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1. 发明申请

WO2007144317A2 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2007144317A2
公开(公告)日：2007-12-21
申请号：PCT/EP2007/055677
申请日：2007-06-08
申请人： GLAXOSMITHLLINE BIOLOGICALS SA , DEVOS, Nathalie , FERON, Christiane , POOLMAN, Jan , WEYNANTS, Vincent
发明人： DEVOS, Nathalie , FERON, Christiane , POOLMAN, Jan , WEYNANTS, Vincent
CPC分类号： A61K39/095 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/6018 , A61K2039/6031 , A61K2039/70
摘要： The present invention relates to the field of neisserial vaccine compositions, their manufacture, and the use of such compositions in medicine. More particularly it relates to processes of making novel engineered meningococcal strains which are more suitable for the production of neisserial, in particular meningococcal, outer- membrane vesicle (or bleb) vaccines. Advantageous processes and vaccine products are also described based on the use of novel LOS subunit or meningococcal outer- membrane vesicle (or bleb) vaccines which have been rendered safer and more effective for use in human subjects.
摘要翻译：本发明涉及奈瑟氏球菌疫苗组合物的领域，它们的制造以及这些组合物在医药中的用途。更具体地说，本发明涉及制备新型工程化脑膜炎球菌菌株的方法，其更适合于产生奈瑟氏菌，特别是脑膜炎球菌，外膜囊泡（或气泡）疫苗。还基于使用新的LOS亚单位或脑膜炎球菌外膜囊泡（或气泡）疫苗，其使用更加安全和更有效地用于人类受试者，有利的过程和疫苗产品也被描述。

2. 发明申请

WO2007144316A3 VACCINE 审中-公开
公开(公告)号：WO2007144316A3
公开(公告)日：2007-12-21
申请号：PCT/EP2007/055676
申请日：2007-06-08
申请人： GLAXOSMITHKLINE BIOLOGICALS SA , DEVOS, Nathalie , FERON, Christiane , POOLMAN, Jan , WEYNANTS, Vincent
发明人： DEVOS, Nathalie , FERON, Christiane , POOLMAN, Jan , WEYNANTS, Vincent
IPC分类号： A61K39/095 , C07H13/00
摘要： The present invention relates to the field of neisserial vaccine compositions, their manufacture, and the use of such compositions in medicine. More particularly it relates to processes of making novel engineered meningococcal strains which are more suitable for the production of neisserial, in particular meningococcal, outer- membrane vesicle (or bleb) vaccines. Advantageous processes and vaccine products are also described based on the use of novel LOS subunit or meningococcal outer- membrane vesicle (or bleb) vaccines which have been rendered safer and more effective for use in human subjects.

3. 发明申请

WO2004015099A2 VACCINE COMPOSITION 审中-公开
标题翻译：疫苗组合物
公开(公告)号：WO2004015099A2
公开(公告)日：2004-02-19
申请号：PCT/EP2003/008569
申请日：2003-07-31
申请人： GLAXOSMITHKLINE BIOLOGICALS SA , THE UNIVERSITY OF QUEENSLAND , BIEMANS, Ralph , DENOEL, Philippe , FERON, Christiane , GORAJ, Karine , JENNINGS, Michael, Paul , POOLMAN, Jan , WEYNANTS, Vincent
发明人： BIEMANS, Ralph , DENOEL, Philippe , FERON, Christiane , GORAJ, Karine , JENNINGS, Michael, Paul , POOLMAN, Jan , WEYNANTS, Vincent
IPC分类号： C12N15/00
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to the field of neisserial vaccine compositions, their manufacture, and the use of such compositions in medicine. More particularly it relates to processes of making novel engineered meningococcal strains which are less phase variable in terms of their LOS immunotype, and from which novel LOS subunit or meningococcal outer-membrane vesicle (or bleb) vaccines can be derived.
摘要翻译：本发明涉及奈瑟氏球菌疫苗组合物的领域，它们的制造以及这些组合物在医药中的应用。更具体地说，涉及制备新的工程化脑膜炎球菌菌株的方法，根据它们的LOS免疫型，它们的相位变化较小，并且可从中产生新的LOS亚单位或脑膜炎球菌外膜囊泡（或气泡）疫苗。

4. 发明申请

WO2011110636A1 IMMUNOGENIC COMPOSITION 审中-公开
标题翻译：免疫组化
公开(公告)号：WO2011110636A1
公开(公告)日：2011-09-15
申请号：PCT/EP2011/053632
申请日：2011-03-10
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , CASTADO, Cindy , DEVOS, Nathalie, Isabelle , POOLMAN, Jan , WEYNANTS, Vincent
发明人： CASTADO, Cindy , DEVOS, Nathalie, Isabelle , POOLMAN, Jan , WEYNANTS, Vincent
IPC分类号： A61K39/095 , A61K39/116 , C07K14/22
CPC分类号： A61K39/095 , A61K2039/60 , A61K2039/70 , C07K14/22 , C07K2319/00
摘要： The present disclosure relates to the field of Neisserial immunogenic compositions and vaccines, their manufacture and the use of such compositions in medicine. In particular the present invention relates to compositions and methods involving the factor H binding protein (fHbp) antigen. The present inventors have recognised that fHbp is poorly expressed in neisserial strains of ST269 clonal complex (a subset of strains which seems to be growing in terms of numbers of reported cases of disease attributed to it), and vaccines comprising fHbp may be made more effective against said strains by formulating the vaccine with a further antigen that can elicit protection against these strains.
摘要翻译：本公开涉及奈瑟氏球菌免疫原性组合物和疫苗的领域，其制造以及在医药中使用这些组合物。特别地，本发明涉及涉及因子H结合蛋白（fHbp）抗原的组合物和方法。本发明人已经认识到fHbp在ST269克隆复合体（似乎以归因于其的所报告病例的数量方面似乎正在增长的菌株的亚类）中的表达很差，并且可以使包含fHbp的疫苗更有效通过用可以引发对这些菌株的保护的另外的抗原配制疫苗来对抗所述菌株。

5. 发明申请

WO2011110634A1 VACCINE COMPOSITION 审中-公开
标题翻译：疫苗组合物
公开(公告)号：WO2011110634A1
公开(公告)日：2011-09-15
申请号：PCT/EP2011/053630
申请日：2011-03-10
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , CASTADO, Cindy , DEVOS, Nathalie Isabelle , POOLMAN, Jan , WEYNANTS, Vincent
发明人： CASTADO, Cindy , DEVOS, Nathalie Isabelle , POOLMAN, Jan , WEYNANTS, Vincent
IPC分类号： A61K39/095 , A61K39/116 , C07K14/22
CPC分类号： A61K39/095 , A61K2039/60 , A61K2039/70 , C07K14/22 , C07K2319/00
摘要： The present invention relates to the field of Neisserial immunogenic compositions and vaccines, their manufacture and the use of such compositions in medicine. Chimeric fHbp (factor H binding protein) proteins and compositions comprising said proteins are described to overcome the problem of immune responses to fHbp being specific to the meningococcal strain from which the fHbp was derived.
摘要翻译：本发明涉及奈瑟氏球菌免疫原性组合物和疫苗的领域，它们的制造以及这些组合物在医药中的应用。描述了嵌合fHbp（因子H结合蛋白）蛋白质和包含所述蛋白质的组合物以克服对来自fHbp的脑膜炎球菌菌株特异性的fHbp的免疫应答的问题。

6. 发明申请

WO2004014418A2 VACCINE COMPOSITION 审中-公开
标题翻译：疫苗组合物
公开(公告)号：WO2004014418A2
公开(公告)日：2004-02-19
申请号：PCT/EP2003/008571
申请日：2003-07-31
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , BERTHET, Francois-Xavier, Jacques , BIEMANS, Ralph , DENOEL, Philippe , FERON, Christiane , GORAJ, Karine , POOLMAN, Jan , WEYNANTS, Vincent
发明人： BERTHET, Francois-Xavier, Jacques , BIEMANS, Ralph , DENOEL, Philippe , FERON, Christiane , GORAJ, Karine , POOLMAN, Jan , WEYNANTS, Vincent
IPC分类号： A61K39/02
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.
摘要翻译：本发明涉及用于治疗和预防奈瑟氏球菌病的免疫原性组合物和疫苗。本发明的免疫原性组合物含有选自至少两种不同类型的抗原的抗原的组合，包括粘附素，自体转运蛋白，毒素，铁获得蛋白和膜相关蛋白（优选整体外膜蛋白）。抗原的这种组合能够针对奈桑氏生命周期的不同方面靶向免疫应答，导致更有效的免疫应答。

7. 发明申请

WO2004014417A2 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2004014417A2
公开(公告)日：2004-02-19
申请号：PCT/EP2003/008568
申请日：2003-07-31
申请人： GLAXOSMITHKLINE BIOLOGICALS SA , BIEMANS, Ralph , DENOEL, Philippe , FERON, Christiane , GORAJ, Karine , POOLMAN, Jan , WEYNANTS, Vincent
发明人： BIEMANS, Ralph , DENOEL, Philippe , FERON, Christiane , GORAJ, Karine , POOLMAN, Jan , WEYNANTS, Vincent
IPC分类号： A61K39/00
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to the field of neisserial vaccine compositions, their manufacture, and the use of such compositions in medicine. More particularly it relates to processes of making novel engineered meningococcal strains which are more suitable for the production of neisserial, in particular meningococcal, outer-membrane vesicle (or bleb) vaccines. Advantageous processes and vaccine products are also described based on the use of novel LOS subunit or meningococcal outer-membrane vesicle (or bleb) vaccines which have been rendered safer and/or more effective for use in human subjects. In particular combinations of gene downregulations are described such as PorA & OpA, PorA and OpC, OpA and OpC, and PorA and OpA and OpC. Alternatively, or in addition, lgtB - is shown to be an optimal mutation for effectively and safely using L3 and/or L2 LOS in Neisseria vaccine compositions. Bleb vaccines derived from lgtB - and capsular polysaccharide deficient meningococcal mutants are further described; as are advantageous methods of making bleb preparations where LOS is to be retained as an important antigen.
摘要翻译：本发明涉及奈瑟氏球菌疫苗组合物的领域，它们的制造以及这些组合物在医药中的应用。更具体地说，本发明涉及制备新型工程化脑膜炎球菌菌株的方法，其更适合于产生奈司菌素，特别是脑膜炎球菌，外膜囊泡（或气泡）疫苗。还基于使用已经变得更安全和/或更有效地用于人类受试者的新型LOS亚单位或脑膜炎球菌外膜囊泡（或泡沫）疫苗来描述有利的方法和疫苗产品。描述了基因下调的组合，例如PorA和OpA，PorA和OpC，OpA和OpC，以及PorA和OpA和OpC。或者或另外，lgtB - 被证明是在奈瑟氏球菌疫苗组合物中有效和安全地使用L3和/或L2 LOS的最佳突变。进一步描述衍生自lgtB - 和荚膜多糖缺乏型脑膜炎球菌突变体的Bleb疫苗; 制备其中保留LOS作为重要抗原的泡制剂的有利方法也是如此。

8. 发明申请

WO2004020452A2 REFOLDING METHOD 审中-公开
标题翻译：重建方法
公开(公告)号：WO2004020452A2
公开(公告)日：2004-03-11
申请号：PCT/EP2003/010085
申请日：2003-08-28
申请人： GLAXOSMITHKLINE BIOLOGICALS SA , UTRECHT UNIVERSITY , BIEMANS, Ralph , BOS, Martine , DENOEL, Philippe , FERON, Christiane , GORAJ, Karine , POOLMAN, Jan , TOMMASSEN, Jan , WEYNANTS, Vincent
发明人： BIEMANS, Ralph , BOS, Martine , DENOEL, Philippe , FERON, Christiane , GORAJ, Karine , POOLMAN, Jan , TOMMASSEN, Jan , WEYNANTS, Vincent
IPC分类号： C07K
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , C07K14/22
摘要： The present invention provides an isolated refolded NspA protein, and a method of preparing it.
摘要翻译：本发明提供了分离的重折叠NspA蛋白质及其制备方法。

9. 发明申请

WO2011110635A1 IMMUNOGENIC COMPOSITION 审中-公开
标题翻译：免疫组化
公开(公告)号：WO2011110635A1
公开(公告)日：2011-09-15
申请号：PCT/EP2011/053631
申请日：2011-03-10
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , CASTADO, Cindy , DEVOS, Nathalie, Isabelle , POOLMAN, Jan , WEYNANTS, Vincent
发明人： CASTADO, Cindy , DEVOS, Nathalie, Isabelle , POOLMAN, Jan , WEYNANTS, Vincent
IPC分类号： A61K39/095 , A61K39/116 , C07K14/22
CPC分类号： A61K39/095 , A61K2039/60 , A61K2039/70 , C07K14/22 , C07K2319/00
摘要： The present disclosure relates to the field of Neisserial immunogenic compositions and vaccines, their manufacture and the use of such compositions in medicine. In particular the present invention relates to compositions and methods involving the factor H binding protein (fHbp) antigen. The present inventors have recognised that fHbp is poorly expressed in neisserial strains of L2 immunotype (and ST11 clonal complex), and vaccines comprising fHbp may be made more effective against said strains by formulating the vaccine with a further antigen that can elicit protection against these strains.
摘要翻译：本公开涉及奈瑟氏球菌免疫原性组合物和疫苗的领域，其制造和在医学中使用这些组合物。特别地，本发明涉及涉及因子H结合蛋白（fHbp）抗原的组合物和方法。本发明人已经认识到，在L2免疫型（和ST11克隆复合物）的奈瑟氏菌属菌株中，fHbp表达差，并且通过用可以引发对这些菌株的保护的另外的抗原配制疫苗，可以使包含fHbp的疫苗更有效。

10. 发明申请

WO2011110655A2 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2011110655A2
公开(公告)日：2011-09-15
申请号：PCT/EP2011/053665
申请日：2011-03-11
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , UTRECHT UNIVERSITY , DEVOS, Nathalie, Isabelle , POOLMAN, Jan , STORK, Michiel , TOMMASSEN, Johannes, Petrus, Maria , WEYNANTS, Vincent
发明人： DEVOS, Nathalie, Isabelle , POOLMAN, Jan , STORK, Michiel , TOMMASSEN, Johannes, Petrus, Maria , WEYNANTS, Vincent
IPC分类号： C07K14/22
CPC分类号： A61K39/095 , A61K39/00 , C07K14/195 , C07K14/22 , C07K16/1217 , Y02A50/401 , Y02A50/476 , Y02A50/478
摘要： The present invention relates to the field of Gram-negative bacterial immunogenic compositions and vaccines, their manufacture and the use of such compositions in medicine. More particularly, it relates to immunogenic compositions comprising outer membrane proteins of Gram-negative bacteria which are involved in uptake of extracellular zinc.
摘要翻译：本发明涉及革兰氏阴性细菌免疫原性组合物和疫苗的领域，它们的制造和这些组合物在医学中的应用。更具体地，本发明涉及包含参与细胞外锌吸收的革兰氏阴性细菌外膜蛋白的免疫原性组合物。

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