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    • 3. 发明申请
    • DEVICE AND METHOD FOR MAKING SOLID BEADS
    • 制造固体珠的装置和方法
    • WO2010004253A2
    • 2010-01-14
    • PCT/GB2009/001492
    • 2009-06-16
    • Q CHIP LIMITEDPALMER, DanielCALDER, RichardSHADICK, Owen
    • PALMER, DanielCALDER, RichardSHADICK, Owen
    • B01J2/08
    • B01J2/08A61K9/1647A61K9/1694
    • A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid 'in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.
    • 公开了一种制备固体珠粒的方法,所述方法包括:(i)提供微流体装置,其包括在连接区域相遇的载体流体导管和功能流体导管; (ii)提供功能流体的层流,其包括沿着功能流体导管的溶剂和溶质,并且沿着载体流体导管提供载体流体的层流,以在载体流中形成功能流体的液滴 流体; (iii)冷却所述微流体装置的管道中的功能流体段以形成冷却(优选冷冻)的液滴; 和(iv)将液体与冷却的液滴紧密混合,以使所述溶剂离开所述冷却的液滴,从而形成固体珠粒。 还公开了一种用于这种方法的微流体装置。