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1. 发明申请

WO2010036344A3 COMPOSITIONS, ORAL CARE PRODUCTS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：组合物，口腔护理产品及其制造和使用方法
公开(公告)号：WO2010036344A3
公开(公告)日：2010-07-08
申请号：PCT/US2009005302
申请日：2009-11-20
申请人： GRACE GMBH & CO KG , MILLER JAMES GEORGE , HOEFER HANS H , GEURTSEN WERNER , LUCKER PETER , WIENS MATTHIAS , SCHROEDER HEINZ C , MUELLER WERNER E
发明人： MILLER JAMES GEORGE , HOEFER HANS H , GEURTSEN WERNER , LUCKER PETER , WIENS MATTHIAS , SCHROEDER HEINZ C , MUELLER WERNER E
IPC分类号： A61K8/66
CPC分类号： A61K8/24 , A61K8/25 , A61K8/66 , A61K8/85 , A61Q11/00
摘要： Compositions and oral care products are disclosed. Methods of making and using compositions and oral care products are also disclosed.
摘要翻译：披露了组合物和口腔护理产品。还公开了制造和使用组合物和口腔护理产品的方法。

2. 发明申请

WO2010036344A2 COMPOSITIONS, ORAL CARE PRODUCTS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：组合物，口腔护理产品及其制备和使用方法
公开(公告)号：WO2010036344A2
公开(公告)日：2010-04-01
申请号：PCT/US2009005302
申请日：2009-11-20
申请人： GRACE GMBH & CO KG , MILLER JAMES GEORGE , HOEFER HANS H , GEURTSEN WERNER , LUCKER PETER , WIENS MATTHIAS , SCHROEDER HEINZ C , MUELLER WERNER E
发明人： MILLER JAMES GEORGE , HOEFER HANS H , GEURTSEN WERNER , LUCKER PETER , WIENS MATTHIAS , SCHROEDER HEINZ C , MUELLER WERNER E
IPC分类号： A61K8/66
CPC分类号： A61K8/24 , A61K8/25 , A61K8/66 , A61K8/85 , A61Q11/00
摘要： Compositions and oral care products are disclosed. Methods of making and using compositions and oral care products are also disclosed.
摘要翻译：公开了组合物和口腔护理产品。还公开了制备和使用组合物和口腔护理产品的方法。

3. 发明申请

WO2008022774A3 BIOSILICA-ADHESIVE PROTEIN NANOCOMPOSITE MATERIALS: SYNTHESIS AND APPLICATION IN DENTISTRY 审中-公开
标题翻译：生物胶粘剂蛋白纳米复合材料的制备及在牙齿整形中的应用
公开(公告)号：WO2008022774A3
公开(公告)日：2008-08-21
申请号：PCT/EP2007007363
申请日：2007-08-21
申请人： GEURTSEN WERNER K , MUELLER WERNER E G , SCHROEDER HEINZ C
发明人： GEURTSEN WERNER K , MUELLER WERNER E G , SCHROEDER HEINZ C
IPC分类号： C12N15/62 , C07K14/435
CPC分类号： C12N15/62 , A61K6/0008 , A61K6/0073 , A61K6/0088 , A61K6/0235 , A61K6/024 , A61K6/0255 , C07K14/43504 , C07K14/43586 , C07K2319/50 , C12N9/88 , A61K6/0023 , C08L89/00 , A61K6/0017 , C08L83/04 , A61K6/093 , A61K6/087
摘要： The invention concerns the application of silicatein-silk fibroin fusion proteins in dentistry to synthesize silica-containing nanocomposite materials used as filling material.
摘要翻译：本发明涉及硅酸盐 - 丝素蛋白融合蛋白在牙科学中用于合成用作填充材料的含二氧化硅的纳米复合材料。

4. 发明申请

WO2010124843A3 USE OF SILINTAPHIN FOR THE STRUCTURE-DIRECTED FABRICATION OF (NANO) COMPOSITE MATERIALS IN MEDICINE AND (NANO) TECHNOLOGY 审中-公开
标题翻译：用于医药和（纳米）技术中（NANO）复合材料的结构指导制造的硅胶片的使用
公开(公告)号：WO2010124843A3
公开(公告)日：2010-12-29
申请号：PCT/EP2010002575
申请日：2010-04-27
申请人： WIENS MATTHIAS , MUELLER WERNER E G , SCHROEDER HEINZ C , WANG XIAOHONG
发明人： WIENS MATTHIAS , MUELLER WERNER E G , SCHROEDER HEINZ C , WANG XIAOHONG
IPC分类号： C07K14/435 , C12P1/00 , C12P3/00
CPC分类号： C07K14/43504
摘要： The invention concerns the application of silintaphin-1 in the sustainable fabrication of hierarchically ordered silica structures from nano- to macro-scale at environmentally benign conditions and low energy costs (low temperature, low pressure, absence of caustic chemicals).
摘要翻译：本发明涉及硅灰蛋白-1在环境条件和低能量成本（低温，低压，不含腐蚀性化学品）的可持续制造层级有序的二氧化硅结构从纳米到宏观尺度的应用。

5. 发明申请

WO0106003A2 METHOD AND KIT FOR DETERMINING DNA DOUBLE/SINGLE STRAND BREAKS AND DEVICE FOR CARRYING OUT THE CONTROLLED FILTRATION OF, IN PARTICULAR, DNA MOLECULES WITH WELL FILTER PLATES 审中-公开
标题翻译：方法和试剂盒用于DNA双/单链骨折受控过滤尤其是DNA分子具有良好的过滤板测定及装置
公开(公告)号：WO0106003A2
公开(公告)日：2001-01-25
申请号：PCT/EP0006842
申请日：2000-07-18
申请人： MUELLER WERNER E G , SCHROEDER HEINZ C , BATEL RENATO
发明人： MUELLER WERNER E G , SCHROEDER HEINZ C , BATEL RENATO
IPC分类号： B01L3/00 , C12Q1/68
CPC分类号： C12Q1/6816 , B01L3/50255 , B01L2200/0689 , B01L2300/0829 , B01L2400/049 , C12Q2527/127 , C12Q2565/137
摘要： The invention relates to, among other things, a method for determining double strand breaks which comprises the following steps: a) depositing cells and/or tissues to be examined on specific filters; b) lysis of the cells/tissue with at least one detergent, with at least one chaotropic substance, and with at least one fluorescence dye that binds specifically a DNA double strand; c) elution of the DNA fragments, released by the lysis, through the specific filters, and; d) carrying out a fluorescence spectroscopic evaluation, whereby only one eluate fraction is collected per well.
摘要翻译：本发明提供，除其他外，DNA双链断裂的测定方法，包括以下步骤：a）要被检查的细胞和/或在特定的组织的过滤器的对象; b）用至少一种清净剂，至少一种离液物质和至少一种裂解细胞/组织特异性双链DNA结合的荧光染料; c）通过特定过滤器洗脱裂解的DNA片段; d）进行荧光光谱评估，其中每个孔只收集一个洗脱物部分。

6. 发明申请

WO2005042442A3 2-METHYLTHIO-1,4-NAPHTHOQUINONE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND USE THEREOF 审中-公开
标题翻译： 2-甲硫基-1,4-萘醌衍生物，用于生产它们，含有它们的用途的药物组合物
公开(公告)号：WO2005042442A3
公开(公告)日：2005-07-07
申请号：PCT/EP2004010465
申请日：2004-09-17
申请人： UNIV MAINZ JOHANNES GUTENBERG , UNIV WUERZBURG J MAXIMILIANS , MUELLER WERNER E G , THAKUR NARSHINH L , THAKUR ARACHANA N , SCHROEDER HEINZ C , LANG GERHARD , TSURUTA HIDEYUKI , BRINGMANN GERHARD
发明人： MUELLER WERNER E G , THAKUR NARSHINH L , THAKUR ARACHANA N , SCHROEDER HEINZ C , LANG GERHARD , TSURUTA HIDEYUKI , BRINGMANN GERHARD
IPC分类号： C07C323/22 , C12P11/00 , A61K31/10 , A61P31/04 , A61P35/00
CPC分类号： C07C323/22 , C12P11/00
摘要： Disclosed are the compounds 2-methylthio-1,4-naphthoquinone (MTN) and MTN derivatives of general formula (2) as well as methods for the production or isolation thereof. MTN and MTN derivatives have antitumor properties, especially antiangiogenetic properties in cell culture models while being provided with characteristics preventing/inhibiting neointimal proliferation.
摘要翻译：有化合物2-甲硫基-1,4-萘醌（MTN）和通式（2）的MTN衍生物; 所描述的，以及它们的制备或分离方法。 MTN和MTN衍生物具有在细胞培养模型的抗肿瘤，尤其是抗血管生成的属性。进一步具有MTN和MTN衍生物内膜增殖预防/抑制性质。

7. 发明申请

WO2005045020A3 ENZYMATIC SYNTHESIS, MODIFICATION AND DECOMPOSITION OF SILICON(IV) COMPOUNDS AND OTHER METAL(IV) COMPOUNDS 审中-公开
标题翻译：酶法合成，修改和硅（IV）脱除 - 及其它金属（IV）化合物
公开(公告)号：WO2005045020A3
公开(公告)日：2005-09-29
申请号：PCT/EP2004012668
申请日：2004-11-09
申请人： UNIV MAINZ JOHANNES GUTENBERG , BIOTEC MARIN GMBH , MUELLER WERNER E G , SCHWERTNER HEIKO , SCHROEDER HEINZ C
发明人： MUELLER WERNER E G , SCHWERTNER HEIKO , SCHROEDER HEINZ C
IPC分类号： C01B33/12 , C07K14/435 , C08G77/02 , C08G77/08 , C12N9/64 , C12N9/88 , C12P3/00
CPC分类号： C01B33/126 , C07K14/43504 , C08G77/08 , C12N9/641 , C12N9/88 , C12P3/00
摘要： The invention relates to the use of recombinant or silicatein beta isolated from natural sources, and silicatein beta fusion proteins as well as silicatein beta -related enzymes for the synthesis, decomposition and modification of silicon dioxide (condensation products of silicic acids, silicates), silicones and other silicon(IV) compounds or metal(IV) compounds, and to the technical use thereof.
摘要翻译：本发明涉及使用重组的或从天然来源silicatein-β以及silicatein-β融合蛋白和用于合成，降解和氧化硅的改性silicateinβ相关酶（硅酸的缩合产物，硅酸盐），有机硅的隔离，并其他硅（IV）或金属（IV）化合物及其技术用途。

8. 发明申请

WO0210420A3 SILICATEIN-MEDIATED SYNTHESIS OF AMORPHOUS SILICATES AND SILOXANES AND USE THEREOF 审中-公开
标题翻译：无定形硅酸盐和硅氧烷及其使用Silicatein介导的合成
公开(公告)号：WO0210420A3
公开(公告)日：2003-04-03
申请号：PCT/EP0108423
申请日：2001-07-20
申请人： MUELLER WERNER E G , SCHROEDER HEINZ C , LORENZ BERND , KRASKO ANATOLI
发明人： MUELLER WERNER E G , SCHROEDER HEINZ C , LORENZ BERND , KRASKO ANATOLI
IPC分类号： C12N15/09 , C01B33/12 , C01B33/18 , C01B37/00 , C07K1/22 , C07K14/435 , C12N1/21 , C12N9/00 , C12N9/88 , C12P3/00 , C12R1/90 , H01L21/314 , C07K14/00 , C08G77/04
CPC分类号： C12N9/00 , C07K14/43504 , C12N9/88 , C12P3/00
摘要： Silicatein is an enzyme from silicate-producing organisms for the synthesis of the silica skeleton thereof. The invention relates to the use of well-expressed and highly-active silicatein from natural source silicatein, isolated after gene induction and silicatein fusion proteins for the synthesis of amorphous silicon dioxide (silicic acids and silicates), siloxanes and modifications of said compounds and the technical application thereof.
摘要翻译： Silicatein是酶硅酸盐形成的生物合成其二氧化硅骨架。本发明涉及使用hochexprimiertem和根据基因诱导绝缘silicatein和无定形二氧化硅（硅酸和硅酸盐）合成silicatein融合蛋白从天然来源高活性重组silicatein的，硅氧烷和以及修改这些化合物和它们的工业用途。

9. 发明申请

WO02099434A2 USE OF 14-3-3 PROTEINS AND A METHOD FOR DETERMINING THE SAME IN THE FLUIDS OR TISSUES OF ORGANISMS 审中-公开
标题翻译： 14-3-3蛋白用途和液体或组织生物体法的测定的
公开(公告)号：WO02099434A2
公开(公告)日：2002-12-12
申请号：PCT/EP0206139
申请日：2002-06-04
申请人： MUELLER WERNER E G , SCHROEDER HEINZ C
发明人： MUELLER WERNER E G , SCHROEDER HEINZ C
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/2828
摘要： The aim of the invention is to provide an identification method and a quantification method for 14-3-3 proteins and their isoforms for the early diagnosis of TSE diseases, which allows the diagnosis to be carried out in living organisms. A further aim is to identify a contamination of the sample by the parallel determination of a second antigen. This is achieved by the use of the biochemical characteristics of a representative of the 14-3-3 protein family, which bind to specific amino acid motives such as X(n)-XSX(n)SXXSX-X(n) or to the motive RSXpSXP within peptides or proteins. Modified solid phases, such as for example microtitre plates, are used to determine one or several isoforms or the entire 14-3-3 protein(s) and for specific binding. Said plates are coated with an artificial or natural peptide, which contains a binding motive for 14-3-3 proteins, for example a chemically synthesised peptide with the motive CAALPKINRSApSEPSLHR. After addition of the extracts or bodily fluids to be analysed, the formed peptide 14-3-3 protein complexes are detected and quantified using tagged antibodies. The inventive application of the 14-3-3 protein family and/or individual isoforms of the 14-3-3 proteins can be used as an effect monitor or biomonitor in aquatic invertebrates of environmental influences such as polychlorinated biphenyls (PCBs), (Xeno)oestrogens or other influences. The method can also be used for the early diagnosis of TSE diseases, such as Creutzfeldt-Jakob disease (CJD) and its new form (variant) in young people (vCJD) and Bovine Spongiform Encephalopathy (BSE) or similar diseases. The invention thus provides a diagnosis tag (surrogate tag), which can be used in the living organism as a screening, confirmation or sole tag.
摘要翻译：要进行的本发明中，14-3-3蛋白或它们对TSE疾病的早期诊断亚型的检测和定量方法的方法的目的可用的，其允许执行对生物体的诊断。此外，它是由平行测定的第二抗原的检测样本的污染的目的。根据本发明的该目的是通过使用14-3-3蛋白家族，代表的生化特性的实现，其在特定的氨基酸基序，如X（n）的-XSX（n）的SXXSX-X（n）或肽内的主题RSXpSXP或蛋白质结合。对于一种或多种同种型的确定或所有14-3-3蛋白（S）和特异性修饰固相结合，例如，例如，微量滴定板，涂有具有用于14-3的结合基序的合成的或天然的肽的 -3含蛋白，例如化学合成的肽具有基序CAALPKINRSApSEPSLHR。此外，提取物的要被测试或之后体液，所形成的肽14-3-3蛋白复合物的检测和定量是使用标记的抗体进行检测。本发明的应用他14-3-3蛋白家族和/或14-3-3蛋白的同种型个体可以用作使用效果监视器或生物监测水生无脊椎动物对环境的影响，例如多氯联苯（PCB），（异种）的雌激素或其它。此外，也可以在年轻人（贾氏）和牛海绵状脑病（BSE）或类似的疾病用于TSE疾病如克雅氏病（CJD）和它的新的形式（变体）的早期诊断方法。这提供了可以用作在活生物体认证Screenings-或单个标记物的诊断用标记物（替代标记）可用。

10. 发明申请

WO9946401A3 14-3-3 PROTEINS USED AS SENSITIVE BIOLOGICAL MARKERS FOR DETECTING POLLUTION CAUSED, INTER ALIA, BY POLYCHLORINATED BIPHENYL (PCB) AND (XENO)OESTROGEN 审中-公开
标题翻译： 14-3-3敏感的生物标志物污染U.A. 多氯联苯AND（异种）雌激素
公开(公告)号：WO9946401A3
公开(公告)日：2000-03-09
申请号：PCT/EP9901545
申请日：1999-03-10
申请人： MUELLER WERNER E G , SCHROEDER HEINZ C
发明人： MUELLER WERNER E G , SCHROEDER HEINZ C
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/5085 , G01N33/5088 , G01N33/6896
摘要： The invention concerns (1) the use of a novel biological marker, namely one or several 14-3-3 proteins, for detecting the load in fresh water, sea water, drinking water or soil samples of natural and anthropogenic chemical products derived from the environment, in particular of polychlorinated biphenyl (PCB) and/or in oestrogen/xenooestrogen [(xeno)oestrogen] and (2) a novel method (ELISA method) for measuring qualitatively and quantitatively 14-3-3 proteins. Said ELISA method can also be used for detecting the occurrence of 14-3-3 protein in human and animal physiological liquids infected by the pathogenic agent responsible for prion diseases.
摘要翻译：本发明提供了（1）的新的生物标记14-3-3蛋白（S），用于（多氯联苯）检测的淡水，海水的负荷，饮用水或土壤样品与自然和人为环境化学品，特别是多氯联苯的应用，和/或雌激素 /异源雌激素[（异种）雌激素]和（2）的新方法（ELISA法）为14-3-3蛋白的快速定性和定量测量。 ELISA方法也可以用于检测蛋白质14-3-3的人类和动物的体液被感染朊病毒病的病原体的存在。

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