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1. 发明申请

WO2004071454A2 SUBSTITUTED AZETIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV 审中-公开
标题翻译：取代的化合物作为DIPEPTIDYL PEPTIDASE IV的抑制剂
公开(公告)号：WO2004071454A2
公开(公告)日：2004-08-26
申请号：PCT/US2004/004222
申请日：2004-02-13
申请人： GUILFORD PHARMACEUTICALS INC. , LI, Weixing , OLIVER, Eddie, Jr. , ROJAS, Camilo , KALISH, Vincent , BELYAKOV, Sergei
发明人： LI, Weixing , OLIVER, Eddie, Jr. , ROJAS, Camilo , KALISH, Vincent , BELYAKOV, Sergei
IPC分类号： A61K
CPC分类号： C07D401/12 , C07D205/04 , C07D403/06
摘要： Novel azetidine-derived inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of such inhibitors, and novel methods of treating medical conditions are provided. The novel DPP IV inhibitors described herein feature an azetidine ring substituted with one or more groups selected from fluoro-, di-fluoro, oxo-, cyano, alkoxy, and alkyl, and are useful in the treatment of neurological disorders, mental illness, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other medical conditions as can be treated with inhibitors of DPP IV.
摘要翻译：提供了新的氮杂环丁烷衍生的二肽基肽酶IV（DPP IV）的抑制剂，包含治疗有效量的这种抑制剂的药物组合物和治疗医学病症的新方法。本文所述的新型DPP IV抑制剂特征在于被一个或多个选自氟，二氟，氧代，氰基，烷氧基和烷基的基团取代的氮杂环丁烷环，并且可用于治疗神经障碍，精神疾病，糖尿病，炎症性疾病如关节炎，肥胖症，骨质疏松症以及可用DPP IV抑制剂治疗的其它医学病症。

2. 发明申请

WO2003057144A3 CHANGE INHIBITORS OF DIPEPTIDYL PEPTIDASE IV 审中-公开
公开(公告)号：WO2003057144A3
公开(公告)日：2003-07-17
申请号：PCT/US2002/041134
申请日：2002-12-24
申请人： GUILFORD PHARMACEUTICALS , BELYAKOV, Sergei , HAMILTON, Gregory, S. , LI, Weixing , XU, William , HURST, David, Chadwick , KALISH, Vincent, J. , WU, Yong-Qian , WANG, Eric , WILKINSON, Douglas
发明人： BELYAKOV, Sergei , HAMILTON, Gregory, S. , LI, Weixing , XU, William , HURST, David, Chadwick , KALISH, Vincent, J. , WU, Yong-Qian , WANG, Eric , WILKINSON, Douglas
IPC分类号： C07D209/02
摘要： Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.

3. 发明申请

WO2003057666A2 INHIBITORS OF DIPEPTIDYL PEPTIDASE IV 审中-公开
标题翻译：二磷酸二肽酶抑制剂IV
公开(公告)号：WO2003057666A2
公开(公告)日：2003-07-17
申请号：PCT/US2002/041469
申请日：2002-12-26
申请人： GUILFORD PHARMACEUTICALS , BELYAKOV, Sergei , HAMILTON, Gregory, S. , HURST, David, Chadwick , KALISH, Vincent, J. , LI, Weixing , WANG, Eric , WILKINSON, Douglas , WU, Yong-Qian , XU, Weizheng
发明人： BELYAKOV, Sergei , HAMILTON, Gregory, S. , HURST, David, Chadwick , KALISH, Vincent, J. , LI, Weixing , WANG, Eric , WILKINSON, Douglas , WU, Yong-Qian , XU, Weizheng
IPC分类号： C07D
CPC分类号： C07D209/48 , A61K38/00 , C04B35/632 , C07D205/04 , C07D207/04 , C07D207/16 , C07D207/20 , C07D207/22 , C07D209/42 , C07D209/46 , C07D217/14 , C07D217/16 , C07D217/26 , C07D263/06 , C07D277/04 , C07D277/06 , C07D295/125 , C07D295/185 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07K5/06156 , C07K5/0821
摘要： Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.
摘要翻译：提供了新的二肽基肽酶IV抑制剂（DPP IV），包含治疗有效量的DPP IV新型抑制剂的药物组合物，以及治疗医学病症的新方法。本文所述的新型DPP IV抑制剂可用于治疗神经疾病，糖尿病，炎性疾病如关节炎，肥胖症，骨质疏松症，以及可用DPP IV抑制剂治疗的其他计数疾病。

4. 发明申请

WO2003057144A2 CHANGE INHIBITORS OF DIPEPTIDYL PEPTIDASE IV 审中-公开
标题翻译：替代肽的变化抑制剂IV
公开(公告)号：WO2003057144A2
公开(公告)日：2003-07-17
申请号：PCT/US2002/041134
申请日：2002-12-24
申请人： GUILFORD PHARMACEUTICALS , BELYAKOV, Sergei , HAMILTON, Gregory, S. , LI, Weixing , XU, William , HURST, David, Chadwick , KALISH, Vincent, J. , WU, Yong-Qian , WANG, Eric , WILKINSON, Douglas
发明人： BELYAKOV, Sergei , HAMILTON, Gregory, S. , LI, Weixing , XU, William , HURST, David, Chadwick , KALISH, Vincent, J. , WU, Yong-Qian , WANG, Eric , WILKINSON, Douglas
IPC分类号： A61K
CPC分类号： C07D209/48 , A61K38/00 , C04B35/632 , C07D205/04 , C07D207/04 , C07D207/16 , C07D207/20 , C07D207/22 , C07D209/42 , C07D209/46 , C07D217/14 , C07D217/16 , C07D217/26 , C07D263/06 , C07D277/04 , C07D277/06 , C07D295/125 , C07D295/185 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07K5/06156 , C07K5/0821
摘要： Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.
摘要翻译：提供了二肽基肽酶IV（DPP IV）的新型抑制剂，包含治疗有效量的新型DPP IV抑制剂的药物组合物，以及治疗医学病症的新方法。本文描述的DPP IV的新型抑制剂可用于治疗神经障碍，糖尿病，炎症性疾病如关节炎，肥胖症，骨质疏松症以及可用DPP IV抑制剂治疗的其他列举的病症。

5. 发明申请

WO2003057666A3 INHIBITORS OF DIPEPTIDYL PEPTIDASE IV 审中-公开
公开(公告)号：WO2003057666A3
公开(公告)日：2003-07-17
申请号：PCT/US2002/041469
申请日：2002-12-26
申请人： GUILFORD PHARMACEUTICALS , BELYAKOV, Sergei , HAMILTON, Gregory, S. , HURST, David, Chadwick , KALISH, Vincent, J. , LI, Weixing , WANG, Eric , WILKINSON, Douglas , WU, Yong-Qian , XU, Weizheng
发明人： BELYAKOV, Sergei , HAMILTON, Gregory, S. , HURST, David, Chadwick , KALISH, Vincent, J. , LI, Weixing , WANG, Eric , WILKINSON, Douglas , WU, Yong-Qian , XU, Weizheng
IPC分类号： C07D403/06
摘要： Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.

6. 发明申请

WO2019245573A1 COMMUNITY WATCH WITH BOT-BASED UNIFIED SOCIAL NETWORK GROUPS 审中-公开
公开(公告)号：WO2019245573A1
公开(公告)日：2019-12-26
申请号：PCT/US2018/038922
申请日：2018-06-22
申请人： LI, Jun , LI, Weixing
发明人： LI, Jun , LI, Weixing
IPC分类号： G06Q99/00
摘要： The present disclosure includes the methods, processes, and systems of a novel community watch with bot-based unified social network groups. The new community watch comprises chatbots, artificial intelligence (Al) engine, social network messaging platforms used by community watch groups with security services based on identity recognition technology and physical threat intelligent information technology. This process turns meaningless text, sensor data, images and videos into context-based physical security information to be analyzed by the/a physical security information and event management system. The analyzed information including the threat severity scores will be sent back to social messaging platforms and varieties of activity options. The various said groups in the heterogeneous social networking and messaging platforms are combined and fused into the unified social network groups through the bots. The present disclosure nicely adapts and integrates new technologies and modern society. The bots and unified social network groups allow users to easily and intuitively use and interact with the community watch system, so the improved process and system can be more widely established, used, and made more effective in adding community security and protecting people.

7. 发明申请

WO2011057209A1 ACIDIC OPHTHALMIC FORMULATIONS 审中-公开
标题翻译：酸性眼科配方
公开(公告)号：WO2011057209A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/055862
申请日：2010-11-08
申请人： QLT, INC. , PATIL, Ghanshyam , LI, Weixing , SENKO, Marina
发明人： PATIL, Ghanshyam , LI, Weixing , SENKO, Marina
IPC分类号： A01N43/08 , A61K31/34
CPC分类号： A61K31/34 , A61K9/0048 , A61K47/36 , A61K47/38
摘要： The invention is directed to ophthalmic formulations formulated to be below physiological pH.
摘要翻译：本发明涉及配制成低于生理pH的眼用制剂。

8. 发明申请

WO2014081988A1 EXTRACTION AND PURIFICATION OF URUSHIOL FROM BOTANICAL SOURCES 审中-公开
标题翻译：从植物来源提取和纯化尿素
公开(公告)号：WO2014081988A1
公开(公告)日：2014-05-30
申请号：PCT/US2013/071355
申请日：2013-11-21
申请人： ROWAN UNIVERSITY , YANG, Catherine, F. , LI, Weixing , ELLIOTT, Ryan , ILTCHENCKO, Nikita
发明人： YANG, Catherine, F. , LI, Weixing , ELLIOTT, Ryan , ILTCHENCKO, Nikita
IPC分类号： A61K36/22 , B01D11/00
CPC分类号： C07C35/14 , A61K36/22 , A61K2236/00 , B01D11/02 , B01D11/0288
摘要： The disclosure relates to methods for preparing urushiol from plants including, for example, poison ivy or poison oak. The methods include extraction of plant material using a primary organic solvent more polar than ethanol, followed by a solvent extraction using substantially immiscible solvents having substantially different polarities, such as hexane and acetonitrile. The method can include further purification, such as by fractionation of solvent- extracted materials using a thiazole-derivatized silica gel chromatography medium. The extracts thus generated can exhibit greater purity, higher concentration, and greater stability than extracts made using previously-known methods. The extracts can be particularly suitable for use in immunotherapeutic methods, such as desensitizing individuals who normally develop allergic contact dermatitis attributable to poison ivy or poison oak.
摘要翻译：本公开涉及从植物制备漆酚的方法，包括例如毒藤或毒栎。所述方法包括使用比乙醇更极性的主要有机溶剂提取植物材料，然后使用基本上不相溶的溶剂（其具有基本上不同的极性，例如己烷和乙腈）进行溶剂萃取。该方法可以包括进一步的纯化，例如通过使用噻唑衍生化的硅胶色谱介质对溶剂萃取物进行分级分离。由此产生的提取物可以表现出比使用先前已知方法制备的提取物更高的纯度，更高的浓度和更高的稳定性。提取物可以特别适用于免疫治疗方法，例如通常发生归因于毒藤或毒栎的过敏性接触性皮炎的个体脱敏。

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