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1. 发明申请

WO1998022575A2 NUCLEOTIDE SEQUENCE OF ESCHERICHIA COLI PATHOGENICITY ISLANDS 审中-公开
标题翻译：具有改性塑性的热稳定聚合物
公开(公告)号：WO1998022575A2
公开(公告)日：1998-05-28
申请号：PCT/US1997021347
申请日：1997-11-21
申请人： HUMAN GENOME SCIENCES, INC. , WISCONSIN ALUMNI RESEARCH FOUNDATION , DILLON, Patrick, J. , CHOI, Gil, H. , WELCH, Rodney, A.
发明人： HUMAN GENOME SCIENCES, INC. , WISCONSIN ALUMNI RESEARCH FOUNDATION
IPC分类号： C12N15/31
CPC分类号： C07K14/245
摘要： The present invention relates to novel genes located in two chromosomal regions within uropathogenic E. coli that are associated with virulence. These chromosomal regions are known as pathogenicity islands (PAIs). In particular, the present application discloses 142 sequenced fragments (contigs) of DNA from two pools of cosmids covering pathogenicity islands PAI IV and PAI V located on the chromosome of the uropathogenic Escherichia coli J96. Further disclosed are 351 predicted protein-coding open reading frames within the sequenced fragments.
摘要翻译：本发明涉及位于致病性大肠杆菌内与毒力相关的两个染色体区域中的新基因。这些染色体区域被称为致病岛（PAIs）。特别地，本申请公开了来自覆盖致病性大肠杆菌J96的染色体上的致病性岛PAI IV和PAI V的两个粘粒池的DNA的142个测序片段（重叠群）。进一步披露了序列片段内的351个预测的蛋白质编码的开放阅读框。

2. 发明申请

WO1998018931A3 STREPTOCOCCUS PNEUMONIAE POLYNUCLEOTIDES AND SEQUENCES 审中-公开
公开(公告)号：WO1998018931A3
公开(公告)日：1998-05-07
申请号：PCT/US1997019588
申请日：1997-10-30
申请人： HUMAN GENOME SCIENCES, INC. , KUNSCH, Charles, A. , CHOI, Gil, H. , DILLON, Patrick, J. , ROSEN, Craig, A. , BARASH, Steven, C. , FANNON, Michael , DOUGHERTY, Brian, A.
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： C12N15/31

3. 发明申请

WO1998018930A3 STREPTOCOCCUS PNEUMONIAE ANTIGENS AND VACCINES 审中-公开
公开(公告)号：WO1998018930A3
公开(公告)日：1998-05-07
申请号：PCT/US1997019422
申请日：1997-10-30
申请人： HUMAN GENOME SCIENCES, INC. , KUNSCH, Charles, A. , CHOI, Gil, H. , JOHNSON, L., Sydnor , HROMOCKYJ, Alex
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： C12N15/31

4. 发明申请

WO1998006859A1 HUMAN CHITINASE ALPHA AND CHITINASE ALPHA-2 审中-公开
标题翻译：人类发展与ALIHA ALPHA-2
公开(公告)号：WO1998006859A1
公开(公告)日：1998-02-19
申请号：PCT/US1996013003
申请日：1996-08-09
申请人： HUMAN GENOME SCIENCES, INC. , THOTAKURA, Nageswara, Rao , CHOPRA, Arvind , CHOI, Gil, H. , GENZT, Reiner, L. , ROSEN, Craig, A.
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： C12N15/56
CPC分类号： C12Y302/01014 , A61K38/00 , C12N9/2442
摘要： The present invention concerns novel human chitinase genes - chitinase alpha and chitinase alpha-2. More particularly, the invention concerns nucleic acid sequences encoding chitinase alpha, chitinase alpha-2, or fragments thereof, the use of such polypeptides for treating disease, as well as processes for producing these polypeptides recombinantly.
摘要翻译：本发明涉及新几丁质酶基因 - 几丁质酶α和几丁质酶α-2。更具体地，本发明涉及编码几丁质酶α，几丁质酶α-2或其片段的核酸序列，这些多肽用于治疗疾病的用途，以及重组产生这些多肽的方法。

5. 发明申请

WO1997035976A3 EPIDERMAL DIFFERENTIATION FACTOR 审中-公开
公开(公告)号：WO1997035976A3
公开(公告)日：1997-10-02
申请号：PCT/US1997004962
申请日：1997-03-27
申请人： HUMAN GENOME SCIENCES, INC. , NI, Jian , DILLON, Patrick, J. , GENTZ, Reiner, L. , LI, Haodong
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： C12N15/12

6. 发明申请

WO1998007749A1 NOVEL HUMAN GROWTH FACTORS 审中-公开
标题翻译：新的人类成长因素
公开(公告)号：WO1998007749A1
公开(公告)日：1998-02-26
申请号：PCT/US1997014139
申请日：1997-08-22
申请人： HUMAN GENOME SCIENCES, INC. , YU, Guo-Liang , DILLON, Patrick, J. , EBNER, Reinhard , ENDRESS, Gregory, A.
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： C07K14/475
CPC分类号： C07K14/475 , A61K38/00 , C12N2799/026
摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. These proteins share homology with the XAG protein of Xenopus laevis and can be found in colon tissue. huXAG-1 is specifically found in cancerous colon cells and may therefore be a growth factor for colon cancer. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity as well as diagnostic and therapeutic uses of the proteins.
摘要翻译：本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。这些蛋白质与非洲爪蟾的XAG蛋白质具有同源性，并且可以在结肠组织中发现。 huXAG-1特异性地存在于癌性结肠细胞中，因此可能是结肠癌的生长因子。特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂以及蛋白质的诊断和治疗用途的筛选方法。

7. 发明申请

WO1996039506A1 FIBROBLAST GROWTH FACTOR-14 审中-公开
公开(公告)号：WO1996039506A1
公开(公告)日：1996-12-12
申请号：PCT/US1995006730
申请日：1995-06-05
申请人： HUMAN GENOME SCIENCES, INC. , GREENE, John, M. , DILLON, Patrick, J.
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： C12N15/12
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： Disclosed is a human Fibroblast growth factor-14 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing, for example as a result of burns and ulcers, to prevent neuronal damage due to/associated with stroke and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译：公开了人成纤维细胞生长因子-14多肽和编码这种多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法。还公开了利用这种多肽促进伤口愈合的方法，例如作为烧伤和溃疡的结果，以防止由于/与中风相关的神经元损伤并促进神经元生长，并且防止皮肤老化和脱发，以刺激血管生成，早期胚胎和肢体再生中胚层诱导。还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖，高血管疾病和上皮细胞增殖的治疗剂的用途。还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

8. 发明申请

WO1998006839A1 CD44-LIKE PROTEIN 审中-公开
标题翻译： CD44型蛋白
公开(公告)号：WO1998006839A1
公开(公告)日：1998-02-19
申请号：PCT/US1996013008
申请日：1996-08-09
申请人： HUMAN GENOME SCIENCES, INC. , NI, Jian , GENTZ, Reiner, L. , DILLON, Patrick, J.
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： C12N15/12
CPC分类号： C07K14/70585 , A61K38/00 , C12N2799/026
摘要： The present invention concerns a novel CD44-like protein receptor. In particular, isolated nucleic acid molecules are provided encoding the CD44-like protein. CD44-like polypeptides are also provided, as are screening methods for identifying agonists and antagonists capable of enhancing or inhibiting CD44-like protein-mediated signaling. The invention further concerns therapeutic methods for treating diseases associated with processes mediated by CD44-like protein signaling.
摘要翻译：本发明涉及一种新型的CD44样蛋白受体。特别地，提供编码CD44样蛋白质的分离的核酸分子。还提供CD44样多肽，以及用于鉴定能够增强或抑制CD44样蛋白介导的信号传导的激动剂和拮抗剂的筛选方法。本发明还涉及用于治疗与由CD44样蛋白信号传导介导的过程相关的疾病的治疗方法。

9. 发明申请

WO1997033986A1 ARGINASE II 审中-公开
公开(公告)号：WO1997033986A1
公开(公告)日：1997-09-18
申请号：PCT/US1996013455
申请日：1996-08-20
申请人： SMITHKLINE BEECHAM CORPORATION , HUMAN GENOME SCIENCES, INC. , DILLON, Patrick, J. , VOCKLEY, Joseph, G.
发明人： SMITHKLINE BEECHAM CORPORATION , HUMAN GENOME SCIENCES, INC.
IPC分类号： C12N09/78
CPC分类号： C12N9/78 , A61K38/00 , A61K48/00
摘要： The invention relates to Arginase II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及精氨酸酶II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

10. 发明申请

WO1997033985A1 ARGINASE II 审中-公开
公开(公告)号：WO1997033985A1
公开(公告)日：1997-09-18
申请号：PCT/US1996003561
申请日：1996-03-14
申请人： SMITHKLINE BEECHAM CORPORATION , HUMAN GENOME SCIENCES, INC. , DILLON, Patrick, J. , VOCKLEY, Joseph, G.
发明人： SMITHKLINE BEECHAM CORPORATION , HUMAN GENOME SCIENCES, INC.
IPC分类号： C12N09/78
CPC分类号： C12N9/78 , A61K38/00 , A61K48/00
摘要： The invention relates to Arginase II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及精氨酸酶II多肽，编码这些多肽的多核苷酸，产生这些多肽的方法，包括多核苷酸的表达，以及这些多肽的激动剂和拮抗剂。本发明还提供了在部分诊断，临床和研究相关的应用中使用这些多核苷酸，多肽，激动剂和拮抗剂的方法。

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