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1. 发明申请

WO2010082804A2 METHOD FOR PRODUCING PHYSIOLOGICALLY ACTIVE PROTEIN OR PEPTIDE USING IMMUNOGLOBULIN FRAGMENT 审中-公开
标题翻译：使用免疫球蛋白片段生产生理活性蛋白质或肽的方法
公开(公告)号：WO2010082804A2
公开(公告)日：2010-07-22
申请号：PCT/KR2010/000342
申请日：2010-01-19
申请人： HANMI PHARM. CO., LTD. , KIM, Jin-Sun , JUNG, Sung Youb , LEE, Jong-Soo , LEE, Byung Sun , KWON, Se Chang , LEE, Gwan Sun
发明人： KIM, Jin-Sun , JUNG, Sung Youb , LEE, Jong-Soo , LEE, Byung Sun , KWON, Se Chang , LEE, Gwan Sun
IPC分类号： C12N15/62 , C12N15/52 , C12N15/09 , C07K19/00
CPC分类号： C07K14/00 , C07K2319/30
摘要： The present invention provides a method for mass-producing a physiologically active protein or peptide using a fusion protein composed of the physiologically active protein or peptide and an immunoglobulin fragment. The present invention also provides such a fusion protein, a DNA encoding the fusion protein, an expression vector comprising the DNA, and a microorganism transformed with the expression vector.
摘要翻译：本发明提供了一种使用由生理活性蛋白或肽和免疫球蛋白片段组成的融合蛋白来批量生产生理活性蛋白或肽的方法。本发明还提供了这样的融合蛋白，编码该融合蛋白的DNA，包含该DNA的表达载体和用该表达载体转化的微生物。

2. 发明申请

WO2007083893A1 CELL SURFACE EXPRESSION VECTOR OF WHITE SPOT SYNDROME VIRUS ANTIGEN AND MICROORGANISM TRANSFORMED WITH THE SAME 审中-公开
标题翻译：白点病毒抗原和微生物转化的细胞表面表达载体
公开(公告)号：WO2007083893A1
公开(公告)日：2007-07-26
申请号：PCT/KR2006/005686
申请日：2006-12-22
申请人： BIOLEADERS CORPORATION , SUNG, Moon Hee , KIM, Chul Joong , HONG, Seung Pyo , LEE, Jong-Soo , KIM, Jong-Taik
发明人： SUNG, Moon Hee , KIM, Chul Joong , HONG, Seung Pyo , LEE, Jong-Soo , KIM, Jong-Taik
IPC分类号： C12N15/64 , C12N15/74 , C12N15/70
CPC分类号： C12N15/74 , A61K39/12 , A61K2039/523 , A61K2039/542 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/70 , C12N2710/18022 , C12N2710/18034
摘要： The present invention relates to a surface expression vector of an antigen of shrimp white spot syndrome virus (WSSV) and a microorganism transformed with the vector. More particularly, the present invention relates to a surface expression vector comprising a gene encoding an antigen of shrimp WSSV and a gene encoding a poly-gamma-glutamate synthetase complex, a bacterium transformed with the vector, and a vaccine for treating or preventing disease caused by shrimp WSSV and a feedstuff additive, which contain a bacterium having the shrimp WSSV antigen expressed on the surface thereof or a crude extracted antigen from the bacterium as an effective ingredient. The inventive bacterium having the shrimp WSSV antigen expressed on the surface thereof or a crude extracted antigen of shrimp WSSV from the bacterium can be used as a vaccine or a feedstuff additive to prevent and treat viral disease caused by shrimp WSSV, thus it contributes to avoiding mass death of crustaceans caused by shrimp WSSV as well as increasing profits in fish farming and fisheries.
摘要翻译：本发明涉及虾白点综合征病毒（WSSV）的抗原表面表达载体和用载体转化的微生物。更具体地，本发明涉及包含编码虾WSSV的抗原的基因和编码聚-γ-谷氨酸合成酶复合物的基因，用载体转化的细菌和用于治疗或预防疾病的疫苗的表面表达载体通过虾WSSV和饲料添加剂，其含有在其表面上表达的虾WSSV抗原的细菌或来自细菌的粗提取抗原作为有效成分。具有表面的虾WSSV抗原的本发明细菌或来自细菌的虾WSSV的粗提取抗原可以用作疫苗或饲料添加剂，以预防和治疗由虾WSSV引起的病毒性疾病，因此有助于避免由虾虾WSSV造成的甲壳类动物大规模死亡，并增加了养鱼业和渔业的利润。

3. 发明申请

WO2004035795A1 VECTOR FOR ANTI-HPV VACCINE AND TRANSFORMED MICROORGANISM BY THE VECTOR 审中-公开
标题翻译：抗病毒药物疫苗和转基因微生物的载体
公开(公告)号：WO2004035795A1
公开(公告)日：2004-04-29
申请号：PCT/KR2003/002163
申请日：2003-10-17
申请人： BIOLEADERS CORPORATION , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , SUNG, Moon-Hee , POO, Ha-Ryoung , LEE, Jong-Soo , JUNG, Chang-Min , HONG, Seung-Pyo , KIM, Chul-Joong , PARK, Sue-nie , PYO, Hyun-mi
发明人： SUNG, Moon-Hee , POO, Ha-Ryoung , LEE, Jong-Soo , JUNG, Chang-Min , HONG, Seung-Pyo , KIM, Chul-Joong , PARK, Sue-nie , PYO, Hyun-mi
IPC分类号： C12N15/63
CPC分类号： C07K14/005 , A61K39/0011 , A61K2039/523 , C12N7/00 , C12N2710/20022 , C12N2730/10122 , C12N2830/008
摘要： The current invention relates to expression vectors that can efficiently produce virion capsid protein, tumor-associated protein of human papillomavirus on a microbial surface and bacterial strains harboring such surface display vectors and the use of the bacterial strains or it's extract, purified products as complex vaccines. More particularly, the present invention relates to surface display vectors contains one or more than two genes selected among pgsB, pgsC and pgsA, encoding a poly- -glutamic acid synthetase complex (pgsBCA) of a Bacillus sp. Strain and genes which encode virion capsid proteins, tumor-associated proteins of human papillomavirus, and method for preparing the same.
摘要翻译：本发明涉及可以有效地产生病毒体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白在微生物表面上的表达载体和含有这种表面显示载体的细菌菌株以及使用细菌菌株或其提取物，纯化产物作为复合疫苗。更具体地，本发明涉及含有一个或多于两个选自pgsB，pgsC和pgsA的基因的表面显示载体，其编码芽孢杆菌属的多聚谷氨酸合成酶复合物（pgsBCA）。编码病毒载体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白的菌株和基因及其制备方法。

4. 发明申请

WO2009014334A2 MAGNETRON 审中-公开
标题翻译：磁控
公开(公告)号：WO2009014334A2
公开(公告)日：2009-01-29
申请号：PCT/KR2008/004122
申请日：2008-07-14
申请人： LG ELECTRONICS INC. , LEE, Young-Min , CHOI, Heung-Shik , LEE, Jong-Soo
发明人： LEE, Young-Min , CHOI, Heung-Shik , LEE, Jong-Soo
IPC分类号： H01J23/15
CPC分类号： H01J25/587 , H01J23/15
摘要： The present invention relates to a magnetron in which choke coils are disposed to be spaced from an insulator protruded at a lower portion of a yoke, at least one area of the choke coils is disposed above a lower surface of the insulator, and an upper insulating unit is disposed to extend an insulating distance to be longer than a distance between the choke coils and an above conductor. Accordingly, it is capable of shortening a height of a filter box in an axial direction of a cathode, thereby reducing a size of the magnetron. And, it is capable of reducing an installation space for a system or a device adapting the magnetron, thereby implementing a compact configuration of the system.
摘要翻译：磁控管技术领域本发明涉及一种磁控管，其中扼流圈设置成与在轭的下部突出的绝缘体间隔开，扼流线圈的至少一个区域设置在绝缘体的下表面上方，并且上绝缘体单元被设置成延伸绝缘距离比扼流线圈和上述导体之间的距离更长。因此，能够缩短过滤箱在阴极的轴向上的高度，从而减小磁控管的尺寸。并且，它能够减少系统或适配磁控管的设备的安装空间，从而实现系统的紧凑配置。

5. 发明申请

WO2007011150A1 PREPARATION OF GLYCEROL DERIVATIVES AND INTERMEDIATES THEREFOR 审中-公开
标题翻译：甘油衍生物的制备及其中间体
公开(公告)号：WO2007011150A1
公开(公告)日：2007-01-25
申请号：PCT/KR2006/002809
申请日：2006-07-18
申请人： ENZYCHEM CO., LTD. , LEE, Tae-Suk , YOOK, Jin-Soo , LEE, Jong-Soo , YOO, Chang-Hyun , LEE, Ju-Cheol , LEE, Cheol-Min , LEE, Wan-Hee
发明人： LEE, Tae-Suk , YOOK, Jin-Soo , LEE, Jong-Soo , YOO, Chang-Hyun , LEE, Ju-Cheol , LEE, Cheol-Min , LEE, Wan-Hee
IPC分类号： C07C41/50
CPC分类号： C11C3/04
摘要： Disclosed is a process for the regioselective preparation of glycerol derivative in a high efficiency and yield. The process for the regioselective preparation of 1-R 1 -2-R 2 - 3-acetyl-glycerol derivative comprises the steps of: obtaining 1-R 1 -3-protecting group-glycerol by introducing a protecting group to 3-position of 1-R 1 -glycerol; obtaining 1-R 1 -2-R 2 - 3-protecting group-glycerol by introducing R 2 group into 2-position of 1-R 1 -3-protecting group- glycerol; and carrying out the deprotection reaction and the acetylation reaction of 1-R 1 -2-R 2 - 3-protecting group-glycerol at the same time. Wherein, R 1 and R 2 are fatty acid groups having 16 to 22 carbon atoms, and are different from each other; and the protecting group is trityl group or trialkylsilyl group.
摘要翻译：公开了以高效率和高产率区域选择性制备甘油衍生物的方法。 1-R 1 - 2R-3-乙酰甘油衍生物的区域选择性制备方法包括以下步骤：获得1-R 1 通过将保护基引入1-R 1 - 甘油的3位;保护基 - 甘油; 通过将R 2 R 2基团引入1-位的2-位，得到1-R 1 -2-R 2 - 3 - 保护基 - 甘油， R 1〜3 - 保护基 - 甘油; 并同时进行1-R 1 - 2 - R 2 - 3 - 保护基 - 甘油的去保护反应和乙酰化反应。其中R 1和R 2是具有16-22个碳原子的脂肪酸基，并且彼此不同; 保护基为三苯甲基或三烷基甲硅烷基。

6. 发明申请

WO2010011952A2 HIGHLY POTENT PEPTIDES TO CONTROL CANCER AND NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：用于控制癌症和神经源性疾病的高度抑制剂
公开(公告)号：WO2010011952A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051730
申请日：2009-07-24
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , JUNG, Jae, U. , LEE, Jong-Soo
发明人： JUNG, Jae, U. , LEE, Jong-Soo
IPC分类号： A61K38/08
CPC分类号： A61K38/162 , A61K38/1761 , C07K7/08 , C07K14/005 , C07K14/4747 , C07K2319/10 , C12N7/00 , C12N2710/16422
摘要： This invention provides compositions and method of diminishing or inhibiting autophagy by administering a FLIP protein that binds to Atg3, interfering with the formation of the LC3-Atg4-Atg7-Atg3 conjugation complex necessary for autophagy induction. This invention also provides FLIP peptide fragments that promote or induce autophagy by interfering with the activity of FLIP.
摘要翻译：本发明提供通过施用结合Atg3的FLIP蛋白来减少或抑制自噬的组合物和方法，干扰自噬诱导所必需的LC3-Atg4-Atg7-Atg3缀合复合物的形成。本发明还提供通过干扰FLIP的活性来促进或诱导自噬的FLIP肽片段。

7. 发明申请

WO2007094577A1 BIO ARTIFICIAL LACRIMAL CANALICULUS 审中-公开
标题翻译：生物人工食管癌
公开(公告)号：WO2007094577A1
公开(公告)日：2007-08-23
申请号：PCT/KR2007/000605
申请日：2007-02-05
申请人： JUN, Mal-Soo , IHN, Kyo-Jin , LEE, Jong-Soo
发明人： JUN, Mal-Soo , IHN, Kyo-Jin , LEE, Jong-Soo
IPC分类号： A61F2/04
CPC分类号： A61F9/00772 , A61L27/446 , A61L2430/16
摘要： The present invention is an artificial lacrimal canaliculus which can be used when a lacrimal canaliculus becomes clogged, and includes tourmaline, any one of nano silver, nano gold and nano platinum, and any one of PP, PE, Pyrex and PMMA.. This artificial lacrimal canaliculus has bactericidal activity or antibacterial activity on pathogenic bacteria, and is beneficial to the human body compared to the case of wearing a conventional artificial lacrimal canaliculus made of Pyrex, because far infrared rays and anions are emitted. The artificial lacrimal canaliculus mainly has a cylindrical shape, but may be manufactured to have a funnel shape, an upper portion of which is formed to be wide. Furthermore, the artificial lacrimal canaliculus may be provided on an outer circumference thereof with a thread or protrusions, and can be strongly fixed around an eye socket, and prevented from falling into a nasal cavity in the case where it is fixed to a lacrimal bone.
摘要翻译：本发明是一种人造泪小管，当泪小管堵塞时可以使用，包括电气石，纳米银，纳米金和纳米铂中的任一种，以及PP，PE，Pyrex和PMMA中的任一种。泪管对致病菌具有杀菌活性或抗菌活性，与佩戴由Pyrex制成的常规人造泪道的情况相比，对人体有益，因为发射远红外线和阴离子。人造泪小管主要具有圆筒形状，但是可以制造为具有漏斗形状，其上部形成为宽。此外，人造泪小管可以在其外周上设置有线或突起，并且可以牢固地固定在眼窝周围，并且在固定到泪液的情况下防止其落入鼻腔中。

8. 发明申请

WO2003041608A1 TOOTH-CLEANING PAPER COMBINED WITH DENTAL FLOSS 审中-公开
标题翻译：牙齿清洁纸组合
公开(公告)号：WO2003041608A1
公开(公告)日：2003-05-22
申请号：PCT/KR2002/002098
申请日：2002-11-11
申请人： LEE, Jong-Soo
发明人： LEE, Jong-Soo
IPC分类号： A61C15/04
CPC分类号： A61C15/04
摘要： Disclosed is a tooth-cleaning paper combined with a dental floss, characterized by combining the dental floss functioning to remove interdental debris to the tooth-cleaning paper for use in scrubbing food debris stuck onto the teeth. Thereby, food debris stuck onto or held between the teeth is easily removed while the mouth is hidden with the cleaning paper, thus not giving other persons an unpleasant feeling. Further, the dental floss which conventionally suffers from difficult storage and excessive use due to slipping thereof is easily and economically used in state combined to the cleaning paper.
摘要翻译：公开了一种与牙线结合的牙齿清洁纸，其特征在于将牙线组合起来，以将齿间碎屑移除到牙齿清洁纸上，以用于擦洗卡在牙齿上的食物碎屑。因此，粘贴在牙齿上或夹在牙齿之间的食物碎屑容易地被清除，同时嘴唇被清洁纸遮住，从而不会给别人带来不愉快的感觉。此外，通常由于其滑动而难以储存和过度使用的牙线在与清洁纸组合的状态下容易且经济地使用。

9. 发明申请

WO2010124212A2 MATERIALS AND METHODS FOR THE PREPARATION OF NANOCOMPOSITES 审中-公开
标题翻译：制备纳米复合材料的材料和方法
公开(公告)号：WO2010124212A2
公开(公告)日：2010-10-28
申请号：PCT/US2010/032246
申请日：2010-04-23
申请人： THE UNIVERSITY OF CHICAGO , TALAPIN, Dmitri V. , KOVALENKO, Maksym V. , LEE, Jong-Soo , JIANG, Chengyang
发明人： TALAPIN, Dmitri V. , KOVALENKO, Maksym V. , LEE, Jong-Soo , JIANG, Chengyang
IPC分类号： C09K9/00
CPC分类号： H01L35/16 , B82Y30/00 , B82Y40/00 , C01B19/002 , C01B19/007 , C01P2002/52 , C01P2002/72 , C01P2002/84 , C01P2002/85 , C01P2004/03 , C01P2004/04 , C01P2004/16 , C09D1/00 , C09D5/22 , C09D5/24 , C09K11/025 , C09K11/562 , C09K11/565 , C09K11/883 , C30B7/00 , C30B29/40 , C30B29/46 , C30B29/60 , H01B1/06 , H01B1/10
摘要： Disclosed herein is an isolable colloidal particle comprising a nanoparticle and an inorganic capping agent bound to the surface of the nanoparticle, a solution of the same, a method for making the same from a biphasic solvent mixture, and the formation of structures and solids from the isolable colloidal particle. The process can yield photovoltaic cells, piezoelectric crystals, thermoelectric layers, optoelectronic layers, light emitting diodes, ferroelectric layers, thin film transistors, floating gate memory devices, imaging devices, phase change layers, and sensor devices.
摘要翻译：本文公开了一种可分离的胶体颗粒，其包含与纳米颗粒的表面结合的纳米颗粒和无机封端剂，其溶液，从双相溶剂混合物制备该纳米颗粒的方法，以及从可分离胶体颗粒。该方法可以产生光伏电池，压电晶体，热电层，光电子层，发光二极管，铁电层，薄膜晶体管，浮动栅极存储器件，成像器件，相变层和传感器器件。

10. 发明申请

WO2008120874A1 TAX REPAYMENT METHOD FOR FOREIGNER 审中-公开
标题翻译：外国人收税方式
公开(公告)号：WO2008120874A1
公开(公告)日：2008-10-09
申请号：PCT/KR2008/001224
申请日：2008-03-04
申请人： RYU, Jae-Keun , LEE, Jong-Soo
发明人： RYU, Jae-Keun , LEE, Jong-Soo
IPC分类号： G06Q40/00
CPC分类号： G06Q20/20 , G06Q20/40 , G06Q40/02 , G07F7/10 , G07G1/0036 , G07G5/00
摘要： The present invention relates to a method of refunding value-added taxes to foreigners, in which when a foreigner purchases certain merchandise at a duty-free store, the value-added tax included in the amount paid for the merchandise is conveniently refunded to the foreigner. According to the present invention, a tax refund slip is not issued separately, but details of entire tax refunds are easily confirmed and printed through a dedicated apparatus, thereby improving efficiency of a tax refund procedure.
摘要翻译：本发明涉及向外国人退还增值税的方法，当外国人在免税店购买某些商品时，包含在商品支付的金额的增值税方便地退还给外国人。根据本发明，不单独发行退税单，而是通过专用装置容易地确认和打印整个退税的细节，从而提高退税程序的效率。

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