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1. 发明申请

WO2012061660A3 REMOVABLE HANDLE FOR USE WITH DENTURES 审中-公开
标题翻译：可拆卸手柄用于牙膏
公开(公告)号：WO2012061660A3
公开(公告)日：2012-09-27
申请号：PCT/US2011059240
申请日：2011-11-03
申请人： GLOBAL DENTAL SCIENCE , THOMPSON TIMOTHY C , KEATING SCOTT C , JAKSON ANDRZEJ J
发明人： THOMPSON TIMOTHY C , KEATING SCOTT C , JAKSON ANDRZEJ J
IPC分类号： A61C13/225 , A61C13/12 , A61C13/23 , A61C13/24 , A61C13/267
CPC分类号： A61C13/12 , A61C13/24
摘要： A tool that includes a handle, a curved stem member and an engagement mechanism. The engagement mechanism can be a mechanical engagement or a heat releasable adhesive. The tool is used to insert a denture into position in the mouth of the wearer in a secure and comfortable manner.
摘要翻译：一种包括手柄，弯曲杆构件和接合机构的工具。接合机构可以是机械接合或可热释放的粘合剂。该工具用于以安全和舒适的方式将义齿插入穿用者口腔中的位置。

2. 发明申请

WO2012061655A2 SYSTEM AND PROCESS FOR OPTIMIZATION OF DENTURES 审中-公开
标题翻译：用于优化牙齿的系统和方法
公开(公告)号：WO2012061655A2
公开(公告)日：2012-05-10
申请号：PCT/US2011059235
申请日：2011-11-03
申请人： GLOBAL DENTAL SCIENCE , THOMPSON TIMOTHY C , KEATING SCOTT C , JAKSON ANDRZEJ J
发明人： THOMPSON TIMOTHY C , KEATING SCOTT C , JAKSON ANDRZEJ J
IPC分类号： A61C13/34 , A61C13/36 , A61C19/04
CPC分类号： A61C13/0004 , A61C13/0001 , A61C13/10 , A61C13/34 , A61C19/05 , G06N5/046
摘要： System and processes for optimal selection of teeth for dentures based on the anatomical measurements and bite impressions of the patient. This information is applied in an iterative manner to rules that balance the anatomical and aesthetic considerations to select the best teeth for a patient. The system may also use this information in an iterative manner to rules that balance the anatomical and aesthetic considerations to design the optimal denture base for the patient as well.
摘要翻译：根据患者的解剖学测量和咬伤印象，最佳选择假牙牙齿的系统和过程。该信息以迭代的方式应用于平衡解剖学和美学考虑因素以选择患者最佳牙齿的规则。该系统还可以以迭代的方式将该信息用于平衡解剖学和美学考虑因素以规定患者的最佳假牙基础的规则。

3. 发明申请

WO2012061652A3 SYSTEMS AND PROCESS FOR FORMING ANATOMICAL FEATURES IN DENTURES 审中-公开
标题翻译：在牙齿中形成解剖特征的系统和过程
公开(公告)号：WO2012061652A3
公开(公告)日：2012-09-20
申请号：PCT/US2011059230
申请日：2011-11-03
申请人： GLOBAL DENTAL SCIENCE , THOMPSON TIMOTHY C , KEATING SCOTT C , JAKSON ANDRZEJ J
发明人： THOMPSON TIMOTHY C , KEATING SCOTT C , JAKSON ANDRZEJ J
IPC分类号： A61C13/34 , A61C13/36 , A61C19/04
CPC分类号： A61C13/0004 , A61C9/0046 , A61C13/01 , G06F17/50
摘要： The system of a preferred embodiment uses a process whereby a true replication of the patient's jaw structure is created in a digital three dimensional model. This true replication is then used to precisely locate and/or copy the anatomical landmarks of the patient for use in fabricating a denture base for use in a denture for the individual patient. This system is able to create a denture with precisely located features corresponding to the anatomical landmarks of the patient with little manual intervention.
摘要翻译：优选实施例的系统使用一种过程，由此在数字三维模型中创建患者的颌骨结构的真实复制。然后使用这种真正的复制来精确地定位和/或复制患者的解剖标志，以用于制造用于单个患者的假牙的义齿基座。该系统能够以很少的手动干预来创建具有对应于患者的解剖标志的精确定位的特征的义齿。

4. 发明申请

WO2012061659A3 SYSTEM AND PROCESS FOR DUPLICATION OF DENTURES 审中-公开
标题翻译：用于复制盗版的系统和过程
公开(公告)号：WO2012061659A3
公开(公告)日：2012-09-27
申请号：PCT/US2011059239
申请日：2011-11-03
申请人： GLOBAL DENTAL SCIENCE , THOMPSON TIMOTHY C , KEATING SCOTT C , JAKSON ANDRZEJ J
发明人： THOMPSON TIMOTHY C , KEATING SCOTT C , JAKSON ANDRZEJ J
IPC分类号： A61C13/34 , A61C13/01 , A61C13/36 , A61C19/04
CPC分类号： A61C13/0004 , A61C9/0006 , A61C13/0009 , A61C13/01 , A61C13/10 , A61C13/26 , A61C13/34 , G06F17/50
摘要： Systems and processes for the duplication of dentures from existing dentures. The interior and exterior of the dentures are scanned and a best fit procedure is used to create a fully digitized denture. The denture teeth are selected from a library that is the closest fit to the original denture teeth. The library teeth are offset a preset distance to compensate for the best fit. The teeth are then subtracted from the digitized denture. The margins of the denture are then cleaned after subtracting the teeth. The denture base is then ready for manufacturing. The teeth are then installed onto the denture base and provided to the patient.
摘要翻译：从现有假牙复制假牙的系统和流程。扫描义齿的内部和外部，并使用最合适的程序来创建完全数字化的义齿。义齿是从与原始义齿最接近的库中选择的。库齿偏移预设距离以补偿最佳配合。然后从数字化义齿中扣除牙齿。扣除牙齿后，清理义齿的边缘。义齿基座然后准备好制造。然后将牙齿安装到义齿基座上并提供给患者。

5. 发明申请

WO2004111200A2 RTVP-GLIPR-LIKE COMPOSITIONS AND METHODS FOR THE DETECTION, TREATMENT AND PREVENTION OF PROSTATE CANCER 审中-公开
标题翻译： RTVP-GLIPR-like组合物和检测，治疗和预防前列腺癌的方法
公开(公告)号：WO2004111200A2
公开(公告)日：2004-12-23
申请号：PCT/US2004018731
申请日：2004-06-08
申请人： BAYLOR COLLEGE MEDICINE , THOMPSON TIMOTHY C , CHENGHUI REN , CHENGZHEN REN
发明人： THOMPSON TIMOTHY C , CHENGHUI REN , CHENGZHEN REN
IPC分类号： C07H21/04 , C07K14/47 , C12N20060101 , C12Q1/68 , C12N
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： The invention is directed to purified and isolated novel RGL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
摘要翻译：本发明涉及纯化和分离的新型RGL多肽，编码此类多肽的核酸，生产此类多肽的重组形式的方法，针对这些多肽产生的抗体，衍生自这些多肽的片段化肽以及上述用途。

6. 发明申请

WO0206344A2 RTVP BASED COMPOSITIONS AND METHODS FOR THE TREATMENT OF PROSTATE CANCER 审中-公开
标题翻译：基于RTVP的组合物和治疗前列腺癌的方法
公开(公告)号：WO0206344A2
公开(公告)日：2002-01-24
申请号：PCT/US0118487
申请日：2001-06-08
申请人： BAYLOR COLLEGE MEDICINE , THOMPSON TIMOTHY C , REN CHENGZHEN
发明人： THOMPSON TIMOTHY C , REN CHENGZHEN
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K14/705
CPC分类号： C07K14/4747 , A61K38/00 , A61K39/00 , C07K14/705
摘要： This invention relates to a gene encoding RTVP that has been shown to be up-regulated by p53 using differential display-PCR and subsequently by co-transfection studies. RTVP-1 mRNA is abundant in normal mouse and human prostatic epithelial cells and primary tumors, but is significantly down regulated in metastatic mouse and human prostate cancer. In prostate cancer cells overexpression of the mouse RTVP-1 gene (mRTVP-1) induced apoptosis that was accompanied by increased caspase 8,9 and 3 activities. MRTVP-1-stimulated apoptosis was also associated with increased levels of bax, bad and activated BID; reduced levels of bcl-2 and bcl-XL; and cytosolic cytochrome c accumulation. Adenoviral-vector-mediated mRTVP-1 expression lead to potent growth suppression and antimetastatic activities in an orthotopic mouse model of prostate cancer in vivo . These therapeutic activities were associated with anti-angiogenic effects and importantly a local and systemic immune response. Accordingly, p53 was linked with suppression of metastasis through its induction of mRTVP-1, which can concurrently induce apoptosis, suppress agiogenesis and stimulate an antitumor immune response. Thus, the invention includes compositions and methods, based on RTVP nucleic acid, polypeptides, and antibodies, for use in the treatment, prevention and detection of neoplastic disease and, specifically, metastatic prostatic neoplasia.
摘要翻译：本发明涉及编码RTVP的基因，已被证明是通过差异显示PCR而被p53上调，随后通过共转染研究。 RTVP-1 mRNA在正常小鼠和人前列腺上皮细胞和原发性肿瘤中丰富，但在转移性小鼠和人前列腺癌中显着下调。在前列腺癌细胞中，小鼠RTVP-1基因（mRTVP-1）的过度表达诱导凋亡，伴随着胱天蛋白酶8,9和3活性的增加。 MRTVP-1刺激的细胞凋亡也与bax，坏和活化的BID水平升高相关; 降低bcl-2和bcl-XL的水平; 和胞质细胞色素c积累。腺病毒载体介导的mRTVP-1表达导致在体内前列腺癌的原位小鼠模型中有效的生长抑制和抗转移活性。这些治疗活动与抗血管生成作用相关，重要的是局部和全身免疫应答。因此，p53通过诱导mRTVP-1与抑制转移相关，可以同时诱导细胞凋亡，抑制生物发生和刺激抗肿瘤免疫反应。因此，本发明包括基于RTVP核酸，多肽和抗体的组合物和方法，用于治疗，预防和检测肿瘤疾病，特别是转移性前列腺肿瘤。

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