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1. 发明申请

WO2008073607A2 A METHOD FOR ESTIMATING ERROR FROM A SMALL NUMBER OF EXPRESSION SAMPLES 审中-公开
标题翻译：从少量表达样本估计错误的方法
公开(公告)号：WO2008073607A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/083333
申请日：2007-11-01
申请人： HELICOS BIOSCIENCES CORPORATION , THAYER, Edward
发明人： THAYER, Edward
IPC分类号： C40B30/02
CPC分类号： G06F19/20
摘要： A method for estimating error in expression data. In one embodiment, the method includes single molecule sequencing a plurality of expression tags from an organism; removing expression tags that ambiguously relate to multiple genes; assigning each remaining expression tag to a respective gene; selecting a random subset of the expression tags; and counting the number of expression tags associated with each gene. The process of selecting a random subset of the expression tags; and counting the number of expression tags associated with each gene is repeated a predetermined number of times, both for expression tags sequenced before and after exposure of the organism to a perturbation. The method also includes the step of calculating a measure of error in response to the counts of the number of expression tags before and after the perturbation.
摘要翻译：一种估计表达数据误差的方法。在一个实施方案中，该方法包括从生物体单个分子测序多个表达标签; 去除与多个基因无关的表达标签; 将每个剩余的表达标签分配给相应的基因; 选择表达标签的随机子集; 并计算与每个基因相关联的表达标签的数量。选择表达标签的随机子集的过程; 并且将与每个基因相关联的表达标签的数量计数重复预定次数，两者对于在生物体暴露于扰动之前和之后测序的表达标签。该方法还包括响应于在扰动之前和之后的表达标签的数量的计数来计算误差测量的步骤。

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