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1. 发明申请

WO2004041337A1 DEVICE 审中-公开
标题翻译：设备
公开(公告)号：WO2004041337A1
公开(公告)日：2004-05-21
申请号：PCT/EP2003/012436
申请日：2003-11-05
申请人： GLAXO GROUP LIMITED , BONNEY, Stanley, George , DAVIES, Michael, Birsha , RAND, Paul, Kenneth
发明人： BONNEY, Stanley, George , DAVIES, Michael, Birsha , RAND, Paul, Kenneth
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/0026 , A61M15/0068 , A61M15/0076 , A61M15/0081 , A61M15/08
摘要： A drug delivery device (1) for delivering to a patient a drug composition from a container (10) which contains the drug composition, the container adapted to be placed in a dispensing mode thereof on application of an actuating condition thereto. The device comprises a dispensing unit (5) adapted to receive the container, the dispensing unit having an actuating mechanism (51) operable to apply the actuating condition to the container and an outlet (59) through which the drug composition is dispensable from the device, and a removable casing unit (3) for the dispensing unit. The dispensing and casing units have securing features (21a,21b,41a,45) for releasably, fixedly securing the units together, and the dispensing unit is operable to apply the actuating condition to the container when fixedly secured to the casing unit and when independent from the casing unit.
摘要翻译：一种用于从容纳药物组合物的容器（10）向患者输送药物组合物的药物递送装置（1），所述容器适于在施加致动条件时被放置在其分配模式中。所述装置包括适于容纳所述容器的分配单元（5），所述分配单元具有可操作以将所述致动条件施加到所述容器的致动机构（51）和所述药物组合物可从所述装置分配的出口（59），以及用于分配单元的可移除的壳体单元（3）。分配和套管单元具有用于将单元可释放地固定地固定在一起的固定特征（21a，21b，41a，45），并且当固定地固定到壳体单元上时，分配单元可操作以将致动状态施加到容器上，并且当独立时从套管单元。

2. 发明申请

WO2004010978A1 MULTICOMPONENT PHARMACEUTICAL DOSAGE FORM 审中-公开
标题翻译：多功能药物剂型
公开(公告)号：WO2004010978A1
公开(公告)日：2004-02-05
申请号：PCT/GB2003/003157
申请日：2003-07-24
申请人： GLAXO GROUP LIMITED , BONNEY, Stanley, George , BROWN, Adrian , DAVIES, Michael, Birsha , MARGETSON, Daniel, N , MATTHEWS, Wayne, M. , MCALLISTER, Stephen, Mark , RAND, Paul, Kenneth , WILSON, Alan, Anthony
发明人： BONNEY, Stanley, George , BROWN, Adrian , DAVIES, Michael, Birsha , MARGETSON, Daniel, N , MATTHEWS, Wayne, M. , MCALLISTER, Stephen, Mark , RAND, Paul, Kenneth , WILSON, Alan, Anthony
IPC分类号： A61K9/20
CPC分类号： A61J3/071 , A61K9/2072 , A61K9/4808
摘要： A multi-component pharmaceutical dosage form suitable for retaining drug substance which drug substance can be released to provide a controlled drug release profile in the gastrointestinal environment, characterised by a body e.g. comprising a delayed release polymeric material such as Eudragit 4135F, the body having at least one cavity said cavity having a mouth opening and a film means e.g. comprising an immediate release polymeric material e.g. Eudragit E100 or a blend thereof, connected to the body and closing the mouth opening.
摘要翻译：一种适用于保留药物物质的多组分药物剂型，该药物物质可以释放，以在胃肠环境中提供受控的药物释放特征，其特征在于身体例如。包括延迟释放聚合材料，例如Eudragit 4135F，所述本体具有至少一个腔，所述腔具有开口和膜装置，例如，包括立即释放的聚合材料，例如 Eudragit E100或其混合物，连接到身体并关闭开口。

3. 发明申请

WO2004011071A1 MEDICAMENT DISPENSER 审中-公开
标题翻译：药物分配器
公开(公告)号：WO2004011071A1
公开(公告)日：2004-02-05
申请号：PCT/EP2003/008152
申请日：2003-07-23
申请人： GLAXO GROUP LIMITED , BONNEY, Stanley, George , DAVIES, Michael, Birsha
发明人： BONNEY, Stanley, George , DAVIES, Michael, Birsha
IPC分类号： A61M15/00
CPC分类号： A61M15/0086 , A61M11/005 , A61M11/06 , A61M15/0003 , A61M15/0026 , A61M15/0028 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/0051 , A61M15/0055 , A61M15/0065 , A61M15/0075 , A61M15/008 , A61M15/0083 , A61M15/0085 , A61M15/009 , A61M15/0093 , A61M15/0096 , A61M15/08 , A61M2016/0021 , A61M2202/064 , A61M2205/3546 , A61M2205/3576 , A61M2205/505 , A61M2205/581 , A61M2205/80 , A61M2205/8206 , A61M2205/825 , A61M2205/8281 , A61M2205/8293 , A61M2206/16
摘要： There is provided a unitary dispensing device for use in the delivery of a first medicament and at least one further medicament. The device comprises a first medicament dispenser (330) for the delivery of the first medicament and at least one further medicament dispenser (340) for the delivery of the at least one further medicament. The first medicament dispenser (330) and the at least one further medicament dispenser (340) enable the first and the at least one further medicament to be kept separate until the point of delivery. The first medicament dispenser (330) is different in type to the at least one further medicament dispenser (340).
摘要翻译：提供了一种用于递送第一药物和至少一种其它药物的单一分配装置。该装置包括用于递送第一药物的第一药物分配器（330）和用于递送至少一种其它药物的至少一个另外的药物分配器（340）。第一药物分配器（330）和至少一个另外的药物分配器（340）使得第一和至少一个其它药物能够保持分开直到输送点。第一药剂分配器（330）的类型与至少一个另外的药物分配器（340）不同。

4. 发明申请

WO2004011068A1 MEDICAMENT DISPENSER 审中-公开
标题翻译：药物分配器
公开(公告)号：WO2004011068A1
公开(公告)日：2004-02-05
申请号：PCT/EP2003/008149
申请日：2003-07-23
申请人： GLAXO GROUP LIMITED , BONNEY, Stanley, George , DAVIES, Michael, Birsha
发明人： BONNEY, Stanley, George , DAVIES, Michael, Birsha
IPC分类号： A61M15/00
CPC分类号： A61M15/00 , A61M15/0003 , A61M15/0071 , A61M15/008 , A61M15/0083 , A61M2205/52 , G06F19/00 , G06Q50/24
摘要： There is provided a medicament dispenser device (10) for use in the delivery of a combination medicament product. The dispenser (10) comprises a first medicament container (41) for containing a first medicament component; a first release means (42) for releasing the contents of said first medicament container (41); at least one further medicament container (41) for containing at least one further medicament component; and at least one further release means (42) for releasing the contents of each said at least one further medicament container 41). The first medicament component is kept separate from the at least one further medicament component until the point of release thereof for delivery in combination. The dispenser (10) additionally comprises an electronic control system (50) for controlling the release of contents from the first and at least one further medicament container (41).
摘要翻译：提供了用于递送组合药物产品的药物分配器装置（10）。分配器（10）包括用于容纳第一药物组分的第一药物容器（41）用于释放所述第一药物容器（41）的内容物的第一释放装置（42）; 至少一个另外的药物容器（41），用于容纳至少一种其它药物成分; 以及用于释放每个所述至少一个另外的药物容器41）的内容物的至少一个另外的释放装置（42）。将第一药物组分与至少一种其它药物组分保持分离直到其释放点为组合递送。分配器（10）还包括用于控制从第一和至少一个另外的药物容器（41）释放内容物的电子控制系统（50）。

5. 发明申请

WO2004011067A1 MEDICAMENT DISPENSER 审中-公开
标题翻译：药物分配器
公开(公告)号：WO2004011067A1
公开(公告)日：2004-02-05
申请号：PCT/EP2003/008144
申请日：2003-07-23
申请人： GLAXO GROUP LIMITED , BONNEY, Stanley, George , DAVIES, Michael, Birsha
发明人： BONNEY, Stanley, George , DAVIES, Michael, Birsha
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0043 , A61M15/0051 , A61M15/0055 , A61M15/0071 , A61M15/0076 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/009
摘要： There is provided a medicament dispenser device (100) for use in the delivery of a combination medicament product. The device comprises a first medicament container (101a) for containing a first medicament component; first release means (106a) for releasing the contents of said first medicament container (101a); at least one further medicament container (101b) for containing at least one further medicament component; at least one further release means (106b) for releasing the contents of each said at least one further medicament container (101b); and mixing means (140) for promoting the mixing of the released contents of the first and at least one further medicament container (101a, b). The first medicament component is kept separate from the at least one further medicament component until the point of release thereof for delivery in combination.
摘要翻译：提供了用于递送组合药物产品的药物分配器装置（100）。该装置包括用于容纳第一药物组分的第一药物容器（101a）用于释放所述第一药物容器（101a）的内容物的第一释放装置（106a）; 用于容纳至少一种其它药物成分的至少一个另外的药物容器（101b）至少一个释放装置（106b），用于释放每个所述至少一个另外的药物容器（101b）的内容物; 以及用于促进第一和至少一个另外的药物容器（101a，b）的释放内容物的混合的混合装置（140）。将第一药物组分与至少一种其它药物组分保持分离直到其释放点为组合递送。

6. 发明申请

WO2003061744A1 MEDICAMENT DISPENSER 审中-公开
标题翻译：药物分配器
公开(公告)号：WO2003061744A1
公开(公告)日：2003-07-31
申请号：PCT/EP2003/000599
申请日：2003-01-22
申请人： GLAXO GROUP LIMITED , BONNEY, Stanley, George , DAVIES, Michael, Birsha
发明人： BONNEY, Stanley, George , DAVIES, Michael, Birsha
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0043 , A61M15/005 , A61M15/0051 , A61M15/0055 , A61M15/0068 , A61M15/007 , A61M15/008 , A61M15/009 , A61M2202/064
摘要： There is provided a medicament dispenser (200)for use in the delivery of a combination medicament product. The dispenser (200) comprises first and second medicament containers (201a, 201b) for containing first and second medicament active component; and first and second release means (216a, 216b) for releasing respective dose portions of the first and second medicament active component from the first and second medicament containers (201a, 201b). The first medicament active component is kept separate from the second medicament active component until the point of release thereof for delivery in combination. The first medicament active component is selected from the group consisting of salmeterol, formoterol and any salts or solvates thereof. The second medicament active component is selected from the group consisting of beclomethasone ester, fluticasone ester and any salts or solvates thereof.
摘要翻译：提供了用于递送组合药物产品的药物分配器（200）。分配器（200）包括用于容纳第一和第二药物活性组分的第一和第二药物容器（201a，201b）以及用于从第一和第二药物容器（201a，201b）释放第一和第二药物活性成分的各剂量部分的第一和第二释放装置（216a，216b）。将第一药物活性成分与第二药物活性成分保持分离，直到其释放点为组合递送。第一药物活性成分选自沙美特罗，福莫特罗及其任何盐或溶剂化物。第二药物活性成分选自倍氯米松酯，氟替卡松酯及其任何盐或溶剂化物。

7. 发明申请

WO2003061743A1 MEDICAMENT DISPENSER 审中-公开
标题翻译：药物分配器
公开(公告)号：WO2003061743A1
公开(公告)日：2003-07-31
申请号：PCT/EP2003/000598
申请日：2003-01-22
申请人： GLAXO GROUP LIMITED , ANDERSON, Gregor, John, McLennan , BONNEY, Stanley, George , DAVIES, Michael, Birsha , LINTELL, Daniel, Thomas, De Sausmarez , WILSON, Alan, Anthony
发明人： ANDERSON, Gregor, John, McLennan , BONNEY, Stanley, George , DAVIES, Michael, Birsha , LINTELL, Daniel, Thomas, De Sausmarez , WILSON, Alan, Anthony
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/00 , A61M15/0003 , A61M15/0043 , A61M15/0051 , A61M15/0055 , A61M15/0068 , A61M15/0078 , A61M15/008 , A61M2016/0021 , A61M2202/064
摘要： There is provided a medicament dispenser (600) for use with plural elongate form medicament carriers (601), each having multiple distinct medicament dose portions carried thereby, the dispenser (600) having a dispensing mechanism (620) for dispensing the distinct medicament dose portions carried by each of the plural medicament carriers (601). The mechanism comprises a receiving station (602) for receiving each of the plural medicament carriers; a release for releasing a distinct medicament dose portion from each of the plural medicament carriers on receipt thereof by the receiving station; an outlet (624), positioned to be in communication with the distinct medicament dose portions releasable by said a release (620); and an indexer (606) for individually indexing the distinct medicament dose portions of each of the plural medicament carriers (601).
摘要翻译：提供了一种用于多个细长形式的药物载体（601）的药物分配器（600），每个细长形式药物载体（601）具有由其承载的多个不同的药物剂量部分，分配器（600）具有分配机构（620），用于分配不同药物剂量部分由多个药物载体（601）中的每一个承载。该机构包括用于接收多个药物载体中的每一个的接收站（602）用于从接收站接收多个药物载体中的每一个释放不同药物剂量部分的释放物; 出口（624），定位成与由所述释放（620）可释放的不同药物剂量部分连通; 以及用于对多个药物载体（601）中的每一个的不同药物剂量部分进行单独索引的分度器（606）。

8. 发明申请

WO2005087615A1 A FLUID DISPENSING DEVICE 审中-公开
标题翻译：流体分配装置
公开(公告)号：WO2005087615A1
公开(公告)日：2005-09-22
申请号：PCT/GB2005/000944
申请日：2005-03-10
申请人： GLAXO GROUP LIMITED , BONNEY, Stanley, George , CONNELL, Hugh, Alexander , DAVIES, Michael, Birsha , GODFREY, James, William , HEDLEY, Mark, Graham , TANSLEY, Robert, William
发明人： BONNEY, Stanley, George , CONNELL, Hugh, Alexander , DAVIES, Michael, Birsha , GODFREY, James, William , HEDLEY, Mark, Graham , TANSLEY, Robert, William
IPC分类号： B65D83/14
CPC分类号： B05B11/3059 , A61M11/08 , B05B11/0037 , B05B11/3052 , B05B11/3056
摘要： The present invention relates to a fluid dispensing device (1405) for dispensing a fluid product having a dispensing outlet (1411) from which the fluid product is dispensable, a supply of the fluid product, a dispensing member (1430) mounted for movement in a dispensing direction along an axis X-X from a first position to a second position which causes a dose of the fluid product in the supply to be dispensed from the dispensing outlet, and a finger-operable actuator member (1420) mounted for movement in an actuating direction which is generally transverse to the axis. The actuator member has at least one cam surface (1422) and the dispensing member has at least one cam follower surface (1492). The at least one cam surface has a commitment section (1423a), oriented at a first angle to the axis, and an adjacent drive section (1423b), which is oriented at a second angle to the axis which is greater than the first angle.
摘要翻译：本发明涉及一种用于分配具有分配出口（1411）的流体产品的流体分配装置（1405），流体产品可从该分配出口（1411）被分配，流体产品的供应，安装成用于移动的分配构件（1430）沿着轴线XX从第一位置到第二位置的分配方向，其使得供应中的流体产品的剂量从分配出口分配;以及手指可操作的致动器构件（1420），其安装成沿致动方向运动其通常横向于轴线。致动器构件具有至少一个凸轮表面（1422），分配构件具有至少一个凸轮从动表面（1492）。所述至少一个凸轮表面具有相对于轴线成一定角度的承诺部分（1423a）和相对于大于第一角度的轴成第二角度的相邻驱动部分（1423b）。

9. 发明申请

WO2004011070A1 MEDICAMENT DISPENSER 审中-公开
标题翻译：药物分配器
公开(公告)号：WO2004011070A1
公开(公告)日：2004-02-05
申请号：PCT/EP2003/008151
申请日：2003-07-23
申请人： GLAXO GROUP LIMITED , BONNEY, Stanley, George , DAVIES, Michael, Birsha
发明人： BONNEY, Stanley, George , DAVIES, Michael, Birsha
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M11/005 , A61M11/06 , A61M15/0003 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/0051 , A61M15/0055 , A61M15/0065 , A61M15/0066 , A61M15/008 , A61M15/0083 , A61M15/0085 , A61M15/0086 , A61M15/009 , A61M15/0096 , A61M2016/0021 , A61M2202/064 , A61M2205/3546 , A61M2205/3576 , A61M2205/505 , A61M2205/581 , A61M2205/80 , A61M2205/8206 , A61M2206/16
摘要： There is provided a medicament dispenser device for use in the delivery of a multi-component combination medicament product. The device comprises a first medicament container containing plural co-formulation compatible medicament components; first release means for releasing the contents of the first medicament container for delivery thereof; at least one further medicament container, each containing at least one co-formulation incompatible medicament component; and at least one further release means for releasing the contents of each at least one further medicament container for delivery thereof. The at least one co-formulation incompatible medicament component is kept separate from the plural co-formulation compatible components until the point of release thereof for delivery in combination.
摘要翻译：提供了用于递送多组分组合药物产品的药物分配器装置。该装置包括含有多个配制成分相容的药物成分的第一药物容器; 第一释放装置，用于释放用于输送第一药物容器的内容物; 至少一个另外的药物容器，每个药物容器含有至少一种共配方不相容的药物成分; 以及至少一个另外的释放装置，用于释放每个至少一个另外的药物容器的内容物用于输送。将至少一种共配方不相容的药物组分与多种共配方相容成分保持分开，直至其释放点组合用于递送。

10. 发明申请

WO2004050153A1 HOLDER FOR A DISPENSING CONTAINER SYSTEM 审中-公开
标题翻译：分配容器系统的支架
公开(公告)号：WO2004050153A1
公开(公告)日：2004-06-17
申请号：PCT/EP2003/012508
申请日：2003-11-05
申请人： GLAXO GROUP LIMITED , DAVIES, Michael, Birsha , GODFREY, James, William , RAND, Paul, Kenneth
发明人： DAVIES, Michael, Birsha , GODFREY, James, William , RAND, Paul, Kenneth
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0068
摘要： A holder (5) for holding a dispensing container system (7) which is adapted to dispense a quantity of a fluid contained therein on movement thereof relative to the holder and further includes a dispensing counter means (12) for counting the number of quantities of the fluid dispensed. The holder has a moulded plastics body (37) with inner and outer (39) surfaces. The inner surface bounds a cavity adapted to receive the dispensing container system in movable relation thereto. The cavity has a moulded counter advance means (61) which is adapted in use to engage the dispensing counter means on relative movement between the dispensing container system and the body to advance the dispensing counter means to indicate the dispensing of a quantity of the fluid. The body is formed with an outlet port (59) in communication with the cavity such that the fluid dispensed from the dispensing container system is dischargeable therethrough. Moreover, an aperture (100) extends through the body from the outer surface to the inner surface in alignment with the counter advance means.
摘要翻译：一种用于保持分配容器系统（7）的保持器（5），所述分配容器系统（7）适于将容纳在其中的流体相对于所述保持器移动，并且还包括分配计数器装置（12）流体分配。支架具有内表面和外表面（39）的模制塑料体（37）。内表面限定适于以可移动关系接收分配容器系统的空腔。空腔具有模制的计数器提前装置（61），其适于在分配容器系统和主体之间的相对运动上接合分配计数装置，以推进分配计数装置以指示一定量的流体的分配。主体形成有与空腔连通的出口（59），使得从分配容器系统分配的流体可从其中排出。此外，孔（100）从计数器提前装置与外表面延伸穿过主体至内表面。

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