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1. 发明申请

WO2012057529A3 METHOD FOR PURIFYING HUMAN GRANULOCYTE-COLONY STIMULATING FACTOR FROM RECOMBINANT E. COLI 审中-公开
公开(公告)号：WO2012057529A3
公开(公告)日：2012-05-03
申请号：PCT/KR2011/008046
申请日：2011-10-26
申请人： HANMI SCIENCE CO., LTD. , CHOI, Sung Chul , KIM, Jin Ki , OH, Young Hak , LEE, Jong Soo
发明人： CHOI, Sung Chul , KIM, Jin Ki , OH, Young Hak , LEE, Jong Soo
IPC分类号： C07K14/53 , C07K1/16 , C12N15/27 , C12N15/70
摘要： The present invention provides a method for purifying a large amount of human granulocyte-colony stimulating factors (hG-CSFs) from a recombinant E. coli with high yield and purity. According to the method of the present invention, human granulocyte-colony stimulating factor, identical to the native form expressed in the human body, can be easily purified with high yield and purity without an additional activation process. In particular, according to the purification method of the present invention, hG-CSF variants expressed in E. coli are efficiently removed to obtain physiologically active hG-CSFs with high purity.

2. 发明申请

WO2013066106A1 METHOD FOR PREPARING PHYSIOLOGICALLY ACTIVE POLYPEPTIDE COMPLEX 审中-公开
标题翻译：制备生理活性多肽复合物的方法
公开(公告)号：WO2013066106A1
公开(公告)日：2013-05-10
申请号：PCT/KR2012/009186
申请日：2012-11-02
申请人： HANMI SCIENCE CO., LTD.
发明人： KIM, Dae Jin , JANG, Myung Hyun , KIM, Seung Su , LEE, Jong Soo , CHOI, Jae Hyuk , KWON, Se Chang
IPC分类号： C07K17/10 , C07K17/08 , C07K1/18
CPC分类号： C07K14/62 , A61K47/60 , C07K1/1077 , C07K17/08 , C07K2319/30 , C07K2319/31
摘要： The present invention relates to a method for preparaing a conjugate of a physiologically active polypeptide and a non-peptide polymer by linking physiologically active polypeptide with non-peptide polymer through a covalent bond using an organic solvent, and for preparing a physiologically active polypeptide complex by linking the conjugate with a carrier, in order to improve in vivo duration and stability of the physiologically active polypeptide. The method of the present invention can prepare the conjugate of the physiologically active polypeptide and non-peptide polymer with high purity and yield, and the physiologically active polypeptide complexes as prepared taking advantage of this can provide a reduction in production cost, and an extension of in vivo activity at a relatively high level and significantly increase in the blood half-life, and thus can be effectively used for development of the sustained-release formulation of physiologically active polypeptide which can raise patient's adaptability of taking the drug.
摘要翻译：本发明涉及一种制备生理活性多肽和非肽聚合物的缀合物的方法，其通过使用有机溶剂通过共价键连接生理活性多肽与非肽聚合物，并通过以下方式制备生理活性多肽复合物：将缀合物与载体连接，以改善生理活性多肽的体内持续时间和稳定性。本发明的方法可以制备具有高纯度和产率的生理活性多肽和非肽聚合物的缀合物，并且利用其制备的生理活性多肽复合物可以降低生产成本，并且延长体内活性较高，血液半衰期显着增加，因此可有效用于开发生理活性多肽的缓释制剂，可提高患者服用药物的适应性。

3. 发明申请

WO2020027915A1 DEICING AND SNOW MELTING COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2020027915A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/035514
申请日：2019-06-05
申请人： LEE, Jong Soo
发明人： LEE, Jong Soo
IPC分类号： E01H10/00 , C09K3/18 , B65D65/46 , B65D73/00 , B65D75/42 , C08J7/00 , C11D17/00
摘要： A composition and method for safely and easily melting snow and ice is disclosed. The composition includes a pellet comprising an active ingredient; and a base comprising a water-soluble film-forming material, the pellet being attached to the base.

4. 发明申请

WO2012057525A2 LIQUID FORMULATIONS OF LONG ACTING INTERFERON ALPHA CONJUGATE 审中-公开
标题翻译：长效干扰素ALPHA联合液的液体制剂
公开(公告)号：WO2012057525A2
公开(公告)日：2012-05-03
申请号：PCT/KR2011/008038
申请日：2011-10-26
申请人： HANMI HOLDINGS CO., LTD. , IM, Dae Seong , LEE, Jae Min , LEE, Jong Soo , BAE, Sung Min , KWON, Se Chang
发明人： IM, Dae Seong , LEE, Jae Min , LEE, Jong Soo , BAE, Sung Min , KWON, Se Chang
IPC分类号： A61K9/08 , A61K47/36 , A61K38/21 , A61P31/12
CPC分类号： A61K47/48415 , A61K9/0019 , A61K38/212 , A61K47/26 , A61K47/68 , A61K47/6813 , C07K14/56 , C07K16/46 , C07K2319/30
摘要： Disclosed is a liquid formulation in which a long-acting INFα conjugate that has improved in vivo duration and stability can be stored stably for a long period of time. It comprises a stabilizer comprising a buffer, a sugar alcohol, a non-ionic surfactant and an isotonic agent. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting INFα conjugates.
摘要翻译：公开了一种液体制剂，其中可长期稳定地存储具有改善的体内持续时间和稳定性的长效INFa缀合物。它包括稳定剂，其包含缓冲剂，糖醇，非离子表面活性剂和等渗剂。没有人体血清白蛋白和其他对身体有害的潜在因素，液体制剂没有对病毒感染的担忧，并保证了对长效INFa共轭物的极好的储存稳定性。

5. 发明申请

WO2006090968A1 COMPOSITION FOR ADJUVANT CONTAINING POLY-GAMMA-GLUTAMIC ACID 审中-公开
标题翻译：用于含有聚氨基酸谷氨酸的混合物的组合物
公开(公告)号：WO2006090968A1
公开(公告)日：2006-08-31
申请号：PCT/KR2005/004160
申请日：2005-12-06
申请人： BIOLEADERS CORPORATION , M.D. LAB CO. LTD. , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , SUNG, Moon Hee , KIM, Chul Joong , POO, Ha Ryoung , HONG, Seung Pyo , LEE, Jong Soo , KIM, Ji Youn
发明人： SUNG, Moon Hee , KIM, Chul Joong , POO, Ha Ryoung , HONG, Seung Pyo , LEE, Jong Soo , KIM, Ji Youn
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A61K2039/55516
摘要： The present invention relates to a composition for an immunopotentiator(adjuvant) containing poly-gamma-glutamic acid and a composition for a vaccine containing the immunopotentiator, and more particularly, to an immunopotentiator containing poly-gamma-glutamic acid capable of enhancing antibody production rate by administering it to an animal together with antigen having low immunogenicity, and a composition for a vaccine containing the immunopotentiator and antigen. The inventive adjuvant has almost no toxicity and side effects, and show high antibody titer even when it is used with antigen having poor immunogenicity, so it can be used by adding to medical composition including preventive or curative vaccine for non-contagious chronic diseases as well as cancer, especially prostatic carcinoma, colon carcinoma, lung cancer, breast cancer, ovarian cancer, head and neck cancer, pudendum cancer, bladder cancer, brain tumor and glioma.
摘要翻译：本发明涉及含有聚-γ-谷氨酸的免疫增强剂（佐剂）组合物和含有免疫增强剂的疫苗组合物，更具体地说，涉及含有能够提高抗体产生率的聚-γ-谷氨酸的免疫增强剂通过将其与抗免疫原性低的抗原一起施用于动物，以及含有免疫增强剂和抗原的疫苗组合物。本发明的佐剂几乎没有毒性和副作用，即使与抗免疫原性差的抗原一起使用也显示高抗体滴度，因此可以通过向非传染性慢性疾病中加入包括预防或治疗性疫苗的医药组合物作为癌症，特别是前列腺癌，结肠癌，肺癌，乳腺癌，卵巢癌，头颈癌，pudendum癌，膀胱癌，脑肿瘤和胶质瘤。

6. 发明申请

WO2012011752A2 NOVEL LONG-ACTING GLUCAGON CONJUGATE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR THE PREVENTION AND TREATMENT OF OBESITY 审中-公开
标题翻译：新型长效胰高血糖素结合物及包含其的用于预防和治疗肥胖症的药物组合物
公开(公告)号：WO2012011752A2
公开(公告)日：2012-01-26
申请号：PCT/KR2011/005375
申请日：2011-07-21
申请人： HANMI HOLDINGS CO., LTD. , WOO, Young Eun , LEE, Jong Soo , SHEN, Ling Ai , KIM, Dae Jin , JUNG, Sung Youb , CHOI, In Young , KWON, Se Chang
发明人： WOO, Young Eun , LEE, Jong Soo , SHEN, Ling Ai , KIM, Dae Jin , JUNG, Sung Youb , CHOI, In Young , KWON, Se Chang
IPC分类号： A61K38/26 , A61K31/4164 , C07K14/605 , A61P3/04 , A61P3/00
CPC分类号： A61K47/48415 , A61K31/4164 , A61K38/26 , A61K45/06 , A61K47/68 , A61K47/6811 , A61K47/6883 , C07K14/605 , A61K2300/00
摘要： Disclosed is a novel long-acting glucagon conjugate in which glucagon or its derivative is covalently linked to a polymer carrier via a non-peptide linker, and a pharmaceutical composition comprising the same as an effective ingredient useful for the prevention and treatment of obesity. Since the long-acting glucagon conjugate of the present invention shows improved in vivo durability and stability, when used in combination with an anti-obesity drug, it is possible to induce synergistic effects on the loss of body weight and decrease in food intake without causing any side-effects such as fluctuation in blood glucose level. Accordingly, the long-acting peptide conjugate of the present invention is very effective for the prevention and treatment of obesity.
摘要翻译：公开了一种新型长效胰高血糖素缀合物，其中胰高血糖素或其衍生物通过非肽接头共价连接至聚合物载体，以及包含其作为有效成分的药物组合物，其可用于预防和治疗肥胖症。由于本发明的长效胰高血糖素缀合物显示出改善的体内耐久性和稳定性，因此当与抗肥胖药组合使用时，可能诱导体重减轻和食物摄取减少的协同效应，而不引起任何副作用如血糖水平的波动。因此，本发明的长效肽缀合物对于预防和治疗肥胖是非常有效的。

7. 发明申请

WO2009148202A1 SPORTING APPARATUS FOR WHOLE BODY EXERCISING 审中-公开
标题翻译：运动装置全身运动
公开(公告)号：WO2009148202A1
公开(公告)日：2009-12-10
申请号：PCT/KR2008/004894
申请日：2008-08-21
申请人： C&C CARE CO., LTD. , CHOI, Gi Hun , LEE, Jong Soo , BAE, Mi Young , CHO, Beam Young
发明人： CHOI, Gi Hun , LEE, Jong Soo , BAE, Mi Young , CHO, Beam Young
IPC分类号： A63B22/20
CPC分类号： A61H1/003 , A61H1/0218 , A61H2201/1642 , A61H2201/5007 , A61H2201/5069 , A61H2203/0493 , A63B22/16 , A63B69/0057 , A63B71/0619 , A63B2208/0247 , A63B2220/24
摘要： The present invention relates to a sporting apparatus for whole body exercising, in which a first slide plate and a second slide plate are disposed in turn on a table exercising part in a lon¬ gitudinal direction and a third slide plate is disposed on an upper part of the second slide plate, includes a support part coupled with the table exercising part through a rotation shaft and rotatably supporting the table exercising part around the rotation shaft; an actuator received in the support part and having a driving shaft connected with a lower face of the table exercising part, the actuator providing driving force so that the table exercising part is pivoted on the rotation shaft; a key input unit for detecting an operation signal of the actuator inputted by a user; and a control unit for outputting a control signal for operation of the actuator on the basis of the operation signal detected from the key input unit.
摘要翻译：本发明涉及一种全身锻炼的运动装置，其中第一滑动板和第二滑动板依次设置在纵向上的运动部分的台上，第三滑动板设置在上部所述第二滑动板包括通过旋转轴与所述台运动部分结合的支撑部分，并且可旋转地支撑所述台运动部分围绕所述旋转轴; 所述致动器容纳在所述支撑部中，并且具有与所述台运动部的下表面连接的驱动轴，所述致动器提供驱动力，使得所述台运动部在所述旋转轴上枢转; 键输入单元，用于检测由用户输入的致动器的操作信号; 以及控制单元，用于基于从键输入单元检测到的操作信号输出用于操作致动器的控制信号。

8. 发明申请

WO2011019190A3 AN AMPHIBIOUS FIGHTING VEHICLE RUNNING ON LAND AND WATER SURFACES 审中-公开
公开(公告)号：WO2011019190A3
公开(公告)日：2011-02-17
申请号：PCT/KR2010/005241
申请日：2010-08-10
申请人： LEE, Jong Soo
发明人： LEE, Jong Soo
IPC分类号： F41H7/02 , B60F3/00 , B62D55/08
摘要： An amphibious fighting vehicle capable of moving on a water surface including a front planning tracked belt disposed on a front portion of the amphibious fighting vehicle, a rear driving tracked belt, side buoys disposed on lateral sides of the amphibious fighting vehicle, a rear buoy disposed on a rear end of the amphibious fighting vehicle, the buoys assisting in setting an immersion line of the amphibious fighting vehicle at a predetermined value, and a set of identical engines that propel the amphibious fighting vehicle at a speed sufficient for movement on the water surface and a land surface.

9. 发明申请

WO2007055437A1 KILLED LACTIC ACID BACTERIA PREPARATION HAVING ENHANCED IMMUNITY AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：具有增强免疫力的杀死乳酸菌细胞的制备及其制备方法
公开(公告)号：WO2007055437A1
公开(公告)日：2007-05-18
申请号：PCT/KR2005/004159
申请日：2005-12-06
申请人： BIOLEADERS CORPORATION , SUNG, Moon Hee , HONG, Seung Pyo , LEE, Jong Soo , LEE, Il Han , CHOI, Yoon Ho , KIM, Hyoung Bum
发明人： SUNG, Moon Hee , HONG, Seung Pyo , LEE, Jong Soo , LEE, Il Han , CHOI, Yoon Ho , KIM, Hyoung Bum
IPC分类号： C12N15/03 , A61K39/00
CPC分类号： C12N1/005 , A61K39/00 , A61K39/12 , A61K39/215 , A61K2039/521 , A61K2039/523 , A61K2039/55594 , A61K2039/70 , C07K2319/00 , C12N1/20 , C12N2770/20034
摘要： The present invention relates to killed lactic acid bacteria preparation having enhanced immunity and a method for preparing the same, and more particularly, relates to killed lactic acid bacteria preparation having enhanced immunity and a method for preparing the same, the method comprising the steps of culturing lactic acid bacteria in a culture medium containing surfactant and carbonate and killing. According to the present invention, it is possible to produce lactic acid bacteria preparation that has enhanced immunity effect, as well as, the effect of preventing functional damage of surface-expressed target protein, with high concentration rate. Since the killed lactic acid bacteria prepared according to the present invention shows improved immunity enhancing effect and enables mass production compared to live bacteria, it is useful as feed additives, animal drugs or vaccines etc.
摘要翻译：本发明涉及具有增强的免疫力的杀死的乳酸菌制剂及其制备方法，更具体地涉及具有增强的免疫力的杀死的乳酸菌制剂及其制备方法，该方法包括以下步骤：培养乳酸菌在含有表面活性剂和碳酸盐的培养基中杀死。根据本发明，可以生产具有增强的免疫效果的乳酸菌制剂以及以高浓度速率防止表面表达的靶蛋白的功能损伤的效果。由于根据本发明制备的杀死的乳酸菌显示出提高的免疫增强效果，并且与活细菌相比能够进行批量生产，因此可用作饲料添加剂，动物药物或疫苗等。

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