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1. 发明申请

WO2017032815A3 BIOMARKERS FOR CARDIOMETABOLIC DISEASES 审中-公开
标题翻译：生物标志物用于心血管疾病
公开(公告)号：WO2017032815A3
公开(公告)日：2017-05-04
申请号：PCT/EP2016070011
申请日：2016-08-24
申请人： HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)
发明人： VON TÖRNE CHRISTINE , HAUCK STEFANIE M , HUTH CORNELIA , THORAND BARBARA , DE LAS HERAS GALA TONIA
IPC分类号： G01N33/68 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/6893 , G01N2500/10 , G01N2800/042 , G01N2800/50
摘要： The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, or for producing a diagnostically informative value of the amount of one or more protein(s) or mRNA(s) encoding said protein(s) for identifying a predisposition for developing a type 2 diabetes mellitus, said method comprising or consisting of (i) assessing in a sample obtained from said subject the amount of one or more protein(s) and/or mRNA(s) encoding said protein(s), wherein said one or more protein(s) is/are selected from a group of proteins as defined in the following, and (ii) determining parameters of said subject, wherein (a) said parameters are age and sex, and said group consists of AP0C2, AP0C3, APOE, CRP, MASP-1, ADIPOQ, ΙΤΊΗ4, and SHBG; (b) said parameters are age, sex and BMI, and said group consists of AP0C2, AP0C3, APOE, MASP-1, ADIPOQ, ITIH4, PZP and SHBG; or (c) said parameters are age, sex, BMI, smoking status, alcohol intake, physical inactivity, actual hypertension, log 10-transformed triacylglycerol levels and Iog10-transformed total cholesterol/HDL-cholesterol ratio and said group consists of MASP-1, ADIPOQ, ITIH4, ORM1 and PZP; wherein an increase in the amount of APOC2, APOC3, APOE, CRP or MASP-1 or of an mRNA encoding APOC2, APOC3, APOE, CRP or MASP-1 or a decrease in the amount of ADIPOQ, ITIH4, SHBG, PZP or ORM1 or of an mRNA encoding ADIPOQ, ITIH4, SHBG, PZP or ORM1 as compared to the amount of said protein(s) or said mRNA(s), respectively, of a control is indicative of a predisposition to develop type 2 diabetes mellitus.
摘要翻译：本发明涉及鉴定在受试者中发展为2型糖尿病的倾向的方法，或用于产生编码所述蛋白质的一种或多种蛋白质或mRNA的量的诊断信息值的方法，所述方法包括以下步骤或由以下步骤组成：（i）评估从所述受试者获得的样品中编码所述蛋白质的一种或多种蛋白质和/或mRNA（一种或多种）的量（其中所述一种或多种蛋白质选自以下定义的一组蛋白质，和（ii）确定所述受试者的参数，其中（a）所述参数是年龄和性别，并且所述参数组由AP0C2，AP0C3，APOE，CRP，MASP-1，ADIPOQ，ITH4和SHBG组成; （b）所述参数是年龄，性别和BMI，并且所述组由AP0C2，AP0C3，APOE，MASP-1，ADIPOQ，ITIH4，PZP和SHBG组成; 或（c）所述参数是年龄，性别，BMI，吸烟状况，酒精摄入量，身体活动不足，实际高血压，log 10转化的甘油三酯水平和log10转化的总胆固醇/ HDL胆固醇比率，并且所述组由MASP-1 ，ADIPOQ，ITIH4，ORM1和PZP; 其中APOC2，APOC3，APOE，CRP或MASP-1或编码APOC2，APOC3，APOE，CRP或MASP-1的mRNA的量的增加或ADIPOQ，ITIH4，SHBG，PZP或ORM1的量的减少或编码ADIPOQ，ITIH4，SHBG，PZP或ORM1的mRNA分别与对照的所述一种或多种蛋白质或所述一种或多种mRNA的量相比较是指示形成2型糖尿病的倾向。

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