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    • 2. 发明申请
    • PROCESS FOR PRODUCING OIL-IN-WATER EMULSIONS
    • 用于生产油包水乳液
    • WO1995011660A1
    • 1995-05-04
    • PCT/EP1994003457
    • 1994-10-20
    • HENKEL KOMMANDITGESELLSCHAFT AUF AKTIENFÖRSTER, ThomasCLAAS, MarcusKÜHN, AxelWACHTER, RolfWADLE, Armin
    • HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN
    • A61K07/00
    • A61K8/062A61K8/375A61K8/86A61K2800/21A61Q19/00
    • Finely dispersed oil-in-water emulsions with a long-term stability, based on oil mixtures containing an organic cosmetic active agent can be obtained if (A) an oil body with (B) 0.5 to 30 wt %. of a non-ionic emulsifier with a hydrophile-lipophile balance of 10 to 18 and (C) or 0.1 to 30 wt % of a co-emulsifier from the group of fatty alcohols with 12 to 22 atoms or the partial esters of polyoles with 3 to 6 C atoms with fatty acids with 12 to 22 atoms and (D) an organic cosmetic active agent selected from the group of deodorizing agents, perfume oils and light-protective factors, provided that i) the sum of components (A) and (D) amounts to 10 to 90 wt % and ii) the proportion of the component (D) amounts to 5 to 100 wt % in relation to the oil body (A), is emulsified in the presence of 8 to 85 wt % of water at a temperature above the melting point of the mixture of components (A) to (D) and the emulsion is heated to a temperature within or above the phase inversion temperature range, or the emulsion is produced at this temperature, after which it is cooled to a temperature below said phase inversion temperature range and possibly further diluted with water.
    • 细分散的和长期稳定的油包水基上含有有机化妆品活性物质油性混合物乳剂可以通过用(B)0.5〜30重量的非离子型乳化剂的%的具有反应(A)的油体来获得 的HLB值为10〜18,(C)0或0.1至30重量从具有12至22个碳原子或含有3至6个C多元醇的偏酯的组中的脂肪醇的辅助乳化剂的% 与具有脂肪酸碳原子数为12〜22,和(D),其选自除臭剂活性成分,芳香油和防晒因子组成的组中的有机化妆品活性成分,条件原子数ⅰ)组分的总和(a)和(D) 10至90重量%,和ii)组分(D)范围为5至100重量%的比例 - 相对于所述油体(A) - 是,在8存在于85重量%的水 在(a)中乳化,以(D)的组分的混合物的熔点以上的温度和Emulsio n是加热到内或高于相转变温度范围内的温度 - 或乳液在该温度下制备的 - 然后将乳液冷却至低于相转变温度的温度范围内并且任选地与水进一步稀释。
    • 6. 发明申请
    • MICRO-EMULSIONS
    • 微乳液
    • WO1995031957A1
    • 1995-11-30
    • PCT/EP1995001765
    • 1995-05-10
    • HENKEL KOMMANDITGESELLSCHAFT AUF AKTIENFÖRSTER, ThomasCLAAS, MarcusSEIPEL, WernerGUCKENBIEHL, BernhardWADLE, Armin
    • HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN
    • A61K07/00
    • A61K8/068A61K8/4973A61K8/604A61Q5/02A61Q19/10B01F17/0092
    • Micro-emulsions of a liquid oil phase (A) consisting to the extent of over 70 wt.% of preferably only hydrocarbons or dialkyl ethers with at least 10 C atoms, can be produced, preferably using an emulsifier combination (B) of (B1) an alkyl glycoside of the formula R O(G))x in which R is a linear alkyl group with 8 to 14 C atoms, G is a glycoside radical and x is its mean degree of oligomerisation and a number from 1 to 3, and (B2) a fatty acid polyol partial ester with an HLB value of under 11, of a fatty acid with 10-18 C atoms and a polyol with 2-8 hydroxyl groups. The preferred oligoglucosides are of the given formula in which R is a C8-C12 alkyl group and (G)x is an oligoglucoside radical with a mean degree of oligomerisation x of 1 to 2. Suitable fatty acid polyol partial esters are technical glycerine or sorbitan monoesters of lauric acid, myristic acid and technical C8 14
    • 液体油相(A),以超过70重量%的微乳液优选的烃或二烷基排他地,醚存在各自具有至少10个碳原子,可以优选使用(B1)的烷基糖苷的乳化剂(B) 式R <1> O(G))的x,其中R是具有8至14个碳原子,G的平均低聚度为<1>的糖苷残基,并且x是一个从1至3,和(B2的直链烷基 )脂肪酸多元醇偏酯具有小于11由具有10的脂肪酸的HLB值 - 制作8个羟基 - 18个碳原子和2个的多元醇。 上式的优选低聚葡糖苷<1>是C8-C12烷基和(G)x是平均低聚度的低聚葡糖苷是在R X 1-2是合适的。 作为脂肪酸多元醇偏酯是技术甘油或月桂酸,肉豆蔻酸和合适的技术C8-C14椰子脂肪酸截面的山梨糖醇单酯。
    • 7. 发明申请
    • DIALKYL ETHER-CONTAINING MICRO-EMULSIONS
    • 含二烷基微乳液
    • WO1995026707A1
    • 1995-10-12
    • PCT/EP1995001134
    • 1995-03-25
    • HENKEL KOMMANDITGESELLSCHAFT AUF AKTIENFÖRSTER, ThomasCLAAS, MarcusWADLE, Armin
    • HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN
    • A61K07/00
    • A61K8/068A61K8/33A61K9/1075A61Q19/00A61Q19/10
    • In a process for producing micro-emulsions, the oil component is a dialkyl ether with 12 to 24 C atoms in a proportion of at least 30 wt % of the oil phase. Micro-emulsions of the water-in-oil type preferably contain 20 to 60 wt % of the dialkyl ether, 0 to 40 wt % of a second oil component, preferably a fatty acid ester with 12 to 26 C atoms or a hydrocarbon oil, 20 to 35 wt % of a lipophilic non-ionic emulsifier with an HLB value of 6 to 10, 1 to 10 wt % of a hydrophilic non ionic or a water-soluble ionic tenside, 1 to 10 wt % of a diol or polyol with 2 to 6 C atoms and 1 to 20 wt % of water. Corresponding micro-emulsions of the oil-in-water type contain 3 to 30 wt % of the dialkyl ether , 0 to 20 wt % of a second oil component, 10 to 20 wt % of a lipophilic non-ionic emulsifier with an HLB value of 6 to 10, 1 to 10 wt % of an hydrophilic non-ionic or a water-soluble ionic tenside and 1 to 10 wt % of a diol or polyol. The micro-emulsions of the invention are suitable as supports for cosmetic and pharmaceutical preparations.
    • 一种微滴乳状液的制备方法是,作为油组分与12二烷基醚 - 24个碳原子为至少30重量%的量使用.-油相的%。 水包油型的微乳状液优选含有20 - 60重量二烷基醚的%,0 - 第二油成分的40重量%,优选具有12​​个脂肪酸酯 - 26个碳原子或烃油,20 - 重量35 - 具有的HLB值的亲脂性非离子乳化剂的%6 - 10 1 - 10重量的亲水性非离子性或水溶性非离子表面活性%,1 - 6个碳原子 - 10重量具有2二醇或多元醇的% 和1 - 20重量%的水。 对应油包水含有3所述类型的微乳液 - 30重量二烷基醚的%,0 - 20重量的第二油成分的%,10 - 20重量具有6-12的HLB值的亲脂性非离子乳化剂的% - 10,1 - 10重量的亲水性非离子性或水溶性非离子表面活性的%,和1 - 二醇或多元醇的10重量%。 本发明的微滴乳状液是适合作为用于化妆品和药物制剂的载体。