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1. 发明申请

WO2007140976A3 ENZYMES AS BIOMARKER FOR ALZHEIMER'S DISEASE 审中-公开
标题翻译： ENZYMES作为ALZHEIMER疾病的生物标记
公开(公告)号：WO2007140976A3
公开(公告)日：2008-02-07
申请号：PCT/EP2007004949
申请日：2007-06-04
申请人： HOFFMANN LA ROCHE , BERNTENIS NIKOLAOS , BOHRMANN BERND , GUENTERT ANDREAS , MUELLER BERND
发明人： BERNTENIS NIKOLAOS , BOHRMANN BERND , GUENTERT ANDREAS , MUELLER BERND
IPC分类号： G01N33/68
CPC分类号： C12Q1/28 , C12Q1/48 , G01N2333/91177 , G01N2800/2821
摘要： The present invention relates to a method for assessing Alzheimer's Disease in vitro comprising measuring in a body fluid sample the level of Peroxiredoxin 5 or Microsomal glutathione S-transferase 3 (MGST-3), or a variant thereof, wherein a decreased level of one of said proteins is indicative that said individual suffers from Alzheimer's Disease.
摘要翻译：本发明涉及体外评估阿尔茨海默病的方法，其包括在体液样品中测量过氧化还原毒素5或微粒体型谷胱甘肽S-转移酶3（MGST-3）或其变体的水平，其中，所述蛋白质表明所述个体患有阿尔茨海默氏病。

2. 发明申请

WO2007140971A3 CELL ADHESION PROTEINS AS BIOMARKER FOR ALZHEIMER'S DISEASE 审中-公开
标题翻译：细胞粘附蛋白作为ALZHEIMER病的生物标记
公开(公告)号：WO2007140971A3
公开(公告)日：2008-04-10
申请号：PCT/EP2007004944
申请日：2007-06-04
申请人： HOFFMANN LA ROCHE , BERNTENIS NIKOLAOS , BOHRMANN BERND , GUENTERT ANDREAS , MUELLER BERND
发明人： BERNTENIS NIKOLAOS , BOHRMANN BERND , GUENTERT ANDREAS , MUELLER BERND
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The present invention relates to a method for assessing Alzheimer's Disease in vitro comprising measuring in a body fluid sample the level of one or more proteins of the group consisting of Myelin-associated glycoprotein precursor (MAG), Claudin-11, Contactin associated protein 1 precursor, Myelin oligodendrocyte glycoprotein precursor I (MOG), Contactin 1 precursor and Contactin 2 precursor, or a variant thereof, wherein an altered level of one of said proteins is indicative that said individual suffers from Alzheimer's Disease.
摘要翻译：本发明涉及一种体外评估阿尔茨海默氏病的方法，其包括在体液样品中测量由髓磷脂相关糖蛋白前体（MAG），紧密连接蛋白-11，接触蛋白相关蛋白1前体的一种或多种蛋白质的水平，髓鞘少突胶质细胞糖蛋白前体I（MOG），接触蛋白1前体和接触蛋白2前体或其变体，其中所述蛋白质之一的水平改变表明所述个体患有阿尔茨海默氏病。

3. 发明申请

WO2005014622A3 RA ANTIGENIC PEPTIDES 审中-公开
标题翻译： RA抗原肽
公开(公告)号：WO2005014622A3
公开(公告)日：2005-05-06
申请号：PCT/EP2004008609
申请日：2004-07-30
申请人： HOFFMANN LA ROCHE , BERNTENIS NIKOLAOS , BUURMAN GERRIT , KROPSHOFER HARALD , MUELLER BERND CHRISTIAN , SPINDELDREHER SEBASTIAN THOMAS , VOGT ANNE , ZOLG WERNER
发明人： BERNTENIS NIKOLAOS , BUURMAN GERRIT , KROPSHOFER HARALD , MUELLER BERND CHRISTIAN , SPINDELDREHER SEBASTIAN THOMAS , VOGT ANNE , ZOLG WERNER
IPC分类号： C07K14/47 , C07K14/74 , C07K1/22 , A61K38/00 , A61K39/00 , C07K1/32 , G01N33/569
CPC分类号： C07K14/4713 , C07K14/70539
摘要： The present invention provides novel naturally-processed MHC class II antigenic peptides; which originate from interferon-gamma-inducible lysosomal thiol reductase, integrin beta-2, phosphatitylinositol-4,5-bisphosphate 3-kinase, urokinase-type plasminogen activator, immunoglobulin heavy chain V-III region (VH26), DJ-1 protein, apolipoprotein B-100, 26S proteasome non-ATPase regulatory subunit 8, interleukin-1 receptor, fibromodulin, GM-CSF/IL-3/IL-5 receptor, sorting nexin 3, inter-alpha-trypsin inhibitor heavy chain H4, complement C4, complement C3 (alpha-chain), complement C3 (beta-chain), SH3 domain-binding glutamic acid-rich-like protein 3, interleukin-4-induced protein 1, hemopexin, Hsc70-interacting protein,invariant chain (Ii), retinoic acid receptor responder protein 2, fibronectin, cathepsin B, tripeptidyl-peptidase II, legumain, platelet activating factor receptor, poly- alpha-2.8-sialyltransferase, and ras-leated protein Rab-11B. Also provided are these antigenic peptides and the proteins they are derived from as markers for erosive and/or non-erosive RA. Moreover, these antigenic peptides linked to MHC class II molecules, antibodies reactive with said antigenic peptides, nucleic acids encoding said antigenic peptides, and nucleic acid constructs, host cells and methods for expressing said antigenic peptides are provided. The antigenic peptides of the invention can be used as markers in diagnosis of RA and in therapy as anti-RA vaccines.
摘要翻译：本发明提供新型天然加工的MHC II类抗原肽; 来源于干扰素-γ诱导型溶酶体硫醇还原酶，整联蛋白β-2，磷脂酰肌醇-4,5-二磷酸3-激酶，尿激酶型纤溶酶原激活物，免疫球蛋白重链V-III区（VH26），DJ-1蛋白，载脂蛋白B-100,26S蛋白酶体非ATPase调节亚单位8，白细胞介素-1受体，纤维调节蛋白，GM-CSF / IL-3 / IL-5受体，分选nexin 3，α间胰蛋白酶抑制剂重链H4，补体C4 ，补体C3（α链），补体C3（β链），SH3结构域结合谷氨酸样蛋白3，白细胞介素-4诱导的蛋白1，血红蛋白，Hsc70相互作用蛋白，不变链（Ii），视黄酸受体反应蛋白2，纤连蛋白，组织蛋白酶B，三肽基肽酶II，豆蔻酰胺，血小板活化因子受体，聚-α-2.8-唾液酸转移酶和ras-leated蛋白Rab-11B。还提供了这些抗原肽和它们作为侵蚀性和/或非侵蚀性RA的标记物衍生的蛋白质。此外，提供了与MHC II类分子连接的这些抗原肽，与所述抗原肽反应的抗体，编码所述抗原肽的核酸和核酸构建体，宿主细胞和用于表达所述抗原肽的方法。本发明的抗原肽可用作RA诊断和抗RA疫苗治疗中的标志物。

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