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1. 发明申请

WO2006014685A1 IMMUNOGLOBULINS COMPRISING PREDOMINANTLY A MAN3GLCNAC2 GLYCOFORM 审中-公开
标题翻译：包含预防性的MAN3GLCNAC2 GLYCOFORFORM的免疫球蛋白
公开(公告)号：WO2006014685A1
公开(公告)日：2006-02-09
申请号：PCT/US2005/025662
申请日：2005-07-19
申请人： GLYCOFI, INC. , GERNGROSS, Tillman, U. , LI, Huijuan , WILDT, Stefan
发明人： GERNGROSS, Tillman, U. , LI, Huijuan , WILDT, Stefan
IPC分类号： C07K16/22
CPC分类号： C07K16/2896 , C07K2317/24 , C07K2317/41 , C07K2317/52
摘要： The present invention relates to immunoglobulin glycoprotein compositions having predominant N -glycan structures on an immunoglobulin glycoprotein which confer a specific effector function. Additionally, the present invention relates to pharmaceutical compositions comprising an antibody having a particular enriched N-glycan structure, wherein said N -glycan structure is Man 3 GlcNAc 2 .
摘要翻译：本发明涉及具有优势的免疫球蛋白糖蛋白组合物

2. 发明申请

WO2006071856A2 IMMUNOGLOBULINS COMPRISING PREDOMINANTLY A MAN5GLCNAC2 GLYCOFORM 审中-公开
标题翻译：包含预期的MAN5GLCNAC2 GLYCOFORFORM的免疫球蛋白
公开(公告)号：WO2006071856A2
公开(公告)日：2006-07-06
申请号：PCT/US2005/047042
申请日：2005-12-22
申请人： GLYCOFI, INC. , GERNGROSS, Tillman, U. , LI, Huijuan , WILDT, Stefan
发明人： GERNGROSS, Tillman, U. , LI, Huijuan , WILDT, Stefan
IPC分类号： C07K16/22 , C07K16/24 , C07K16/28
CPC分类号： C07K16/2878 , C07K16/2896 , C07K2317/41 , C07K2317/52 , C07K2317/72
摘要： The present invention relates to immunoglobulin glycoprotein compositions having predominant N -glycan structures on an immunoglobulin glycoprotein which confer a specific effector function. Additionally, the present invention relates to pharmaceutical compositions comprising an antibody having a particular enriched N-glycan structure, wherein said N-glycan structure is Man 5 GlcNAc 2
摘要翻译：本发明涉及在赋予特异性效应子功能的免疫球蛋白糖蛋白上具有主要N-聚糖结构的免疫球蛋白糖蛋白组合物。另外，本发明涉及药物组合物，其包含具有特定富集的N-聚糖结构的抗体，其中所述N-聚糖结构是Man 5'CaccNAc 2

3. 发明申请

WO2006071280A1 IMMUNOGLOBULINS COMPRISING PREDOMINANTLY A GA1G1CNACMAN5GLCNAC2 GLYCOFORM 审中-公开
标题翻译：包含优先GA1G1CNACMAN5GLCNAC2甘油糖的免疫球蛋白
公开(公告)号：WO2006071280A1
公开(公告)日：2006-07-06
申请号：PCT/US2005/025663
申请日：2005-07-19
申请人： GLYCOFI, INC. , GERNGROSS, Tillman, U. , LI, Huijuan , WILDT, Stefan
发明人： GERNGROSS, Tillman, U. , LI, Huijuan , WILDT, Stefan
IPC分类号： C07K16/22 , C07K16/24 , C07K16/28 , C12N15/09 , C12N15/10 , A61K39/395
CPC分类号： C07K16/00
摘要： The present invention relates to immunoglobulin glycoprotein compositions having predominant N -glycan structures on an immunoglobulin glycoprotein which confer a specific effector function. Additionally, the present invention relates to pharmaceutical compositions comprising an antibody having a particular enriched N-glycan structure, wherein said N -glycan structure is GalGlcNAcMan 5 GlcNAc 2 .
摘要翻译：本发明涉及免疫球蛋白糖蛋白组合物，其在免疫球蛋白糖蛋白上具有主要的Nα - 聚糖结构，其赋予特定的效应子功能。此外，本发明涉及包含具有特定富集的N-聚糖结构的抗体的药物组合物，其中所述N-聚糖结构是GalGlcNAcMan 5 GlcNAc 2， /子>

4. 发明申请

WO2006014726A2 IMMUNOGLOBULINS COMPRISING PREDOMINANTLY A MAN5GLCNAC2 GLYCOFORM 审中-公开
标题翻译：包含预期的MAN5GLCNAC2 GLYCOFORFORM的免疫球蛋白
公开(公告)号：WO2006014726A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/025731
申请日：2005-07-19
申请人： GLYCOFI, INC. , GERNGROSS, Tillman, U. , LI, Huijuan , WILDT, Stefan
发明人： GERNGROSS, Tillman, U. , LI, Huijuan , WILDT, Stefan
IPC分类号： C07K16/22 , C07K16/24 , C07K16/28 , C12N15/09 , C12N15/10 , A61K39/395
CPC分类号： C07K16/2896 , C07K16/00 , C07K2317/41 , C07K2317/52
摘要： The present invention relates to immunoglobulin glycoprotein compositions having predominant N -glycan structures on an immunoglobulin glycoprotein which confer a specific effector function. Additionally, the present invention relates to pharmaceutical compositions comprising an antibody having a particular enriched N -glycan structure, wherein said N -glycan structure is Man 5 GlcNAc 2 .
摘要翻译：本发明涉及具有优势的免疫球蛋白糖蛋白组合物

5. 发明申请

WO2007028144A2 IMMUNOGLOBULINS COMPRISING PREDOMINANTLY A GLCNACMAN3GLCNAC2 GLYCOFORM 审中-公开
标题翻译：包含预期的免疫球蛋白GLCNACMAN3GLCNAC2 GLYCOFORM
公开(公告)号：WO2007028144A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/034465
申请日：2006-09-01
申请人： GLYCOFI, INC , GERNGROSS, Tillman, U. , WILDT, Stefan , LI, Huijuan
发明人： GERNGROSS, Tillman, U. , WILDT, Stefan , LI, Huijuan
IPC分类号： A61K39/395
CPC分类号： C07K16/2887 , C07K2317/24 , C07K2317/41 , C07K2317/72
摘要： Compositions and methods for producing compositions comprising immunoglobulins or immunoglobulin fragments having an N-linked glycosylation pattern consisting predominantly of the GlCNAcMan 3 GlcNAc 2 N-glycan structure are disclosed. The GlCNAcMan 3 GlcNAc 2 N-glycan structure effects an increase in binding to the FcγRiπ receptors and a decrease in binding to the FcγRH receptors.
摘要翻译：公开了用于生产组合物的组合物和方法，所述组合物包含具有主要由GlCNAcMan 3 GlcNAc 2 N-聚糖结构组成的N-连接的糖基化图案的免疫球蛋白或免疫球蛋白片段。 GlCNAcMan 3 GlcNAc 2 N - 聚糖结构会增加与FcγRip受体的结合，并降低与FcγR受体的结合。

6. 发明申请

WO2004074458A2 N-ACETYLGLUCOSAMINYLTRANSFERASE III EXPRESSION IN LOWER EUKARYOTES 审中-公开
标题翻译：较低级别的N-乙酰胆碱氨基转移酶III表达
公开(公告)号：WO2004074458A2
公开(公告)日：2004-09-02
申请号：PCT/US2004/005128
申请日：2004-02-20
申请人： BOBROWICZ, Piotr , HAMILTON, Stephen, R. , GERNGROSS, Tillman, U. , WILDT, Stefan , CHOI, Byung-Kwon , NETT, Juergen, Hermann , DAVIDSON, Robert, C.
发明人： BOBROWICZ, Piotr , HAMILTON, Stephen, R. , GERNGROSS, Tillman, U. , WILDT, Stefan , CHOI, Byung-Kwon , NETT, Juergen, Hermann , DAVIDSON, Robert, C.
IPC分类号： C12N
CPC分类号： C07K14/39 , A61K38/00 , C07K2319/05 , C12N9/1051 , C12P21/005 , Y02A50/396
摘要： The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. Host cells with modified lipid-linked oligosaccharides are created or selected. N -glycans made in the engineered host cells exhibit GnTIII activity, which produce bisected N -glycan structures and may be modified further by heterologous expression of one or more enzymes, e.g., glycosyltransferases, sugar transporters and mannosidases, to yield human-like glycoproteins. For the production of therapeutic proteins, this method may be adapted to engineer cell lines in which any desired glycosylation structure may be obtained.
摘要翻译：本发明涉及具有修饰的寡糖的真核宿主细胞，其可以通过异源表达一组糖基转移酶，糖转运体和甘露糖苷酶进一步修饰，以成为用于产生哺乳动物例如人治疗性糖蛋白的宿主菌株。该方法提供了可用于表达和靶向参与糖基化的任何所需基因的工程化宿主细胞。产生或选择具有修饰的脂质连接寡糖的宿主细胞。在工程化宿主细胞中制备的N-聚糖表现出GnTIII活性，其产生二等分N-聚糖结构，并且可以进一步通过异源表达一种或多种酶，例如糖基转移酶，糖转运蛋白和甘露糖苷酶，以产生人样糖蛋白。为了生产治疗性蛋白质，该方法可适用于工程化可能获得任何所需糖基化结构的细胞系。

7. 发明申请

WO2004074498A2 EXPRESSION OF CLASS 2 MANNOSIDASE AND CLASS III MANNOSIDASE IN LOWER EUKARYOTIC CELLS 审中-公开
标题翻译：在较低的原核细胞中表达2类曼卡塞菌素和第3类芒果苷
公开(公告)号：WO2004074498A2
公开(公告)日：2004-09-02
申请号：PCT/US2004/005132
申请日：2004-02-20
申请人： HAMILTON, Stephen, R. , GERNGROSS, Tillman, U. , WILDT, Stefan , CHOI, Byung-Kwon , NETT, Juergen, Hermann , BOBROWICZ, Piotr , DAVIDSON, Robert, C.
发明人： HAMILTON, Stephen, R. , GERNGROSS, Tillman, U. , WILDT, Stefan , CHOI, Byung-Kwon , NETT, Juergen, Hermann , BOBROWICZ, Piotr , DAVIDSON, Robert, C.
IPC分类号： C12P21/00
CPC分类号： C12P21/005 , A01K2217/075 , C12N9/1051 , C12N9/2488 , C12N15/79 , C12Y302/01024 , C12Y302/01114
摘要： A method for producing human-like glycoproteins by expressing a Class 2 α-mannosidase having a substrate specificity for Manαl,3 and Manαl,6 glycosidic linkages in a lower eukaryote is disclosed. Hydrolysis of these linkages on oligosaccharides produces substrates for further N-glycan processing in the secretory pathway.
摘要翻译：公开了通过在低等真核生物中表达具有Manalphal，3和Manalphal，6个糖苷键的底物特异性的2类α-甘露糖苷酶来生产人样糖蛋白的方法。在寡糖上的这些键合的水解产生用于在分泌途径中进一步N-聚糖加工的底物。

8. 发明申请

WO2004074499A2 COMBINATORIAL DNA LIBRARY FOR PRODUCING MODIFIED N-GLYCANS IN LOWER EUKARYOTES 审中-公开
标题翻译：用于生产修复的N-GLYCANS在下一代的组合DNA文库
公开(公告)号：WO2004074499A2
公开(公告)日：2004-09-02
申请号：PCT/US2004/005244
申请日：2004-02-20
申请人： GERNGROSS, Tillman, U. , WILDT, Stefan , CHOI, Byung-Kwon , NETT, Juergen, Hermann , BOBROWICZ, Piotr , HAMILTON, Stephen, R. , DAVIDSON, Robert, C.
发明人： GERNGROSS, Tillman, U. , WILDT, Stefan , CHOI, Byung-Kwon , NETT, Juergen, Hermann , BOBROWICZ, Piotr , HAMILTON, Stephen, R. , DAVIDSON, Robert, C.
IPC分类号： C12P21/00
CPC分类号： C12P21/005 , C07K14/47 , C12N9/1051 , C12N15/1082 , C12N15/79
摘要： The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The invention provides nucleic acid molecules and combinatorial libraries which can be used to successfully target and express mammalian enzymatic activities such as those involved in glycosylation to intracellular compartments in a eukaryotic host cell. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. Host cells with modified oligosaccharides are created or selected. N-glycans made in the engineered host cells have a Man5GlcNAc2 core structure which may then be modified further by heterologous expression of one or more enzymes, e.g., glycosyltransferases, sugar transporters and mannosidases, to yield human-like glycoproteins. For the production of therapeutic proteins, this method may be adapted to engineer cell lines in which any desired glycosylation structure may be obtained.
摘要翻译：本发明涉及具有修饰的寡糖的真核宿主细胞，其可以通过异源表达一组糖基转移酶，糖转运体和甘露糖苷酶进一步修饰，以成为用于产生哺乳动物例如人治疗性糖蛋白的宿主菌株。本发明提供核酸分子和组合文库，其可用于成功靶向和表达哺乳动物酶活性，例如参与糖基化的真核宿主细胞中的细胞内区室的那些。该方法提供了可用于表达和靶向参与糖基化的任何所需基因的工程化宿主细胞。建立或选择具有修饰寡糖的宿主细胞。在工程化宿主细胞中制备的N-聚糖具有Man5GlcNAc2核心结构，然后可以通过异源表达一种或多种酶，例如糖基转移酶，糖转运蛋白和甘露糖苷酶来进一步修饰，以产生人样糖蛋白。为了生产治疗性蛋白质，该方法可适用于工程化可能获得任何所需糖基化结构的细胞系。

9. 发明申请

WO2006116657A2 SINGLE-CHAIN ANTIBODY WITH CLEAVABLE LINKER 审中-公开
标题翻译：单链抗体与可清洗链接器
公开(公告)号：WO2006116657A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/016166
申请日：2006-04-26
申请人： GLYCOFI, INC. , ZHA, Dongxing , CHOI, Byung-Kwon , GERNGROSS, Tillman, U.
发明人： ZHA, Dongxing , CHOI, Byung-Kwon , GERNGROSS, Tillman, U.
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C12N1/18 , C07K16/44 , C12N15/74
CPC分类号： G01N33/531 , C07K16/00 , C07K2317/41 , C07K2317/50 , C07K2317/52 , C07K2317/56 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/50
摘要： Disclosed are antibodies and methods for making antibodies with desired glycosylation and efficient production. Host cells transformed with a nucleic acid encoding a fusion protein comprising a signal sequence, light and heavy immunoglobulin chains, each comprising a variable region and a constant region and separated by a spacer peptide comprising at least one proteolytic cleavage site are cultured to express the nucleic acids and are cleaved by appropriate proteases to produce antibodies.
摘要翻译：公开了用于制备具有所需糖基化和有效生产的抗体的抗体和方法。培养用编码融合蛋白的核酸转化的宿主细胞，其包含信号序列轻链和重免疫球蛋白链，每个包含可变区和恒定区，并由包含至少一个蛋白水解切割位点的间隔肽分离，以表达核酸酸，并被适当的蛋白酶切割以产生抗体。

10. 发明申请

WO2010105256A1 RATIONALLY DESIGNED, SYNTHETIC ANTIBODY LIBRARIES AND USES THEREFOR 审中-公开
标题翻译：方案设计，合成抗体库及其用途
公开(公告)号：WO2010105256A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/027312
申请日：2010-03-15
申请人： ADIMAB, INC. , VASQUEZ, Maximilliano , FELDHAUS, Michael , GERNGROSS, Tillman, U. , WITTRUP, K., Dane
发明人： VASQUEZ, Maximilliano , FELDHAUS, Michael , GERNGROSS, Tillman, U. , WITTRUP, K., Dane
IPC分类号： C07K16/00
CPC分类号： C12N15/1093 , C07K16/00 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
摘要翻译：本发明通过专门设计具有定向序列和长度多样性的文库来克服已知的用于产生抗体编码多核苷酸文库的方法中的不足之处。图书馆的设计旨在反映人类免疫系统自然产生的免疫缺陷文库，具有或不具有衍生自其他物种的DH片段，并且基于通过检查可公开获得的抗体序列数据库而获得的合理设计。

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