WO2002086122A3
公开(公告)日：2002-10-31
申请号：PCT/EP2002/003768
申请日：2002-03-14
申请人： HYBRIGENICS , LEGRAIN, Pierre , DAVIET, Laurent
发明人： LEGRAIN, Pierre , DAVIET, Laurent
IPC分类号： C12N15/12
摘要： The present invention relates to protein-protein interactions in adipocytes. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antiodies to the complexes. Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.

3. 发明申请

WO2003000891A3 PROTEIN-PROTEIN INTERACTIONS IN THE INNER EAR 审中-公开
公开(公告)号：WO2003000891A3
公开(公告)日：2003-01-03
申请号：PCT/EP2002/008065
申请日：2002-06-21
申请人： HYBRIGENICS , INSTITUT PASTEUR , DAVIET, Laurent , LEGRAIN, Pierre , PETIT, Christine , BOËDA, Batiste , EL-AMRAOUI, Aziz
发明人： DAVIET, Laurent , LEGRAIN, Pierre , PETIT, Christine , BOËDA, Batiste , EL-AMRAOUI, Aziz
IPC分类号： C12N15/12
摘要： The present invention relates to protein-protein interactions involved in deafness or in hearing disorders and/or diseases. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.

4. 发明申请

WO2003075014A3 PROTEIN-PROTEIN INTERACTIONS IN HUMAN TUMOURS INVOLVING BCMP-7 AND BCMP-11 审中-公开
公开(公告)号：WO2003075014A3
公开(公告)日：2003-09-12
申请号：PCT/GB2003/000931
申请日：2003-03-06
申请人： OXFORD GLYCOSCIENCES (UK) LTD , HYBRIGÉNICS , DAVIET, Laurent , LEGRAIN, Pierre , TERRETT, Jonathan, Alexander
发明人： DAVIET, Laurent , LEGRAIN, Pierre , TERRETT, Jonathan, Alexander
IPC分类号： C12N15/12
摘要： The present invention relates to protein-protein interactions involving Breast Cancer Membrane Proteins-7 and -11 (BCMP-7 and BCMP-11). More specifically, the present invention relates to complexes of the interacting proteins, antibodies to the complexes, selected interaction domains of the protein-protein interactions, methods for screening for agents which modulate the protein-protein interactions and pharmaceutical compositions comprising active agents that are capable of modulating the protein-protein interactions.

5. 发明申请

WO2003075014A2 tROTEIN-PROTEIN INTERACTIONS IN HUMAN TUMOURS 审中-公开
标题翻译：人肿瘤中的蛋白质 - 蛋白质相互作用
公开(公告)号：WO2003075014A2
公开(公告)日：2003-09-12
申请号：PCT/GB2003/000931
申请日：2003-03-06
申请人： OXFORD GLYCOSCIENCES (UK) LTD , HYBRIGÉNICS , DAVIET, Laurent , LEGRAIN, Pierre , TERRETT, Jonathan, Alexander
发明人： DAVIET, Laurent , LEGRAIN, Pierre , TERRETT, Jonathan, Alexander
IPC分类号： G01N33/574
CPC分类号： C07K14/705 , G01N33/57415 , G01N2500/00 , G01N2800/52
摘要： The present invention relates to protein-protein interactions involving Breast Cancer Membrane Proteins-7 and -11 (BCMP-7 and BCMP-11). More specifically, the present invention relates to complexes of the interacting proteins, antibodies to the complexes, selected interaction domains of the protein-protein interactions, methods for screening for agents which modulate the protein-protein interactions and pharmaceutical compositions comprising active agents that are capable of modulating the protein-protein interactions.
摘要翻译：本发明涉及涉及乳腺癌膜蛋白-7和-11（BCMP-7和BCMP-11）的蛋白质 - 蛋白质相互作用。更具体地，本发明涉及相互作用蛋白质的复合物，复合物的抗体，蛋白质 - 蛋白质相互作用的选择的相互作用域，筛选调节蛋白质 - 蛋白质相互作用的试剂的方法和包含能够活化的活性剂的药物组合物调节蛋白质 - 蛋白质相互作用。

6. 发明申请

WO2002066504A2 MORE PROTEIN-PROTEIN INTERACTIONS IN SACCHAROMYCES cerevisiae 审中-公开
标题翻译：更多的蛋白质 - 蛋白质相互作用在酿酒酵母中
公开(公告)号：WO2002066504A2
公开(公告)日：2002-08-29
申请号：PCT/EP2002/002299
申请日：2002-02-14
申请人： HYBRIGENICS , LEGRAIN, Pierre
发明人： LEGRAIN, Pierre
IPC分类号： C07K14/395
CPC分类号： C12N15/1055 , A61K38/00 , A61K2039/523 , C07K14/395 , C12Q1/6897
摘要： The present invention relates to proteins that interact with other proteins of Saccharomyces cerevisiae . More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening for agents which modulate the interaction of proteins and compositions that are capable of modulating the protein-protein interactions, such as, for example, drug in pharmaceutical composition.
摘要翻译：本发明涉及与酿酒酵母的其他蛋白质相互作用的蛋白质。更具体地，本发明涉及编码多肽的多肽或多核苷酸的复合物，多肽的片段，复合物的抗体，由于蛋白质 - 蛋白质相互作用而鉴定的选择性相互作用域（SID），筛选试剂的方法其调节能够调节蛋白质 - 蛋白质相互作用的蛋白质和组合物的相互作用，例如药物组合物中的药物。

7. 发明申请

WO2002059255A2 PROTEIN-PROTEIN INTERACTIONS IN $I(SACCHAROMYCES CEREVISIAE) 审中-公开
标题翻译：蛋白质 - 蛋白质相互作用在IOL（SACCHAROMYCES CEREVISIAE）
公开(公告)号：WO2002059255A2
公开(公告)日：2002-08-01
申请号：PCT/EP2002/001350
申请日：2002-01-25
申请人： HYBRIGENICS , LEGRAIN, Pierre
发明人： LEGRAIN, Pierre
IPC分类号： C12N
CPC分类号： C07K14/395 , A61K39/00 , A61K2039/523
摘要： The present invention relates to proteins that interact with other proteins of Saccharomyces cerevisiae . More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening for agents which modulate the interaction of proteins and compositions that are capable of modulating the protein-protein interactions, such as, for example, drug in pharmaceutical composition.
摘要翻译：本发明涉及与酿酒酵母的其他蛋白质相互作用的蛋白质。更具体地，本发明涉及编码多肽的多肽或多核苷酸的复合物，多肽的片段，复合物的抗体，由于蛋白质 - 蛋白质相互作用而鉴定的选择性相互作用域（SID3），筛选试剂的方法调节能够调节蛋白质 - 蛋白质相互作用的蛋白质和组合物的相互作用，例如药物组合物中的药物。

8. 发明申请

WO2002090544A2 PROTEIN-PROTEIN INTERACTIONS IN ADIPOCYTE CELLS (3) 审中-公开
标题翻译： ADIPOCYTE细胞中的蛋白质 - 蛋白质相互作用（3）
公开(公告)号：WO2002090544A2
公开(公告)日：2002-11-14
申请号：PCT/EP2002/006333
申请日：2002-05-03
申请人： HYBRIGENICS , LYNX THERAPEUTICS INC. , LEGRAIN, Pierre , WHITESIDE, Simon , MAO, Jen-I , KHREBTUKOVA, Irina , LUO, Shujun
发明人： LEGRAIN, Pierre , WHITESIDE, Simon , MAO, Jen-I , KHREBTUKOVA, Irina , LUO, Shujun
IPC分类号： C12N15/12
CPC分类号： C40B30/04 , A61K38/00 , A61K2039/51 , C07K14/47 , G01N33/54353 , G01N33/552 , G01N33/6845 , G01N2500/10
摘要： The present invention relates to protein-protein interactions of adipocytes. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.
摘要翻译：本发明涉及脂肪细胞的蛋白质 - 蛋白质相互作用。更具体地，本发明涉及编码多肽的多肽或多核苷酸的复合物，多肽的片段，复合物的抗体，由于蛋白质 - 蛋白质相互作用而鉴定的选择性相互作用域（SID），用于筛选药剂的方法其调节能够调节蛋白质 - 蛋白质相互作用的蛋白质和药物组合物的相互作用。

9. 发明申请

WO2002074901A3 PROTEIN-PROTEIN INTERACTION MAP INFERENCE USING INTERACTING DOMAIN PROFILE PAIRS 审中-公开
公开(公告)号：WO2002074901A3
公开(公告)日：2002-09-26
申请号：PCT/EP2002/003766
申请日：2002-03-19
申请人： HYBRIGENICS , LEGRAIN, Pierre , WOJCIK, Jérôme , SCHACHTER, Vincent
发明人： LEGRAIN, Pierre , WOJCIK, Jérôme , SCHACHTER, Vincent
IPC分类号： G06F19/00
摘要： A technique to predict protein-protein interaction maps across organisms is described which is called the "interacting-domain profile pair" method. The method uses a high-quality protein interaction map with interaction domain information as input to predict an interaction map in another organism. It combines sequence similarity searches with clustering based on interaction patterns and interaction domain information. The results are compared with predictions from a naive inference method based only on full-length protein sequence similarity. This domain-based method is shown to elimintate a significant amount of false-positives compared to the naive method that are the consequences of multi-domain proteins; and increase the sensitivity compared to the naive method by identifying new potential interactions.

10. 发明申请

WO2002074901A2 PROTEIN-PROTEIN INTERACTION MAP INFERENCE USING INTERACTING DOMAIN PROFILE PAIRS 审中-公开
标题翻译：蛋白质 - 蛋白质相互作用地图使用互动域配置文件
公开(公告)号：WO2002074901A2
公开(公告)日：2002-09-26
申请号：PCT/EP2002/003766
申请日：2002-03-19
申请人： HYBRIGENICS , LEGRAIN, Pierre , WOJCIK, Jérôme , SCHACHTER, Vincent
发明人： LEGRAIN, Pierre , WOJCIK, Jérôme , SCHACHTER, Vincent
IPC分类号： C12N
CPC分类号： G06F19/18 , G06F19/22
摘要： A technique to predict protein-protein interaction maps across organisms is described which is called the "interacting-domain profile pair" method. The method uses a high-quality protein interaction map with interaction domain information as input to predict an interaction map in another organism. It combines sequence similarity searches with clustering based on interaction patterns and interaction domain information. The results are compared with predictions from a naive inference method based only on full-length protein sequence similarity. This domain-based method is shown to elimintate a significant amount of false-positives compared to the naive method that are the consequences of multi-domain proteins; and increase the sensitivity compared to the naive method by identifying new potential interactions.
摘要翻译：描述了一种用于预测跨生物的蛋白质 - 蛋白质相互作用图的技术，其被称为“相互作用域分布对”方法。该方法使用具有交互作用域信息的高质量蛋白质相互作用图作为输入，以预测另一生物体中的相互作用图。它将序列相似性搜索与基于交互模式和交互域信息的聚类相结合。将结果与仅基于全长蛋白质序列相似性的幼稚推理方法的预测进行比较。与基于多结构域蛋白质后果的初始方法相比，这种基于领域的方法被证明可以消除大量的假阳性; 并通过识别新的潜在相互作用来提高与天真的方法相比的灵敏度。

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