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1. 发明申请

WO2007064376A2 ORGANOMETALLIC PRECURSORS AND RELATED INTERMEDIATES FOR DEPOSITION PROCESSES, THEIR PRODUCTION AND METHODS OF USE 审中-公开
标题翻译：有机质前体及相关中间体沉积工艺及其生产及使用方法
公开(公告)号：WO2007064376A2
公开(公告)日：2007-06-07
申请号：PCT/US2006033207
申请日：2006-08-25
申请人： HONEYWELL INT INC , THENAPPAN ALAGAPPAN , LI CHIEN-WEI , NALEWAJEK DAVID , CHENEY MARTIN , LAO JINGYU , EISENBRAUN ERIC , LI MIN , BERLINER NATHANIEL , RITALA MIKKO , LESKELA MARKKU , KUKLI KAUPO
发明人： THENAPPAN ALAGAPPAN , LI CHIEN-WEI , NALEWAJEK DAVID , CHENEY MARTIN , LAO JINGYU , EISENBRAUN ERIC , LI MIN , BERLINER NATHANIEL , RITALA MIKKO , LESKELA MARKKU , KUKLI KAUPO
IPC分类号： C07F15/00 , C23C16/18
CPC分类号： C07F17/02 , C23C16/18
摘要： Vapor deposition precursors that can deposit conformal thin ruthenium films on substrates with a very high growth rate, low resistivity and low levels of carbon, oxygen and nitrogen impurities have been provided. The precursors described herein include a compound having the formula CMC', wherein M comprises a metal or a metalloid; C comprises a substituted or unsubstituted acyclic alkene, cycloalkene or cycloalkene-like ring structure; and C' comprises a substituted or unsubstituted acyclic alkene, cycloalkene or cycloalkene-like ring structure; wherein at least one of C and C' further and individually is substituted with a ligand represented by the formula CH(X)R 1 , wherein X is a N, P, or S-substituted functional group or hydroxyl, and R 1 is hydrogen or a hydrocarbon. Methods of production of the vapor deposition precursors and the resulting films, and uses and end uses of the vapor deposition precursors and resulting films are also described.
摘要翻译：已经提供了可以在非常高的生长速率，低电阻率和低水平的碳，氧和氮杂质的基底上沉积保形薄钌薄膜的气相沉积前体。本文所述的前体包括具有式CMC'的化合物，其中M包含金属或准金属; C包括取代或未取代的无环烯烃，环烯烃或环烯烃环结构; 和C'包括取代或未取代的无环烯烃，环烯烃或环烯烃环结构; 其中C和C'中的至少一个进一步和单独地被式CH（X）R 1表示的配体取代，其中X是N，P或S-取代的官能团或羟基和R 1是氢或烃。还描述了气相沉积前体和所得膜的生产方法，以及气相沉积前体和所得膜的用途和最终用途。

2. 发明申请

WO2011097581A9 THE USE OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND PACAP ANALOGS AS ADJUNCTIVE TREATMENTS WITH INHIBITORS OF CALCINEURIN OR INHIBITORS OF THE MAMMALIAN TARGET OF RAPAMYCIN (mTOR) COMPLEXES 审中-公开
标题翻译：作为ADAMYLATE CYCLASE-ACTIVATING POLYPEPTIDE（PACAP）和PACAP ANALOGS作为与RAPAMYCIN（mTOR）复合物的MAMMALIAN目标的CALCINEURIN或抑制剂的抑制剂的ADJUNCTIVE TREATORS的联合使用
公开(公告)号：WO2011097581A9
公开(公告)日：2011-11-24
申请号：PCT/US2011023930
申请日：2011-02-07
申请人： UNIV TULANE , COY DAVID HOWARD , MADERDRUT JEROME L , LI MIN , BATUMAN VECIHI
发明人： COY DAVID H , MADERDRUT JEROME L , LI MIN , BATUMAN VECIHI
IPC分类号： A61K38/13 , A61K38/16 , A61K38/17 , A61P25/00 , A61P35/00 , A61P37/00
CPC分类号： A61K38/2235 , A61K38/13 , A61K45/06 , A61K2300/00

3. 发明申请

WO2007087424A2 METHOD OF TREATING KCNQ RELATED DISORDERS USING ORGANOZINC COMPOUNDS 审中-公开
标题翻译：使用有机酸化合物治疗KCNQ相关疾病的方法
公开(公告)号：WO2007087424A2
公开(公告)日：2007-08-02
申请号：PCT/US2007002116
申请日：2007-01-25
申请人： UNIV JOHNS HOPKINS , LI MIN , SUN HAIYAN , XIONG QIAOJIE
发明人： LI MIN , SUN HAIYAN , XIONG QIAOJIE
IPC分类号： A61K31/555
CPC分类号： A61K31/555
摘要： The instant invention describes methods of treating KCNQ related diseases and disorders using organozinc compounds. In certain embodiments, pain is treated using Zinc Pyrithione.
摘要翻译：本发明描述了使用有机锌化合物治疗KCNQ相关疾病和病症的方法。在某些实施方案中，使用硫酸锌治疗疼痛。

4. 发明申请

WO2011144075A3 INTERNET DATA TRANSMISSION APPARATUS, TRANSMISSION LINE AND ETHERNET OVER COAXIAL-CABLE DEVICE 审中-公开
标题翻译：互联网数据传输装置，同轴电缆装置的传输线和以太网
公开(公告)号：WO2011144075A3
公开(公告)日：2012-04-26
申请号：PCT/CN2011074632
申请日：2011-05-25
申请人： HUAWEI TECH CO LTD , LI MIN
发明人： LI MIN
IPC分类号： H04L12/28
CPC分类号： H04L12/2801
摘要： Disclosed are an Internet data transmission apparatus, a transmission line and an Ethernet Over Coaxial-cable (EOC) device, and the apparatus includes: a Serial Attached Small computer system interface (SAS) socket or a Serial Advanced Technology Attachment (SATA) socket, the SAS socket or SATA socket includes at least 19 pins, wherein 4 pins are used for transmitting Internet data signals, 3 pins are used for transmitting board-on signals of an EOC modem module, 6 pins are used for transmitting power supply signals, and 6 pins are used for Inter-Integrated Circuit (I2C) control signals. The apparatus, transmission line and EOC device can reduce the cost and volume of EOC devices, and realize the capacity expansion of the EOC devices.
摘要翻译：公开了互联网数据传输装置，传输线和以太网同轴电缆（EOC）装置，并且该装置包括：串行连接小型计算机系统接口（SAS）插座或串行高级技术附件（SATA）插座， SAS插座或SATA插座至少包括19个引脚，其中4个引脚用于传输互联网数据信号，3个引脚用于传输EOC调制解调器模块的板上信号，6个引脚用于发送电源信号， 6个引脚用于集成电路（I2C）控制信号。设备，传输线和EOC设备可以降低EOC设备的成本和体积，实现EOC设备的容量扩容。

5. 发明申请

WO2011054001A8 ANALOGS OF PITUTARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND METHODS FOR THEIR USE 审中-公开
标题翻译：类固醇腺苷酸环化酶多肽（PACAP）的类似物及其使用方法
公开(公告)号：WO2011054001A8
公开(公告)日：2011-07-14
申请号：PCT/US2010055164
申请日：2010-11-02
申请人： UNIV TULANE , COY DAVID HOWARD , MADERDRUT JEROME L , LI MIN
发明人： COY DAVID H , MADERDRUT JEROME L , LI MIN
IPC分类号： A61K38/16 , A61P25/00 , A61P25/28 , A61P35/00
CPC分类号： C07K14/57563 , A61K33/24 , A61K38/00 , A61K38/2278 , A61K45/06 , A61K47/64 , A61K51/088 , A61L31/08 , A61L31/16 , A61L2300/252 , A61L2300/40 , A61L2420/00 , C07K2319/50 , A61K2300/00
摘要： This invention relates to novel analogs of pituitary adenylate cyclase- activating polypeptide (PACAP), which are agonists for the PACAP/vasoactive intestinal peptide (VIP) receptors: PAC1, VPAC1 and VPAC2 receptors. These PACAP analogs can be used as prophylactic/therapeutic agents for a wide range of medical disorders, including (but not limited to) cancer and autoimmune disease. These PACAP analogs can be coupled to suitable radionuclides and used in the localization, diagnosis and treatment of disseminated cancers and metastatic tumors, or coupled to small molecule therapeutics and used as vectors for targeted drug delivery. This invention also provides pharmaceutical compositions of one or more PACAP-like compounds of the invention either alone or in combination with one or more other prophylactic/therapeutic agents.
摘要翻译：本发明涉及垂体腺苷酸环化酶活化多肽（PACAP）的新类似物，它们是PACAP /血管活性肠肽（VIP）受体的激动剂：PAC1，VPAC1和VPAC2受体。这些PACAP类似物可用作各种医学疾病的预防/治疗剂，包括（但不限于）癌症和自身免疫性疾病。这些PACAP类似物可以与合适的放射性核素偶联，用于弥散性癌症和转移性肿瘤的定位，诊断和治疗，或者与小分子治疗药物偶联，并用作靶向药物递送的载体。本发明还单独或与一种或多种其他预防/治疗剂组合提供一种或多种本发明的PACAP样化合物的药物组合物。

6. 发明申请

WO2009015382A3 NOVEL PEPTIDES THAT ENHANCE TIGHT JUNCTION PERMEABILITY 审中-公开
标题翻译：提高紧密透气性的新型胶囊
公开(公告)号：WO2009015382A3
公开(公告)日：2009-04-23
申请号：PCT/US2008071321
申请日：2008-07-28
申请人： ALBA THERAPEUTICS CORP , TAMIZ AMIR , LI MIN
发明人： TAMIZ AMIR , LI MIN
IPC分类号： C07K5/00
CPC分类号： C07K7/06 , A61K38/00 , C07K14/28
摘要： The present invention provides novel peptides that facilitate the opening of mammalian tight junctions, i.e. tight junction agonists. The present invention also provides methods for the treatment of disease by administering to a subject suffering from the disease a composition comprising a peptide tight junction agonist of the invention in combination with a therapeutically effective amount of an active agent.
摘要翻译：本发明提供了促进哺乳动物紧密连接的开放的新型肽，即紧密连接的激动剂。本发明还提供了通过向患有该疾病的受试者施用包含本发明的肽紧密连接激动剂与治疗有效量的活性剂的组合来治疗疾病的方法。

7. 发明申请

WO0229111A8 METHODS FOR INTRODUCING BIOMOLECULES AND USES THEREOF 审中-公开
标题翻译：引入生物分子的方法及其用途
公开(公告)号：WO0229111A8
公开(公告)日：2004-02-19
申请号：PCT/US0131409
申请日：2001-10-05
申请人： LI MIN
发明人： LI MIN
IPC分类号： C12N15/87 , C12Q1/68 , C12N1/15 , C12N1/21 , C12N5/10 , C12N15/63 , C12Q1/70
CPC分类号： C12N15/87
摘要： This invention relates generally to biomolecule, especially nucleic acid, transfer and analysis. In particular, the present invention provides a method for controllably transferring multiple types or combinations of biomolecules from one biological host to another biological host whereby a sufficient amount of a unique type or combination of the biomolecules is transferred from one biological host to another biological host. Kits for such controlled biomolecules transfer are also provided. Methods and kits for assessing effects of RNA in a host cell using the present biomolecule-transfer techniques are further provided.
摘要翻译：本发明一般涉及生物分子，特别是核酸，转移和分析。特别地，本发明提供了一种可控制地将生物分子的多种类型或组合从一种生物宿主转移到另一种生物宿主的方法，由此足够量的独特类型或生物分子的组合从一种生物宿主转移到另一种生物宿主。还提供了用于这种受控生物分子转移的试剂盒。还提供了使用本发明的生物分子转移技术评估宿主细胞中RNA的影响的方法和试剂盒。

8. 发明申请

WO2011085351A9 METHOD OF TREATING KCNQ RELATED DISORDERS 审中-公开
标题翻译：治疗KCNQ相关疾病的方法
公开(公告)号：WO2011085351A9
公开(公告)日：2011-12-22
申请号：PCT/US2011020784
申请日：2011-01-11
申请人： UNIV JOHNS HOPKINS , LI MIN , MCMANUS OWEN B , LONG SHUNYOU , YU HAIBO
发明人： LI MIN , MCMANUS OWEN B , LONG SHUNYOU , YU HAIBO
IPC分类号： A61K31/167 , A61K31/166 , A61K31/44 , A61K31/505 , A61K31/506 , A61P25/00 , A61P25/18
CPC分类号： A61K31/166 , A61K31/167 , A61K31/44 , A61K31/505 , A61K31/506 , A61K45/06 , A61K2300/00

9. 发明申请

WO2010036936A9 USE OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND PACAP ANALOGS AS ADJUNCTIVE TREATMENTS WITH ANTICANCER AGENTS 审中-公开
标题翻译：作为辅助治疗剂，用抗炎剂代谢使用亚硝酸酯环化酶活化多肽（PACAP）和PACAP类似物
公开(公告)号：WO2010036936A9
公开(公告)日：2010-07-15
申请号：PCT/US2009058445
申请日：2009-09-25
申请人： UNIV TULANE , LI MIN , MADERDRUT JEROME L , COY DAVID HOWARD , BATUMAN VECIHI
发明人： LI MIN , MADERDRUT JEROME L , COY DAVID H , BATUMAN VECIHI
IPC分类号： A61K38/16 , A61P35/00
CPC分类号： A61K38/16

10. 发明申请

WO2009062104A2 ABERRANT EXPRESSION OF ZINC TRANSPORTER ZIP4 (SLC39A4) SIGNIFICANTLY CONTRIBUTES TO HUMAN PANCREATIC CANCER PATHOGENESIS AND PROGRESSION 审中-公开
标题翻译：锌转运蛋白ZIP4（SLC39A4）的异常表达对人类胰腺癌发病机制和进展有重要贡献
公开(公告)号：WO2009062104A2
公开(公告)日：2009-05-14
申请号：PCT/US2008082892
申请日：2008-11-07
申请人： BAYLOR COLLEGE MEDICINE , YAO QIZHI , LI MIN , CHEN CHANGYI
发明人： YAO QIZHI , LI MIN , CHEN CHANGYI
IPC分类号： A61K48/00
CPC分类号： C07K14/705
摘要： This invention identifies a previously uncharacterized factor in pancreatic malignancy, ZIP4, and thereby identifies a target for cancer therapy. Agents that inhibit ZIP4 provide methods and compositions to treat cancer, specifically, pancreatic cancer.
摘要翻译：本发明鉴定了先前在胰腺恶性肿瘤中未表征的因子ZIP4，并由此鉴定了癌症治疗的目标。抑制ZIP4的药物提供治疗癌症的方法和组合物，特别是胰腺癌。

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