专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009152825A1 NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS 审中-公开
标题翻译：新型苯并咪唑衍生物作为PDE10A酶抑制剂
公开(公告)号：WO2009152825A1
公开(公告)日：2009-12-23
申请号：PCT/DK2009/050134
申请日：2009-06-19
申请人： H. Lundbeck A/S , RITZÉN, Andreas , KEHLER, Jan , LANGGÅRD, Morten , NIELSEN, Jacob , KILBURN, John Paul , FARAH, Mohamed M.
发明人： RITZÉN, Andreas , KEHLER, Jan , LANGGÅRD, Morten , NIELSEN, Jacob , KILBURN, John Paul , FARAH, Mohamed M.
IPC分类号： C07D403/12 , C07D487/04 , A61K31/519 , A61K31/4353 , A61K31/4184 , A61P25/00
CPC分类号： C07D487/04 , C07D403/12 , C07D471/04
摘要： This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective, amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).
摘要翻译：本发明涉及PDE10A酶抑制剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供制备式（I）化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括给予受试者治疗有效量的式（I）化合物。本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式（I）化合物。本发明还提供了治疗患有精神障碍的受试者的方法，其包括向受试者施用治疗有效量的式（I）化合物。

2. 发明申请

WO2010145668A1 NOVEL PHENYLIMIDAZOLE DERIVATIVE AS PDE10A ENZYME INHIBITOR 审中-公开
标题翻译：新型苯乙烯胺衍生物作为PDE10A酶抑制剂
公开(公告)号：WO2010145668A1
公开(公告)日：2010-12-23
申请号：PCT/DK2010/050147
申请日：2010-06-17
申请人： H. LUNDBECK A/S , RITZEN, Andreas , KEHLER, Jan , LANGGÅRD, Morten , NIELSEN, Jacob , KILBURN, John Paul , FARAH, Mohamed M.
发明人： RITZEN, Andreas , KEHLER, Jan , LANGGÅRD, Morten , NIELSEN, Jacob , KILBURN, John Paul , FARAH, Mohamed M.
IPC分类号： C07D403/12 , C07D487/04 , A61K31/519 , A61K31/4353 , A61K31/4184 , A61P25/00
CPC分类号： C07D487/04
摘要： This invention provides the compound 5,8-Dimethyl-2-[2-(1 -methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]thazolo[1,5-a]pyrazine and pharmaceutically acceptable acid addition salts thereof.
摘要翻译：本发明提供化合物5,8-二甲基-2- [2-（1-甲基-4-苯基-1H-咪唑-2-基） - 乙基] - [1,2,4]噻唑并[1,5- a]吡嗪及其药学上可接受的酸加成盐。

3. 发明申请

WO2012007006A1 TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR 审中-公开
标题翻译：作为PDE10A酶抑制剂的三唑并 - 吡唑并喹啉衍生物
公开(公告)号：WO2012007006A1
公开(公告)日：2012-01-19
申请号：PCT/DK2011/050278
申请日：2011-07-15
申请人： H. LUNDBECK A/S , KEHLER, Jan , RITZÉN, Andreas , LANGGÅRD, Morten , NIELSEN, Jacob , FARAH, Mohamed , LETH-PETERSEN, Sebastian , KILBURN, John Paul
发明人： KEHLER, Jan , RITZÉN, Andreas , LANGGÅRD, Morten , NIELSEN, Jacob , FARAH, Mohamed , LETH-PETERSEN, Sebastian , KILBURN, John Paul
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention relates to compounds of the formula (I) and their use as pharmaceutical ingredients, in particular for the treatment of CNS related diseases.
摘要翻译：本发明涉及式（I）化合物及其作为药物成分的用途，特别是用于治疗CNS相关疾病。

4. 发明申请

WO2012000519A1 ARYL- AND HETEROARYLAMID DERIVATIVES AS PDE10A ENZYME INHIBITOR 审中-公开
标题翻译：作为PDE10A酶抑制剂的ARYL-和HETEROARYLAMID衍生物
公开(公告)号：WO2012000519A1
公开(公告)日：2012-01-05
申请号：PCT/DK2011/050257
申请日：2011-07-01
申请人： H. LUNDBECK A/S , KEHLER, Jan , LARSEN, Mogens , ERICHSEN, Mette Norman , LETH-PETERSEN, Sebastian , KILBURN, John Paul
发明人： KEHLER, Jan , LARSEN, Mogens , ERICHSEN, Mette Norman , LETH-PETERSEN, Sebastian , KILBURN, John Paul
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/4427 , A61K31/4178 , A61P25/18 , A61P25/28
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The invention relates to compounds of the formula and their use as pharmaceutical ingredients, in particular for the treatment of CNS related diseases (PDE 10A inhibitors).
摘要翻译：本发明涉及式的化合物及其作为药物成分的用途，特别是用于治疗CNS相关疾病（PDE 10A抑制剂）。

5. 发明申请

WO2013107856A1 IMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS 审中-公开
标题翻译：咪唑衍生物作为PDE10A酶抑制剂
公开(公告)号：WO2013107856A1
公开(公告)日：2013-07-25
申请号：PCT/EP2013/050932
申请日：2013-01-18
申请人： H. LUNDBECK A/S
发明人： KEHLER, Jan , KILBURN, John Paul , JESSING, Mikkel , NIELSEN, Jacob
IPC分类号： C07D519/00 , A61K31/4985 , A61P25/18 , A61P25/28
CPC分类号： C07D519/00
摘要： This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
摘要翻译：本发明涉及PDE10A酶抑制剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神障碍的受试者的方法，其包括向治疗有效量的式I化合物。本发明涉及化合物，其为PDE10A酶抑制剂。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神障碍的受试者的方法，其包括向治疗有效量的式I化合物。

6. 发明申请

WO2013092974A1 QUINOLINE DERIVATIVES AS PDE10A ENZYME INHIBITORS 审中-公开
标题翻译：喹啉衍生物作为PDE10A酶抑制剂
公开(公告)号：WO2013092974A1
公开(公告)日：2013-06-27
申请号：PCT/EP2012/076590
申请日：2012-12-21
申请人： H. LUNDBECK A/S
发明人： KEHLER, Jan , NIELSEN, Jacob , PÜSCHL, Ask , KILBURN, John Paul , LANGGÅRD, Morten
IPC分类号： C07D471/04
CPC分类号： A61K31/4985 , A61K31/4709 , A61K31/519 , C07D471/04 , C07D487/04
摘要： The present invention provides quinoline derivatives of formula (I) that are PDE10A enzyme inhibitors, and as such are useful to treat neurodegenerative and psychiatric disorders. Especially, the invention provides compounds that are highly selective for PDE10 over other PDE subtypes. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.
摘要翻译：本发明提供式（I）的喹啉衍生物，其为PDE10A酶抑制剂，因此可用于治疗神经变性和精神疾病。特别地，本发明提供对PDE10比其它PDE亚型具有高度选择性的化合物。本发明还提供包含本发明化合物的药物组合物和使用本发明化合物治疗病症的方法。

7. 发明申请

WO2014057080A2 CYCLIC AMINES 审中-公开
标题翻译：循环氨基酸
公开(公告)号：WO2014057080A2
公开(公告)日：2014-04-17
申请号：PCT/EP2013/071253
申请日：2013-10-11
申请人： H. LUNDBECK A/S
发明人： KILBURN, John Paul , RASMUSSEN, Lars Kyhn , JESSING, Mikkel , ELDEMENKY, Eman Mohammed , CHEN, Bin , JIANG, Yu
IPC分类号： C07D401/06 , A61K31/40 , A61K31/4453 , A61K31/4545 , A61K31/5375 , A61K31/5377 , A61K31/553 , C07D403/06 , C07D239/26 , C07D413/06 , C07D267/10 , C07D209/52 , C07D295/13 , C07D213/40
CPC分类号： A61K31/553 , A61K31/40 , A61K31/445 , A61K31/4453 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/625 , C07D209/52 , C07D211/38 , C07D213/40 , C07D239/26 , C07D267/10 , C07D295/13 , C07D401/06 , C07D403/06 , C07D413/06
摘要： The present invention is directed to novel cyclic amines which inhibit the P2X 7 receptor.
摘要翻译：本发明涉及抑制P2X7受体的新型环胺。

8. 发明申请

WO2013050527A1 QUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITORS 审中-公开
标题翻译：喹喔啉衍生物作为PDE10A酶抑制剂
公开(公告)号：WO2013050527A1
公开(公告)日：2013-04-11
申请号：PCT/EP2012/069718
申请日：2012-10-05
申请人： H. LUNDBECK A/S
发明人： KEHLER, Jan , KILBURN, John Paul , NIELSEN, Jacob , PÜSCHL, Ask , LANGGÅRD, Morten , JESSING, Mikkel , MARIGO, Mauro
IPC分类号： C07D403/06 , C07D403/12 , C07D417/14 , C07D403/02 , A61K31/381 , A61K31/505 , A61P25/00
CPC分类号： C07D403/06 , C07D403/02 , C07D403/12 , C07D417/14
摘要： This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
摘要翻译：本发明涉及PDE10A酶抑制剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神障碍的受试者的方法，其包括向治疗有效量的式I化合物。

9. 发明申请

WO2013045607A1 QUINAZOLINE LINKED HETEROAROMATIC TRICYCLE DERIVATIVES AS PDE10A ENZYME INHIBITORS 审中-公开
标题翻译：喹喔啉连接异佛尔酮衍生物作为PDE10A酶抑制剂
公开(公告)号：WO2013045607A1
公开(公告)日：2013-04-04
申请号：PCT/EP2012/069179
申请日：2012-09-28
申请人： H. LUNDBECK A/S
发明人： MARIGO, Mauro , KILBURN, John Paul , NIELSEN, Jacob , PÜSCHL, Ask , LANGGÅRD, Morten , JESSING, Mikkel , KEHLER, Jan
IPC分类号： C07D471/14 , C07D487/04 , A61K31/4184 , A61K31/437 , A61P25/00
CPC分类号： C07D471/14 , C07D487/04
摘要： This invention is directed to compounds of formula I which are PDE10A enzyme inhibitors, pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier and processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder, a drug addiction or a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. Formula I, wherein Q is selected from the group consisting of (Q1), (Q2), (Q3), (Q4), and (Q5).
摘要翻译：本发明涉及式I化合物，其为PDE10A酶抑制剂，药物组合物，其包含治疗有效量的本发明化合物和药学上可接受的载体以及制备式I化合物的方法。本发明进一步提供治疗患有神经变性疾病，药物成瘾或精神障碍的受试者的方法，其包括给予受试者治疗有效量的式I化合物。式I其中Q选自（Q1），（Q2），（Q3），（Q4）和（Q5）。

10. 发明申请

WO2014057078A1 BENZAMIDES 审中-公开
标题翻译：苯甲酰胺类
公开(公告)号：WO2014057078A1
公开(公告)日：2014-04-17
申请号：PCT/EP2013/071247
申请日：2013-10-11
申请人： H. LUNDBECK A/S
发明人： KILBURN, John Paul , RASMUSSEN, Lars Kyhn , JESSING, Mikkel , ELDEMENKY, Eman Mohammed , CHEN, Bin , JIANG, Yu , HOPPER, Allen T.
IPC分类号： C07D309/04 , C07D231/12 , C07D233/64 , C07D401/06 , C07D403/04 , C07D403/06 , C07D237/08 , C07D405/04 , C07D239/26 , C07C233/66 , C07C233/73 , C07C233/78 , C07D211/26 , C07D213/40 , C07D213/61
CPC分类号： A61K31/505 , C07C233/66 , C07C233/73 , C07C233/75 , C07C233/78 , C07C2601/08 , C07D211/26 , C07D213/40 , C07D213/61 , C07D231/12 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12 , C07D309/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06
摘要： The present application relates to compounds of formula (I), wherein R1 to R5 are as defined in claim 1, a pharmaceutical composition thereof and said compounds for use in the treatment of diseases related with the activity of P2X7 receptor.
摘要翻译：本申请涉及式（I）化合物，其中R 1至R 5如权利要求1所定义，其药物组合物和用于治疗与P2X7受体活性相关的疾病的所述化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式