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1. 发明申请

WO2013052568A1 ANTIBACTERIAL COMPOUNDS 审中-公开
标题翻译：抗菌化合物
公开(公告)号：WO2013052568A1
公开(公告)日：2013-04-11
申请号：PCT/US2012/058595
申请日：2012-10-04
申请人： GLAXO GROUP LIMITED , SHIONOGI & CO., LTD. , LIAO, Xiangmin , PEARSON, Neil, David , PENDRAK, Israil , SANO, Masayuki
发明人： LIAO, Xiangmin , PEARSON, Neil, David , PENDRAK, Israil , SANO, Masayuki
IPC分类号： A01N57/00
CPC分类号： C07D501/60 , A61K31/546 , C07D501/56 , Y02A50/473 , Y02A50/481
摘要： The present Invention relates to cephalosporin antibacterial compounds of Formula (!): corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods for bacterial infections, especially those caused by gram-negative bacteria.
摘要翻译：本发明涉及式（！）的头孢菌素抗菌化合物：其相应的药学上可接受的盐，相应的药物组合物，细菌感染的化合物制备和治疗方法，特别是由革兰氏阴性菌引起的那些。

3. 发明申请

WO2004002992A1 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2004002992A1
公开(公告)日：2004-01-08
申请号：PCT/EP2003/006756
申请日：2003-06-25
申请人： GLAXO GROUP LIMITED , AXTEN, Jeffrey, Michael , DAINES, Robert, A. , DAVIES, David, Thomas , GALLAGHER, Timothy, Francis , JONES, Graham, Elgin , MILLER, William, Henry , PEARSON, Neil, David , PENDRAK, Israil
发明人： AXTEN, Jeffrey, Michael , DAINES, Robert, A. , DAVIES, David, Thomas , GALLAGHER, Timothy, Francis , JONES, Graham, Elgin , MILLER, William, Henry , PEARSON, Neil, David , PENDRAK, Israil
IPC分类号： C07D491/06
CPC分类号： C07D493/04 , C07D417/12 , C07D513/04
摘要： Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man. A compound of formula (I) or a pharmaceutically acceptable derivative thereof: (I) R A is an optionally substituted bicyclic carbocyclic or heterocyclic ring system of structure: containing 0-3 heteroatmoms in each ring in which: at least one of the rings (x) and (y) is aromatic; one of Z 4 and Z 5 is C or N and the other is C; Z 3 is N, NR 13 , O, S(O) x , CO, CR 1 or CR 1 R 1a ; Z1 and Z2 are indendently a 2 or 3 atom linker group each atom of which is independently selected from N, NR 13 , O, S(O) x , CO, CR 1 , and CR 1 R 1a ; such that each ring is independently substituted with 0-3 groups R 1 and/or R 1a . R 4 is a group -CH 2 -R 5 1 in which R 5 1 is selected from: (C 4-8 ) alkyl; hydroxy (C 4-8 ) alkyl; (C 1-4 )alkoxy (C 4-8 )alkyl; (C 1-4 ) alkanoyloxy (C 4-8 ) alkyl; (C 3-8 )cycloalkyl (C 4-8 )alkyl;hydroxy-, (C 1-6 ) alkoxy- or (C 1-6 ) alkanoyloxy-(C 3-8 )cycloalkyl (C 4-8 )alkyl; cyano(C 4-8 )alkyl; (C 4-8 )alkenyl; (C 4-8 )alkynyl; tetrahydrofuryl; mono- or di-(C 1-6) alkylamino (C 4-8 )alkyl; acylamino (C 4-8 )alkyl; C( 1-6 )alkyl- or acyl-aminocarbonyl (C 4-8 ) alkyl; mono- or di- (C 1-6 )alkylamino(hydroxy) (C 4-8 )alkyl; or R 4 is a group-U-R 5 2 where R 5 2 is an optionally substituted bicyclic carbocyclic or heterocyclic ring system (A): containing up to four heteroatoms in each ring in which at least one of rings (a) and (b) is aromatic; X 1 is C or N when part of an aromatic ring or CR 14 when part of a non-aromatic ring.
摘要翻译：环己烷和环己烯衍生物及其药学上可接受的衍生物可用于治疗哺乳动物，特别是人的细菌感染的方法。式（I）化合物或其药学上可接受的衍生物：（I）R AA是任选取代的双环碳环或杂环体系，其结构为：在每个环中含有0-3个异质体，其中：至少一个环（x）和（y）是芳族的; Z 4和Z 5之一是C或N，另一个是C; Z 3为N，NR 13，O，S（O）x，CO，CR 1或CR 1 R 1a; Z1和Z2独立地是2或3个原子连接基团，其各自的原子独立地选自N，NR 13，O，S（O）x，CO，CR 1和CR 1 R 1a >; 使得每个环独立地被0-3个基团R 1和/或R 1a取代。 R 4是基团-CH 2 -R 5 1，其中R 5选自：（C 4-8）烷基; 羟基（C 4-8）烷基; （C 1-4）烷氧基（C 4-8）烷基; （C 1-4）烷酰氧基（C 4-8）烷基; （C 3-8）烷基;羟基 - ，（C 1-6）烷氧基 - 或（C 1-6）烷酰氧基 - （C 3-8）环烷基（C 4-8）烷基; 氰基（C 4-8）烷基; （C4-8）链烯基; （C4-8）炔基; 四氢呋喃; 单 - 或二 - （C 1-6）烷基氨基（C 4-8）烷基; 酰基氨基（C 4-8）烷基; C（1-6）烷基 - 或酰基 - 氨基羰基（C 4-8）烷基; 单 - 或二 - （C 1-6）烷基氨基（羟基）（C 4-8）烷基; 或R 4是基团UR 5，其中R 5是任选取代的双环碳环或杂环系统（A）：在每个环中含有至多四个杂原子，其中至少一个环（ a）和（b）是芳香族的; 当芳族环的一部分或非芳族环的一部分时，X 1为C或N。

4. 发明申请

WO2003064431A3 AMINOPIPERIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
公开(公告)号：WO2003064431A3
公开(公告)日：2003-08-07
申请号：PCT/EP2003/000824
申请日：2003-01-27
申请人： GLAXO GROUP LIMITED , DAINES, Robert, A , MILLER, William, Henry , PEARSON, Neil, David , PENDRAK, Israil , SEEFELD, Mark, Andrew
发明人： MILLER, William, Henry , PEARSON, Neil, David , PENDRAK, Israil , SEEFELD, Mark, Andrew
IPC分类号： C07D513/04
摘要： Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.

5. 发明申请

WO2003064431A2 AMINOPIPERIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：氨基哌啶化合物，其制备方法和含有它们的药物组合物
公开(公告)号：WO2003064431A2
公开(公告)日：2003-08-07
申请号：PCT/EP2003/000824
申请日：2003-01-27
申请人： GLAXO GROUP LIMITED , DAINES, Robert, A , MILLER, William, Henry , PEARSON, Neil, David , PENDRAK, Israil , SEEFELD, Mark, Andrew
发明人： MILLER, William, Henry , PEARSON, Neil, David , PENDRAK, Israil , SEEFELD, Mark, Andrew
IPC分类号： C07D513/04
CPC分类号： C07D417/14 , C07D513/04
摘要： Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
摘要翻译：氨基哌啶衍生物及其药学上可接受的衍生物可用于治疗哺乳动物，特别是人的细菌感染的方法。

6. 发明申请

WO2004002490A2 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2004002490A2
公开(公告)日：2004-01-08
申请号：PCT/EP2003/006754
申请日：2003-06-25
申请人： GLAXO GROUP LIMITED , AXTEN, Jeffrey, Michael , DAINES, Robert, A. , DAVIES, David, Thomas , GALLAGHER, Timothy, Francis , JONES, Graham, Elgin , MILLER, William, Henry , PEARSON, Neil, David , PENDRAK, Israil
发明人： AXTEN, Jeffrey, Michael , DAINES, Robert, A. , DAVIES, David, Thomas , GALLAGHER, Timothy, Francis , JONES, Graham, Elgin , MILLER, William, Henry , PEARSON, Neil, David , PENDRAK, Israil
IPC分类号： A61K31/535
CPC分类号： C07D491/04 , A61K31/03 , A61K31/535 , A61K31/54 , C07D513/04
摘要： Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
摘要翻译：哌啶衍生物及其药学上可接受的衍生物可用于哺乳动物，特别是人的细菌感染治疗方法。

7. 发明申请

WO2003064421A1 AMINOPIPERIDINE DERIVATIVES 审中-公开
标题翻译：氨基哌啶衍生物
公开(公告)号：WO2003064421A1
公开(公告)日：2003-08-07
申请号：PCT/EP2003/000823
申请日：2003-01-27
申请人： GLAXO GROUP LIMITED , DAINES, Robert, A , MILLER, William, Henry , PEARSON, Neil, David , PENDRAK, Israil , SEEFELD, Mark, Andrew
发明人： MILLER, William, Henry , PEARSON, Neil, David , PENDRAK, Israil , SEEFELD, Mark, Andrew
IPC分类号： C07D471/04
CPC分类号： C07D417/14 , C07D471/04 , C07D491/04 , C07D513/04
摘要： Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
摘要翻译：哌啶衍生物及其药学上可接受的衍生物可用于哺乳动物，特别是人的细菌感染治疗方法。

8. 发明申请

WO2006002047A2 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2006002047A2
公开(公告)日：2006-01-05
申请号：PCT/US2005/020950
申请日：2005-06-15
申请人： GLAXO GROUP LIMITED , MILLER, William, Henry , PENDRAK, Israil , SEEFELD, Mark Andrew
发明人： MILLER, William, Henry , PENDRAK, Israil , SEEFELD, Mark Andrew
IPC分类号： A61K31/496 , A61K31/4709
CPC分类号： C07D513/04 , C07D471/04 , C07D493/04 , C07D497/04 , C07D498/04
摘要： Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
摘要翻译：本文公开了用于治疗哺乳动物特别是人的细菌感染的萘，喹啉，喹喔啉和萘啶衍生物。

9. 发明申请

WO2014068388A1 2 SUBSTITUTED CEPHEM COMPOUNDS 审中-公开
标题翻译： 2替代CEPHEM化合物
公开(公告)号：WO2014068388A1
公开(公告)日：2014-05-08
申请号：PCT/IB2013/002423
申请日：2013-10-29
申请人： GLAXO GROUP LIMITED , SHIONOGI & CO., LTD.
发明人： LIAO, Xiangmin , PEARSON, Neil, David , PENDRAK, Israil , THALGI, Reema , YAMAWAKI, Kenji , YOKOO, Katsuki , SATO, Jun , KUSANO, Hiroki , AOKI, Toshiaki
IPC分类号： C07D505/24 , A61K31/546 , C07D501/50
CPC分类号： C07D501/48 , A61K9/0019 , C07D501/50 , C07D505/24 , Y02A50/473
摘要： The compounds of formula (I) of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.
摘要翻译：本发明的式（I）化合物与具有广谱抗菌谱的2-取代头孢烯化合物有关，特别是对产生β-内酰胺酶的革兰氏阴性细菌表现出有效的抗微生物活性，以及包含该化合物的药物组合物。

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