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1. 发明申请

WO2011159621A2 METHODS AND SYSTEMS FOR DETERMINING VASCULAR BODILY LUMEN INFORMATION AND GUIDING MEDICAL DEVICES 审中-公开
标题翻译：用于确定血管内皮细胞信息和指导医疗器械的方法和系统
公开(公告)号：WO2011159621A2
公开(公告)日：2011-12-22
申请号：PCT/US2011/040208
申请日：2011-06-13
申请人： ANGIOMETRIX CORPORATION , GOPINATHAN, Venugopal , SUBRAMANIYAN, Raghavan , DUTTA, Goutam , PATIL, Nitin , PATKI, Abhijit
发明人： GOPINATHAN, Venugopal , SUBRAMANIYAN, Raghavan , DUTTA, Goutam , PATIL, Nitin , PATKI, Abhijit
IPC分类号： A61B8/12 , A61B5/027 , A61B5/04
CPC分类号： A61B5/1075 , A61B5/02007 , A61B5/0538 , A61B5/064 , A61B5/066 , A61B5/068 , A61B5/1076 , A61B5/1079 , A61B5/4851 , A61B5/489 , A61B5/6851 , A61B5/6852 , A61B5/6853 , A61B5/7271 , A61B6/504 , A61B6/5211 , A61B6/541 , A61B8/565 , A61B8/582 , A61B2034/2065 , A61B2090/061 , A61B2090/3966 , A61B2090/3983 , A61B2505/05 , A61B2562/043 , A61B2562/08 , A61M2025/0166 , G06T7/246 , G06T2207/10116 , G06T2207/30021 , G06T2207/30101 , G06T2207/30204 , G06T2207/30241
摘要： Methods and systems for determining information about a vascular bodily lumen are described. An exemplary method includes generating an electrical signal, delivering the electrical signal to a plurality of excitation elements in the vicinity of the vascular bodily lumen, measuring a responsive electrical signal from a plurality of sensing elements in response to the delivered electrical signal, and determining a lumen dimension. Specific embodiments include generating a multiple frequency electrical signal. Another embodiment includes measuring a plurality of responsive signals at a plurality of frequencies. Still other embodiments include using spatial diversity of the excitation elements. Yet other embodiments use method for calibration and de-embedding of such measurements to determine the lumen dimensions. Diagnostic devices incorporating the method are also disclosed, including guide wires, catheters and implants. The methods and systems described herein are advantageous as they do not include injecting a second fluid for the measurements.
摘要翻译：描述了用于确定关于血管体内腔的信息的方法和系统。一种示例性方法包括产生电信号，将电信号传送到血管体腔附近的多个激励元件，响应于输送的电信号测量来自多个感测元件的响应电信号，以及确定流明尺寸。具体实施例包括产生多频电信号。另一实施例包括以多个频率测量多个响应信号。其他实施例包括使用激励元件的空间分集。其他实施例使用用于校准和解嵌这些测量以确定管腔尺寸的方法。还公开了包括引导线，导管和植入物的包括该方法的诊断装置。本文描述的方法和系统是有利的，因为它们不包括为测量注入第二流体。

2. 发明申请

WO2011158166A1 SYSTEMS AND METHODS FOR MEASUREMENTS OF ANATOMICAL PARAMETERS 审中-公开
标题翻译：解剖学参数测量的系统和方法
公开(公告)号：WO2011158166A1
公开(公告)日：2011-12-22
申请号：PCT/IB2011/052553
申请日：2011-06-13
申请人： GOPINATHAN, Venugopal , DUTTA, Goutam , PATIL, Nitin , PATKI, Abhijit , SUBRAMANIYAN, Raghavan
发明人： GOPINATHAN, Venugopal , DUTTA, Goutam , PATIL, Nitin , PATKI, Abhijit , SUBRAMANIYAN, Raghavan
IPC分类号： A61B5/053 , A61B5/00
CPC分类号： A61B5/0535 , A61B5/0538 , A61B5/204 , A61B5/6823 , A61B5/6831 , A61B5/6847 , A61B5/6868 , A61B2576/023 , A61N1/36521 , A61N1/3962
摘要： Systems and methods for measurements of anatomical parameters in a region of interest in a subject are provided. A diagnostic device comprises one or more pairs of electrodes for transmitting an electrical signal in the volume of interest and for receiving the voltage signals from the region of interest. A method of using electrical measurements, such as voltage or current, across a range of frequencies derived from data representative of the voltage signals is also provided. These measurements may be used to determine parameters of one or more anatomical features of the subject.
摘要翻译：提供了用于测量受试者感兴趣区域中的解剖学参数的系统和方法。诊断装置包括一对或多对电极，用于传输感兴趣体积中的电信号，并用于从感兴趣区域接收电压信号。还提供了在表示电压信号的数据导出的频率范围内使用诸如电压或电流之类的电测量的方法。这些测量可用于确定受试者的一个或多个解剖特征的参数。

3. 发明申请

WO2011159600A2 DIAGNOSTIC KIT AND METHOD FOR MEASURING BALLOON DIMENSION IN VIVO 审中-公开
标题翻译：诊断试剂盒和用于测量血液中的气泡尺寸的方法
公开(公告)号：WO2011159600A2
公开(公告)日：2011-12-22
申请号：PCT/US2011/040158
申请日：2011-06-13
申请人： ANGIOMETRIX CORPORATION , SUBRAMANIYAN, Raghavan , DUTTA, Goutam , GOPINATHAN, Venugopal
发明人： SUBRAMANIYAN, Raghavan , DUTTA, Goutam , GOPINATHAN, Venugopal
IPC分类号： A61B1/32
CPC分类号： A61B5/1075 , A61B5/02007 , A61B5/0538 , A61B5/064 , A61B5/066 , A61B5/068 , A61B5/1076 , A61B5/1079 , A61B5/4851 , A61B5/489 , A61B5/6851 , A61B5/6852 , A61B5/6853 , A61B5/7271 , A61B6/504 , A61B6/5211 , A61B6/541 , A61B8/565 , A61B8/582 , A61B2034/2065 , A61B2090/061 , A61B2090/3966 , A61B2090/3983 , A61B2505/05 , A61B2562/043 , A61B2562/08 , A61M2025/0166 , G06T7/246 , G06T2207/10116 , G06T2207/30021 , G06T2207/30101 , G06T2207/30204 , G06T2207/30241
摘要： A method for measuring a balloon expansion profile in vivo is provided. The method comprises providing a balloon with at least one sensing element as a diagnostic device, where the at least one sensing element is characterized by at least one attribute that is representative of balloon dimension; measuring the at least one attribute to obtain an observed attribute value; and estimating the balloon dimension and the balloon expansion profile based on the observed attribute value. A diagnostic kit for measuring a balloon expansion profile in vivo is also provided. The diagnostic kit comprises the diagnostic device; a measurement module for measuring an observed attribute value for the attribute; and a processor module for processing the observed attribute value to estimate the balloon expansion profile as one or more outputs.
摘要翻译：提供了一种用于测量体内球囊膨胀曲线的方法。该方法包括提供具有至少一个感测元件作为诊断装置的球囊，其中所述至少一个感测元件的特征在于至少一个代表气球尺寸的属性; 测量所述至少一个属性以获得观察到的属性值; 以及基于观察到的属性值来估计气球尺寸和气球膨胀曲线。还提供了用于在体内测量气囊膨胀曲线的诊断试剂盒。诊断套件包括诊断装置; 用于测量所述属性的观察属性值的测量模块; 以及处理器模块，用于处理观察到的属性值以将球囊扩展轮廓估计为一个或多个输出。

4. 发明申请

WO2011158165A2 DIAGNOSTIC KIT AND METHOD FOR MEASURING BALLOON DIMENSION IN VIVO 审中-公开
标题翻译：诊断试剂盒和测量体内球囊尺寸的方法
公开(公告)号：WO2011158165A2
公开(公告)日：2011-12-22
申请号：PCT/IB2011/052552
申请日：2011-06-13
申请人： ANGIOMETRIX CORPORATION , DUTTA, Goutam , GOPINATHAN, Venugopal , SUBRAMANIYAN, Raghavan
发明人： DUTTA, Goutam , GOPINATHAN, Venugopal , SUBRAMANIYAN, Raghavan
IPC分类号： A61B1/005
CPC分类号： A61B5/1075 , A61B5/02007 , A61B5/0538 , A61B5/064 , A61B5/066 , A61B5/068 , A61B5/1076 , A61B5/1079 , A61B5/4851 , A61B5/489 , A61B5/6851 , A61B5/6852 , A61B5/6853 , A61B5/7271 , A61B6/504 , A61B6/5211 , A61B6/541 , A61B8/565 , A61B8/582 , A61B2034/2065 , A61B2090/061 , A61B2090/3966 , A61B2090/3983 , A61B2505/05 , A61B2562/043 , A61B2562/08 , A61M2025/0166 , G06T7/246 , G06T2207/10116 , G06T2207/30021 , G06T2207/30101 , G06T2207/30204 , G06T2207/30241
摘要： A method for measuring a balloon expansion profile in vivo is provided. The method comprises providing a balloon with at least one sensing element as a diagnostic device, where the at least one sensing element is characterized by at least one attribute that is representative of balloon dimension; measuring the at least one attribute to obtain an observed attribute value; and estimating the balloon dimension and the balloon expansion profile based on the observed attribute value. A diagnostic kit for measuring a balloon expansion profile in vivo is also provided. The diagnostic kit comprises the diagnostic device; a measurement module for measuring an observed attribute value for the attribute; and a processor module for processing the observed attribute value to estimate the balloon expansion profile as one or more outputs.
摘要翻译：提供了一种用于测量体内球囊扩张曲线的方法。该方法包括提供具有至少一个传感元件作为诊断设备的球囊，其中至少一个传感元件的特征在于表示球囊尺寸的至少一个属性; 测量所述至少一个属性以获得观察到的属性值; 以及基于观测到的属性值估计球囊尺寸和球囊扩张剖面。还提供了用于测量体内球囊扩张特征的诊断试剂盒。诊断工具包含诊断设备; 测量模块，用于测量属性的观察属性值; 以及处理器模块，用于处理观察到的属性值，以将球囊扩展分布图估计为一个或多个输出。

5. 发明申请

WO2012173697A1 MULTIFUNCTIONAL GUIDEWIRE ASSEMBLIES AND SYSTEM FOR ANALYZING ANATOMICAL AND FUNCTIONAL PARAMETERS 审中-公开
标题翻译：用于分析解剖学和功能参数的多功能指导装置和系统
公开(公告)号：WO2012173697A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/034557
申请日：2012-04-20
申请人： ANGIOMETRIX CORPORATION , PATIL, Nitin , SUBRAMANIYAN, Raghavan , DUTTA, Goutam
发明人： PATIL, Nitin , SUBRAMANIYAN, Raghavan , DUTTA, Goutam
IPC分类号： A61B5/00
CPC分类号： A61B5/02007 , A61B5/0538 , A61B5/068 , A61B5/1076 , A61B5/6852 , A61M25/10188
摘要： Multifunctional guidewire assemblies and system for analyzing anatomical and functional parameters are described. Using a single guidewire, functional and anatomical measurements and identification of lesions may be made. Functional measurements such as pressure may be obtained with a pressure sensor on while anatomical measurements such as luminal dimensions may be obtained by utilizing an electrode. The vascular network and stenosed lesions may be modeled into an equivalent electrical network and solved based on the measured parameters. Treatment plan options may be constructed where each plan may correspond to the treatment of a subset of particular lesions. The anatomical outcome for each treatment plans may be estimated and the equivalent modified electrical parameters may be determined. Then, each of the electrical networks for each plan may be solved to determine the functional outcome for each treatment plan and the outcomes for all treatment plans may be presented to a physician.
摘要翻译：描述了用于分析解剖和功能参数的多功能导丝组件和系统。使用单个导丝，可以进行功能和解剖学测量和识别病变。诸如压力的功能测量可以用压力传感器来获得，而通过利用电极可以获得诸如腔尺寸的解剖学测量。可以将血管网络和狭窄的病变模型化为等效电网，并根据测量参数进行求解。可以构建治疗计划选项，其中每个计划可以对应于特定病变的子集的治疗。可以估计每个处理计划的解剖结果，并且可以确定等效的修改的电参数。然后，可以解决每个计划的每个电气网络以确定每个治疗计划的功能结果，并且可以向医师呈现所有治疗计划的结果。

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