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1. 发明申请

WO2003070715A1 AN ANTIMICROBIAL AGENT 审中-公开
标题翻译：抗菌药物
公开(公告)号：WO2003070715A1
公开(公告)日：2003-08-28
申请号：PCT/AU2003/000222
申请日：2003-02-21
申请人： GRIFFITH UNIVERSITY , MONASH UNIVERSITY , VON ITZSTEIN, Laurence, Mark , COPPEL, Ross, Leon , DAVIS, Christopher, Bonner , THOMSON, Robin, Joy , OWEN, David, James
发明人： VON ITZSTEIN, Laurence, Mark , COPPEL, Ross, Leon , DAVIS, Christopher, Bonner , THOMSON, Robin, Joy , OWEN, David, James
IPC分类号： C07D307/20
CPC分类号： A61K31/341 , C07D307/20
摘要： A compound of general formula (I): wherein R1 and R2 may be the same or different and are selected from the group consisting of hydrogen, optionally substituted C4-30 alkyl and optionally substituted C4-30 alkenyl, provided that R1 and R2 may not both be hydrogen, or R1 and R2 together with the nitrogen atom from which they depend form a saturated or unsaturated, optionally substituted heterocyclic group which may include additional heteroatoms selected from the group consisting of O, N and S, or R1 and R2 together with the nitrogen atom from which they depend form an optionally substituted lactam moiety; X1 is selected from the group consisting of OR3, SR3, NR3R'3, hydrogen, halogen, CN, C(O)NR3R'3, C(O)OR3, OSO3R3, OPO3R3, NNR3R'3, SNR3R'3, NHSR3, SSR3 and substituted alkyl; X2 is selected from the group consisting of OR4, SR4, NR4R'4, hydrogen, halogen, CN, C(O)NR4R'4, C(O)OR4, OSO3R4, OPO3R4, NNR4R'4, SNR4R'4, NHSR4, SSR4 and substituted alkyl; X3 is selected from the group consisting of OR5, SR5, NR5R'5, hydrogen, halogen, CN, C(O)NR5R'5, C(O)OR5, OSO3R5, OPO3R5R'5, NNR5R'5, SNR5R'5, NHSR5, SSR5 and substituted alkyl; X4 is selected from the group consisting of OR6, SR6, NR6R'6, hydrogen, halogen, CN, C(O)NR6R'6, C(O)OR6, OSO3R6, OPO3R6R'6, NNR6R'6, SNR6R'6, NHSR6, SSR6 and substituted alkyl; R3, R'3, R4, R'4, R5, R'5, R6 and R'6 are the same or different and are selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted aralkyl, optionally substituted aryl, optionally substituted acyl and a carbohydrate moiety; or a pharmaceutically acceptable salt thereof.
摘要翻译：通式I的化合物：其中R 1和R 2可以相同或不同，并且选自氢，任选取代的C 4-30烷基和任选取代的C 4-30烯基，条件是R 1和R 2不能均为氢或R1和R2与它们所依赖的氮原子一起形成饱和或不饱和的任选取代的杂环基，其可以包括另外的选自O，N和S的杂原子，或者R 1和R 2与氮它们所依赖的原子形成任选取代的内酰胺部分X1选自OR3，SR3，NR3R'3，氢，卤素，CN，CONR3R'3，COOR3，OSO3R3，OPO3R3，NNR3R'3，SNR3R'3 ，NHSR 3，SSR 3和取代的烷基X 2选自OR4，SR4，NR4R'4，氢，卤素，CN，CONR4R'4，COOR4，OSO3R4，OPO3R4，NNR4R4，SNR4R'4，NHSR4，SSR4 并且取代的烷基X 3选自OR 5，S R5，NR5R'5，氢，卤素，CN，CONR5R'5，COOR5，OSO3R5，OPO3R5R'5，NNR5R'5，SNR5R'5，NHSR5，SSR5和取代的烷基X4选自OR6，SR6， NR6R'6，氢，卤素，CN，CONR6R'6，COOR6，OSO3R6，OPO3R6R'6，NNR6R'6，SNR6R'6，NHSR6，SSR6和取代的烷基R3，R'3，R4，R'4，R5， R'5，R 6和R 6相同或不同，并且选自氢，任选取代的烷基，任选取代的芳烷基，任选取代的芳基，任选取代的酰基和碳水化合物部分或其药学上可接受的盐。

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